Analgesic and anti-inflammatory effects of Glycyrrhiza protein in an acute inflammatory pain model: Insights from metabolomic and transcriptomic profiling.

Ethnopharmacological Relevance: Licorice has been used as an herbal remedy in alternative medicinal systems, such as Ayurveda and traditional Chinese medicine (TCM), for millennia. According to traditional Chinese medicine theory, Glycyrrhiza protein (GP) relieves pain. Some studies have found that GP can be used as a drug delivery carrier, indirectly or directly promoting anti-inflammatory and analgesic effects.

Integrated chemical composition, transcriptomics, and network pharmacology to reveal the mechanism of Jia-Wei-Si-Miao-Yong-An Decoction in ACS model rats.

Background: Acute Coronary Syndrome (ACS), as the most critical pathological type of coronary atherosclerotic heart disease, has a high morbidity and lethality, and the long-term treatment of modern medicine is still faced with the problems of restenosis, microcirculation obstruction and drug resistance. The addition of Traditional Chinese Medicine provides new ideas for ACS treatment. Our previous study found that Jia-Wei-Si-Miao-Yong-An decoction (HJ11) can improve the inflammatory response and cardiac function in ACS.

Substance basis and fermentation mechanism study of the analgesic and anti-inflammatory effects of Tibetan medicine Wuwei Ganlu based on JiuQu fermentation.

Ethnopharmacological Relevance: Wuwei Ganlu, as an integral part of the Tibetan medical system known as "Sowa Rigpa" originates from the formulations documented in the "Four Tantras". It is recognized by UNESCO as an intangible cultural heritage, representing a body of traditional knowledge and practice. Fermentation, a crucial step in the preparation of Wuwei Ganlu, has not been fully understood in terms of its mechanisms and its impact on the material basis and pharmacological efficacy of the medicine.