Macrophage Polarization in Heterotopic Ossification: Inflammation, Osteogenesis, and Emerging Therapeutic Targets.

Heterotopic ossification (HO) refers to an abnormal process characterized by the aberrant development of bone within soft tissues, leading to significant impairments in patients' mobility and overall quality of life. Macrophages, as a crucial element of the immune system, are instrumental in the different stages of heterotopic ossification through their dynamic polarization state (pro-inflammatory M1 and anti-inflammatory M2 phenotypes) and secretion of different cytokines. This review explores novel mechanisms of M1 and M2 macrophage-mediated heterotopic ossification, emphasizing the involvement of the inflammatory microenvironment, osteogenic factors, and osteogenic signaling pathways.

Anxiolytic Effects of L. Oligo-Polysaccharides by Modulating Gut Microbiota, Neuronal Signaling Pathways, and Neuroinflammation in Chronic Sleep Deprivation-Stressed Mice.

Prolonged sleep deprivation impairs brain function and increases the risk of mental health disorders. L. Oligo-polysaccharides (JSO), bioactive compounds derived from chicory, belong to the category of food-medicine homologous substances, possess gut microbiota-modulating and anti-inflammatory properties, and serve as a natural prebiotic, having significant research value in food science.

Comparison of Perfusion CT and Conventional Thin-slice Multiphase CT in the Diagnosis of Pancreatic Adenocarcinoma.

Rationale And Objectives: Perfusion CT parameters are reported to correlate with pancreatic adenocarcinoma's histopathological response to radiochemotherapy, yet research on morphological diagnosis of perfusion CT for the diagnosis of pancreatic adenocarcinoma is lacking. This study compares mean temporal (MT) post-processed perfusion CT with conventional thin-slice multiphase CT in visualizing tumors, small pancreatic arteries, and assessing tumor resectability.

Materials And Methods: 60 patients (mean age 61.

Study on the regulatory effects of Δ4-DES and LACS genes on the synthesis of LC-PUFAs, based on the transcriptome changes induced by fluridone in Aurantiochytrium limacinum OUC86.

In this study, fluridone was utilized to induce Aurantiochytrium limacinum OUC86 to identify the key genes involved in the synthesis of Long-chain Polyunsaturated Fatty Acids (LC-PUFAs). With the increase of fluridone concentration, the lipid content increased, the proportion of EPA was the highest under the treatment of 75 mg/L fluridone ethanol solution. Transcriptome sequencing analysis of A.

Rigid organic molecule pillared TiC towards high rate capability and fast sodium ion storage.

MXenes are promising two-dimensional layered anode materials for rechargeable batteries due to their outstanding electrical conductivity, high specific surface area, and tunable surface functional groups. However, serious self-stacking of the layered structure and the sluggish sodium diffusion kinetics lead to inferior rate capability and cycling stability. Herein, an organic molecular pillaring strategy is reported to enlarge the interlayer spacing of TiC through a dehydration condensation reaction between the -COOH groups of 3,3',4,4'-benzene tetracarboxylic acid (BTCA) molecules and the -NH groups of TiC-NH, which enables rigid organic BTCA molecules to be chemically pillared into the interlayers of TiC (TiC-BTCA).

Fibroblasts in heterotopic ossification: mechanisms and therapeutic targets.

Heterotopic ossification (HO) refers to the abnormal formation of bone in non-skeletal tissues. Fibroblasts have traditionally been viewed as stationary cells primarily responsible for producing extracellular matrix during tissue repair and fibrosis. However, recent discoveries regarding their plasticity-encompassing roles in inflammation, extracellular matrix remodeling, and osteogenesis-highlight their potential as key contributors to the development of HO.

Non-surgical vs. surgical treatment of distal radius fractures: a meta-analysis of randomized controlled trials.

Purpose: To compare the clinical outcomes between nonsurgical and surgical treatment of distal radius fracture.

Methods: We performed a systematic literature search by using multiple databases, including Medline, PubMed, and Cochrane. All databases were searched from the earliest records through February 2023.

Angiogenesis in heterotopic ossification: From mechanisms to clinical significance.

Heterotopic ossification (HO) refers to the formation of pathologic bone in nonskeletal tissues (including muscles, tendons or other soft tissues). HO typically occurs after a severe injury and can occur in any part of the body. HO lesions are highly vascularized.

AMPK induces PIAS3 mediated SUMOylation of E3 ubiquitin ligase Smurf1 impairing osteogenic differentiation and traumatic heterotopic ossification.

AMP-activated protein kinase (AMPK) is a typical sensor of intracellular energy metabolism. Our previous study revealed the role of activated AMPK in the suppression of osteogenic differentiation and traumatic heterotopic ossification, but the underlying mechanism remains poorly understood. The E3 ubiquitin ligase Smurf1 is a crucial regulator of osteogenic differentiation and bone formation.

Cardiovascular and renal safety outcomes of hypoxia-inducible factor prolyl-hydroxylase inhibitor roxadustat for anemia patients with chronic kidney disease: a systematic review and meta-analysis.

This systematic review and meta-analysis were conducted to evaluate the cardiac and kidney-related adverse effects of roxadustat for the treatment of anemia in CKD patients. 18 trials with a total of 8806 participants were identified for analysis. We employed a fixed-effects model for analysis.

Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study.

Objectives: Type 2 diabetic kidney disease (DKD), a chronic microvascular complication of diabetes, may exhibit a complex interrelation with coagulation function. This study is aimed at elucidating the association between coagulation function and DKD.

Methods: This was a real-world observational study conducted in Beijing, involving 2,703 participants.

Association between serum complements and kidney function in patients with diabetic kidney disease.

Objective: We aimed to explore the association between serum complements and kidney function of diabetic kidney disease (DKD) in Chinese patients.

Methods: This is a retrospective study involving 2,441 participants. DKD was diagnosed according to the Kidney Disease: Improving Global Outcomes (KDIGO) categories.

Berberine and aspirin prevent traumatic heterotopic ossification by inhibition of BMP signalling pathway and osteogenic differentiation.

Heterotopic ossification (HO) is a pathological process that often occurs in soft tissues following severe trauma. There is no effective therapy for HO. The BMP signalling pathway plays an essential role in the pathogenesis of HO.

Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease.

The study aimed to examine the association of three anemia-related biomarkers with the adequacy of peritoneal dialysis (PD) in patients with chronic kidney disease (CKD). This study included 127 PD patients. The total Kt/V urea (Kt/V) was calculated according to the Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines.

BaoShenTongLuo formula protects against podocyte injury by regulating AMPK-mediated mitochondrial biogenesis in diabetic kidney disease.

Background: Mitochondrial dysfunction is considered to be an important contributor in podocyte injury under diabetic conditions. The BaoShenTongLuo (BSTL) formula has been shown to reduce podocyte damage and postpone the progression of diabetic kidney disease (DKD). The potential mechanisms underlying the effects of BSTL, however, have yet to be elucidated.

Association between thyroid hormones and diabetic kidney disease in Chinese adults.

Objective: We aimed to explore the association between thyroid hormones and different stages of diabetic kidney disease (DKD) in Chinese adults.

Methods: This is a retrospective study involving 2,832 participants. DKD was diagnosed and classified according to the Kidney Disease: Improving Global Outcomes (KDIGO) categories.

Metabolic reprogramming: A novel therapeutic target in diabetic kidney disease.

Diabetic kidney disease (DKD) is one of the most common microvascular complications of diabetes mellitus. However, the pathological mechanisms contributing to DKD are multifactorial and poorly understood. Diabetes is characterized by metabolic disorders that can bring about a series of changes in energy metabolism.

A predicting model of child-bearing-aged women' spontaneous abortion by co-infections of TORCH and reproductive tract.

To develop a predicting model of child-bearing-aged women' spontaneous abortion (SA) by co-infections of TORCH and reproductive tract, in order to provide a reference tool for accurately predicting the risk of SA and guide the early prevention, diagnosis and treatment of SA. A prospective cohort study was designed based on 218 958 child-bearing-aged women following up in Hebei province in China from 2010 to 2017. Multivariable logistic regression analysis was used to select candidate predictive variables.

A Deletion Upstream of SOX10 Causes Light Yellow Plumage Colour in Chicken.

Chicken plumage colour is a complex trait controlled by many genes. Herein, through Rhode Island Red (RIR) and White Leghorn (WL) F1 cross populations, the segregation of plumage color was observed in females, showing white in males, and dark red (DR) and light yellow (LY) in females. The white has been found to be caused by dominant white alleles () and the DR phenotype is attributed to a sex-linked recessive silver allele (S∗S).

Estimation of nitrogen supply for winter wheat production through a long-term field trial in China.

Excessive synthetic nitrogen (N) applications, high mineral N accumulation and low N use efficiency (NUE) are current issues in intensively cultivated winter wheat production system impeding the sustainable development of agriculture in China. To solve these problems, soil accumulated N in the top 1 m of the soil profile before sowing (N), returned straw-N from the previous maize crop (N) and fertilizer N application (N) should be comprehensively considered N supply sources in N management. As such, the objective of this research was to determine the optimal total N supply (TN) level needed to meet crop requirements while minimizing environmental impacts.

Author Correction: Record thermopower found in an IrMn-based spintronic stack.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Record thermopower found in an IrMn-based spintronic stack.

The Seebeck effect converts thermal gradients into electricity. As an approach to power technologies in the current Internet-of-Things era, on-chip energy harvesting is highly attractive, and to be effective, demands thin film materials with large Seebeck coefficients. In spintronics, the antiferromagnetic metal IrMn has been used as the pinning layer in magnetic tunnel junctions that form building blocks for magnetic random access memories and magnetic sensors.

Long-distance propagation of short-wavelength spin waves.

Recent years have witnessed a rapidly growing interest in exploring the use of spin waves for information transmission and computation toward establishing a spin-wave-based technology that is not only significantly more energy efficient than the CMOS technology, but may also cause a major departure from the von-Neumann architecture by enabling memory-in-logic and logic-in-memory architectures. A major bottleneck of advancing this technology is the excitation of spin waves with short wavelengths, which is a must because the wavelength dictates device scalability. Here, we report the discovery of an approach for the excitation of nm-wavelength spin waves.

Origin of the emergence of higher T than bulk in iron chalcogenide thin films.

Fabrication of epitaxial FeSeTe thin films using pulsed laser deposition (PLD) enables improving their superconducting transition temperature (T ) by more than ~40% than their bulk T . Intriguingly, T enhancement in FeSeTe thin films has been observed on various substrates and with different Se content, x. To date, various mechanisms for T enhancement have been reported, but they remain controversial in universally explaining the T improvement in the FeSeTe films.

[Clinical intervention research on mental stress-induced myocardial ischemia].

Objective: To observe the impact of Xinkeshu on top of standard medication on psychological stress-related emotional and biophysiological parameters in patients with mental stress-induced myocardial ischemia (MSIMI).

Methods: A randomized controlled clinical trial was conducted on 40 patients with MSIMI and patients were randomized into treatment group (n = 21) and control group (n = 19) by random number table method. Patients in the treatment group received Xinkeshu (12 capsules/d) on top of standard therapy, and the control group received placebo on top of standard therapy.