Long-term effectiveness and safety of ustekinumab in patients with Crohn's disease: real-world evidence.

Background: Ustekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist approved for the treatment of Crohn's disease (CD). Although UST has demonstrated good efficacy and safety in CD, long-term real-world data in Chinese patients are relatively scarce.

Methods: A single-center, observational retrospective study was conducted in the First Affiliated Hospital of Anhui Medical University.

Thermodynamic Miscibility-Guided Engineering of Bismuth-Tin Janus Catalysts for Durable Electrocatalytic CO Reduction.

Interfaces in heterogeneous bimetallic catalysts play a pivotal role in providing rich active sites and accelerating charge transfer during reaction process. However, designing an interface-rich catalyst with sufficient exposed active sites is crucial yet challenging. Janus catalysts containing bifunctional surfaces segregated by interfaces can boost the performance of electrochemical CO reduction by optimizing electronic structure and reaction pathway.

Dynein-Dependent Endo-Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology.

Dementia with Lewy bodies (DLB) is a significant cause of dementia. However, the limited availability of animal and cellular models that accurately replicate early DLB pathogenesis hampers the understanding of how Aβ plaques influence α-synuclein (αSyn) pathologies. This study addresses this gap by co-culturing primary neurons with adult hippocampal brain slices from either wild-type or Alzheimer's disease (AD) mice containing abundant Aβ plaques and cytokines.

Current Progress and Challenges of Electromagnetic Wave Absorbing Materials at High Temperature.

With the rapid development of science and technology, electromagnetic waves have deeply penetrated various fields. However, they also bring a higher demand for electromagnetic protection. Electromagnetic wave absorbing materials (EMWAMs) can significantly reduce or even eliminate the reflection and scattering of electromagnetic waves by converting electromagnetic wave energy into heat energy and dissipation.

Preventive and controlling effects of -acetylneuraminic acid in regulating glucose and lipid metabolism disorders the gut-liver axis in high-fat diet mice.

A high-fat diet may disrupt sialic acid homeostasis indirectly by altering the gut microbiota and metabolic pathways. Sialic acid interventions have immune-regulatory effects and can improve gut health, but their impact on glucose and lipid metabolism disorders, both before and after obesity induced by a high-fat diet, remains unclear. This study used two models: a preventive experiment (intervention during high-fat diet feeding) and a control experiment (intervention after obesity induction).

Pressure-Boosted C-C Coupling for CO Electroreduction to Ethanol over the Cascade Sites of Cu Single-Atom and Cu Cluster.

Tandem catalysis of the CO electroreduction reaction (CORR) offers a promising way to obtain multicarbon products (C) with high Faradaic efficiency (FE). However, the synchronously changed CO supply and consumption with potentials and the mismatch between the two potential windows of the different components in tandem catalysts impede further understanding and development of tandem catalysis. Herein, a novel strategy of pressure regulating to separately promote the CO supply and consumption is reported on the cascade sites of Cu single-atom and Cu cluster, where a near-linear relationship between CO pressure, CO supply, and ethanol FE is well established.

Dose-response association of total and leisure-time physical activity with the risk of different subtypes of stroke: a systematic-review and meta-analysis.

Background: This study aimed to investigate the dose-response relationship of total physical activity (TPA), leisure-time physical activity (LTPA), and occupational physical activity (OPA) with the risk of stroke.

Methods: PubMed, Cochrane Library, Embase, and Web of Science were searched to collect relevant studies on PA and stroke risk up to December 2024, and cohort research was considered to include. The Newcastle-Ottawa Scale was used to assess the quality of included studies.

Aryl hydrocarbon receptor-regulated long non-coding RNAs: implications for glycolipid metabolism and prognosis in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths with limited treatment options. Tumor metabolic disorder is elevated in HCC and activates the aryl hydrocarbon receptor (AHR), a transcription factor implicated in cancer progression. However, the role of AHR in regulating long non-coding RNAs (lncRNAs) and their impact on glycolipid metabolism remains underexplored.

ARAP1-AS1 Overexpression Increases Diffuse Large B Cell Lymphoma Progression by Sponging miR-508-5p to Activate the EMP1-PI3K/AKT Pathway.

Diffuse large B cell lymphoma (DLBCL) is a type of common and fatal non-Hodgkin lymphoma. This study aimed to detect the specific function of lncRNA ARAP1-AS1 in DLBCL. The in vitro experiments were performed using RT-qPCR, western blotting, MTT, colony formation, flow cytometry analysis, FISH, RNA pulldown, and luciferase reporter assays.

Clinical characteristics and therapeutic direction of HER2 low-expression breast cancer.

Human epidermal growth factor receptor 2 (HER2) is one of the oncogenic drivers of breast cancer and is often used as a definitive therapeutic marker for breast cancer. This has led to significant improvements in both targeted therapy and prognosis for HER2-targeted breast cancer. Due to the differences in HER2 gene and protein expression levels, they are clinically classified into HER2 zero-expression breast cancer, low-expression breast cancer and high-expression breast cancer.

N4-Acetylcytidine-Mediated CD2BP2-DT Drives YBX1 Phase Separation to Stabilize CDK1 and Promote Breast Cancer Progression.

Long noncoding RNAs (lncRNAs) play critical roles in the initiation and progression of breast cancer. However, the specific mechanisms and biological functions of lncRNAs in breast cancer remain incompletely understood. Bioinformatics analysis identifies a novel lncRNA, CD2BP2-DT, that is overexpressed in breast cancer and correlates with adverse clinicopathological features and poor overall survival.

Associations between physical activity and heart disease among middle-aged and older Chinese adults.

Objective: To quantify the risk of heart diseases (HD) and determine the relationship between physical activity (PA) dimensions and HD among Chinese middle-aged and older individuals.

Methods: Using data from the China Health and Retirement Longitudinal Study (CHARLS, 2018), 16,927 participants were included in this study. Multivariate logistic regression was performed to determine the association between HD risk and PA dimensions, including volume, intensity, frequency, and duration.

Robust and ultra-thin nanocellulose/MXene composite film and its performance in efficient electricity-generation and sensing.

The conversion of mechanical energy into electrical energy by triboelectric nanogenerators (TENG) has attracted attention in recent years, particularly in the field of wearable sensor. In this work, TEMPO-oxidized cellulose nanofibers (TOCNF) with carboxylate groups were compounded with MXene to serve as both the negative friction layer and the electrode in assembling a TENG with nylon. The synergistic effect between TOCNF and MXene was analyzed to disclose its influence on the performance of the as-prepared TENG.

Age-related variations in heart rate variability profiles among patients with schizophrenia and major depressive disorder.

Patients with psychiatric disorders exhibit general autonomic dysregulation and elevated cardiovascular risks, which could be indexed by heart rate variability (HRV). However, HRV is susceptible to age and other patient-specific factors. This study aimed to investigate the HRV profile and age-related variations, as well as the potential influence of sex, BMI, and HR on HRV in psychiatric populations.

Widespread presence of gut bacterium Glutamicibacter ectropisis sp. nov. confers enhanced resistance to the pesticide bifenthrin in tea pests.

The gut microbiota in Lepidopterans demonstrates variability and susceptibility to environmental influences, thereby presenting opportunities for the acquisition of novel bacterial strains. Ectropis grisescens (Warren), a notorious Lepidopteran pest, causes substantial damage to tea crops. Prolonged application usage of bifenthrin for the management of this pest has led to increased resistance.

Ampere-Level Hydrogen Generation via 1000 H Stable Seawater Electrolysis Catalyzed by Pt-Cluster-Loaded NiFeCo Phosphide.

Seawater electrolysis can generate carbon-neutral hydrogen but its efficiency is hindered by the low mass activity and poor stability of commercial catalysts at industrial current densities. Herein, Pt nanoclusters are loaded on nickel-iron-cobalt phosphide nanosheets, with the obtained Pt@NiFeCo-P electrocatalyst exhibiting excellent hydrogen evolution reaction (HER) activity and stability in alkaline seawater at ampere-level current densities. The catalyst delivers an ultralow HER overpotential of 19.

Ubiquitin-specific protease 1 facilitates hepatocellular carcinoma progression by modulating mitochondrial fission and metabolic reprogramming via cyclin-dependent kinase 5 stabilization.

Although deubiquitinases (DUBs) have been well described in liver tumorigenesis, their potential roles and mechanisms have not been fully understood. In this study, we identified ubiquitin-specific protease 1 (USP1) as an oncogene with essential roles during hepatocellular carcinoma (HCC) progression. USP1, with elevated expression levels and clinical significance, was identified as a hub DUB for HCC in multiple bioinformatics datasets.

miR-497-5p Expression and Biological Activity in Gastric Cancer.

This research aims to investigate the expression and biological roles of miR-497-5p in gastric cancer (GC), and its possible mechanisms. Real Time Quantitative PCR (RT-qPCR) was performed to detect miR-497-5p in GC and normal tissues, as well as GC cell lines versus normal gastric mucosal cells (GES-1). The effects of miR-497-5p overexpression on proliferation were measured by the cell counting kit-8 (CCK8) assay and ethidium bromide (EdU) assay.

Epigenetic modulations in triple-negative breast cancer: Therapeutic implications for tumor microenvironment.

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking estrogen receptors, progesterone receptors and lacks HER2 overexpression. This absence of critical molecular targets poses significant challenges for conventional therapies. Immunotherapy, remarkably immune checkpoint blockade, offers promise for TNBC treatment, but its efficacy remains limited.

Correlative relationship between body mass index and heart rate variability in psychiatric disorders.

Indicators of heart rate variability (HRV) have been used to assess the autonomic activity. However, the influence of obesity on HRV in these patients remains to be determined. This study aimed to examine how obesity (measured with the body mass index [BMI]) affects HRV and determine whether the effect varies among different psychiatric disorders.

Non-proteolytic ubiquitination of HBx controls HBV replication.

• The expression level of TRIM21 in patients is negatively correlated with the replication and integration of HBV. • TRIM21 was found to trigger non-proteolytic ubiquitination of X protein of HBV. • This study proposes that the PRYSPRY and RING domains in TRIM21 dimer can form a docking conformation for HBx binding.

Reliability and validity of the Chinese version of the COMPI Fertility Problem Stress Scale-Short Form for infertile women.

Objective: To translate and culturally adapt the COMPI Fertility Problem Stress Scale-Short form (COMPI-FPSS-SF) and to test its reliability and validity in China.

Methods: The cross-sectional study adopted Brislin's translation model to translate, synthesize, back-translate, and cross-culturally adapt the COMPI-FPSS-SF for the Chinese setting. A total of 279 infertile women were invited to participate in the study to test the reliability and validity of the scale between March and June 2021.