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Measurement While Drilling (MWD) technology plays a significant role in enhancing the geological steering and subsurface evaluation capabilities of extended-reach wells, challenging horizontal wells, and multilateral wells. With the increasing complexity of underground exploration, there is a heightened demand for the continuous wave mud pulse data transmission capacity. To address the inter-symbol interference(ISI) caused by the inherent inertia of the motor during high-speed data transmission using traditional modulation methods such as Frequency Shift Keying (FSK) and Phase Shift Keying (PSK), a novel approach has been proposed. This method employs Continuous Gradation Frequency Keying (CGFK) modulation combined with Convolution Neural Network (CNN) demodulation for continuous mud pulse data transmission. By controlling the waveform frequency to uniformly increase from zero to a predetermined value and then uniformly decrease back to zero within a symbol period, and utilizing the rate of frequency change as the feature for modulation and demodulation, this method effectively mitigates the issue of ISI caused by the motor's inability to rapidly switch to the next speed due to its inertia during symbol transitions. Simulation tests indicate that, compared to the traditional Matched Filter method, Support Vector Machine (SVM), Long Short-Term Memory (LSTM) networks, and CNN exhibit superior performance in recognizing CGFK, with CNN demonstrating the best results. Physical tests show that CGFK, particularly when assisted by CNN demodulation, possesses the capability to avoid or reduce ISI caused by motor inertia, and achieves favorable information transmission rates and bit error rate (BER) compared to traditional FSK and PSK.
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http://dx.doi.org/10.1038/s41598-025-08806-5 | DOI Listing |
BMC Public Health
September 2025
Department of Mathematics, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Gottlieb-Daimler-Str.48, Kaiserslautern, 67663, Germany.
We study the dynamics of coexisting influenza and SARS-CoV-2 by adapting a well-established age-specific COVID-19 model to a multi-pathogen framework. Sensitivity analysis and adjustment of the model to real-world data are used to investigate the influence of age-related factors on disease dynamics. Our findings underscore the critical role that transmission rates play in shaping the spread of influenza and COVID-19.
View Article and Find Full Text PDFNat Commun
September 2025
Institute of Neurosciences and Medicine, Brain & Behaviour (INM-7), Research Centre Juelich; Wilhelm-Johnen-Straße 1, Juelich, Germany.
Autism is a neurodevelopmental condition associated with altered resting-state brain function. An increased excitation-inhibition ratio is discussed as a pathomechanism but in-vivo evidence of disturbed neurotransmission underlying functional alterations remains scarce. We compare local resting-state brain activity and neurotransmitter co-localizations between autism (N = 405, N = 395) and neurotypical controls (N = 473, N = 474) in two independent cohorts and correlate them with excitation-inhibition changes induced by glutamatergic (ketamine) and GABAergic (midazolam) medication.
View Article and Find Full Text PDFAerosp Med Hum Perform
September 2025
Introduction: Pilots have an increased incidence of cutaneous melanoma compared to the general population; occupational exposure to ultraviolet (UV) radiation is one of several potential risk factors. Cockpit windshields effectively block UVB (280-315 nm) but further analysis is needed for UVA (315-400 nm). The objective of this observational study was to assess transmission of UVA through cockpit windshields and to measure doses of UVA at pilots' skin under daytime flying conditions.
View Article and Find Full Text PDFJ R Soc Interface
September 2025
Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
In temperate regions, respiratory viruses such as SARS-CoV-2 are better transmitted in winter than in summer. Understanding how the weather is associated with SARS-CoV-2 transmissibility can enhance projections of COVID-19 incidence and improve estimation of the effectiveness of control measures. During the pandemic, transmissibility was tracked by the reproduction number .
View Article and Find Full Text PDFJ Hosp Infect
September 2025
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; Tropical Infectious Diseases Unit, Liverpool University Hospitals Foundation Trust, Liverpool, UK.
Background: Antimicrobial resistance (AMR) transmission is shaped by a complex interplay of health system factors, many of which remain underexplored or insufficiently addressed. This study investigates concrete systemic transmission drivers in hospitals and long-term care facilities (LTCFs) for older adults in Merseyside, UK.
Methods: Qualitative data were collected through semi-structured interviews with 37 purposively selected participants across hospitals, LTCFs, community settings, and ambulance services.