Pemafibrate treatment produces antidepressant-like effects in CUMS and CRS models through activation of hippocampal PPARa and BDNF signaling.

Background: It is well established that peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the pathogenesis of depression. Several PPARα agonists, including WY14643, fenofibrate, and gemfibrozil, have been reported to produce antidepressant-like effects in mouse models through PPARα-mediated enhancement of hippocampal brain-derived neurotrophic factor (BDNF) signaling and neurogenesis. Pemafibrate is a novel and highly selective modulator of PPARα, and therefore, we hypothesised that it might also exhibit antidepressant-like efficacy.

The ETS transcription factor GABPA inhibits bladder cancer aggressiveness by repressing extracellular matrix deposition and mechanotransduction signaling.

The ETS transcription factor GABPA exhibits an oncogenic effect by activating telomerase in many cancers; however, some studies imply its tumor suppressive activities. It is thus important to define its different roles in oncogenesis. By examining GABPA-transgenic mice, we unexpectedly observed that Collagen I and III (Col I and III) contents were significantly reduced in murine dermis, which was accompanied by downregulation of prolyl 4-hydroxylase (P4HA2), an enzyme catalyzing collagen folding and fiber stabilization.

High Oxidation State V-O-Co Structure Promotes the Role of V-O Intermediates in Efficient HMF Oxidation.

Designing heterometallic oxygen-bridge structure (M1-O-M2) to achieve the efficient and stable electrochemical conversion of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) has become an important approach to address the rapid consumption of fossil fuels and mitigate white pollution. However, designing effective M1-O-M2 structures and elucidating their catalytic mechanisms remains a key challenge in this field. In this study, a high oxidation state V-O-Co structure is constructed by doping V into reconstructed CoOOH, which promotes the formation of the active intermediate V-O.

Early human albumin infusion was associated with 28-day mortality in patients with acute respiratory failure and hypoalbuminaemia in the intensive care unit: a retrospective study of the MIMIC-IV database.

Background: To investigate the relationship between different timing of human albumin infusion and mortality in patients with acute respiratory failure in an Intensive Care Unit (ICU).

Methods: This cohort study utilized data from the Medical Information Mart for Intensive Care (MIMIC-IV 2.0) database.

Wind-tide modulated net ecosystem metabolism in a Changjiang River Estuary aquaculture zone during mid-autumn.

The Changjiang River Estuary (CRE) supports critical fisheries and aquaculture industries. Net Ecosystem Metabolism (NEM) serves as a key indicator for assessing aquaculture ecosystem health, providing early warning of hypoxia risks, determining environmental carrying capacity, and guiding scientific aquaculture management. However, the hydrologic regime of the CRE, influenced by monsoons and strong tides, makes the combined effects of high-frequency wind and tidal variations on NEM dynamics poorly understood.

Comprehensive analyses of telomerase component DKC1 and its association with clinical, molecular and immune landscapes in uterine corpus endometrial carcinoma.

Background: Telomerase activation is essential to malignant transformation and progression including uterine corpus endometrial carcinoma (UCEC), while telomerase co-factor DKC1-mediated RNA pseudouridylation is required for functional telomerase by stabilizing telomerase RNA component (TERC) and its upregulation occurs in many cancers. Surprisingly, there is only one publication studying DKC1 in UCEC, which shows its significant downregulation.

Objective: DKC1 expression, its role in the UCEC molecular pathogenesis and clinical implications were comprehensively investigated.

ENDOGLUCANASE SlCEL2 and EXPANSIN SlEXP1 synergistically affect cellulose degrading and tomato fruit softening.

Delayed fruit softening in tomato (Solanum lycopersicum) is highly desirable for extending shelf life, facilitating long-distance transportation, and reducing post-harvest losses caused by mechanical damage. Fruit softening is a natural ripening process characterized by the increased expression of genes involved in cell wall modification, leading to the breakdown of cell wall polysaccharides and the gradual disintegration of cellular structure. The yft1 mutant (yellow-fruited tomato 1, originally designated n3122) exhibits inhibited ethylene production, preventing normal ripening and resulting in firmer fruit.

Photoelectrochemical biosensor with single atom sites for norepinephrine sensing and brain region synergy in epilepsy.

Norepinephrine (NE), a pivotal neurotransmitter in the central and sympathetic nervous systems, is crucial for numerous physiological and pathophysiological processes. Distinguishing NE from structurally similar dopamine and epinephrine in complex in vivo environments is a significant challenge. Herein, we propose a molecular docking strategy for selective, sensitive, and ultrafast detection of NE in vivo.

Metal-organic frameworks for NH adsorption and separation.

Ammonia (NH) is not only an air pollutant but also a versatile and favourable chemical with widespread applications in human life. As a key component of nitrogen fertilizers, it plays a crucial role in improving crop yields. Additionally, NH serves as a hydrogen carrier and working fluid, contributing to the energy transition process.

Antidepressant-like activity of Bezafibrate in mice models of depression: a behavioral and neurobiological characterization.

Background: Depression represents a major global public health challenge, inflicting profound suffering on patients while imposing substantial socioeconomic burdens on families and healthcare systems. Although monoamine-based antidepressants remain first-line pharmacotherapy, accumulating clinical evidence reveals several limitations of these medications, including delayed pharmacodynamics and low remission rates. Therefore, it is necessary to search for new drugs and develop effective strategies for depression treatment.

Bioinspired Dual-Site Photocathode with Atomic Molybdenum and Alkynyl Networks for Scalable Solar Ammonia Synthesis.

The Haber-Bosch process, while pivotal for global ammonia production, remains energy-intensive and environmentally unsustainable. Here, we report a nitrogenase-inspired photocathode (Mo/HsGDY@CuO) that synergistically integrates light-harvesting CuO nanowires, hydrogen-radical-generating alkynyl-rich graphdiyne (HsGDY), and atomically dispersed molybdenum sites for solar-driven nitrogen fixation. Mimicking the Fe/MoFe-cofactor collaboration in nitrogenase, the photocathode enables efficient N adsorption at Mo sites and hydrogen radical transfer from adjacent alkynyl groups, significantly lowering the energy barrier for N hydrogenation.

Regeneration and defense: unveiling the molecular interplay in plants.

In both plants and animals, tissue or organ regeneration typically follows wounding, which also activates defense responses against pathogenic microbes and herbivores. Both intrinsic and environmental cues guide the molecular decisions between regeneration and defense. In animal studies, extensive research has highlighted the role of various microbes - including pathogenic, commensal, and beneficial species - in influencing the signaling interplay between immunity and regeneration.

Effect of Functional Group-Modified UiO-66 on the Dehydrogenation of Ammonia Borane.

Ammonia borane (AB) has attracted much attention in the field of solid-state hydrogen storage due to its high hydrogen storage capacity. Nanoconfinement in UiO-66 can reduce the hydrogen release temperature. In particular, terephthalic acid was used as a linker to further improve the dehydrogenation properties through the modification of -NH, -OH, -NO, -Br, and -F groups.

Insomnia and its risk factors in patients with type 2 diabetes: A cross-sectional study.

Aims: Insomnia is notably prevalent among individuals with type 2 diabetes and adversely affects both glycemic control and overall quality-of-life. The objective of this study was to evaluate the possible risk factors for insomnia in patients diagnosed with type 2 diabetes and co-morbid insomnia.

Methods: This is a baseline study analyzing cross-sectional data at baseline timepoint collected in a randomized controlled trial study.

Microbial transformation of oleanonic acid by and the -anti-neuroinflammatory properties of products.

This research explored the microbial conversion of oleanonic acid by CGMCC 3.86. The scaled-up biotransformation processes produced ten distinct metabolites.

Fabrication of poly(vinyl alcohol)/sulfonated itaconic starch blend film with enhanced antibacterial performance and soil absorption capacity for environment-friendly packaging.

Plastic packaging is widely used due to its light weight, ease of processing, and cost-effectiveness, but improper disposal causes environmental pollution and resource waste. Developing environment-friendly packaging materials is urgent. Herein, a water-soluble poly(vinyl alcohol) (PVA)/starch blend film was proposed by combining modification and thermal processing, and its performance was evaluated.

Comprehensive integration of diagnostic biomarker analysis and immune cell infiltration features in sepsis via machine learning and bioinformatics techniques.

Introduction: Sepsis, a critical medical condition resulting from an irregular immune response to infection, leads to life-threatening organ dysfunction. Despite medical advancements, the critical need for research into dependable diagnostic markers and precise therapeutic targets.

Methods: We screened out five gene expression datasets (GSE69063, GSE236713, GSE28750, GSE65682 and GSE137340) from the Gene Expression Omnibus.

UV/blue-light-blocking polylactide films derived from bio-sources for food packaging application.

Transparent biodegradable packaging materials capable of blocking the broad-spectrum of UV and blue light (200-500 nm) are crucial for packaging of light-sensitive food. This study offers a fully bio-based solution based on polylactide and natural light absorbers, aloe-emodin (AE) and riboflavin (RF), whose combined UV-vis absorption spectrum covers all the light between 200 and 500 nm. AE and RF were bonded to polylactide chains by serving as initiators for the ring-opening polymerization of lactide, resulting in the synthesis of light-blocking polylactides, PLA-E and PLA-R.

Implantable photoelectrochemical-therapeutic methotrexate monitoring system with dual-atomic docking strategy.

The need for precise modulation of blood concentrations of pharmaceutical molecule, especially for high-risk drugs like Methotrexate (MTX), is underscored by the significant impact of individual variations on treatment efficacy. Achieving selective recognition of pharmaceutical molecules within the complex biological environment is a substantial challenge. To tackle this, we propose a synergistic atomic-molecular docking strategy that utilizes a hybrid-dual single-atom Fe1-Zn1 on a TiO2 photoelectrode to selectively bind to the carboxyl and aminopyrimidine groups of MTX respectively.

O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway.

Background: Lung ischemia-reperfusion (I/R) injury is a common clinical pathology associated with high mortality. The pathophysiology of lung I/R injury involves ferroptosis and elevated protein O-GlcNAcylation levels, while the effect of O-GlcNAcylation on lung I/R injury remains unclear. This research aimed to explore the effect of O-GlcNAcylation on reducing ferroptosis in pulmonary epithelial cells caused by I/R.

Triterpenoid saponins from Rubus setchuenensis roots and their anti-inflammatory activities in vitro.

Previously undescribed triterpenoid saponins (1-8), along with eight previously reported analogues (9-16), were isolated from an EtOAc extract obtained from the roots of Rubus setchuenensis. Structures were established based on HRESIMS, 1D and 2D NMR, as well as by literature comparisons. All compounds were isolated for the first time from the genus Rubus.

Predicting delayed neurological sequelae in patients with carbon monoxide poisoning using machine learning models.

Introduction: Delayed neurological sequelae is a common complication following carbon monoxide poisoning, which significantly affects the quality of life of patients with the condition. We aimed to develop a machine learning-based prediction model to predict the frequency of delayed neurological sequelae in patients with carbon monoxide poisoning.

Methods: A single-center retrospective analysis was conducted in an emergency department from January 01, 2018, to December 31, 2023.

Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment.

Cardiovascular diseases (CVDs) are the leading cause of mortality among individuals with noncommunicable diseases worldwide. Obesity is associated with an increased risk of developing cardiovascular disease (CVD). Mitochondria are integral to the cardiovascular system, and it has been reported that mitochondrial transfer is associated with the pathogenesis of multiple CVDs and obesity.

Characterization of a tomato chlh mis-sense mutant reveals a new function of ChlH in fruit ripening.

Tomato fruit ripening is a complex developmental process that is important for fruit quality and shelf life. Many factors, including ethylene and several key transcription factors, have been shown to play important roles in the regulation of tomato fruit ripening. However, our understanding of the regulation of tomato fruit ripening is still limited.

The Effect of Vegetation Ecological Restoration by Integrating Multispectral Remote Sensing and Laser Point Cloud Monitoring Technology.

This research aims to evaluate and monitor the effectiveness of vegetation ecological restoration by integrating Multispectral Remote Sensing (MRS) and laser point cloud (LPC) monitoring technologies. Traditional vegetation restoration monitoring methods often face challenges of inaccurate data and insufficient coverage, and the use of MRS or LPC techniques alone has its limitations. Therefore, to more accurately monitor the vegetation restoration status, this study proposes a new monitoring method that combines the advantages of the large-scale coverage of MRS technology and the high-precision three-dimensional structural data analysis capability of LPC technology.