Hydrogen protects against autoimmune myocarditis by inhibiting necroptosis via the TNF/TNFR1 signalling pathway.

Autoimmune myocarditis refers to the inflammation of myocardial tissue caused by innate and adaptive immune responses, characterized by elevated levels of tumour necrosis factor-α (TNF-α), a classic pro-inflammatory factor. Although hydrogen exhibits anti-inflammatory and antioxidant properties, its therapeutic effects in autoimmune myocarditis have not been evaluated. Therefore, the present study aimed to explore whether hydrogen can alleviate autoimmune myocarditis via TNF-α.

Study on the effect of sustained -release icariin-loaded Graphene oxide-hydrogel composite scaffold on bone defect repair.

In orthopedic treatment, long-term nonunion of bone defects has always been a significant issue. As bone graft materials, tetra-armed polyethylene glycol (Tetra-PEG) hydrogel scaffolds are anticipated to address this issue due to their extracellular matrix (ECM)-like structure. However, poor osteoinductivity and cell adhesion after implantation restricted its clinical application in bone tissue engineering.

Numerical simulation on residual axial compression bearing capacity of square in square CFDST columns after lateral impact.

Square in square concrete-filled double-skin steel tube (CFDST) columns are widely preferred on account of their convenient nodal structural form and efficient construction process. In order to investigate the axial compression behavior of the columns after lateral impact, a precise numerical model for the post-impact axial compression of square in square CFDST columns was established using the finite element package, and was validated by existing experiments and studies. The residual axial compression bearing capacity of the columns after lateral impact has been analyzed.

Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) among patients with oral infections in Sana'a City-Yemen.

Background: (, a pathogenic bacterium capable of causing systemic and dental infections, is increasingly developing resistance to multiple classes of antibiotics, causing growing concern in modern times. This study was intended to assess the prevalence of methicillin-resistant (MRSA) in Sana’a City, Yemen, among patients with oral cavity infections.

Methods: This cross-sectional study conducted among 100 patients visiting dental clinics at Sana’a, Yemen, between September 2022 and September 2023.

Effects of Paeoniae Radix Rubra on lowering lipid via bioinformatics and gut microbiome.

Hyperlipidemia, a metabolic disorder characterized by abnormal lipid levels, is closely linked to an increased risk of cardiovascular disease. In this study, we investigated the hypolipidemic properties of Paeoniae Radix Rubra and its regulatory effects on gut microbiota composition in a high-fat diet model. Using UHPLC-QE-MS/MS, we identified its chemical constituents and applied bioinformatics, network pharmacology, and molecular docking to virtually screen for bioactive compounds and molecular targets.

Expert consensus on management of instrument separation in root canal therapy.

Instrument separation is a critical complication during root canal therapy, impacting treatment success and long-term tooth preservation. The etiology of instrument separation is multifactorial, involving the intricate anatomy of the root canal system, instrument-related factors, and instrumentation techniques. Instrument separation can hinder thorough cleaning, shaping, and obturation of the root canal, posing challenges to successful treatment outcomes.

Photocatalytic TiO/HAP nanocomposite for antimicrobial treatment, promineralization, and tooth whitening.

Early dental caries and tooth staining are prevalent clinical conditions, so it is of great clinical significance to develop a multifunctional material. Photocatalytic therapies play a significant role in the medical field. However, the use of photocatalytic materials in the dental field is relatively limited.

Predictive value of change in percent calcified plaque burden based on serial coronary computed tomographic angiography for cardiovascular events.

Background: Plaque progression is an independent risk factor for major adverse cardiovascular events (MACE), and change in the total plaque burden (PB) is a common indicator of plaque progression. However, the type of component (calcification or non-calcification) and the magnitude of changes cannot be determined. We aimed to analyze the capability of the percent calcified PB (PCPB) in reflecting the total and its noncalcified and calcified component PB change, and the predictive value of PCPB for MACE.

HSPB1 suppresses oxLDL-induced vascular smooth muscle cell ferroptosis by inhibiting DPP4.

Background: Atherosclerosis is the major pathological basis of cardiovascular diseases. Vascular smooth muscle cell (VSMC) dysfunction and death induced by oxidized low-density lipoprotein (oxLDL) play a key role in atherosclerosis. Ferroptosis is a novel iron-dependent lipid peroxidation regulated cell death, which is implicated in atherosclerosis.

Evolution of Esophageal Adenocarcinoma From Precursor Lesion Stem Cells.

Background & Aims: Metastatic cancers arise from a decades-long succession of increasingly virulent precursor lesions, each of which represents prospective targets for therapeutic intervention. This evolutionary process has been particularly vivid in esophageal adenocarcinoma (EAC), as this cancer and associated precursor lesions, including Barrett's esophagus (BE), low-grade dysplasia (LGD), and high-grade dysplasia (HGD), coexist in an accessible, 2-dimensional pattern in esophageal mucosa. Given the durability of these precursor lesions, it is likely that they, like EAC, rely on stem cells for their regenerative growth.

Hydrogen alleviates myocardial infarction by impeding apoptosis via ROS-mediated mitochondrial endogenous pathway.

Background: Acute myocardial infarction (AMI) is a deadly cardiovascular disease with no effective solution except for percutaneous coronary intervention and coronary artery bypass grafting. Inflammation and apoptosis of the injured myocardium after revascularization seriously affect the prognosis. Hydrogen possesses anti-inflammatory, anti-oxidative, and anti-apoptotic effects and may become a new treatment for AMI.

Expert consensus on intentional tooth replantation.

Intentional tooth replantation (ITR) is an advanced treatment modality and the procedure of last resort for preserving teeth with inaccessible endodontic or resorptive lesions. ITR is defined as the deliberate extraction of a tooth; evaluation of the root surface, endodontic manipulation, and repair; and placement of the tooth back into its original socket. Case reports, case series, cohort studies, and randomized controlled trials have demonstrated the efficacy of ITR in the retention of natural teeth that are untreatable or difficult to manage with root canal treatment or endodontic microsurgery.

Microenvironment engineering by targeted delivery of Ag nanoparticles for boosting electrocatalytic CO reduction reaction.

Creating and maintaining a favorable microenvironment for electrocatalytic CO reduction reaction (eCORR) is challenging due to the vigorous interactions with both gas and electrolyte solution during the electrocatalysis. Herein, to boost the performance of eCORR, a unique synthetic method that deploys the in situ reduction of precoated precursors is developed to produce activated Ag nanoparticles (NPs) within the gas diffusion layer (GDL), where the thus-obtained Ag NPs-Skeleton can block direct contact between the active Ag sites and electrolyte. Specifically, compared to the conventional surface loading mode in the acidic media, our freestanding and binder free electrode can achieve obvious higher CO selectivity of 94%, CO production rate of 23.

Expert consensus on apical microsurgery.

Apical microsurgery is accurate and minimally invasive, produces few complications, and has a success rate of more than 90%. However, due to the lack of awareness and understanding of apical microsurgery by dental general practitioners and even endodontists, many clinical problems remain to be overcome. The consensus has gathered well-known domestic experts to hold a series of special discussions and reached the consensus.

Nerolidol inhibits proliferation and triggers ROS-facilitated apoptosis in lung carcinoma cells via the suppression of MAPK/STAT3/NF-κB and P13K/AKT pathways.

Background: Lung cancer (LC) is the leading cause of malignancy-related mortalities globally, and the existing treatment interventions are associated with harmful side effects. In the current study, we evaluated the anti-tumor efficiency of nerolidol (NRD) on human non-small cell lung cancer (NSCLC) cells.

Objectives: Nerolidol is a sesquiterpene alcohol extracted from the essential oils of aromatic flora with known anti-cancer activities.

Exploring the environmental contamination toxicity and potential carcinogenic pathways of perfluorinated and polyfluoroalkyl substances (PFAS): An integrated network toxicology and molecular docking strategy.

The objective of this study was to investigate the potential carcinogenic toxicity and mechanisms of PFAS in thyroid, renal, and testicular cancers base on network toxicology and molecular docking techniques. Structural modeling was performed to predict relevant toxicity information, and compounds and cancer-related targets were screened in multiple databases. The interaction of PFAS with three cancers and their key protein targets were explored by combining protein network analysis, enrichment analysis and molecular docking techniques.

Advancements in Nanomaterial Dispersion and Stability and Thermophysical Properties of Nano-Enhanced Phase Change Materials for Biomedical Applications.

Phase change materials (PCMs) are materials that exhibit thermal response characteristics, allowing them to be utilized in the biological field for precise and controllable temperature regulation. Due to considerations of biosafety and the spatial limitations within human tissue, the amount of PCMs used in medical applications is relatively small. Therefore, researchers often augment PCMs with various materials to enhance their performance and increase their practical value.

Expert consensus on endodontic therapy for patients with systemic conditions.

The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. A systemic consideration of the patient's overall health along with oral conditions holds the utmost importance in determining the necessity and feasibility of endodontic therapy, as well as selecting appropriate therapeutic approaches. This expert consensus is a collaborative effort by specialists from endodontics and clinical physicians across the nation based on the current clinical evidence, aiming to provide general guidance on clinical procedures, improve patient safety and enhance clinical outcomes of endodontic therapy in patients with compromised overall health.

Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.

Molecular hydrogen is an emerging broad-spectrum antioxidant molecule that can be used to treat myocardial infarction (MI). However, with hydrogen inhalation, the concentration that can be reached within target organs is low and the duration of action is short, which makes it difficult to achieve high dose targeted delivery of hydrogen to the heart, seriously limiting the therapeutic potential of hydrogen for MI. As a result of reactions with the internal environment of the body, subcutaneous implantation of magnesium slices leads to continuous endogenous hydrogen production, leading to a higher hydrogen concentration and a longer duration of action in target organs.

Understanding the effect of foreign atoms occupation on the metamagnetic behaviors in MnCoSi-based alloys: taking Pt-doping as an example.

Present research on TiNiSi-type MnCoSi-based alloys focuses on finding a suitable doping element to effectively reduce the critical magnetic field () required to induce a metamagnetic transition. This paper provides a guide to achieve this goal through an experimental investigation of MnPtCoSi and MnCoPtSi alloys. In MnPtCoSi, asincreases,at room temperature decreases, while in MnCoPtSi, it increases.

MNTZNN for Solving Hybrid Double-Deck Dynamic Nonlinear Equation System Applied to Robot Manipulator Control.

Compared with conventional dynamic nonlinear equation systems, a hybrid double-deck dynamic nonlinear equation system (H3DNES) not only has multiple layers describing more different tasks in practice, but also has a hybrid nonlinear structure of solution and its derivative describing their nonlinear constraints. Its characteristics lead to the ability to describe more complicated problems involving multiple constraints, and strong nonlinear and dynamic features, such as robot manipulator tracking control. Besides, noises are inevitable in practice and thus strong robustness of models solving H3DNES is also necessary.