Construction of chitin nanocrystal/poly(deep eutectic solvent) elastomers via glycidyl methacrylate associated modification, polymerization and crosslinking for artificial skin applications.

A one-pot strategy was developed to fabricate a strong and ductile elastomer composed of chitin nanocrystals and poly(deep eutectic solvent) (ChNC/PDES), based on a dual-network structure formed through glycidyl methacrylate (GMA)associated modification, polymerization and crosslinking. This approach enables the integrated pretreatment, chemical modification, and nanodispersion of chitin within a lactic acid/choline chloride deep eutectic solvent (DES) system. Whereafter, the ultraviolet initiated polymerization of GMA with ChNC and DES components produced a homogeneous elastomer with a maximum tensile strength of 4.

Individual and combined effects of maternal per- and polyfluoroalkyl substances exposure on preterm birth: a nested case-control study in China.

Background: Per- and polyfluoroalkyl substances (PFAS) are a large class of synthetic chemicals with ubiquitous human exposure. Maternal PFAS exposure has been linked with adverse birth outcomes, but their associations with preterm birth (PTB) remained ambiguous.

Methods: To assess the associations of individual and mixed PFAS exposure with preterm birth (PTB) and its subtypes (spontaneous and iatrogenic), a nested case-control study involving 177 PTB cases and 531 controls was conducted in Shanghai, China.

Analysis of Chemical Composition and Odor Characteristics in Particleboards Decorated by Resin-Impregnated Paper, Polypropylene Film and Polyvinyl Chloride Film.

Analysis of changes in TVOC and VOCs chemical composition or odor characteristics of particleboard before and after decoration treatment with resin-impregnated paper (RIP), polypropylene (PP) film and polyvinyl chloride (PVC) film were studied. The effects of these three decoration treatments on masking or suppressing the release of VOCs and odorants from particleboard were explored. The substances that were covered or suppressed and newly introduced before and after processing were identified to provide a basis for reducing the odor emissions of PVC-, PP- and RIP-decorated particleboard.

Investigation of Four Sets of NMR Spectra for One Racemic Compound of Pseudoresonance Structures.

A racemic compound, (*)-3-[(1*,3*)-3-hydroxy-1,3-dihydroisobenzofuran-1-yl]-2-(naphthalen-1-yl)-isoindolin-1-one (), was synthesized and found to exhibit four distinct sets of H and C NMR signals in CDCl solution. The four sets of H NMR signals displayed relative integration ratios of approximately 1:1:0.8:0.

The adverse impact of early postoperative complications after liver transplantation on long-term prognosis in patients with hepatocellular carcinoma.

Purpose: Liver transplantation (LT) is the main treatment for HCC patients, but postoperative complications such as early allograft dysfunction (EAD), acute rejection (AR), and biliary complications can affect the prognosis of patients. However, whether the occurrence of early complications after transplantation will affect the overall survival and tumor recurrence of patients have not been fully studied. We conducted a retrospective clinical study to evaluate the impact of early complications on overall survival and their relationship with HCC recurrence after liver transplantation.

NR4A1 Mediates Bronchopulmonary Dysplasia-Like Lung Injury Induced by Intrauterine Inflammation in Mouse Offspring.

Intrauterine inflammation (IUI) is involved in the development of bronchopulmonary dysplasia (BPD). Previously, we observed BPD-like pathological changes in a mouse model of IUI. This study aimed to identify the key molecules involved in IUI-induced lung injury, focusing on NR4A1.

Effects of myo-inositol on oocyte and early embryo development in Tibetan sheep.

Myo-inositol (MYO) is an essential compound within the ovarian follicular microenvironment, which facilitates the transmission of follicle-stimulating hormone signals in oocytes, thereby aiding in their maturation. Metabolomics analysis of follicular fluid from Tibetan sheep and in vitro maturation experiments have revealed the presence of myo-inositol; however, it remains uncertain whether the administration of exogenous myo-inositol can effectively enhance the maturation of Tibetan sheep oocytes. Consequently, this study was designed to explore the effects of myo-inositol supplementation on oocyte maturation and early embryo development.

Recovery of rare earth elements from sediments affected by mining activities.

Sediments affected by diverse mining activities contain elevated levels of rare earth elements (REEs), yet the feasibility of recovering REEs from these sediments remains unclear. In this study, we reviewed literature on REE-rich sediments impacted by various mining activities and focused on reservoir sediments in southern China affected by ion-adsorption REE mining as a case study. These sediments, formed from the aggregation of suspended colloids and particles transported by streams in mining areas, contained total REEs ranging from 0.

Toxic effects of microplastics on freshwater fish (Channa argus): mechanisms of inflammation, apoptosis, and autophagy.

This study examined the impact of Polystyrene microplastics (PS-MPs) on inflammation, apoptosis and autophagy within the liver, intestine, kidney, and gill of northern snakehead (Channa argus). In this study, 600 snakeheads (mean body weight: 10.5 ± 0.

sp. nov. and sp. nov., two -cryptoxanthin-producing bacteria isolated from intestinal contents of .

Four Gram-stain-positive, facultative anaerobic, yellow-pigmented and short rod-shaped strains, designated zg-Y625, zg-Y843, zg-Y1090 and zg-Y1211, were isolated from the intestinal contents of in Qinghai Province, PR China. Strains zg-Y625 and zg-Y1090 showed the highest 16S rRNA gene sequence similarities of 99.7% and 99.

Techniques, perioperative outcomes, prognosis, and survival associated with laparoscopic surgery for T3-T4a colon cancer.

Background: The efficacy of laparoscopic surgery for the treatment of T3-T4a colon cancer remains a subject of debate in the medical community.

Aim: To explore the surgical techniques, perioperative outcomes, follow-up results, patient prognosis, and survival status associated with laparoscopic surgery for T3-T4a colon cancer.

Methods: A total of 202 patients with T3-T4a colon cancer treated at the Affiliated Hospital of Hebei University between January 2020 and December 2024 were selected for this study and divided into two groups based on the type of surgery: Open surgery group (101 cases) and laparoscopic surgery group (LAP group, 101 cases).

Dapagliflozin promotes metabolic reprogramming against myocardial infarction through the MAPK-FOXO3-STC1 and HIF-1a-STC1 pathways.

Background: Myocardial infarction (MI) results in mitochondrial dysfunction and metabolic imbalance, ultimately causing cellular injury and impaired cardiac function. Dapagliflozin (DAPA) has been shown to reduce cardiovascular mortality; however, the underlying mechanisms by which it confers cardioprotection in MI remain incompletely understood.

Methods: To explore the protective role of DAPA, an oxygen-glucose deprivation (OGD) model was established in H9c2 cardiomyoblasts to assess its effects on cell proliferation, apoptosis, metabolism, and mitochondrial function.

Characterization of OSA-starch/tea polyphenol complexes with enhanced oil-water interfacial properties by molecular dynamics simulation and isothermal titration calorimetry.

Modifying the structure of natural emulsifiers can significantly alter their bulk properties and interfacial behavior. In this study, the binding mechanisms and interfacial adsorption of octenyl succinic anhydride starch (OSA-starch)/ epigallocatechin-3-gallate (EGCG) complexes were investigated for developing functional emulsifiers. Molecular dynamics simulations and isothermal titration calorimetry demonstrated that OSA-starch and EGCG interacted via van der Waals forces, electrostatic interactions, and hydrogen bonding.

Dietary aflatoxin B1 exposure induced the inflammation and apoptosis in freshwater fish (Channa argus) via disturbing ROS/ERS signaling axis.

This study examined the impact of aflatoxin B (AFB) on inflammation and apoptosis within the intestine and head kidney of freshwater fish - northern snakehead (Channa argus), focusing on the interaction between oxidative stress and endoplasmic reticulum stress (ERS) within the signaling pathways. In this study, 600 snakeheads, each weighing approximately 7.52 ± 0.

High-frequency KRAS mutations in pancreatic adenocarcinoma: prognostic significance and potential co-targeting therapies.

Background: Kirsten rat sarcoma viral oncogene homolog (KRAS) is among the most frequently mutated oncogenes across multiple cancers. Developing prognostic indicators based on KRAS mutations and advancing targeted KRAS inhibitors remain critical challenges in oncology. Notably, different KRAS mutations are associated with distinct biological behaviors, each carrying unique prognostic and therapeutic implications.

Kaempferol protects against doxorubicin-induced myocardial damage by inhibiting mitochondrial ROS-dependent ferroptosis.

Background: Doxorubicin (DOX), a widely used chemotherapeutic agent, is limited in clinical application due to its dose-dependent cardiotoxicity. Therefore, it is crucial to explore alternative therapeutic molecules or drugs for mitigating DOX-induced cardiomyopathy (DIC). In this study aimed to explore underlying mechanisms of the cardioprotective effects of Kaempferol (KP) against DIC.

Poly (vinyl alcohol)/carboxylated cellulose nanofibers composite hydrogel flexible strain sensors.

This study introduces a method for constructing a dual cross-linked hydrogel network via combined chemical and physical processes. Carboxylated cellulose nanofibers (CNF-C) and tannic acid (TA) were integrated into a borax-polyvinyl alcohol (PVA) matrix, followed by the incorporation of metal cations (Al) to fabricate PVA/CNF-C composite hydrogels. The PVA-TA@CNF-C-Borax-Al hydrogel forms a multi-crosslinked 3D network through dynamic borate ester bonds between PVA and borax, coordination bonds between TA and Al, and hydrogen bonds from CNF, endowing the hydrogel with excellent mechanical properties.

A synchronous control strategy of robot social behavior driven by scenario information and neural modulation mechanism.

Robots have been widely employed in scenarios that involve various environmental factors and social individuals. As one kind of social companion, robot is supposed to obey human social protocol and display anthropomorphic behaviors. In this paper, we focus on the problem of robot behavior control in multi-individuals scenarios, and build a coordinated robot behavior model containing body movement/orientation, head rotation and eyeball movement.

Altered Pharmacokinetics of Ropivacaine in Patients Undergoing Laparoscopic Major Hepatectomy.

Ropivacaine is primarily metabolized by the liver. High doses of ropivacaine, combined with altered pharmacokinetics due to hepatectomy, raise concerns about potential drug toxicity. We investigated the impact of LMH (laparoscopic major hepatectomy) on the pharmacokinetics of high-dose ropivacaine.

Natural History and Clinical Outcomes of Patients With Variant-Related Arrhythmogenic Right Ventricular Cardiomyopathy.

Background: Genetic variants in desmosomal cadherins, desmoglein 2 () and desmocollin 2 (), cause a distinct form of arrhythmogenic right ventricular cardiomyopathy (ARVC), which remains poorly reported. In this study, we aimed to provide a comprehensive description of the phenotypic expression, natural history, and clinical outcomes of patients with this ARVC subset.

Methods: Genetic and clinical data of and variant carriers were collected from 5 countries in Europe and Asia.

Pilot study of ultrasound-guided microwave ablation for inactivating excess remnant thyroid after surgery in patients with differentiated thyroid cancer.

Objectives: To evaluate the safety and efficacy of ultrasound (US)-guided microwave ablation (MWA) for inactivating excess remnant thyroid (RT) after surgery in patients with differentiated thyroid cancer (DTC).

Methods: This study was registered in the Chinese Clinical Trial Registry under the identifier ChiCTR2200063200 on September 1, 2022. This study enrolled consecutive postsurgery DTC patients who were scheduled for radioactive iodine ablation (RAI) therapy.

Investigating Causal Links Between Gut Microbiota and Neurological Disorders via Genome-Wide Association Studies.

Many reports have highlighted the involvement of the gut microbiome in the occurrence, progression, and outcomes of neurological disorders. However, current reports are somewhat chaotic, especially concerning whether the gut microbiota has a causal effect on various neurological diseases. Furthermore, whether there is a common mechanism involving gut microbial communities in these neurological disorders has not to be revealed.

Preparation and characterization of covalent starch-protein-tea polyphenol complexes with enhanced interfacial properties.

In this study, covalent octenyl succinic anhydride starch-soy protein- (-)-Epigallocatechin-3-gallate (OSAS-SP-EGCG) complexes were synthesized by HO/ ascorbic acid radical grafting method. Particle size, ζ-potential, Fourier transform infrared, and thermogravimetric results proved the formation of covalent OSAS-SP-EGCG complexes. The results of scanning electron microscopy and atomic force microscopy confirmed that the particles of the covalent complexes (especially 1:4 complexes) were more uniformly distributed.