Association of waist-to-height ratio with all-cause and obesity-related mortality in adults: a prospective cohort study.

Background: The waist-to-height ratio (WHtR) is the optimal indicator for assessing obesity-related diseases. Establishing a unified standard for investigating the relationship between WHtR and mortality is an urgent need.

Methods: This cohort study included 47,741 U.

Sensory and neural responses to flavor compound 3-Methylbutanal in dry fermented sausages: Enhancing perceived overall aroma.

This study investigated the impact of 3-methylbutanal (0, 60, 120, 180, 240, and 300 μg/kg) on aroma and neural responses in fermented sausages. Among 33 volatiles identified, 3-methylbutanal exhibited the highest odor activity value of 868, indicating its dominant contribution. Sensory analysis showed that samples with 180 μg/kg received the highest ratings for savory (7.

Dienoic-Acid Coupling Effect Induced Hierarchical Interface for High-Performance Zinc Metal Batteries.

Rational pre-design of self-decomposed electrolyte additives to construct solid electrolyte interphase (SEI) for suppressing hydrogen evolution reaction (HER) and dendrite growth of zinc (Zn) anode confronts enormous challenges, especially for the in-depth understanding of structure-function relationship and the lack of reasonable design criteria. In this work, the dienoic-acid coupling effect is innovatively proposed to in-situ construct a hierarchical SEI layer (HSL) through the structural screening of a series of organic-acid molecules. Strong electron-withdrawing ability of dual carboxyl and metastable double bond can strengthen the self-decomposition tendency of trace electrolyte additive to form HSL via chemical and electrochemical reaction.

Multi-omics Analysis Reveals miR-7220-5p Alleviates NO Addictive Behaviors via NR2B/ERK/CREB Signaling.

Nitrous oxide use disorder (NUD) has recently received increasing social concern for its sharp rise among young people. However, the underlying mechanisms of NUD remain largely unexplored, which obstructs treatment strategy development and may exacerbate the epidemic of NO abuse. Thus, specifying the essential mechanisms and targets in NUD are desperately needed.

Protein Frustration Reveals Active Sites in Co-Evolved GPCR:G Protein Complexes and in Engineered Targeted Degrader Complexes.

The folded structure of a protein is understood to be an optimal energy state. However, previous studies have shown that certain amino acid residue positions that play a critical role in protein function are often in a suboptimal energy state or "frustrated". Here, we leverage over 1200 three-dimensional structures of G protein-coupled receptors (GPCRs) to demonstrate that residues at the interface between GPCR and its ligand or G protein contain a higher density of frustrated residues compared to other structural regions in the receptor.

Decorated high-dispersity Fe(OH) nanoparticles on NiZn LDH nanosheets towards enhanced alkaline oxygen evolution reaction.

The creation of efficient, earth-abundant electrocatalysts is crucial to address the sluggish kinetics of the oxygen evolution reaction (OER). In this study, a straightforward immersion technique is employed to fabricate a NiZnFe LDH composite by embedding Fe(OH) nanoparticles onto NiZn LDH nanosheets. The optimized NiZnFe LDH catalyst exhibits an overpotential of just 191 mV at 10 mA cm, significantly outperforming traditional OER catalysts.

Regulation of epigenetics and chromosome structure by human ORC2.

We report a multi-omics study in a human cell line with mutations in three subunits of origin-recognition complex (ORC). Although the ORC subunits should bind DNA as part of a common six-subunit ORC, there are thousands of sites in the genome where one subunit binds but not another. DNA-bound ORC2 compacts chromatin and attracts repressive histone marks to focal areas of the genome, but ORC2 also activates chromatin at many sites and protects the genes from repressive marks.

Enhancing Chemotherapy-Related Immune Responses via Bioorthogonal Metabolic Engineering-Driven Tumor Exosomes Elimination.

Tumor cell-driven exosomes (TExo) have exhibited several major drawbacks that hinder antitumor therapy. A representative immunosuppressive mechanism is the depletion of CD8+ cytotoxic T cells with the help of exosomal PD-L1. Another common mechanism is to promote tumor metastasis by promoting the seeding and growth of metastatic cancer cells in distant organs.

ameliorates fatty liver through microbiota-derived α-ketoisovaleric acid metabolism and hepatic PI3K/Akt signaling.

(Akk) has been shown to improve obesity via gut microbiota, while its effects on modulating gut fungi remain underexplored. This study investigates the effects of Akk on obese mice, focusing on gut fungi, metabolites, and hepatic lipid metabolism. We found that Akk treatment significantly modulated gut fungal diversity, enhanced gut immune responses, and improved fatty liver.

Xihuang pill suppressed primary liver cancer growth by downregulation of AFP and YAP signaling.

Ethnopharmacological Relevance: Xihuang Pill (XHP) is a traditional Chinese medicine formula that was originally used to treat malignant ulcers. Recent studies revealed its therapeutic effects on various malignant tumors. However, its potential efficacy and mechanisms in primary liver cancer (PLC) were not thoroughly investigated.

Economic Argument for Innovative Design From Valuing Patient-Centered Stroke Rehabilitation.

This study examines the economic benefits of innovative design in a hospital ward with the capital and operational costs and societal and government benefits. An economic view of health care delivery options considers both the costs and benefits of an intervention for the economy, funders, and patients. Previous studies have focused on the financial costs of capital as an asset class for hospital development.

Meplazumab, a CD147 antibody, for severe COVID-19: a double-blind, randomized, placebo-controlled, phase 3 clinical trial.

Meplazumab, a humanized CD147 antibody, showed favorable safety and clinical benefits in phase 1 and phase 2/3 seamless clinical studies. Further evaluation of its therapeutic efficacy in patients with severe COVID-19 is needed. In this phase 3 add-on study, we randomized patients with severe COVID-19 in a 1:1 ratio to receive 0.

Perimenopausal depression: Targeting inflammation and oxidative stress (Review).

Depressive disorder is a highly disabling condition that affects more than 300 million individuals worldwide, with women affected at a higher rate than men. With the aging of the population, the incidence of perimenopausal depression has risen markedly, seriously jeopardizing women's physical and mental health. Symptoms of perimenopausal depression include feelings of depression, stress, anxiety and endocrine dysfunctions, particularly hypogonadism and senescence.

Self-recoverable elastico mechanoluminescence of a hybrid metal halide crystal.

Materials exhibiting self-recoverable elastico mechanoluminescence (EML) are highly sought after due to their utility in sensing and information encryption. However, the current pool of identified EML materials remains limited, exclusively comprising purely inorganic substances. This study delves into the investigation of the EML properties of a zero-dimensional (0D) organic-inorganic metal halide denoted as [CHP]MnBr (where CHP signifies methyl triphenyl phosphonium).

XueBiJing injection reduced mortality in sepsis patients with diabetes.

Introduction: Sepsis patients with diabetes are at a high clinical risk. It is well reported that XueBiJing injection has good clinical benefit in sepsis individuals. However, there is no relevant report about the efficacy and safety of XBJ in sepsis patients with comorbid diabetes.

Biomimetic shunt effects to simultaneously regulate solvation and interface structure for high-performance Zn metal anode.

High-safety aqueous zinc (Zn) ion batteries confront hydrogen evolution reaction (HER) and dendrite growth of Zn anode, which can be well solved by electrolyte optimization and electrode modification. However, the simultaneously implementation of the electrolyte solvation structure and electrode/electrolyte interface regulation has been ignored and rarely investigated. In this work, inspired by shunt mechanism of hemicellulose in plant kingdom, xylan (XL) was designed and developed as a trace electrolyte additive (ZS@XL) to disperse in aqueous electrolyte and adsorb on Zn anode to simultaneously regulate solvation structure and electrode/electrolyte interface of Zn anode.

Insights from protein frustration analysis of BRD4-cereblon degrader ternary complexes show separation of strong from weak degraders.

PROteolysis TArgeting Chimeras (PROTACs), also known as ligand-directed degraders (LDDs), are an innovative class of small molecules that leverage the ubiquitin-proteasome system to induce the degradation of target proteins. Structure based design methods are not readily applicable for designing LDDs due to the dynamic nature of the ternary complexes. This study investigates the dynamic properties of five LDD-mediated BRD4-cereblon complexes, focusing on the challenges of evaluating linker efficiency due to the difficulty in identifying suitable computational metrics that correlate well with the cooperativity or degradation propensity of LDDs.

Unveiling the synergistic interface effects of Ag-deposited FeO/biochar catalysts to enhance wastewater degradation.

Photo-Fenton reaction is a sustainable and cost-effective wastewater treatment strategy capable of removing persistent organic pollutants. We utilized biochar (referred to as C) as a key component to enhance catalytic efficiency. Using a biomimetic templating method, we synthesized FeO on the biochar and deposited Ag on its surface, resulting in the Ag@FeO/C composite material (referred to as AFC).

Exploration of hospital room design on emotions, activity, and social connections after stroke: a qualitative study of patient experiences using virtual reality.

Unlabelled: Stroke patients are rarely asked about their responses to specific design attributes. Virtual reality (VR) offers a promising tool to explore how hospital environments are experienced after stroke.

Purpose: To gather perspectives and emotional responses regarding physical design attributes of hospital patient rooms after stroke.

Regulation of epigenetics and chromosome structure by human ORC2.

We report a multi-omics study in a human cell line with mutations in three subunits of Origin Recognition Complex (ORC). The ORC subunits bind to DNA independent of each other in addition to as part of a common six-subunit ORC. DNA-bound ORC2 compacts chromatin and attracts repressive histone marks to focal areas of the genome, but ORC2 also activates chromatin at many sites and protects the genes from repressive marks.

The disordered negatively charged C-terminus of the large HECT E3 ubiquitin ligase HERC2 provides structural and thermal stability to the HECT C-lobe.

Homologous to the C-terminus of E6AP (HECT) and RCC1-like domain (RLD)-containing protein 2 (HERC2) is a large, 528 kDa E3 ubiquitin ligase that is associated with cancer, oculocutaneous albanism type 2, Prader-Willi syndrome, and other neurological diseases. HERC2 has been found to contribute to double-stranded DNA break repairs, tumor suppression, maintaining centrosome architecture, and ubiquitylation. The C-terminal portion of the HECT domain (C-lobe) of HERC2 is responsible for transferring ubiquitin to a substrate but the precise function of the other eight domains in HERC2 are unknown.

High-viscoelasticity alginate-based coatings for reversible zinc metal anodes.

High-safety aqueous zinc (Zn) ion batteries are troubled by dendrite growth and hydrogen evolution reaction on Zn anode, which can be well solved via the construction of surface protective layer. The recent researches mainly focus on the bulk property of the protective layer, but its separation from Zn anode is ignored. In this work, high-viscoelasticity alginate-based (HVAA) layer was in-situ constructed on Zn anodes by the cross-linking of sodium alginate with formaldehyde and the plastifying of glycerin.

Anatomical study of pterygoid implants: artery and nerve passage through bone dehiscence of the greater palatine canal.

Purpose: Pterygoid implants are an alternative approach to avoid sinus-lifting or other grafting procedures. During pterygoid implant placement, dental surgeons risk damaging the greater palatine canal (GPC). However, they do not have sufficient reasons to avoid GPC injury.

Ultra-High Metal-Ion Selectivity Induced by Intramolecular Cation-π Interactions for the One-Pot Synthesis of Precise Heterometallic Architectures.

Heterometallic supramolecules, known for their unique synergistic effects, have shown broad applications in photochemistry, host-guest chemistry, and catalysis. However, there are great challenges to precisely construct heterometallic supramolecules rather than a statistical mixture, due to the limited metal-ion selectivity of coordination units. In particular, heterometallic architectures precisely encoded with different metal ions usually fail to form in a one-pot method when only one type of coordinated motif exists due to its poor metal-ion selectivity.