Publications by authors named "Yuhan Mao"
Physiological Changes and Transcriptomics of in Response to High-Temperature Stress.
Biology (Basel)
August 2025
is a significant submerged macrophyte utilized in shrimp and crab aquaculture, yet it exhibits low thermotolerance. This study investigated the physiological responses and transcriptomic characteristics of under high-temperature stress (HTS). The results indicated that HTS significantly reduced the absolute growth rate (AGR) and photosynthetic efficiency of while concurrently elevating antioxidant enzyme activities, malondialdehyde (MDA) content, and concentrations of osmotic adjustment compounds.
View Article and Find Full Text PDFRespiratory syncytial virus (RSV) exploits host proteases to enhance its replication efficiency; however, the precise mechanisms remain unclear. Through high-throughput screening, we identified four matrix metalloproteinase 9 (MMP-9) inhibitors (including JNJ0966 and doxycycline hyclate) that suppress RSV infection in vitro and in vivo. Mechanistic studies revealed a proteolytic cascade wherein MMP-9 cleaves transglutaminase 2 (TGM2) at the PVP375↓VR site, generating an N-terminal fragment (1-375) that activates its protein disulfide isomerase (PDI) activity.
View Article and Find Full Text PDFThis case report introduces Professor 's experience of treating a patient with Wernicke encephalopathy using the "regulating spirit and promoting acupuncture method". The patient was diagnosed as spleen and stomach deficiency with internal liver wind. The treatment principle focused on regulating spirit and awakening the brain, strengthening the spleen, calming wind, and relaxing the tendons.
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- * A ferritin-based nanoparticle vaccine displaying a neutralizing epitope of FMDV was developed and tested for immunogenicity and protection in mice and guinea pigs, with positive results in immune responses observed.
- * The studied Hpf-T34E nanoparticles demonstrated superior vaccination potential, offering effective immunity and partial protection against FMD in model animals, indicating a promising direction for safe and efficient FMD vaccines.
[Recombinant porcine interferon-gamma expressed in CHO cells and its antiviral activity].
Sheng Wu Gong Cheng Xue Bao
December 2023
The aim of this study was to produce recombinant porcine interferon gamma (rPoIFN-γ) by Chinese hamster ovarian (CHO) cells expression system and to analyze its antiviral activity. Firstly, we constructed the recombinant eukaryotic expression plasmid pcDNA3.1-PoIFN-γ and transfected into suspension cultured CHO cells for secretory expression of rPoIFN-γ.
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- Juicing vegetables, particularly kale and dandelion, is believed to have anticancer properties, with kale showing the greatest effectiveness based on the bioavailability of beneficial phytochemicals.
- A new in vitro model was developed to test the effects of different vegetable juices on neuroblastoma cells, revealing that high concentrations of kale and dandelion juice significantly inhibited cancer cell growth, while spinach exhibited cytotoxic effects due to the presence of oxalate.
- The findings suggest that kale and dandelion are superior in promoting healthy cell function and inhibiting cancer growth, supporting their use in anticancer treatments and validating the model for further screening of juice-based interventions.