Primary vulval sebaceous carcinoma: rare case report and literature review.

This study presents a rare case of primary vulval sebaceous carcinoma (SC) and a literature review. Sebaceous carcinoma is an aggressive skin malignancy, predominantly periocular, with extraocular cases being particularly uncommon. We detail a 50-year-old female patient diagnosed with primary vulval SC, exhibiting a 0.

Genetic diversity, prevalence and risk factors of trichomonads from captive non-human primates in China.

Trichomonads are flagellated protozoan parasites, some of which are pathogenic and have zoonotic potential. This study aimed to investigate the prevalence, genetic diversity, phylogenetic relationships and risk of trichomonads in captive non-human primates (NHPs) in China. Data on trichomonad prevalence and diversity in captive NHPs are limited.

Gradient-structured directional porous floatable aerogels for effective solar-driven hydrogen production and steam generation.

Solar-driven reaction technology offers a promising route to clean energy generation and sustainable development. Despite significant advancements in photocatalysts and photothermal materials, challenges remain in device structural design, including insufficient light utilization, slow water transport, and inefficient gas separation. Here, we design a floatable cellulose nanofiber aerogel featuring a gradient-structured directional porous architecture to address these challenges.

Predictive Value of the Estimation of Physiologic Ability and Surgical Stress for Postoperative Recurrent Laryngeal Nerve Injury in Patients With Type 2 Diabetes Mellitus Complicated by Thyroid Cancer: A Retrospective Cohort Study.

In the postoperative management of patients with type 2 diabetes mellitus (T2DM) and thyroid cancer, recurrent laryngeal nerve (RLN) injury is a significant complication. Due to existing metabolic abnormalities, surgical stress may further impair the recovery of physiological functions in these patients. This study aimed to investigate the predictive value of the Estimation of Physiologic Ability and Surgical Stress (E-PASS) system for postoperative RLN injury in patients with T2DM complicated by thyroid cancer.

Hydrogen protects against autoimmune myocarditis by inhibiting necroptosis via the TNF/TNFR1 signalling pathway.

Autoimmune myocarditis refers to the inflammation of myocardial tissue caused by innate and adaptive immune responses, characterized by elevated levels of tumour necrosis factor-α (TNF-α), a classic pro-inflammatory factor. Although hydrogen exhibits anti-inflammatory and antioxidant properties, its therapeutic effects in autoimmune myocarditis have not been evaluated. Therefore, the present study aimed to explore whether hydrogen can alleviate autoimmune myocarditis via TNF-α.

Acupuncture for induction of labor in uncomplicated term pregnancies and the role of the acupoint selection: A systematic review and meta-analysis.

Introduction: Acupuncture is increasingly used for inducing labor; however, its effects on labor progression and birth outcomes remain inconclusive, and differences in acupuncture techniques are not fully considered by previous reviews. This study aims to evaluate the effects of acupuncture for induction of labor (AC-IOL) after 37 weeks of gestation on labor progression and birth outcomes, with a particular focus on comparing the combined stimulation of local and distant (L-D) acupoints with the selective use of either local or distant acupoints.

Material And Methods: Following PRISMA 2020 guidelines, we searched PubMed, Embase, Web of Science, and three Chinese databases for randomized controlled trials (RCTs) evaluating AC-IOL in uncomplicated pregnancies.

Efficacy and safety of anti-PD-1/PD-L1 antibodies in patients with relapsed refractory diffuse large B-cell lymphoma: A meta-analysis.

This article conducts a meta-analysis to evaluate the safety and efficacy of PD-1/PD-L1 inhibitors in patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). A total of 63 papers were initially retrieved, and eight clinical studies were collected. The estimated effect of ORR was [OR = 0.

Mitochondrial metabolism and cancer therapeutic innovation.

Mitochondria are dynamic organelles that are essential for cellular energy generation, metabolic regulation, and signal transduction. Their structural complexity enables adaptive responses to diverse physiological demands. In cancer, mitochondria orchestrate multiple cellular processes critical to tumor development.

CookAR: Affordance Augmentations in Wearable AR to Support Kitchen Tool Interactions for People with Low Vision.

Cooking is a central activity of daily living, supporting independence as well as mental and physical health. However, prior work has highlighted key barriers for people with low vision (LV) to cook, particularly around safely interacting with tools, such as sharp knives or hot pans. Drawing on recent advancements in computer vision (CV), we present , a head-mounted AR system with real-time object affordance augmentations to support safe and efficient interactions with kitchen tools.

Chinese soy-based microbiome and associated microbial risks: a metagenomic investigation.

Fermented foods are a longstanding part of the Chinese diet and have been recognized for promoting gut microbial diversity. However, their microbial composition remains poorly defined, raising concerns about potential exposure to pathogens and antibiotic resistance genes (ARGs). Using shotgun metagenomics, we examined microbiota of 93 representative samples spanning three major categories of traditional Chinese fermented soybean products.

Electron-Donating Boronic Salicylhydrazones as Dual-State Emissive Fluorophores for Lipid Droplet Imaging.

We report a novel class of electron-donating boron-chelated salicylhydrazone (BOSHY) fluorophores synthesized through an efficient "two-step, one-pot" condensation strategy. These structurally versatile dyes incorporate a stereogenic boron center within a rigid 6,7-fused bicyclic architecture, demonstrating remarkable dual-state emission characteristics with high quantum yields (up to 95% in solution and 74% in the solid state) and large Stokes shifts up to 7200 cm, along with promising chiroptical activity. Notably, selected BOSHY derivatives display outstanding specificity for lipid droplet imaging in live cells.

Innovative Benefit-Risk-Value Assessment for Cadmium and Selenium Coexposure in Black Shale Regions.

The coexistence of cadmium (Cd) and selenium (Se) in black shale regions poses challenges for assessing health risks in local populations. Traditional risk assessments focus exclusively on single Cd contamination and total dietary intake, neglecting the interactions between them and the digestion and adsorption processes in the human body. This study established a novel benefit-risk-value (BRV) criterion to assess coexposure effects.

A three-classification machine learning model for non-invasive prediction of molecular subtypes in diffuse glioma: a two-center study.

Background: Determining the molecular status of gliomas is crucial for evaluating treatment efficacy and prognosis. However, this process currently requires the invasive and cumbersome method of histological analysis. We aimed to develop and validate a non-invasive three-classification machine learning (ML) model to predict the three molecular subtypes of adult-type diffuse gliomas according to the 2021 World Health Organization classification of tumors of the central nervous system 5 edition (WHO CNS 5).

Soil aggregate and organic nitrogen distributions as influenced by vermicompost application in vegetable greenhouse.

Vermicompost application can improve soil physical structure and increase soil nitrogen (N) sequestration, yet its specific impact on soil aggregates in relation to changes in organic N fractions remains underexplored, especially in protected vegetable fields. We compared the effects of vermicompost substitution (commercial organic fertilizer, COF; reduced COF + vermicompost, RCOF + VC; vermicompost, VC) on soil dry aggregate size distribution, aggregate stability, particulate organic N (PON) and mineral-associated organic N (MON) distributions within aggregates, as well as their interrelationships in a protected continuous tomato cropping system. Compared with COF, RCOF + VC was not beneficial for soil macro-aggregation and aggregate stability in 20-40 cm, leading to diminished physical protection and loss of organic N fractions.

Construction and Biological Characteristics of a Quadruple Gene-Deleted Strain of Orf Virus as a Vaccine Candidate.

(1) Background: Contagious ecthyma, also known as orf, is an epitheliotropic zoonotic disease caused by the orf virus (ORFV), primarily affecting the skin and mucous membranes of ruminants such as goats and sheep, leading to the formation of papules and pustules. Vaccination is the most effective way to prevent this disease in susceptible animals; however, traditional attenuated vaccines carry the potential risk of reversion to virulence. Therefore, there is an urgent need to develop safe and effective vaccines for the prevention and control of orf.

Di--Coumaroyl Spermidine From Bee Pollen Alleviates Chronic Nonbacterial Prostatitis.

Bee pollen and its extracts have been used for decades as therapeutic agents or health food supplements to alleviate chronic nonbacterial prostatitis (CNP). However, the functional compounds in bee pollen that are anti-CNP remain still unclear. In this study, we evaluated the anti-CNP properties of six principal phenolamides in bee pollen.

[Lipid-lowering effect of sodium alginate in patients with hypercholesterolemia].

Objective: To investigate the effects of sodium alginate(SA) on serum total cholesterol(TC) levels in individuals with hypercholesterolemia.

Methods: A randomized double-blind controlled trial was conducted on hypercholesterolemic patients(TC≥5.2 mmol/L, n=84), who were divided into a control group and an SA intervention group.

Electrospun Mats of Fluorosiloxane Copolymers with Antifouling and Antibacterial Performances.

Background: The adsorption and accumulation of biomolecules and microorganisms on materials can significantly shorten the service life of materials. Fibrous materials featuring hydrophobic and anti-protein adsorption properties are urgently required for numerous applications, particularly in environments requiring liquid repellency and biofouling resistance.

Methods: In this work, electrospun fibers are fabricated via the electrospinning of fluorosiloxane copolymers of methyl methacrylate (MMA), isobornyl methacrylate (IBMA), and methacryloyl-terminated poly[methyl(3,3,3-trifluoropropyl)siloxane] (PMTFPS-MA).

Competitive transport of heavy metals in soil: Cadmium dynamics with numerical modeling.

Transport of composite heavy metals in the soil profile is a complex process that poses significant risks to groundwater and deep soil layer. This study conducts an in-depth simulation and analysis of Cd transport behavior in single and composite contamination through soil penetrate tests and leaching tests, combined with the HYDRUS and CXTFIT models. The study found that Pb significantly promoted the transport rate of Cd in the soil profile, reducing the initial breakthrough time from 12 to 5 pore volumes (PV).

First linear B-cell epitope identified on the nucleocapsid protein of bovine coronavirus.

Bovine coronavirus (BCoV) is an important pathogen that can cause diarrhea in calves, respiratory disease, and winter dysentery in adult dairy cows. BCoV nucleocapsid protein (N) is highly conserved structural proteins that stimulate a strong immune response in the host, inducing both humoral and cellular immune responses, and are key targets for early and rapid diagnosis of coronaviruses and vaccine development. Therefore, the identification and screening of epitopes on N proteins is essential for the development of sensitive and specific diagnostic methods.

Intermittent fasting and cardiovascular health: a circadian rhythm-based approach.

Intermittent fasting (IF) is increasingly recognized as an effective dietary intervention for slowing aging process and alleviating metabolic disturbances in multiple chronic diseases, especially in cardiovascular diseases (CVDs). Despite recent progress, the mechanisms behind its effects on cardiovascular health from the perspective of circadian rhythms are not yet fully understood. This review aims to explore the interaction between IF and circadian rhythms, focusing on their combined effects on cardiometabolic risks and cardiovascular outcomes.

Establishment of an indirect ELISA antibody detection method based on the stable expression of LSDV P32 protein in CHO-K1 cells.

Background: Lumpy skin disease (LSD), caused by infection with the lumpy skin disease virus (LSDV), is a highly infectious disease that poses a notable challenge to the cattle industry worldwide. To conduct epidemiological monitoring of LSDV infection in cattle and evaluate the immune efficacy of LSDV vaccines, it is essential to develop a rapid, sensitive, and specific ELISA-based antibody detection method.

Results: We utilized the LSDV P32 protein, stably expressed in a CHO-K1 suspension cell system, as a coating antigen to develop an indirect ELISA for Capripoxvirus (CaPV) antibody detection.

Successful treatment of refractory erythrodermic pemphigus foliaceus with low-dose rituximab and intravenous immunoglobulin.

Background: Erythrodermic pemphigus foliaceus (EPF) is a severe, often refractory autoimmune disease.

Method: We report successful treatment of refractory EPF in a 59-year-old male using low-dose rituximab (RTX) and intravenous immunoglobulin (IVIG).

Results: Initial high-dose corticosteroids and IVIG failed, complicated by infections.

A rapid and sensitive UHPLC-MS/MS method for epalrestat detection in micro-volumes of human plasma for the first time.

Aim: A rapid and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for epalrestat detection in human plasma.

Materials And Methods: A triple quadrupole tandem mass spectrometer equipped with an electrospray ionization (ESI) source was used to quantify epalrestat and the internal standard epalrestat-d in the negative ion mode using multiple reaction monitoring (MRM). After acetonitrile-mediated protein precipitation, chromatographic separation was achieved using a reversed-phase C column (ACQUITY UPLC BEH, 2.

HDAC6 is involved in diabetic nephropathy by regulating TGFβ/Smads and NF-κB signaling pathways.

Histone deacetylase 6 (HDAC6), a cytoplasmic member of the histone deacetylase family, plays an incompletely understood role in diabetic nephropathy (DN). While the TGF-β/Smads and NF-κB signaling pathways are established mediators of renal fibrosis and inflammation respectively, the potential regulatory effect of HDAC6 on these pathways in DN remains to be elucidated. Notably, Smad7 has been documented as a negative regulator of both TGF-β/Smads and NF-κB signaling pathways.