Early human albumin infusion was associated with 28-day mortality in patients with acute respiratory failure and hypoalbuminaemia in the intensive care unit: a retrospective study of the MIMIC-IV database.

Background: To investigate the relationship between different timing of human albumin infusion and mortality in patients with acute respiratory failure in an Intensive Care Unit (ICU).

Methods: This cohort study utilized data from the Medical Information Mart for Intensive Care (MIMIC-IV 2.0) database.

Targeted next-generation sequencing enhances precision and rapid detection in healthcare-associated infection Surveillance: Unveiling multidrug-resistant colonization in ICUs.

Objectives: This study aims to evaluate the potential advantages of targeted next-generation sequencing (tNGS) over conventional bacterial culture methods for pathogen detection in hospital-associated infections (HAIs).

Methods: All EICU medical staff and all medical staff from the Physical Examination Centre completed a questionnaire. Nasopharyngeal specimens were collected from medical staff who met all of the inclusion criteria and none of the exclusion criteria.

Nerolidol inhibits proliferation and triggers ROS-facilitated apoptosis in lung carcinoma cells via the suppression of MAPK/STAT3/NF-κB and P13K/AKT pathways.

Background: Lung cancer (LC) is the leading cause of malignancy-related mortalities globally, and the existing treatment interventions are associated with harmful side effects. In the current study, we evaluated the anti-tumor efficiency of nerolidol (NRD) on human non-small cell lung cancer (NSCLC) cells.

Objectives: Nerolidol is a sesquiterpene alcohol extracted from the essential oils of aromatic flora with known anti-cancer activities.

Research on a Recognition Algorithm for Traffic Signs in Foggy Environments Based on Image Defogging and Transformer.

The efficient and accurate identification of traffic signs is crucial to the safety and reliability of active driving assistance and driverless vehicles. However, the accurate detection of traffic signs under extreme cases remains challenging. Aiming at the problems of missing detection and false detection in traffic sign recognition in fog traffic scenes, this paper proposes a recognition algorithm for traffic signs based on pix2pixHD+YOLOv5-T.

The mechanism of action and biodistribution of a novel EGFR/VEGF bispecific fusion protein that exhibited superior antitumor activities.

Despite the promising clinical benefits of therapies targeting epidermal growth factor receptor (EGFR) or vascular endothelial growth factor (VEGF) with antibodies in various cancers, resistance to these therapies will inevitably develop following treatment. Recent studies suggest that crosstalk between the EGFR and VEGF signaling pathways might be involved in the development of resistance. Therefore, simultaneous blockade of EGFR and VEGF signaling may be able to counteract this resistance and improve clinical outcomes.

Unmanned stationary online monitoring system based on buoy for marine gamma radioactivity.

Research on unmanned online monitoring equipment for marine radioactivity surrounding nuclear power plants is of great significance. In this work, a small radioactivity monitoring system based on buoy was designed and manufactured for the emergency situation of nuclear accidents. The core of the radioactivity monitoring system is the underwater gamma spectrometer.

PRKAR2A deficiency protects mice from experimental colitis by increasing IFN-stimulated gene expression and modulating the intestinal microbiota.

Protein kinase A (PKA) plays an important role in regulating inflammation via its catalytic subunits. Recently, PKA regulatory subunits have been reported to directly modulate some signaling pathways and alleviate inflammation. However, the role of PKA regulatory subunits in colonic inflammation remains unclear.

IRE1α-targeting downregulates ABC transporters and overcomes drug resistance of colon cancer cells.

Drug resistance is a big problem in cancer treatment and one of the most prominent mechanisms underlain is overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1, ABCC1 and ABCG2. Inhibition of ABC transporters is an important approach to overcome drug resistance. The inositol-requiring enzyme 1α (IRE1α), an arm of unfolded protein response (UPR), splices XBP1 mRNA to generate an active transcription factor XBP1s.

Prolyl hydroxylase 3 controls the intestine goblet cell generation through stabilizing ATOH1.

Intestinal epithelia self-renew constantly and generate differentiated cells such as secretary goblet cells. The intestine goblet cells secrete gel-forming mucins that form mucus to create a barrier of defense. We reported previously that loss of prolyl hydroxylase (PHD) 3 led to disruption of the intestinal epithelial barrier function.

CircRNA CDR1as knockdown inhibits progression of non-small-cell lung cancer by regulating miR-219a-5p/SOX5 axis.

Background: Circular RNAs (circRNAs) participate in the development of human cancers by regulating multiple cell processes. CircRNA antisense to the cerebellar degeneration-related protein 1 transcript (circCDR1as) expression is dysregulated in many cancers, including non-small-cell lung cancer (NSCLC). However, the mechanism by which circCDR1as mediates the development of NSCLC remains unknown.

Spectrometry analysis algorithm based on R-L deconvolution and fuzzy inference.

A spectrometry analysis algorithm based on Richardson-Lucy (R-L) deconvolution and fuzzy inference is developed to identify radionuclides of overlapping spectra obtained by a low-resolution detector. The effectiveness of the algorithm was experimentally verified. It is shown that the algorithm can be used for radionuclide analysis of low-resolution spectra in a marine environment with high accuracy of nuclide identification.

Comparison of the Therapeutic Effects of Acupuncture at PC6 and ST36 for Chronic Myocardial Ischemia.

We aimed to compare the differences of the effects on chronic myocardial ischemia (MI) of acupuncture at PC6 and ST36. The chronic MI model of minipigs was created by implanting an Ameroid constrictor on the left anterior descending coronary artery (LAD) and then two weeks' acupuncture was stimulated at PC6 or ST36, respectively. The results showed that both acupoints' stimulation decreased the serous cardiac troponin T (cTnT) and ischemia modified albumin (IMA) significantly and improved the ischemic ECG changes.

[Spatial Heterogeneity of Soil Respiration in the Soil Erosion Area of West Mountains in Fujian Province, China].

The spatial heterogeneity of soil respiration () is of great significance in accurately estimating the carbon budget in erosion areas. This study investigated the soil respiration (), total nitrogen (TN), carbon-nitrogen ratio (C/N), soil organic carbon content (SOC), leaf area index (LAI), soil temperature (), and soil moisture () in 59 soil samples collected from Hetian Town in Fujian Province. Both classical statistics and geostatistics were used to analyze the spatial heterogeneity of soil respirations and other measured factors.

[Effect of Needle Embedded in Neiguan (PC6) on Changes of ECG in Chronic Myocardial Ischemia Model Mini-pigs].

Objective To observe the effect of needle embedded in Neiguan (PC6) on electro- cardiogram (ECG) changes in model mini-pigs with chronic myocardial ischemia. Methods The protein shrink narrow ring (Ameroid Ring) was placed in the proximal part of the left coronary anterior descend- ing branch of 12 Chinese mini-pigs to prepare animal model. One died during the modeling.

Curcumin reduces lung inflammation via Wnt/β-catenin signaling in mouse model of asthma.

Objectives: Asthma is a chronic inflammatory, heterogeneous airway disease affecting millions of people around the world. Curcumin has been found to have anti-inflammatory and antifibrosis effects. Researchers reported that curcumin regulated Wnt/β-catenin signaling in lots of cells.

House dust mite allergens mediate the activation of c‑kit in dendritic cells via Toll‑like receptor 2.

Several studies have demonstrated that the c‑kit proto‑oncogene and its ligand, stem cell factor, are important in the development of asthma. House dust mite (HDM; Dermatophagoides pteronyssinus) allergens are a major trigger in the development and exacerbation of asthma. HDM allergens can induce the activation of c‑kit in dendritic cells (DCs), leading to the development of allergic asthma.