siRNA nanodelivery systems in the treatment of skin Diseases: Research progress and clinical translation prospects.

Background: Skin diseases affect approximately one-third of the global population. RNA interference (RNAi) technology, through the use of small interfering RNAs (siRNAs), enables precise silencing of pathogenic gene expression. However, clinical application of siRNA is hindered by the stratum corneum barrier of the skin and the inherent instability of siRNAs, which are prone to degradation.

Gender differences in caregiver burden among informal caregivers of people with mental illness: A cross-sectional survey.

Purpose: Little is known about gender differences in caregiver burden among informal caregivers of people with mental illness in China. Given the still high prevalence of traditional gender roles in caregiving, it is essential to investigate the association between caregiver/care recipient gender and caregiver burden.

Methods: A total of 1174 informal caregivers of people with mental illness in China were recruited.

The effect of digital health intervention on perinatal negative emotions: A meta-analysis.

Background: Women are prone to negative emotions, including fear symptoms, anxiety symptoms and depressive symptoms. Digital health intervention (DHI) has the potential to alleviate these symptoms.

Objective: The purpose of this study was to evaluate the efficacy of DHI on perinatal negative emotions including fear symptoms, anxiety symptoms and depressive symptoms.

Successional patterns of microbial communities across various stages of leaf litter decomposition in poplar plantations.

Introduction: Litter decomposition drives nutrient cycling in terrestrial ecosystems, yet the dynamics of phyllosphere microbial communities during this process remain poorly understood. Poplar leaf litter decomposition is particularly critical due to its widespread plantation use. While prior studies highlight the roles of microbes in decomposition, stage-specific community succession patterns and their driving factors are underexplored.

Effects of Syntactic Complexity on the Comprehension of Passive Clauses and wh-questions in Children with Developmental Language Disorder and Autism Plus Language Impairment.

There is considerable debate over the similarities and differences between developmental language disorder (DLD) and autism spectrum disorder plus language impairment (ALI). Few studies have compared these in terms of complex syntactic operations. This study aimed to explore the similarities and differences between children with DLD and children with ALI via investigating the effects of syntactic complexity operationalized in terms of movement and intervention in Mandarin passives and wh-questions.

Yeast diversity in traditional fermented foods of ethnic minorities in China, with the descriptions of four new yeast species.

Fermented foods have been produced by humans since prehistoric times and are consumed worldwide today due to their enhanced nutritional value, taste and flavor, and benefits for human health. Various microorganisms are essential agents responsible for food fermentation and have been extensively studied using both culture-dependent and -independent methods. However, previous research has mainly focused on fermented foods produced on a large scale in urbanized areas.

Continuous wave mud pulse data transmission method based on continuous gradation frequency keying modulation and Convolution neural network demodulation.

Measurement While Drilling (MWD) technology plays a significant role in enhancing the geological steering and subsurface evaluation capabilities of extended-reach wells, challenging horizontal wells, and multilateral wells. With the increasing complexity of underground exploration, there is a heightened demand for the continuous wave mud pulse data transmission capacity. To address the inter-symbol interference(ISI) caused by the inherent inertia of the motor during high-speed data transmission using traditional modulation methods such as Frequency Shift Keying (FSK) and Phase Shift Keying (PSK), a novel approach has been proposed.

Factors influencing resilience and its relationship with spiritual coping strategies among nursing college students: a latent profile analysis.

Background: Previous studies have primarily examined overall resilience about coping strategies and demographics, overlooking individual heterogeneity. This study identifies distinct resilience profiles among nursing students, examines their associations with spiritual coping strategies, and determines demographic factors associated with these profiles.

Method: A cross-sectional study of 1,223 nursing students was conducted using convenience sampling from May 13 to 24, 2024.

Factors influencing career plateau in nurses: a protocol for systematic review and meta-analysis.

Introduction: Career plateau is a situation that has many negative effects on individual nurses, nursing management and nursing profession. Despite global research examining career plateaus among nurses, a comprehensive data synthesis on its prevalence and influential factors is still missing. The study aims to systematically analyse the prevalence of career plateau in nurses and explore the related influencing factors.

Saccharomycopsis yichangensis sp. nov., a Novel Predacious Yeast Species Isolated From Soil.

Two yeast strains belonging to the ascomycetous yeast genus Saccharomycopsis were isolated from soil collected from a forest in Wufeng Tujia Autonomous County, Yichang, Hubei province, China. Phylogenetic analyzes of the internal transcribed spacer (ITS) region and the D1/D2 domain of the large subunit rRNA gene showed that they closely related to S. fermentans and S.

sp. nov., a novel ascomycetous yeast species isolated from China and Thailand.

A yeast strain isolated from chestnut tree bark collected in Guangshan County, Xinyang, Henan Province, China and a strain isolated from soil collected in Phu Wiang District, Khon Khen Province, Thailand possess identical sequences in the 26S ribosomal RNA gene D1/D2 domain and the internal transcribed spacer (ITS) region. Phylogenetic analysis showed that the two strains belong to the genus and are closely related to but differed from the species by 7 (1.26%, 7 substitutions and 0 gap) and 43 (5.

Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus.

JOURNAL/nrgr/04.03/01300535-202602000-00045/figure1/v/2025-05-05T160104Z/r/image-tiff Neural stem cells (NSCs) have the potential for self-renewal and multidirectional differentiation, and their transplantation has achieved good efficacy in a variety of diseases. However, only 1%-10% of transplanted NSCs survive in the ischemic and hypoxic microenvironment of posthemorrhagic hydrocephalus.

Dispersed Graphene Nanosheets Enhance Piezoelectricity of Poly (L-lactic acid) Nanofibrous Scaffold to Promote Bone Defect Repair.

The reconstruction of a localized electrical microenvironment at the defect site is considered an effective strategy to promote bone regeneration by mimicking the electrophysiological properties of natural bone tissue. Nano-piezoelectric materials have attracted significant attention in recent years due to their ability to generate electrical fields under external stress. However, this process can sometimes lead to negative consequences, such as inflammation at the lesion site.

Synthesis of multi-template imprinted mesoporous silica nanoparticles via micelle-based interface imprinting strategy for specific and efficient extraction of five cinnamic acid derivatives from traditional Chinese medicines.

Cinnamic acid derivatives, a crucial group of active components in traditional Chinese medicines (TCMs), encompass chlorogenic acid, caffeic acid, 4-hydroxycinnamic acid, ferulic acid, and cinnamic acid. These compounds exhibit a wide array of pharmacological activities, such as free radical scavenging, antioxidation, antibacterial effects, and antitumor activity. However, traditional separation and detection methods often suffer from poor selectivity, low extraction efficiencies, and insufficient sensitivity, thus limiting their applicability in studying the complex and diverse active component groups in TCMs.

Test-retest precision of brain metabolites in healthy participants using P-MRS and H MEGA-PRESS on a 3T multi-nuclear MRI system.

Background: Magnetic resonance spectroscopy (MRS) enables the non-invasive quantification of brain metabolites, and its reliability is crucial for accurate interpretation of disease state. This study assessed the test-retest precision of phosphorus-31 (P)-MRS and hydrogen (H)-MEscher-GArwood Point RESolved Spectroscopy (MEGA-PRESS) in measuring P metabolites, γ-aminobutyric acid (GABA), and glutathione (GSH) using a 3T multi-nucleus magnetic resonance imaging (MRI) system.

Methods: In total, 32 participants, who underwent two scanning sessions within three days, using two dimensional (2D)-chemical shift imaging (CSI)-P-MRS and H-MEGA-PRESS sequences, were enrolled in the study.

Pregnane X receptor alleviates sepsis-induced liver injury through activation of yes-associated protein in mice.

The severity of sepsis is attributed to excessive inflammatory responses leading to liver injury. Pregnane X receptor (PXR), a nuclear receptor that controls xenobiotic and endobiotic metabolism, has been implicated in regulating inflammation and liver regeneration. This study aimed to investigate the role of PXR in sepsis-induced liver injury and the underlying mechanisms.

Multichannel microperfusion cell-capture system for screening anticancer active ingredients in traditional Chinese medicine formulas.

The screening of effective active ingredients from traditional Chinese medicine (TCM) formulas is currently a key focus of research. In this study, a multichannel microperfusion cell-capture system utilizing human hepatocellular carcinoma HepG2 cells was established and used to screen for anticancer active ingredients in the ancient formula Huangqisan. A polypropylene solid film carrying HepG2 cells was used as the cell-capture platform, and a multichannel microperfusion system was utilized for perfusion, enabling the screening of multiple ingredients' activities.

Discovery of Potent and Balanced Dual RIPK2 and 3 Inhibitors as a New Strategy for the Treatment of Inflammatory Bowel Diseases.

Receptor-interacting serine/threonine protein kinase 2 (RIPK2) and RIPK3 have been demonstrated to be promising targets for treating multiple inflammatory diseases, including inflammatory bowel diseases (IBDs). Due to the complexity of IBD pathogenesis, on the basis of synergy strategies, we herein describe the discovery and optimization of a series of ,7-diaryl-quinazolin-4-amine derivatives as dual RIPK2 and RIPK3 inhibitors. Based on a step-by-step process involving three rounds of structural modifications, compound was identified as the most one, exhibiting balanced potency against RIPK2 (IC = 12 nM) and RIPK3 (IC = 18 nM), as well as demonstrating good selectivity over other kinase targets.

Development and Validation of a HPLC-MS/MS Method for the Determination of Compound 13b in Rat Plasma and Its Application to a Pharmacokinetic Study.

Compound 13b, a newly identified anthraquinone derivative, has demonstrated potent efficacy against the Zika virus. To explore the bioavailability and pharmacokinetic properties of compound 13b, a robust and sensitive HPLC-MS/MS method was established and verified to determine its plasma concentration in rats. Sample preparation involved protein precipitation using acetonitrile with testosterone as an internal standard.

Four new species of (Pichiales, Pichiaceae) isolated from China.

The genus belonging to the family Pichiaceae is widely distributed worldwide and has garnered significant attention due to its importance in various industries and its potential role in human infections. During our investigation of yeast diversity in China, several strains representing undescribed taxa were isolated from forests in Hainan province, Hubei province, Beijing city and a mudflat in Guangdong province. Based on phylogenetic analyses of the internal transcribed spacer (ITS) region and the D1/D2 domain of the large subunit (LSU) rRNA, these strains were identified as four new species: (holotype strain CGMCC 2.

sp. nov., a novel ascomycetous yeast species from Xinghuacun Fenjiu old workshop, Shanxi province of China.

Four yeast strains belonging to the ascomycetous yeast genus were isolated from the mixture of remnants of steamed sorghum, Daqu powder and the fermented grain that fell off during transportation on the ground in the workshop which were collected in Xinghuacun Fenjiu old workshop, Shanxi province, PR China. We propose the name sp. nov.

Can digital literacy promote farmers' cultivated land quality protection behaviors?

Cultivated land is the most valuable agricultural resource and the most important factor of production. The protection of cultivated land quality is not only the foundation of national food security but also a strategic issue related to the sustainable development of the economy and society as a whole. This paper uses survey data from Jiangxi Province's "Double Hundred and Thousand" in 2023 and empirically analyzes the impact of digital literacy on farmers' cultivated land quality protection behaviors and its mechanism by using the O-probit model and the mediating effect model.

Care Tasks and Caregiver Burden Among Family Caregivers of Patients With Mental Disorders in China: Illness Perception as a Mediator and Social Support as a Moderator.

Introduction: Caring for a family member with mental disorders is burdensome, which may not only damage the caregivers' well-being and health, but also hinder patients' recovery. It is critical to investigate the underlying mechanisms for caregiver burden.

Aim: To examine the mediating effect of illness perception and the moderating function of social support on the association between care tasks and caregiver burden.

Burden of respiratory tract cancers in China and its provinces, 1990-2021: a systematic analysis of the Global Burden of Disease Study 2021.

Background: Respiratory tract cancers emerged as a public health challenge with the highest incidence and mortality among all cancer types in China, despite many national policies in place, such as early cancer screening. It is of outmost importance to monitor the burden of respiratory tract cancers across China and its provinces for refining health strategies.

Methods: Based on Global Burden of Disease (GBD) estimates, the present study investigated the age-sex specific pattern alterations of incidence, prevalence, mortality, and disability adjusted life years (DALYs) of respiratory tract cancers in China from 1990 to 2021, as well as its Estimated Annual Percentage Change (EAPC), Age-Standardized Incidence Rate (ASIR), and Age-Standardized Mortality Rate (ASMR).