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Rationale: Salivary gland tumors account for approximately 3% of all tumors, most of which are benign, with pleomorphic adenomas being the most common, occurring mostly in middle-aged women, mostly originating from the major salivary glands and, to a lesser extent, from the minor salivary glands, with the tongue being a very rare site of occurrence. To date, case reports of pleomorphic adenoma at the root of the tongue are also rare.
Patient Concerns: A 56-year-old male patient with no obvious cause of foreign body sensation in the pharynx, sputum, no pain, no blood in the sputum, no dysphagia, and no difficulty in swallowing and breathing, which was significantly aggravated in the past 2 weeks, with difficulty in swallowing, breath-holding on lying down.
Diagnoses: computed tomography and magnetic resonance imaging revealed a soft tissue mass at the root of the left tongue, which involved the tongue body in the forward direction. Electronic laryngopharyngoscopy showed a left-sided tongue root mass with a poorly smooth mucosa, covered with a mucous white pseudomembrane and a localized brownish-black crust without active bleeding. The final pathological findings showed a pleomorphic adenoma.
Interventions: Postoperative symptomatic treatment was given, and the patient recovered well. Eight days after surgery, the patient was discharged from the hospital, and the pharyngeal pain basically subsided at the time of discharge, with no fever and no pharyngeal discomfort. Postoperative laryngoscopy showed smooth mucosa of the pharyngeal cavity, good pseudomembrane formation in the operated area, no active bleeding, no purulent secretions, and normal blood routine on recheck. The medical advice after discharge was firstly, full rest for 1 week, secondly, continue the oral anti-inflammatory treatment, 1 week after the operation need to review the outpatient clinic, finally, if there are any uncomfortable symptoms, seek medical attention in time.
Outcomes: At present, the patient has been followed up for half a year and has recovered well from the operation without any discomfort.
Lessons: It is very rare to find a pleomorphic adenoma of the tongue, and it occurs mostly in middle-aged women. In clinical diagnosis, it is sometimes difficult to distinguish it from malignant tumor of the tongue.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036001 | PMC |
http://dx.doi.org/10.1097/MD.0000000000033348 | DOI Listing |
Eye (Lond)
September 2025
Department of Ophthalmology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, China.
Case Rep Pathol
August 2025
Department of Pathology and Laboratory Medicine, University of California, Irvine, California, USA.
Salivary gland carcinosarcoma is a combination of malignant epithelial and sarcomatous tumors and can develop from a preexisting pleomorphic adenoma or de novo. These tumors are rapidly growing infiltrative tumors and have an extremely poor prognosis, with a high frequency of lymphatic and hematogenous spread at the time of diagnosis. Approximately half of the cases of carcinosarcoma arise from preexisting pleomorphic adenoma with a long-standing clinical history of parotid mass.
View Article and Find Full Text PDFLin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
September 2025
To summarize the clinical characteristics, diagnosis and treatment experience of salivary pleomorphic adenoma in children. Thirty patients with salivary pleomorphic adenomas treated in Beijing Childrens Hospital from January 2008 to December 2022 were retrospectively reviewed, including 11 boys and 19 girls, with the age ranging from 0.3 to 14.
View Article and Find Full Text PDFCureus
July 2025
Department of Oral and Maxillofacial Radiology, School of Dentistry, Matsumoto Dental University, Shiojiri, JPN.
Pleomorphic adenoma (PA) is the most common benign salivary gland tumor, typically arising from the parotid gland. PA of the submandibular gland is relatively uncommon and may present diagnostic challenges, particularly when imaging findings raise suspicion of malignancy. A 66-year-old woman presented with a painless mass in the left submandibular region.
View Article and Find Full Text PDFJ Dent (Shiraz)
September 2025
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Background: Progesterone (PR) plays a role in the differentiation and growth of various tissues. One of the most common carcinogenic mechanisms of PR is increasing cell proliferation and inhibiting their apoptosis. There are contradictory results from various studies about the expression level of PR receptors in salivary tumors.
View Article and Find Full Text PDF