A High-Quality Chromosome-Level Genome Assembly and Comparative Analyses Provide Insights into the Adaptation of (Fabricius, 1794) (Diptera: Calliphoridae).

, as one of the common blowflies, displays biological characteristics, such as ovoviviparity and carrion-feeding adaptation. Thus, this species is generally considered of significant ecological, medical, and forensic importance. However, without a high-quality pseudo-chromosome genome for , elucidating its evolutionary trajectory proved difficult.

Corrigendum to "Advances in sciatic nerve regeneration: A review of contemporary techniques" [Regen Ther, Volume 29C, (June 2025), 563-574].

[This corrects the article DOI: 10.1016/j.reth.

Nrf2 Activation Mitigates Silver Nanoparticle-Induced Ferroptosis in Hepatocytes.

Silver nanoparticles (AgNPs), a promising class of metallic nanomaterials with strong antibacterial properties and biomedical potential, are increasingly being used in a variety of consumer products. The widespread application of AgNPs has raised concerns about their toxicological effects, particularly their accumulation in the liver and the associated oxidative stress. However, the precise molecular mechanisms driving these effects remain unclear.

Patient-reported outcomes of the prognostic nutritional index for resectable esophageal squamous cell carcinoma.

Background: The prognostic nutritional index (PNI) involves both the nutritional status and immune function as crucial factors linked to the prognosis of various gastrointestinal cancers. The relationship between the PNI and postoperative quality of life (QOL) in patients with esophageal cancer (EC) has not been examined. This study sought to examine the effects of the PNI on the postoperative patient-reported outcomes (PROs) of patients with esophageal squamous cell carcinoma (ESCC).

Crystal facet regulation of tin for electrochemical carbon dioxide reduction to formate.

The electrochemical CO reduction reaction (CORR) to formate represents a promising route for high-value CO utilization, which helps address environmental issues and enables energy storage. Tin (Sn)-based catalysts are widely used in CORR for formate production, yet the impact of crystal facets remains unreported. Here, we revealed the effect of Sn facets on CORR to formate.

Perceiving Speaker's Certainty: The Interaction Among Subjectivity of Statement, Evidential Markers, and Evidence Strength.

Evidentiality is a linguistic category whose primary meaning is the source of information, which is generally divided into firsthand perception, hearsay, and inference. Evidential markers are the linguistic devices that indicate information sources. While considerable studies have revealed that evidential markers have an effect on the perceived speaker's certainty, no comparison on such an effect has been carried out in subjective and objective sentences.

Defect-Rich Porous Cu with Abundant Cu(100) for Acidic CO Electroreduction in Membrane Electrode Assembly.

Acidic electrocatalytic CO reduction (CORR) faces slow C-C coupling kinetics and dominant hydrogen evolution, resulting in low C yields and selectivity. Here, the porous copper nanosheets (pCu NS) are reported with abundant Cu(100) and defect sites for efficient acidic CORR to C products. In a membrane electrode assembly (MEA), the pCu NS electrodes achieved a remarkable 75.

Post-stroke aphasia analysis using topological alterations in brain functional networks.

. Nearly one-third of stroke patients develop aphasia. Although the function of classical language areas (e.

Orbital eccentricity and internal feedbacks drove the Triassic megamonsoon variability.

The evolution of the Triassic megamonsoon was closely linked to Earth's orbital variations. Despite recognizing secular orbital cycles as a fundamental pacemaker of the megamonsoon, the driving mechanisms remain unclear. Here, we use data-model synthesis to study orbital-scale megamonsoon variability during the Middle Triassic (~ 246-239 Ma).

Comparison of recurrence patterns between patients with thoracic esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy and postoperative adjuvant chemoradiotherapy.

Purpose: To compare the recurrence patterns and survival outcomes between patients with esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (NCRT) and adjuvant chemoradiotherapy (ACRT).

Methods: We retrospectively analyzed 267 patients with locally advanced ESCC who received treatment at Sichuan Cancer Hospital and Institute (Chengdu, China) between January 2018 and December 2020. Based on different treatment protocols, the patients were divided into two groups: NCRT (n=181) and ACRT (n=86).

Global cooling drove diversification and warming caused extinction among Carboniferous-Permian fusuline foraminifera.

The fossil record provides the only direct evidence of changes in biodiversity over time. Patterns in more inclusive taxonomic levels (e.g.

Impact of perineural invasion in thoracic esophageal squamous cell carcinoma-a retrospective study with long-term follow-up outcomes.

Background: The prognostic role of perineural invasion (PNI) in esophageal squamous cell carcinoma (ESCC) remains unclear. We aimed to assess the prognostic effects of PNI in resectable ESCC patients.

Methods: We retrospectively examined the medical records of patients who underwent esophagectomy from January 2010 to December 2017 at Sichuan Cancer Hospital.

Consistent spatial-temporal variations of stigmatic pollen load among co-flowering species across six sub-alpine meadows.

Co-flowering species may have evolved strategies to avoid or tolerate the adverse effects of heterospecific pollen deposition. However, the precondition for this evolutionary response is spatial-temporal stability, an aspect currently understudied. Here, we examined the spatial-temporal stability in conspecific and heterospecific pollen loads on stigmas across 19 co-flowering species in six sub-alpine meadow communities over four consecutive years.

Advances in sciatic nerve regeneration: A review of contemporary techniques.

Sciatic nerve injury, affecting the longest and thickest nerve in the human body, often leads to severe pain, weakness, and impaired motor function in the lower extremities. Despite the peripheral nervous system's inherent capacity for some degree of regeneration, complete recovery remains elusive, necessitating advanced therapeutic approaches. This review explores two promising modalities electrical stimulation (ES) and platelet-rich plasma (PRP) that have shown the potential to enhance nerve repair and functional recovery.

Neoadjuvant chemotherapy or chemoradiotherapy plus sintilimab versus neoadjuvant chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma: a study protocol of a multicentre, randomised, controlled, phase III trial (SCIENCE study).

Introduction: Oesophageal squamous cell carcinoma (ESCC) is a globally challenging digestive tract malignancy with poor prognosis and limited treatment options. Early-stage ESCC is often asymptomatic, leading to a late-stage diagnosis in many cases. Neoadjuvant therapy combined with surgery is the standard treatment approach for locally advanced ESCC.

Influencing factors and prediction model construction of posterior capsular opacification after intraocular lens implantation treated with Nd: YAG laser.

Objective: To explore the influencing factors of posterior capsular opacification (Posterior Capsular Opacification, PCO) after intraocular lens implantation treated with Nd: YAG(Neodymium: Yttrium-Aluminum-Garnet) laser and to establish a predictive model to evaluate its risk.

Methods: From January 2018 to June 2023, the data of 312 patients with posterior capsule opacification and Nd: YAG laser treatment in our hospital were retrospectively analyzed. All patients were randomly divided into training group (218 cases) and verification group (94 cases) at the ratio of 7:3.

Drug-Loaded Mitochondrial Targeted Nanoparticles for Tumor Imaging and PDT/PTT Combined Chemotherapy in Muscle-Invasive Bladder Cancer.

Neoadjuvant chemotherapy combined with radical cystectomy is the standard treatment for muscle-invasive bladder cancer (MIBC). While cisplatin-based regimens reduce postoperative recurrence, their severe toxicity often limits clinical application. Moreover, the need for urinary diversion after radical cystectomy significantly impacts quality of life, leading to reluctance toward surgery.

Floral trait dissimilarity indirectly decreases heterospecific pollen transfer through pollinator sharing in a subalpine meadow.

Co-flowering species are suggested to exhibit divergent floral traits to minimize interspecific competition. However, few studies have evaluated whether and by which pathways floral trait dissimilarity affects interspecific pollen transfer among co-flowering species, which limits our understanding of the interplay between mutualistic and competitive interactions within plant-pollinator networks. We conducted a three-year field investigation from 2021 to 2023 in a sub-alpine meadow in southwest China.

A Facile Method for Preparing Fluorinated Poly(aryl ether)s Toward High-Frequency Low Dielectric Materials.

Two fluorinated monomers M1 and M2 based on pentafluorostyrene, are synthesized via an aromatic nucleophilic substitution reaction (SNAr) at room temperature, with high yields of up to 90%. Subsequently, M1 and M2 are converted to fluorinated poly(aryl ether)s through thermo-crosslinking. Among the two polymers, cured M2 possessing higher fluorine content, demonstrates superior overall performance with a 5% weight loss temperature (T) of 465 °C, a low water uptake of 0.

An Investigation of Changes in Hemispheric Functional Connectivity after Stroke Based on fNIRS.

Stroke is a severe cerebrovascular disease. The understanding of the process of post-stroke brain recovery is crucial for prescribing rehabilitation plan. The resting-state functional connectivity (rsFC) has been used to analyze the brain functional networks with the aim to understand the post-stroke neuroplasticity.

Molecular residual disease assessment based on tumor-informed assay predict disease progression and postoperative recurrence of hepatobiliary cancer: A preliminary study.

BackgroundHepatobiliary cancers present a heterogeneous group of diseases, and molecular residual disease (MRD) evaluation based on circulating tumor DNA (ctDNA) is anticipated to offer greater sensitivity in monitoring disease progression than glycoprotein-based tumor markers such as alpha-fetoprotein or carbohydrate antigen 19-9 (CA199).MethodsThe panels for MRD surveillance were customized for each patient based on their specific genetic mutation characteristics. The changes in ctDNA mean variant allele frequencies (mVAF) and single nucleotide variants (SNVs) were analyzed from baseline to post-operative and between post-operative measurements.