Financial toxicity and psychological distress in cardiovascular non-cancer multimorbidity: a latent profile analysis and causal weighting.

Background: Cardiovascular disease with multimorbidity imposes substantial long-term financial burdens. Financial toxicity, the financial burden associated with healthcare, is increasingly recognized as a psychosocial stressor affecting health outcomes among chronically ill populations. However, its psychological heterogeneity in non-cancer patients is understudied.

Effect of protease species on structure, interfacial behavior, and foaming properties of limited enzyme hydrolysis products of soybean protein isolate and mung bean protein.

Plant protein foams face limitations in foaming capacity (FC) despite their industrial potential. This study innovatively employed six distinct proteases (Trypsin, Alcalase, Papain, Neutrase, Compound proteinase, Flavourzyme) for limited enzymatic hydrolysis of soy protein isolate (SPI) and mung bean protein (MBP) to enhance their interfacial and foaming properties. Crucially, hydrolysis significantly reduced molecular weight and particle size, increased molecular flexibility, and lowered surface tension for both proteins.

Identification of the Novel HLA-E*01:154 Allele Using PolyseqOne and Oxford Nanopore Sequencing Technology.

HLA-E*01:154 differs from HLA-E*01:01:01:01 by a single nonsynonymous nucleotide substitution in codon 199 of exon 3.

Advances in emulsion stability: A review on mechanisms, role of emulsifiers, and applications in food.

Emulsions, as thermodynamically unstable systems with multiscale and multiphase structures, naturally destabilize over time. Their stability plays a vital role in industries like food, cosmetics, and chemical materials. For emulsion-based foods, stability is essential to preserve their nutritional value, texture, appearance, and flavor.

Research status and hotspots of oral frailty in older adults: a bibliometric analysis from 2013 to 2024.

Background: Oral frailty has emerged as a critical focus in public health due to its strong association with adverse health outcomes in older adults, such as cognitive decline, malnutrition, falls, disability, and mortality. Despite a growing body of research over the past decade, a comprehensive bibliometric analysis of this field remains lacking. This study addresses this gap by providing an overview of the research landscape, highlighting key achievements, identifying emerging trends, and proposing directions for future exploration.

Research trends and hotspots in the mental health of widowed older adults: a bibliometric analysis.

Background: The mental health of widowed older adults has garnered increasing research attention due to its profound impact on well-being and quality of life. Despite growing scholarly interest, a comprehensive bibliometric analysis of evolving research trends, key topics, and knowledge structures remains scarce. This study aims to identify key research themes, emerging trends, and interdisciplinary linkages to inform future studies on the mental health of widowed older adults.

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading.

The success of cancer immunotherapies is predicated on the targeting of highly expressed neoepitopes, which preferentially favours malignancies with high mutational burden. Here we show that early responses by type-I interferons mediate the success of immune checkpoint inhibitors as well as epitope spreading in poorly immunogenic tumours and that these interferon responses can be enhanced via systemic administration of lipid particles loaded with RNA coding for tumour-unspecific antigens. In mice, the immune responses of tumours sensitive to checkpoint inhibitors were transferable to resistant tumours and resulted in heightened immunity with antigenic spreading that protected the animals from tumour rechallenge.

Co-loaded aspirin and doxorubicin by chondroitin sulphate nanoparticles inhibited metastasis of breast cancer by squelching circulating tumor microemboli.

Platelets (PLTs) play a critical role in proliferation and migration of cancers, combination therapy based on chemotherapeutical and anti-PLT agents could inhibit tumor development. In this study, chondroitin sulphate (CS) was conjugated with doxorubicin (DOX) to synthesize CS-DOX through hydrazone bond, and aspirin (ASP) was encapsulated into CS-DOX to prepare a pH-responsive nanoparticle (ASP/CS-DOX). After being characterized, the anti-tumor effects of ASP/CS-DOX were pursued further.

Chromosome-level genome assembly of Nothapodytes nimmoniana.

Nothapodytes nimmoniana is a plant species belonging to the genus Nothapodytes in the family Icacinaceae. This species holds significant medicinal value due to its camptothecin content. In this study, we present the first chromosome-level genome assembly of N.

Health benefits of anthocyanins against age-related diseases.

Anthocyanins, a class of polyphenol flavonoids widely present in various fruits and vegetables, have attracted significant attention due to their potent anti-inflammatory, antioxidant, and anti-aging properties. Recent studies indicate that anthocyanins may play important roles in extending life and preventing or treating age-related diseases. This review systematically summarizes the chemical characteristics of anthocyanins and their potential roles in age-related diseases, including lifespan extension, neurodegenerative diseases, skeletal diseases, cardiovascular diseases, cancer, and metabolic syndrome.

Trace elements in Mytella strigata and Perna viridis from three Chinese coastal regions: comparison and safety assessments.

Food safety concerns affect life health. Mussels are a significant source of high-quality marine protein in China, but their ability to bioaccumulate heavy metals raises concerns regarding food safety, warranting further investigation. This study compares the concentrations of seven trace elements include six heavy metals (Cd, Cr, Hg, Pb, Cu, Zn) and harmful element inorganic arsenic (iAs) in the soft tissues of two mussel species, i.

Crystal Structure of EstZF172 Catalyzing Stereoselectively ()‑CNDE in Pregabalin Biosynthesis.

Pregabalin has garnered extensive clinical application for the management of neuropathic pain and epilepsy owing to its high efficacy and broad drug concentration range. EstZF172 is a key enzyme in the biosynthesis of pregabalin, capable of stereoselectively catalyzing the production of ()-CCMA from the key intermediate -CNDE. The novel crystal structure of EstZF172 indicates that it contains a highly conserved Ser-Lys-Tyr catalytic triad and belongs to the family VIII carboxylesterases.

S100A8 Mediates Autophagy and Apoptosis in Ovarian Cancer Cells via the PI3K/Akt Pathway.

Background: Ovarian cancer (OC) is one of the most lethal forms of gynecological malignancies. Previous studies indicate that S100 calcium-binding protein A8 (S100A8) regulation of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway has been implicated in the development and progression of a variety of cancers, but its effects and mechanisms in OC cells remain unclear. This study aims to explore the effect of S100A8 on autophagy and apoptosis in OC cells and the regulatory effects of the PI3K/Akt signaling pathway.

Development of Wearable Wireless Multichannel f-NIRS System to Evaluate Activities.

Functional near-infrared spectroscopy is a noninvasive neuroimaging technique that uses optical signals to monitor subtle changes in hemoglobin concentrations within the superficial tissue of the human body. This technology has widespread applications in long-term brain-computer interface monitoring within both traditional medical domains and, increasingly, domestic settings. The popularity of this approach lies in the fact that new single-channel brain oxygen sensors can be used in a variety of scenarios.

Investigating Anti-Tumor Effects of Irisin in Cervical Cancer Cells: Cell Viability, Migration, and Tumor-Associated Macrophage Polarization.

Background: Cervical cancer is a major concern in women's health. Investigating the biological behavior of cancer cells can help to understand the underlying pathogenesis and offer novel insights into disease management. Therefore, this study evaluated the effect of irisin on the biological behaviors of cervical cancer cells and elucidated its underlying mechanism.

The need for routine detection of the Asian-type DEL allele in individuals with weak or partial D phenotypes from East and Southeast Asian populations.

Background And Objectives: Among the rare serologically D-negative (D-) individuals in Asia, those carrying the Asian-type DEL allele (RHD*DEL1) can be safely managed as D+ individuals during transfusion and pregnancy. Recently, some individuals carrying RHD*DEL1, who exhibit serologically weak/partial D phenotypes rather than the serologically D- phenotype, have also been described. Whether anti-D alloimmunization can occur among them was explored.

Metal-organic frameworks for NH adsorption and separation.

Ammonia (NH) is not only an air pollutant but also a versatile and favourable chemical with widespread applications in human life. As a key component of nitrogen fertilizers, it plays a crucial role in improving crop yields. Additionally, NH serves as a hydrogen carrier and working fluid, contributing to the energy transition process.

p16INK4a downregulation alleviates temporomandibular joint osteoarthritis combined with type 2 diabetes by driving M2 polarization.

Temporomandibular joint osteoarthritis (TMJOA), sometimes combined with type 2 diabetes (T2DM-TMJOA), has a restricting effect on quality of life and currently has few efficacious treatment options. As such, this project sought to determine the role of p16INK4a (p16) in T2DM-TMJOA development. In vivo, p16 knockout (P16KO) mice experienced less condylar bone loss and altered macrophage polarities from the inflammatory M1 to anti-inflammatory M2.

Colorimetric sensor array constructed based on bimetallic porphyrin-based metal organic framework nanozyme for the detection and recognition of tannic acid.

Colorimetric sensor arrays based on nanozymes hold promise for the simultaneous detection of multiple target analytes, but the rational design of nanozymes with high catalytic activity remains a major challenge. Herein, a porphyrin-based metal organic framework (Zr-MOF) with bimetallic reaction centers (M - N) were prepared by solvothermal method. Zr-MOF nanozyme formed a redox cycle between different valence states, which significantly improved the peroxidase-like activity of the nanozyme, and further revealed its catalytic mechanism.

Boosting virus enrichment with macroporous magnetic sorbent based on ketoenamine covalent organic framework.

Effective surveillance and discovery of emerging and reemerging infectious viruses are crucial for predicting and controlling epidemic outbreaks. However, these efforts are significantly hindered by the low-titer existence of genetically diverse viruses in most field samples. Here, we report a macroporous-structured magnetic sorbent based on β-ketoenamine covalent organic framework (COF).

Ghrelin increases cis-platinum resistance and promotes aggressiveness of osteosarcoma by activating AKT and Wnt/β-catenin pathways.

Osteosarcoma (OS) is the most common primary bone malignancy because of its extra high tendency of metastasis. In-depth research is needed to uncover the pathogenesis of patients with OS cells. We collected 74 tissue samples from patients with OS cells and measured the expression levels of ghrelin by immunohistochemistry.

Dephenolization Methods, Quality Characteristics, Applications, and Advancements of Dephenolized Cottonseed Protein: Review.

Dephenolized cottonseed protein is a high-protein product obtained through the further dephenolization of cottonseed meal or by removing the lint and shell of cottonseed, extracting the oil at a low temperature, and subsequently eliminating toxic substances (gossypol). This paper presents a review of the latest advancements in the dephenolization methods, quality characteristics, and application domains of dephenolized cottonseed protein. It focuses on enhanced dephenolization methods, and summarizes the composition, structural characteristics, functional properties, and recent research developments.

Populations of the Invasive Mussel in China Showed Lower Genetic Diversity in Autumn than in Spring.

Native to tropical America, the charru mussel, , has been spreading rapidly in the West Pacific Ocean, including the South China Sea. In order to study the adaptive evolution of and examine the present status of invasion in China, the mitochondrial gene fragment was employed to analyze the genetic variations of seven populations sampled in both spring and autumn 2023. Results showed that all the populations had high haplotype diversity (>0.

Development of a prediction model based on Hemoglobin, Albumin, Lymphocyte count, and Platelet-score for lymph node metastasis in rectal cancer.

This study aimed to evaluate the ability of the preoperative Hemoglobin, Albumin, Lymphocyte count, and Platelet (HALP) score to predict lymph node metastasis (LNM) in patients with rectal cancer (RC) and improve prediction accuracy by incorporating clinical parameters. Data from 263 patients with RC were analyzed. The receiver operating characteristic (ROC) curve was used to determine the optimal cutoff value (OCV) for the HALP score in predicting LNM.

Physical Exercise: A Promising Treatment Against Organ Fibrosis.

Fibrosis represents a terminal pathological manifestation encountered in numerous chronic diseases. The process involves the persistent infiltration of inflammatory cells, the transdifferentiation of fibroblasts into myofibroblasts, and the excessive deposition of extracellular matrix (ECM) within damaged tissues, all of which are characteristic features of organ fibrosis. Extensive documentation exists on fibrosis occurrence in vital organs such as the liver, heart, lungs, kidneys, and skeletal muscles, elucidating its underlying pathological mechanisms.