A Case of Pleomorphic Adenoma of the Submandibular Gland Radiologically Suspected to be Malignant.

Pleomorphic adenoma (PA) is the most common benign salivary gland tumor, typically arising from the parotid gland. PA of the submandibular gland is relatively uncommon and may present diagnostic challenges, particularly when imaging findings raise suspicion of malignancy. A 66-year-old woman presented with a painless mass in the left submandibular region.

Influence of implant macrodesign and insertion load during implant placement on primary stability in artificial bone.

Background: Implant placement is a critical step for achieving primary stability. During this process, a compressive force, referred to as an "insertion load," is applied through a handpiece or manual driver. However, the influence of the insertion load has not been quantitatively investigated.

Relationship Between the Morphology of Oral Membranous Substances and Oral Wetness in Older Individuals Undergoing Long-Term Tube Feeding in Japan.

Aims: Oral membranous substances in tube-fed patients undergo temporal morphological changes, increasing the risk of asphyxiation. While xerostomia is hypothesized to influence these alterations, its precise relationship with oral wetness and specific morphological stages remains unclear. This study aimed to investigate oral wetness as an indicator of xerostomia and predictor of membranous substance formation.

Community-Based Micro-Elimination of Hepatitis C Virus in a Defined Rural Cohort: Outcomes From the Nagawa Project.

Background And Aims: Hepatitis C virus (HCV) infection remains a global public health concern, with many carriers remaining undiagnosed because of its asymptomatic nature. Although Japan was previously considered to be on track for national HCV elimination by 2030, recent global modeling studies and updated elimination dashboards indicate that Japan is currently not on track. This underscores the importance of locally coordinated efforts to detect residual cases.

Application of Gene Therapy to Oral Diseases.

Gene therapy has emerged as a promising therapeutic approach across various oral diseases. This review examines current applications and future prospects of gene therapy in dentistry, focusing on five key areas: oral cancer, cancer-related pain, xerostomia (dry mouth), dental caries, and periodontal disease. Recent advances in viral and non-viral vectors have enabled more efficient gene delivery systems, with particular success in cancer pain management through µ-opioid receptor gene transfer and xerostomia treatment using aquaporin-1 gene therapy.

Effect of insertion load on insertion torque value.

Background/purpose: This study examined the effect of insertion load on implant primary stability by evaluating the insertion torque and insertion time in various implant designs.

Materials And Methods: Four implant designs were tested, including one cylindrical implant standard (S), two hybrid implants tapered effect (TE) and bone level (BL), and one conical implant bone level tapered (BLT). Polyurethane bone models of the maxillary posterior region were used.

A cross-sectional interventional study on the effects of periodontal treatment on periodontal inflamed surface area and masticatory efficiency values according to the 2018 periodontal status classification.

Background: Periodontal inflamed surface area (PISA) and masticatory efficiency have been used to evaluate the relationship between systemic diseases and oral diseases. However, clear standards for PISA values and masticatory efficiency in relation to the severity of periodontitis are lacking. This study aims to evaluate PISA values and masticatory efficiency based on the 2018 periodontal status classification system.

Identification of novel macrophages and bone morphogenetic protein signals causing ectopic calcification and impairing muscle regeneration.

Ectopic calcification is an abnormal regenerative response occurring in various tissues following injury, surgery, or genetic mutations. However, its underlying mechanisms remain unclear. By comparing three macrophage depletion methods using clodronate liposome, Csf1r neutralizing antibody, and macrophage-specific gene deletion (), we found that F4/80(+)Csf1r(-) macrophages were specifically increased in calcified muscles in notexin-injected mice and BaCl-injected mice.

Differentiation of Oral Spindle Cell and Pleomorphic Lipomas From Their Mimics via Retinoblastoma Status Through Immunohistochemistry and Fluorescence In Situ Hybridization.

Background: The incidence of spindle cell/pleomorphic lipomas ranges from 2.2% to 47.2%.

Nitrate Prevents Sjögren's Disease by Modulating T Helper Cells via NF-κB Pathway Suppression.

Objective: Sjögren's disease (SjD) is a chronic autoimmune disease characterized by abnormal T helper (Th) cell distribution in the salivary glands (SGs). Although nitrate can regulate immune responses and preserve SGs function, its preventive effects on SjD remain unexplored.

Methods: Nonobese diabetic (NOD)/Ltj mice were used as a secondary Sjögren's disease (sSjD) animal model.

Asia-Pacific consensus for the management of osteoporosis in men.

Unlabelled: Osteoporosis in men is an underdiagnosed and undertreated condition that leads to significant morbidity and mortality, particularly in the aging population. This consensus report provides tailored guidelines for diagnosing, preventing, and treating male osteoporosis in the Asia-Pacific region by integrating global best practices with regional adaptations.

Purpose: To establish evidence-based, region-specific guidelines for the management of male osteoporosis in the Asia-Pacific region, addressing demographic and lifestyle factors.

Oral diadochokinesis performance correlates with mild cognitive impairment: a cross-sectional study.

Background: Oral dysfunctions that affect masticatory function, such as tooth loss, reportedly lead to malnutrition, which contributes to cognitive decline and the onset and progression of dementia. Previous studies on oral dysfunction have focused on older people already in need of nursing care. Therefore, we conducted a study of older people able to travel independently or with minor assistance to examine the relationship between oral and cognitive function in memory clinic study participants classified as cognitively normal, with mild cognitive impairment, or with dementia.

Association Between the Mandibular Inferior Cortical Shape on Panoramic Radiographs and the Prognosis of Hydroxyapatite Implant Placement.

Objective Dental implant therapy is a widely accepted treatment option for edentulous patients. However, implant success can be influenced by various factors, including systemic bone conditions such as osteoporosis. This study aimed to evaluate the association between the mandibular inferior cortical shape observed on panoramic radiographs and the prognosis of hydroxyapatite (HA)-coated implant placement in the maxilla.

Repetitive/rhythmic masticatory muscle activity under urethane anesthesia in guinea pigs: a descriptive pilot study.

Objectives: Rhythmic/repetitive masticatory muscle activity may occur spontaneously during cyclic alternations in unconscious brain states such as sleep. An experimental model is needed to clarify these underlying mechanisms. This study investigated jaw movements and masticatory muscle activity during cyclic state alternations under urethane anesthesia.

Macrophage depletion in male mice impairs extraction socket healing by disrupting bone regeneration and tissue repair.

Objectives: Macrophages play a critical role in tissue repair and bone regeneration by regulating inflammation, angiogenesis, and osteoblast differentiation. The present study examined the role of macrophages in extraction socket healing using a clodronate liposome-induced macrophage depletion model in mice, with a focus on both soft and hard tissue regeneration. We also investigated the involvement of cytokines, such as TGF-β, PDGF, and BMP2.

A Rare Case of Lipidized Fibrous Histiocytoma of the Oral Cavity.

Benign fibrous histiocytoma (FH) is a common cutaneous tumor that rarely occurs in the oral cavity. Lipidized FH is an uncommon variant characterized by abundant foam cells in collagenized stroma. To our knowledge, only a single case of oral lipidized FH affecting the tongue has been reported.

The Possibility of Plasma Membrane Transporters as Drug Targets in Oral Cancers.

Plasma membrane transporters are increasingly recognized as potential drug targets for oral cancer, particularly oral squamous cell carcinoma (OSCC). These transporters play crucial roles in cancer cell metabolism, drug resistance, and the tumor microenvironment, making them attractive targets for therapeutic intervention. Among the two main families of plasma membrane transporters, ATP-binding cassette (ABC) transporters have long been known to be involved in drug efflux and contribute to chemoresistance in cancer cells.

Antiresorptive Therapy to Reduce Fracture Risk and Effects on Dental Implant Outcomes in Patients With Osteoporosis: A Systematic Review and Osteonecrosis of the Jaw Taskforce Consensus Statement.

Objective: Placement of a dental implant in a patient on antiresorptive therapy has been hypothesized to increase the risk of medication-related osteonecrosis of the jaw (MRONJ) and/or impact implant survival. In patients with osteoporosis, the risk of MRONJ with antiresorptive therapy is only marginally higher than observed in the general population.

Methods: The International ONJ Taskforce conducted a systematic review of the literature and evaluated the outcomes of implant placement in individuals with osteoporosis receiving antiresorptive therapy.

Evaluation of Image Clarity in Smartglass-Supported Dynamic Computer-Assisted Implant Surgery: A Clinical Pilot Trial.

Objectives: This study evaluated the image quality of smartglass-supported Dynamic Computer-Assisted Implant Surgery (dCAIS) by testing discernibility with a Landolt ring chart reproduced with smartglasses and on the dCAIS monitor.

Materials And Methods: 15 participants' discernibility was measured under four conditions using Landolt rings. Each condition measured 13 visual acuity levels, with each level comprising three rings (39 rings per condition).

Difference in Bone Density in Young Women With Normal Occlusion and Malocclusion.

Introduction Acquisition of higher peak bone mass in young women may prevent postmenopausal osteoporosis. Many factors, including nutritional intake, influence peak bone mass. The masticatory ability associated with nutritional intake may be lower in young women with malocclusion than in those with normal occlusion.

Developmental Endothelial Locus-1 Promotes Osteoclast Differentiation and Activation.

Developmental endothelial locus-1 (DEL-1) has traditionally been characterized within the scientific community as having anti-inflammatory properties with potential inhibitory effects on osteoclast formation. Our investigation challenges this paradigm by examining expression in RAW264.7 cells and bone marrow-derived macrophages (BMMs) during osteoclastogenesis, as well as its functional impact on osteoclast development and activity.

Association Between the Bone Density of Alveolar and General Skeletal Bones in the Young.

Objective Osteoporosis-related fractures are a significant health issue in aging societies, necessitating effective screening and prevention strategies. While panoramic radiographs are widely used for osteoporosis screening via mandibular cortical bone morphology, there is insufficient consensus on the quantitative analysis of alveolar bone mineral density (al-BMD) using intraoral radiographs. This study aimed to measure al-BMD in young adults and investigate its relationship with general skeletal bone mineral density (gs-BMD) at the lumbar spine (LSBMD) and femoral neck (FNBMD).

Spontaneous Spheroids of hUC-MSCs Regulate Osteogenic Differentiation for Enhancing Osteogenesis.

Stem cells play a critical role in the regeneration process by proliferating and differentiating to form new bone tissue. However, stem cells tend to lose their stemness and pluripotency during expansion, resulting in reduced bone regeneration capacity after osteogenic induction. Our aim is to enhance the osteogenic impact of human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) through spontaneous spheroid .