Ultrasound-assisted enzymatic extraction optimization of Cistanche deserticola polysaccharides, and combined analysis of the relationship between polysaccharide structure and activity by liquid chromatography and GC-MS.

Cistanche deserticola polysaccharide (CDPS) serves as a key active component in both medicinal and edible functional foods. By optimizing the enzyme ratio and ultrasonic extraction parameters, the extraction yield was raised to 23.83 %, and four fractions (CDPS-1 to CDPS-4) were obtained through graded purification.

Acid-Responsive Self-Healing Waterborne Epoxy Coating: Preparation, Release Behavior, and Anticorrosion Performance Based on Bowl-Shaped Mesoporous Polydopamine Nanocontainer Loaded with 2-MBI Inhibitors.

We present a straightforward emulsion-induced interfacial anisotropic assembly method for in- situ synthesis of bowl-shaped, self-encapsulated mesoporous polydopamine (BMPDA) nanocontainers (M-M@P) loaded with 2-mercaptobenzimidazole (2-MBI). Results showed that the loading capacity of the bowl-shaped mesoporous polydopamine reaches 24 wt.%.

Tunable Magnetoresistive Gas Sensing Enabled by La-Deficient LaFeO.

Resistive sensors are widely used to detect gases, but integrating magnetoresistive effects for enhanced selectivity and sensitivity remains largely unexplored. Here we have investigated several magnetic materials in a metal oxide semiconductor (MOS) sensor, showing that iron oxides can exhibit both positive and negative magnetoresponses at relatively low operating temperatures (120-160 °C), with no simple correlation between magnetoresponse and bulk magnetization, leading to the discovery of LaFeO as an outstanding material for magnetoresistive gas sensing. Under a 0.

Saturated Alcohols Electrocatalytic Oxidations on Ni-Co Bimetal Oxide Featuring Balanced B- and L-Acidic Active Sites.

Investigating structural and hydroxyl group effects in electrooxidation of alcohols to value-added products by solid-acid electrocatalysts is essential for upgrading biomass alcohols. Herein, we report efficient electrocatalytic oxidations of saturated alcohols (C-C) to selectively form formate using NiCo hydroxide (NiCo-OH) derived NiCoO solid-acid electrocatalysts with balanced Lewis acid (LASs) and Brønsted acid sites (BASs). Thermal treatment transforms BASs-rich (89.

A Fall Prevention Program Integrated in Primary Health Care for Older People in Rural China: The FAMILY Cluster Randomized Clinical Trial.

Importance: With rapidly aging populations globally, there is a lack of evidence on effective fall prevention strategies among community-dwelling older people in resource-constrained areas.

Objective: To assess the effectiveness of a fall prevention program integrated in primary health care systems on the risk of falls among Chinese rural older adults.

Design, Setting, And Participants: A 12-month, open-label, cluster randomized clinical trial, conducted in 128 rural villages from 4 Chinese provinces, involving adults 60 years or older at risk of falls (recruitment from September 19, 2023, to November 15, 2023; last follow-up, January 15, 2025).

Portable Real-Time Detection of Hydrogen Sulfide in Wastewater Using a Pt/CrWN-Based Electrochemical Sensor.

Efficient monitoring of hydrogen sulfide (HS) in wastewater is essential for preventing environmental contamination and safeguarding public health. Current methods for assessing sulfide levels are limited by complex, time-consuming processes. Here, we introduce a Pt/CrWN-based electrochemical gas sensor designed for real-time detection of HS gas, offering a fast, reliable, and cost-effective solution for monitoring sulfate concentrations in wastewater.

Analysis of Chemical Composition and Odor Characteristics in Particleboards Decorated by Resin-Impregnated Paper, Polypropylene Film and Polyvinyl Chloride Film.

Analysis of changes in TVOC and VOCs chemical composition or odor characteristics of particleboard before and after decoration treatment with resin-impregnated paper (RIP), polypropylene (PP) film and polyvinyl chloride (PVC) film were studied. The effects of these three decoration treatments on masking or suppressing the release of VOCs and odorants from particleboard were explored. The substances that were covered or suppressed and newly introduced before and after processing were identified to provide a basis for reducing the odor emissions of PVC-, PP- and RIP-decorated particleboard.

Photoelectrochemical biosensor based on BiS/BiOCO for lactic acid detection.

Photoelectrochemical biosensor based on BiS/BiOCO heterojunction as photoelectrically active material and lactate oxidase was constructed for sensitive detection of lactic acid in serum. Topological transformation method was utilized to prepare BiS/BiOCO composites, which can generate electron-hole pairs triggering photoelectrochemical reactions under light illumination. The BiS/BiOCO heterojunction effectively promoted the separation and transportation of photogenerated electrons and holes, leading to improved photoelectric conversion efficiency.

Effects of pre-operative continuing oral anticoagulants or antiplatelets on health outcomes among older patients with hip fracture: a systematic review and meta-analysis.

Unlabelled: Continuing antiplatelets during hip fracture surgery may be safe for older adults, while early surgery after discontinuation reduces hospital stay without adverse outcomes.

Purpose: The safety of continuing antiplatelets or direct oral anticoagulants (DOACs) before surgery in older patients with hip fractures remains uncertain. The feasibility of timely surgery after discontinuation also warrants further investigation.

Rational Engineering of Precision-Tuned Fluoro-Photoacoustic Probe for Physiological-Level Glutathione Dynamics Monitoring.

Glutathione (GSH), one of the most abundant antioxidants in eukaryotic cells, maintains redox homeostasis and acts as a signaling molecule at physiological levels. However, most existing GSH-activated probes are highly sensitive with a limit of detection as low as micromoles, making them unable to discriminate different mammalian cell lines based on GSH levels, as GSH concentrations in most cells are approximately 1-2 mM. In this study, we found a novel GSH trigger, 2-furan formate, with moderate reactivity, and developed a precision-tuned fluoro-photoacoustic (PA) probe () by combining with a near-infrared fluorescence (NIRF)/PA dual scaffold (HDS) for accurately monitoring of GSH dynamics.

Foliar nanoparticles alleviated cadmium-induced phytotoxicity in dandelion via regulation of ionomics, metabolomics, and rhizobacterial networks.

Foliar application of beneficial nanoparticles (NPs) demonstrates potential in alleviating heavy metal (HM) stress in plants. Yet, their effects on rhizosphere microbial communities, nutrient dynamics, and metabolic adaptations in dandelion remain underexplored. This study investigated the mechanisms underlying Cadmium (Cd) stress mitigation in dandelion via foliar application of ZnONPs, TiONPs, SiONPs, and FeONPs by integrating high-throughput sequencing, metabolomic profiling, and physiological analyses.

Anion-Exchange Membrane Electrolysis for Efficient Uranium Extraction from Saline Wastewater.

Recovery of uranium from residual spent fuel dissolution liquor in nuclear power plants is economically and environmentally desirable. While electrochemical extraction offers a greener alternative to solvent-based methods like the PUREX (plutonium uranium reduction extraction) process, it has been limited to batch processing of non-saline waters. Here, a high-performance ZrN/copper foam (ZrN/CF) electrode is presented that enables a continuous electroextraction-purification-reuse (EE-PR) process, achieving >98% pure UO directly from saline wastewater for direct reuse as nuclear fuel.

Multivariate metal-organic frameworks enable chemical shift-encoded MRI with femtomolar sensitivity for biological systems.

Fluorescent molecules with specific target moieties are essential for histopathological analysis, but their limited tissue penetration depth makes in vivo, in situ color encoding analysis challenging. Magnetic resonance imaging (MRI) offers deep tissue penetration. When combined with chemical shift-encoded MRI reporters, it enables in vivo chemical shift encoding for biotarget imaging and analysis.

Multi-omics study of mitochondrial dysfunction in the pathogenesis of hyperuricemia.

Background: Mitochondrial dysfunction is linked to hyperuricemia (HUA), but its genetic pathophysiology is not yet fully understood. We employed Mendelian randomization (MR) to integrate multi-omics data and explore the associations between mitochondrial-related genes and HUA.

Methods: We conducted a summary data-based MR analysis to investigate potential targets associated with HUA by integrating mitochondrial-related DNA methylation, gene expression, and protein quantitative trait loci.

Acoustofluidic Fabrication of Calcium Pyrophosphate-Enzyme Nanocatalysts for Oral Treatment of Metabolic Disorders.

Catalytic medicine, particularly enzyme-based therapies, has emerged as a promising approach for disease treatment. However, the development of enzyme-based catalytic medicines faces significant challenges, including a complex fabrication processes, poor stability, and limited efficacy in oral administration. Herein, we present an approach to fabricate calcium pyrophosphate (CaP)-enzyme nanocatalysts via acoustofluidic synthesis, enabling rapid and scalable encapsulation of natural enzymes (e.

Mode-Specific Quantum and Quasi-Classical Trajectory Dynamics of the F + CHI → I + CHF S2 Reaction.

Bimolecular nucleophilic substitution (S2) reactions in the gas phase are of great importance in chemistry, whose microscopic mechanisms are, however, not comprehensively understood. In this work, the mode-specific quantum dynamics of the prototypical S2 reaction F + CHI → I + CHF are investigated using reduced six-dimensional quantum wave packet and full-dimensional quasi-classical trajectory methods. The reaction probabilities are calculated for both the ground and excited vibrational states of the reactant CHI at collision energies up to 2.

Tumor deposits in the impact of esophageal squamous cell carcinoma prognosis and recurrence: A multicenter retrospective cohort study.

Purposes: Tumor deposits (TDs) are considered poor prognostic factors in esophageal squamous cell carcinoma (ESCC). However, the impact of tumor deposits-positivity (TDP) on ESCC prognosis and recurrence remains unclear. This multicenter retrospective cohort study aimed to investigate the influence of TDP on recurrence and the potential benefit of adjuvant therapy in ESCC.

To explore the targeting of toluidine blue: low molecular dextran-40 to the lymphatic system and its effect assessment.

To investigate the targeting effect of toluidine blue-dextran-40 (TB-Dex-40) on the head and neck lymphatic system. Thirty healthy adult New Zealand white rabbits were randomly divided into two groups: the experimental group (TB-Dex-40 group, n = 15) and the control group (TB group, n = 15). In the experimental group, 1.

Plastisphere Promotes Gill-Rot Disease: A Retrospective Study on a Sudden Fish Mortality Incident.

Plastisphere is a hotspot for some potential pathogens. Herein, a sudden incident of gill-rot disease in the Haihe River, China, is speculated to be related to the effects of the plastisphere. Significantly higher levels of microplastics (MPs) were present in the gills of dying carps identified with gill-rot disease, while was identified as the main pathogenic microorganism.

Synthesis and Evaluation of I-IMPY: Application in Neuroblastoma Tracing and Treatment.

Background: Radiolabeled compounds can serve as diagnostic or therapeutic agents depending on the characteristics of the isotopes used. IMPY (6-iodo-2-(4'-dimethylamino)-phenyl-imidazo[1,2-a]pyridine) is a lipophilic derivative of thioflavin-T, designed to function as a tracer when labeled with radioactive iodine. While it has been primarily studied for imaging applications, its potential therapeutic effects when labeled with iodine-125 (I) remain to be explored.

Humidity-Resistant Pt/CrVN Fuel Cell Sensor for HS Biomarker Detection.

Real-time, remote monitoring of human biomarkers is essential for personalized medical diagnostics. Hydrogen sulfide (HS), a key endogenous gas, serves as a crucial biomarker for conditions such as oral diseases. However, accurately detecting ppb-level HS in high-humidity environments remains a challenge.

Z-Scheme Bismuth-Based Ternary Heterostructured Photoelectrochemical Sensor Integrated with CuP Nanoparticles as a Multifunctional Signal Probe for Quantifying Circulating Tumor Cells.

Circulating tumor cells (CTCs) are widely acknowledged as critical biomarkers for early cancer diagnosis and prognosis, highlighting the urgent need for the development of sensitive and accurate detection methods for CTCs. Herein, a photoelectrochemical (PEC) sensor was developed based on dual Z-scheme BiS/BiOCO/ZnCdS heterojunctions as the high-efficiency photoactive material and CuP nanoparticles (CuP NPs) as the multifunctional signal probe, thereby achieving sensitivity and precise detection of MCF-7 cells. The Z-scheme heterojunction structure significantly enhances the photoelectric conversion efficiency, while CuP NPs can suppress the photocurrent through p-n semiconductor quenching and enzyme-mimetic catalytic precipitation, which involves the catalytic oxidation of 4-chloro-1-naphthol (4-CN) to form the insoluble precipitate benzo-4-chloro-hexadienone (4-CD).

Ten-Year Trends in Pelvic Fractures Among China's Aging Population: A Retrospective Single-Center Study.

BACKGROUND Pelvic fractures are a growing concern, particularly among the elderly, but data on fracture patterns in mainland China are limited. This study investigated the epidemiological trends of pelvic fractures amid an aging population in China. MATERIAL AND METHODS This retrospective study enrolled consecutive pelvic fracture patients aged ≥14 years treated at a level-1 trauma center in Beijing, China, between January 2013 and December 2022.

Bioprofiling and vaccine development for Zika virus.

Zika virus (ZIKV) has emerged as a global health priority due to its association with severe congenital abnormalities, including microcephaly and neonatal mortality in infants born to infected mothers. In adults, ZIKV infection is epidemiologically linked to Guillain-Barré Syndrome (GBS). These clinical manifestations prompted the World Health Organization (WHO) to declare ZIKV a Public Health Emergency of International Concern (PHEIC).