Revocable Identity-Based Matchmaking Encryption with Equality Test for Smart Healthcare.

Smart healthcare establishes a safe, reliable, and efficient medical information system for the public with the help of the Internet of Things, cloud storage, and other Internet technologies. To enable secure data sharing and case-matching functions in smart healthcare, we construct a revocable identity-based matchmaking encryption with an equality test (RIBME-ET) scheme for smart healthcare. Our scheme not only ensures the confidentiality and authenticity of messages and protects the privacy of users, but also enables a cloud server to perform equality tests on encrypted ciphertexts from different identities to determine whether they contain the same plaintext and protects the confidentiality of data in the system through a user revocation mechanism.

Accelerated Monte Carlo-driven statistical reconstruction for CBCT scatter correction.

The traditional cone-beam computed tomography (CBCT) model has not sufficiently accounted for the effects of X-ray scattering, resulting in cupping and streak artifacts in the reconstructed images. These artifacts significantly degrade the quality of soft tissue imaging, severely impacting the accuracy of medical diagnosis. Accurately modeling the X-ray scattering process and efficiently solving it are crucial for scattering correction.

Non-agriculturalization of cultivated land in densely populated areas at the watershed scale: a case study of the Minjiang River Basin, China.

Zero hunger is a top priority in the Sustainable Development Goals, however, millions of people worldwide still face hunger. Over the years, China has experienced rapid population growth, industrialization and urbanization, leading to significant agricultural land loss, which threats the nation's food supply. Understanding the patterns and driving factors of non-agriculturalization is crucial for its protection.

Efficacy of probiotics pretreatment in eradication therapy: a systematic review and meta-analysis of clinical outcomes.

Background: Probiotics inhibit growth and alter gut microbiome, in addition to alleviating the side effects of eradication. It has also been reported that be eradicated after fecal microbiota transplantation in some cases. However, whether probiotics used before eradication improves the eradication rate remains unclear.

Lacticaseibacillus paracasei Glu-07: A Promising Probiotic Candidate for the Management of Type 2 Diabetes Mellitus.

The global prevalence of type 2 diabetes mellitus (T2DM) is currently surging, posing significant health and socioeconomic burdens. Probiotics have emerged as promising interventions due to their safety and potential metabolic benefits. Gut microbiota plays a critical role in the pathophysiology of metabolic diseases in humans, offering valuable insights for therapeutic strategies such as probiotics.

Prediction of axillary lymph node metastasis in triple negative breast cancer using MRI radiomics and clinical features.

To develop and validate a machine learning-based prediction model to predict axillary lymph node (ALN) metastasis in triple negative breast cancer (TNBC) patients using magnetic resonance imaging (MRI) and clinical characteristics. This retrospective study included TNBC patients from the First Affiliated Hospital of Soochow University and Jiangsu Province Hospital (2016-2023). We analyzed clinical characteristics and radiomic features from T2-weighted MRI.

The Comparison Between Endoscopic Ligation and Sclerotherapy on the Treatment Effect and Anorectal Function in Patients With Internal Hemorrhoids.

Objective: To evaluate the treatment effect of endoscopic ligation and cap-assisted endoscopic sclerotherapy (CAES) for patients with internal hemorrhoids, symptom relief, complication rate and psychological condition, and the anorectal function were observed.

Methods: Thirty-two patients who underwent minimally invasive endoscopic treatment for internal hemorrhoids were recruited, with a 3-month follow-up. Patients were divided into 2 groups, with Group A undergoing endoscopic ligation (n=14) and Group B receiving CAES (n=18).

Establishment of an indirect ELISA antibody detection method based on the stable expression of LSDV P32 protein in CHO-K1 cells.

Background: Lumpy skin disease (LSD), caused by infection with the lumpy skin disease virus (LSDV), is a highly infectious disease that poses a notable challenge to the cattle industry worldwide. To conduct epidemiological monitoring of LSDV infection in cattle and evaluate the immune efficacy of LSDV vaccines, it is essential to develop a rapid, sensitive, and specific ELISA-based antibody detection method.

Results: We utilized the LSDV P32 protein, stably expressed in a CHO-K1 suspension cell system, as a coating antigen to develop an indirect ELISA for Capripoxvirus (CaPV) antibody detection.

Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors.

Low-dose methotrexate (MTX) is the first-line drug for treating rheumatoid arthritis as an immunosuppressor. We have identified that low-dose MTX exhibits antitumor immune activity. MTX treatment reduced tumor metastasis and enhanced the efficacy of radiation therapy and immune checkpoint blockade therapy in mice.

Circular RNA in liver cancer research: biogenesis, functions, and roles.

Liver cancer, characterized by its insidious nature, aggressive invasiveness, and propensity for metastasis, has witnessed a sustained increase in both incidence and mortality rates in recent years, underscoring the urgent need for innovative diagnostic and therapeutic approaches. Emerging research indicates that CircRNAs (circular RNAs) are abundantly and stably present within cells, with their expression levels closely associated with the progression of various malignancies, including hepatocellular carcinoma. In the context of liver cancer progression, circRNAs exhibit promising potential as highly sensitive diagnostic biomarkers, offering novel avenues for early detection, and also function as pivotal regulatory factors within the carcinogenic process.

SORBS3-β suppresses lymph node metastasis in cervical cancer by promoting the ubiquitination of β-catenin.

Background: Cervical cancer (CC) is a prevalent gynecological malignancy, with lymph node metastasis (LNM) serving as a critical factor influencing patient prognosis. SORBS3, an adaptor protein with two known isoforms (α and β), has been implicated in tumor suppression, but the specific roles of its isoforms in CC metastasis remains unexplored. This study aimed to identify the functional isoform of SORBS3 driving LNM suppression and elucidate its mechanisms.

Particle size effect of defatted rice bran on the gel properties and flavor of silver carp surimi gels.

This study evaluated the impact of defatted rice bran (DRB) particle sizes (103.67-6.04 μm) on the gel properties and flavor of silver carp surimi gels.

Mechanistic insights and therapeutic approaches in tic disorders: The distinctive role of ethnomedicine and modern medical interventions.

Tic disorders (TDs) are a class of neurodevelopmental disorders that have received considerable scientific attention. The genesis of TDs is increasingly understood as a complex interplay of neurobiological, genetic, and immunological factors. Animal model studies have elucidated the pathophysiology of TDs, paving the way for innovative therapeutic approaches.

Clinical characteristics and therapeutic direction of HER2 low-expression breast cancer.

Human epidermal growth factor receptor 2 (HER2) is one of the oncogenic drivers of breast cancer and is often used as a definitive therapeutic marker for breast cancer. This has led to significant improvements in both targeted therapy and prognosis for HER2-targeted breast cancer. Due to the differences in HER2 gene and protein expression levels, they are clinically classified into HER2 zero-expression breast cancer, low-expression breast cancer and high-expression breast cancer.

Self-Compassion and Medical Coping Modes of Patients With Rheumatoid Arthritis: Mediating Role of Personal Mastery.

Aim: To test the mediating role of personal mastery in the relationship between self-compassion and medical coping modes in patients with rheumatoid arthritis (RA).

Design: A cross-sectional questionnaire survey was administered.

Methods: We enrolled a convenience sampling of patients with RA from a Class A tertiary hospital.

High-Performance Ionogels from Dynamic Polyrotaxane-Based Networks.

The swelling of a polymer matrix by ionic liquids and additional lithium salts may lead to the formation of ionogel electrolytes. However, the introduction of additional ions usually results in a decreased lithium-ion transference number, because of the trapping of the lithium ions in clusters and polymer-ion complexes. Achieving highly efficient lithium-ion migration and increasing lithium-ion transference number (t ) are however crucial for the successful application of ionogel electrolytes.

Antioxidant potential of peptides from poultry hemoglobin via probiotic-assisted hydrolysis: Deciphering mechanisms at the cellular level and through molecular dynamics simulations.

Achieving the therapeutic goal of treating diseases by effectively controlling the excessive accumulation of intracellular free radicals is still very challenging, which motivates researchers to develop efficient novel antioxidant peptides from sustainable resources continuously. This study first pioneered a probiotic-assisted enzymatic hydrolysis of hemoglobin, which obtained 149 peptides. Two antioxidant peptides were rapidly screened using advanced molecular dynamics simulation techniques, revealing their molecular interaction mechanisms with Keap1.

One-pot synthesis of long-range aligned nanochannels for Li-ion transfer pathways.

Limited ionic conductivity () of solid polymer electrolytes (SPEs) is a bottleneck for their practical application. Constructing ordered ionic transfer highways is a prospective direction to promote . Here, we propose a straightforward one-pot synthesis strategy for the obtention of long-range aligned nanochannels, which is based on the evaporation of the solvent to induce the self-assembly of Pluronic® F127-resol micelles.

N4-Acetylcytidine-Mediated CD2BP2-DT Drives YBX1 Phase Separation to Stabilize CDK1 and Promote Breast Cancer Progression.

Long noncoding RNAs (lncRNAs) play critical roles in the initiation and progression of breast cancer. However, the specific mechanisms and biological functions of lncRNAs in breast cancer remain incompletely understood. Bioinformatics analysis identifies a novel lncRNA, CD2BP2-DT, that is overexpressed in breast cancer and correlates with adverse clinicopathological features and poor overall survival.

Selecting projection views based on error equidistribution for computed tomography.

Background: Nonuniform sampling is a useful technique to optimize the acquisition of projections with a limited budget. Existing methods for selecting important projection views have limitations, such as relying on blueprint images or excessive computing resources.

Methods: We aim to develop a simple nonuniform sampling method for selecting informative projection views suitable for practical CT applications.

Keratin 1 modulates intestinal barrier and immune response kallikrein kinin system in ulcerative colitis.

Background: External factors in ulcerative colitis (UC) exacerbate colonic epithelial permeability and inflammatory responses. Keratin 1 (KRT1) is crucial in regulating these alterations, but its specific role in the progression of UC remains to be fully elucidated.

Aim: To explore the role and mechanisms of KRT1 in the regulation of colonic epithelial permeability and inflammation in UC.

Prominence of Microbiota to Predict Fibrous Stenosis in Crohn's Disease.

Purpose: Intestinal fibrous stenosis due to Crohn's disease (CD) is highly prevalent. Although several clinical risk factors for fibrous stenosis have been identified, such as perianal fistulizing disease, small bowel disease location, and deep mucosal ulceration, predicting fibrous stenosis remains challenging. The intestinal microbiota plays a crucial role in the development and progression of CD.

Enhancing charge transfer efficiency through carboxyl-modification to improve the photocatalytic activity of covalent organic frameworks for hydrogen evolution from water splitting.

The design of photocatalysts based on covalent organic frameworks (COFs) has attracted considerable interest. Nevertheless, the low efficiency in separating photogenerated carriers remains a substantial challenge. Herein, carboxyl modification is employed to enhance the separation efficiency of photogenerated carriers within imine-based porphyrin COFs through the resultant built-in electric field, thereby improving the photocatalytic performance of COFs in hydrogen evolution from water splitting.

CD47 is a tumor cell-derived exosomal signature and regulates tumor immune microenvironment and immunotherapy responses.

Background: The pathogenesis of ovarian cancer (OvCa) involves a complex interplay of genetic, environmental, and hormonal factors. With the in-depth exploration of tumor ecosystem, exosomes can mediate the immunological status of tumor microenvironment (TME). Therefore, we aimed to recognize the tumor-derived exosomes (TEXs) which can distinguish the immune-hot and cold tumors and reflect the immunotherapeutic responses.