Transcatheter aortic valve implantation in a patient with isolated aortic regurgitation using JenaValve.

This case report details the successful use of JenaValve for transcatheter aortic valve implantation in a male patient in his early 50s with severe aortic regurgitation. The patient had multiple comorbidities, including chronic kidney disease and heart failure, increasing the risk of surgical intervention. JenaValve, a second-generation device with unique positioning and anchoring mechanisms, was deployed successfully, resulting in immediate improvements in cardiac function without significant regurgitation or paravalvular leakage.

Extraction of maize growth stages in the Sanjiang Plain of China from 2003 to 2022 and their spatio-temporal changes in response to meteorological variables.

How to quickly monitor the growth process of maize on a large scale is crucial for regional maize growth assessment, yield estimation, and farmland management. This article takes the Sanjiang Plain in Northeast China as the research area, which is the main grain production area in China. Using MODIS NDVI time series data and Savitzky Golay and Whittaker filtering techniques, a remote sensing extraction method for key growth stages of maize (i.

Development of a Nanostructured Lipid Carrier Drug Delivery System for the Essential Oil of Zanthoxylum Bungeanum Maxim. To Effectively Ameliorate Depression.

Zanthoxylum bungeanum Maxim., a traditional Chinese cash crop, produces pericarps (huajiao) that are widely used as condiments and herbal medicines. Zanthoxylum bungeanum Maxim.

APPLICATION OF SHELL TECHNIQUE IN C-TIRADS COMBINED WITH STE IN DIAGNOSIS OF C-TIRADS GRADE 4-5 NODULES.

Objective: To analyze the diagnostic value of the Shell technique in the Chinese Thyroid Imaging Reporting and Data System (C-TIRADS) combined with Shear Wave Elastography (STE) for differentiating benign and malignant C-TIRADS grade 4-5 nodules.

Methods: A retrospective analysis was performed on 279 patients (with a total of 286 C-TIRADS grade 4-5 nodules) who underwent thyroid fine-needle aspiration biopsy (FNA) or surgery. Nodules were differentiated as benign or malignant using C-TIRADS classification, STE, and their combination.

PKD-YOLOv8: A Collaborative Pruning and Knowledge Distillation Framework for Lightweight Rapeseed Pest Detection.

As an important oil and vegetable crop, rapeseed is widely planted and has important economic value worldwide. Rapeseed is often threatened by various pests during its growth. In order to effectively deal with rapeseed pests, this paper proposes a lightweight method based on collaborative compression learning.

The ROS-FOXO pathway mediates broad-spectrum detoxification of acaricides in Tetranychus cinnabarinus.

Arthropods have evolved advanced metabolic detoxification pathways that have helped them adapt to complex stresses induced by plant secondary metabolites and synthetic pesticides. Nonetheless, how xenobiotics induce the suite of intracellular metabolic changes important for detoxification in arthropods remains unexplored. In this study, we found that the ancient oxidative stress signaling pathway has adapted to transmit the detoxification signal in T.

Optimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment.

This work describes the discovery of a new series of Aurora kinase inhibitors based on quinazoline skeleton derived from , as well as the first X-ray cocrystal structure complexes of vinyl-quinazoline with Aurora A. Replacing pyrimidine with quinazoline improved anticancer activity and facilitated cocrystal formation. Compounds and showed excellent Aurora A kinase inhibition, with IC values of 6.

Construction of a 3D bioprinted skin model for psoriasis research and drug evaluation.

Psoriasis is a chronic inflammatory skin disease involving complex genetic, immune, and environmental interactions. Currentmodels fail to fully replicate the human psoriatic microenvironment, while animal models are limited by species differences and ethical concerns, restricting their applicability in pathogenesis studies and drug screening. Here, we present a human-derivedpsoriasis model constructed via 3D bioprinting.

Novel Indoline Derivatives as Ferroptosis Inhibitors: Synthesis, Biological Evaluation, and Mechanistic Investigation.

Ferroptosis, a form of regulated cell death characterized by excessive lipid peroxidation, has been implicated in various neurological disorders. Ferrostatin-1 (Fer-1), a well-known ferroptosis inhibitor, exhibits therapeutic potential but suffers from poor metabolic stability, limiting its applications. In this study, a phenotype-based screening of an in-house compound library is conducted and a novel ferroptosis inhibitor, TJC-2-1, is identified.

Effects of aromatherapy on sleep quality in patients: Protocol for an umbrella review.

Introduction: Poor sleep quality affects disease recovery and overall quality of life. Aromatherapy has been shown to improve sleep quality by alleviating anxiety, promoting relaxation, and enhancing blood circulation. Several meta-analyses have reported the effects of aromatherapy on sleep quality, however, the efficacy varies widely, with some studies showing that the effects are negligible or inconsistent.

Multi-omics reveals Fuyuan Xingnao Decoction's therapeutic mechanism in cerebral infararction via gut microbiota and JAK2-STAT3 pathway.

Ethnopharmacological Relevance: Cerebral infarction is a cerebrovascular disorder characterized by ischemic and hypoxic necrosis of brain tissue resulting from vascular occlusion, leading to subsequent neurological deficits. Fuyuan Xingnao Decoction (FYXN) has been traditionally used for the prevention and treatment of cerebral infarction at Longhua Hospital, affiliated with Shanghai University of Traditional Chinese Medicine. However, its targeted intervention in the brain remains to be fully elucidated.

The molecular mechanism by which miR-206-regulated JunD expression influences myoblast proliferation and differentiation in yaks.

Jun dimerization protein D (JunD), a member of the activating protein-1 transcription factor family, serves as a key regulator of mammalian myogenesis by orchestrating cell cycle progression and coordinating the network of myogenic differentiation determinants. miR-206 exhibits tissue-specific expression in skeletal muscle, with abundant representation across miRNA expression profiles in multiple mammalian species. Although both JunD and miR-206 are critically involved in muscle development, their specific roles in yak skeletal muscle ontogeny remain poorly characterized, particularly regarding the regulatory axis involving miR-206-mediated targeting of JunD during myoblast proliferation and differentiation.

Wearable pulse monitoring system for evaluating cardiovascular parameters based on tapered no-core fiber.

We developed a highly sensitive tapered no-core fiber (TNCF)-based cardiovascular monitoring system featuring a glycerol-filled polydimethylsiloxane (PDMS) sac design that minimizes alignment errors. The system achieves 0.339 dB/kPa vibration sensitivity, 0.

Predicting Anti-Cancer Drug Response Based on Hypergraph Representation Learning.

Accurate prediction of drug responses is critical for advancing personalized cancer therapies. Although current graph neural network (GNN)-based approaches predominantly focus on pairwise interactions between cell lines and drugs, they often neglect the potential of higher-order interactions. In this study, we present HRLCDR, a novel computational framework that utilizes Hypergraph Representation Learning to predict Cancer Drug Responses.

Using Multi-Feature Weak Consensus Model to Discover Essential Proteins.

Essential proteins play an essential role in cell survival and replication. Currently, more and more computational methods are developed to identify essential proteins, which overcome the time-consuming, costly and inefficient shortcomings with biological experimental methods. In order to improve the recognition rate, some new methods by fusing multiple features are developed, but they seldom consider the connection among features.

Lactate Dehydrogenase C4 Accelerates Triple-Negative Breast Cancer Progression by Promoting Acetyl-CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation.

Lactate-induced protein lysine (K) lactylation is inherently connected to cellular metabolism and is implicated in oncogenesis. As a crucial glycolytic enzyme in lactate metabolism, lactate dehydrogenase C4 (LDHC4) has undefined yet potentially significant biological functions and mechanistic roles in triple-negative breast cancer (TNBC) that warrant further investigation. This study aims to determine whether and how LDHC4 affects TNBC progression by regulating protein lactylation.

MMP-9 regulates disulphide isomerase activity of TGM2 to enhance fusion glycoprotein-mediated syncytium formation of respiratory syncytial virus.

Respiratory syncytial virus (RSV) exploits host proteases to enhance its replication efficiency; however, the precise mechanisms remain unclear. Through high-throughput screening, we identified four matrix metalloproteinase 9 (MMP-9) inhibitors (including JNJ0966 and doxycycline hyclate) that suppress RSV infection in vitro and in vivo. Mechanistic studies revealed a proteolytic cascade wherein MMP-9 cleaves transglutaminase 2 (TGM2) at the PVP375↓VR site, generating an N-terminal fragment (1-375) that activates its protein disulfide isomerase (PDI) activity.

Association between neutrophil percentage to albumin ratio and cardiovascular disease in the metabolic syndrome population.

The association between inflammation and cardiovascular disease (CVD) is increasingly garnering attention. However, the association between neutrophil percentage to albumin ratio (NPAR) and CVD in the metabolic syndrome population remains unclear. Therefore, we employed a large-scale epidemiological database to investigate this association.

Trapezoidal prism-coupled SPR.

The reason the prism-based SPR scheme can be regarded as a commercial solution is that it has some advantages, such as good stability, high-sensitivity, and so on. However, due to the special optical propagation property of the traditional commonly used triangular prism, there is a seemingly random and inaccurate surface plasmon excitation angle that is unfavorable to regulate the light path and limit SPR miniaturization. Thus, a prism-coupled SPR system is developed by using a special trapezoidal prism function as a coupling element.

Most eligible candidates for primary tumor resection among metastatic colorectal cancer patients: a SEER-based population analysis.

Background: Primary tumor resection (PTR) can improve the prognosis and survival of some patients with metastatic colorectal cancer (mCRC). However, selecting candidates that may benefit from this intervention may be challenging. Therefore, we aim to construct a predictive model to help identify the most eligible candidates for PTR.

Preparation of water-soluble flame retardant by cottonseed meal degradation for durable homologous flame retardant of cotton fiber.

The concept of homologous flame retardant of cottonseed meal to cotton fiber is reported. According to the chemical bond characteristics of the amide bond, ester bond, and glycosidic bond in crude protein, crude fiber, and crude fat of cottonseed meal, we developed a new system of HO-HPO degradation of dissolved cottonseed meal to prepare flame retardant. The study focuses on preparing water-soluble flame retardant (HO-HPO degradation Cottonseed meal, HPCm) by one-pot degradation of cottonseed meal and achieving durable flame retardancy for cotton fiber.

Mixed-grade papillary urothelial carcinoma with a minor high-grade component shows a significantly worse clinical outcome than low-grade papillary urothelial carcinoma.

Grade heterogeneity is common in papillary urothelial carcinoma (PUC) of the urinary bladder. Mixed-grade PUC is generally treated as high-grade if the high-grade component accounts for ≥5 % of the tumor. However, the clinical behavior of predominantly low-grade PUC with a minor high-grade (<5 %) component remains uncertain.

The TCF7L2/miR-206/Cofilin1 axis promotes the metastasis of bladder cancer cells by regulating the formation of invadopodia.

Bladder cancer (BCa) is one of the most common malignant tumors of the urinary system, but its pathogenesis is still unclear. T1G3 BCa is particularly invasive and relapses readily after treatment, with progression to invasive cancer or distant metastasis. Therefore, identification of the molecular mechanism by which it invades and metastasizes to guide treatment and predict patient prognosis is needed.