Masculine Norms and Their Associations With Social Anxiety and Body Appreciation Among College Men in the United States.

Previous research has identified the link between conformity to masculine norms and negative mental health outcomes. The present study thus examined how conformity to eight distinct masculine norms is associated with social anxiety and body appreciation among a sample of 271 college men living in the United States. College men living in the United States filled out an online questionnaire that assessed the variables of interest.

Prognostic Value of Extramural Depth of Tumor Invasion to Thickness of Mesorectum Ratio at Pretreatment Endorectal Ultrasound in T3 Rectal Cancer Patients.

Objective: To evaluate the prognostic value of the extramural depth (EMD)/thickness of mesorectum (TM) ratio in patients with cT3 rectal cancer (RC).

Methods: This study enrolled 382 treatment-naive cT3 RC patients undergoing endorectal ultrasound from January 2018 to January 2020. The last follow-up date was January 31, 2025.

Immunotherapy in central nervous system tumour.

Immunotherapy, defined as strategies that enhance host antitumor immunity by activating innate and adaptive immune responses, has demonstrated remarkable efficacy in hematologic malignancies. However, its application in solid tumours, particularly those affecting the central nervous system (CNS) such as gliomas, brain metastases, primary CNS lymphoma (PCNSL), and medulloblastomas, has been considerably slower. Major barriers to immunotherapy in these contexts include the physical and functional constraints imposed by the blood-brain barrier, tumour immune evasion, immunosuppressive microenvironments, tumour heterogeneity, and therapeutic resistance.

Experienced weight stigma among Asian, Black, and Latinx sexual and gender minorities: A systematic review.

Research has highlighted the increasing prevalence and necessity to examine weight stigma, especially among underserved populations. Guided by minority stress and intersectionality theories, the present systematic review examined experienced weight stigma and its effects on health outcomes among Asian, Black, and Latinx sexual and gender minority individuals. Using PubMed, Web of Science, and PSYCInfo, we identified 18 studies that met our eligibility criteria.

Tumour immunotherapy: past, present, and future.

The seminal contributions of Jenner and Pasteur marked a paradigm shift in the field, transitioning immunology from the realm of mystical experience to that of reproducible science. The foundational principle underlying this transition, namely the utilisation of pathogen characteristics to stimulate specific bodily defences, continues to serve as a foundational principle in contemporary immunotherapy. In this review, commencing with the origins and development of immunotherapy, we propose a "synergistic functional loop" model of tumour immunity, which comprises an antigen-sensing loop, a cytotoxic-killing loop, an immunoregulatory loop, and a tumour-educating loop.

Ugi-reaction-derived ionizable lipids with cyclic tertiary amine heads enable spleen-targeted mRNA delivery.

Lipid nanoparticles (LNPs) have become an important platform for nucleic acid delivery. However, LNP-mediated delivery to non-hepatic organs and specific cell types remains a non-negligible challenge. As a key component of LNPs, ionizable lipids were rationally designed to adjust the LNPs properties to achieve organ-targeted delivery.

Biomimetic self-gelling and adhesive powder for seamless sealing and neural regeneration after brain injury.

Brain injury (BI) is often accompanied by dural rupture, cerebrospinal fluid (CSF) leakage combined with acute hemorrhage, which causes damage cascades that result in deterioration of the brain parenchyma. The simultaneous benefit of immediate long-lasting sealing and brain regeneration poses a great challenge in the clinical treatment of BI. Herein, a fully physically crosslinked bioactive sealing powder (BSP) is developed for surgical uses.

Emodin-derived red-emissive carbon dots: Light-driven ROS generation and antioxidant activities in non-illuminative regimes.

Reactive oxygen species (ROS) play dual roles in physiological processes and disease pathogenesis, making their precise regulation crucial for therapeutic applications. Herein, we report the rational design of red-emissive carbon dots (CDs) with light-switchable pro-oxidant/antioxidant bifunctionality for precision nanomedicine. Synthesized from emodin and urea via a solvothermal method, these N-doped CDs exhibit: (1) red emission (>650 nm) with enhanced tissue penetration, (2) efficient type I/II ROS generation under light irradiation, (3) effective ROS scavenging in darkness , and superior water solubility and biocompatibility for in vivo applications.

Mid-term efficacy of OLIF combined with unilateral pedicle screw fixation in the treatment of lumbar degenerative diseases.

Unilateral pedicle screw (UPS) fixation has been applied in oblique lumbar interbody fusion (OLIF). However, the internal fixation strength required by OLIF is still controversial. Although satisfactory short-term outcome has been achieved with OLIF combined with UPS, the maintenance of stability in the fused segment remains a concern due to the lack of mid-term to long-term clinical follow-up reports.

Semipermeable Membrane-Mediated Hydrogen Bonding Interface for Fabricating High-Performance Pure PEDOT:PSS Hydrogels.

Conductive poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) hydrogels are potential bioelectronic interface materials because of their favorable mechanical properties and tunable electrochemical performances. Owing to intrinsic core-shell colloidal microstructure composed of insulative phase and conductive phase, inducing phase separation via diverse methods are proposed to improve their performances. However, fabrication of high-performance pure PEDOT:PSS hydrogels via a simple, mild strategy remains challenges.

A Weight-Aware-Based Multisource Unsupervised Domain Adaptation Method for Human Motion Intention Recognition.

Accurate recognition of human motion intention (HMI) is beneficial for exoskeleton robots to improve the wearing comfort level and achieve natural human-robot interaction. A classifier trained on labeled source subjects (domains) performs poorly on unlabeled target subject since the difference in individual motor characteristics. The unsupervised domain adaptation (UDA) method has become an effective way to this problem.

Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus.

JOURNAL/nrgr/04.03/01300535-202602000-00045/figure1/v/2025-05-05T160104Z/r/image-tiff Neural stem cells (NSCs) have the potential for self-renewal and multidirectional differentiation, and their transplantation has achieved good efficacy in a variety of diseases. However, only 1%-10% of transplanted NSCs survive in the ischemic and hypoxic microenvironment of posthemorrhagic hydrocephalus.

Computer-aided diagnosis tool utilizing a deep learning model for preoperative T-staging of rectal cancer based on three-dimensional endorectal ultrasound.

Background: The prognosis and treatment outcomes for patients with rectal cancer are critically dependent on an accurate and comprehensive preoperative evaluation.Three-dimensional endorectal ultrasound (3D-ERUS) has demonstrated high accuracy in the T staging of rectal cancer. Thus, we aimed to develop a computer-aided diagnosis (CAD) tool using a deep learning model for the preoperative T-staging of rectal cancer with 3D-ERUS.

Gendered racial microaggressions and Asian American women's hazardous alcohol use: The role of drinking to cope.

Research indicates the importance of investigating psychosocial factors that contribute to Asian American women's hazardous alcohol use. Thus, the present study examines how gendered racial microaggressions and racial collective self-esteem are associated with hazardous alcohol use among Asian American women, as well as the potential indirect effect of drinking to cope. A final sample of 300 Asian American women filled out a cross-sectional survey consisting of our study variables.

Biomaterial-based strategies: a new era in spinal cord injury treatment.

Enhancing neurological recovery and improving the prognosis of spinal cord injury have gained research attention recently. Spinal cord injury is associated with a complex molecular and cellular microenvironment. This complexity has prompted researchers to elucidate the underlying pathophysiological mechanisms and changes and to identify effective treatment strategies.

Dissolving microneedles for melanoma: Most recent updates, challenges, and future perspectives.

Skin cancer is one among the common types of cancers, affecting millions of individual globally. The conventional anticancer therapy such as chemotherapy results in worst systemic and local side effects as well as inhibit the growth of healthy cells around the tumor cells. Dissolving microneedles (DMNs) is a groundbreaking technology with less invasive and more targeted features.

Global burden of central nervous system tumors and cancers in older adults: the global burden of disease study 2021.

Background: This study aims to elucidate and predict the global disease burden and trends associated with central nervous system (CNS) tumors and cancers among older patients.

Methods: Data from the Global Burden of Disease 2021 database were used to calculate the age-standardized incidence rate (ASIR), prevalence rate (ASPR), death rate (ASDR), disability-adjusted life-years (DALYs), and the average annual percentage change (AAPC) to assess burden and trends from 1990 to 2021. A Bayesian age-period-cohort model was applied to project the global burden of CNS tumors and cancers in older patients over the next 30 years.

Molecular Mechanisms and Therapeutic Prospects of Immunotherapy and Targeted Therapy in Primary Central Nervous System Lymphoma.

Primary central nervous system lymphoma (PCNSL) is a very rare extranodal non-Hodgkin's lymphoma confined to the brain, eyes, spinal cord, and cerebrospinal fluid (CSF). This disease is highly aggressive. For decades, high-dose methotrexate-based induction regimens have been the standard treatment for PCNSL and have significantly improved patient overall survival (OS).

In-situ profiling of glycosylation on single cells with surface plasmon resonance imaging.

Cellular glycosylation is crucial for cell recognition, signal transduction, and the development of various diseases, especially in tumor initiation, progression, and metastasis. Current glycosylation profiling methods normally involve laborious sample processing and labeling and lack in-situ quantitative analysis. Here, we present a direct optical method to investigate and quantify the glycan expression on single cells based on lectin-glycan kinetic quantification with plasmonic imaging.

Probing Single-Cell Adhesion Kinetics and Nanomechanical Force with Surface Plasmon Resonance Imaging.

Single cell adhesion plays a significant role in numerous physiological and pathological processes. Real-time imaging and quantification of single cell adhesion kinetics and corresponding cell-substrate mechanical interaction forces are crucial for elucidating the cellular mechanisms involved in tissue formation, immune responses, and cancer metastasis. Here, we present the development of a plasmonic-based nanomechanical sensing and imaging system (PNMSi) for the real-time measurement of single cell adhesion kinetics and associated nanomechanical forces with plasmonic tracking and monitoring of cell-substrate interactions and the accompanying nanoscale fluctuations.

Asian Americans' childhood emotional abuse, emotional neglect, and opioid use: Distress intolerance as moderator.

Asian Americans are highly underrepresented in opioid use research, despite recent studies demonstrating the presence of opioid use behaviors in Asian Americans and distinct negative outcomes of opioid use among Asian Americans in comparison to White adults. Emotional abuse and emotional neglect are important risk factors that may impact opioid use. Thus, the purpose of this study was to investigate (a) the associations between childhood emotional trauma (emotional abuse and emotional neglect) and opioid use, and (b) the role of distress intolerance as a moderator.

CLIP-based multimodal endorectal ultrasound enhances prediction of neoadjuvant chemoradiotherapy response in locally advanced rectal cancer.

Background: Forecasting the patient's response to neoadjuvant chemoradiotherapy (nCRT) is crucial for managing locally advanced rectal cancer (LARC). This study investigates whether a predictive model using image-text features extracted from endorectal ultrasound (ERUS) via Contrastive Language-Image Pretraining (CLIP) can predict tumor regression grade (TRG) before nCRT.

Methods: A retrospective analysis of 577 LARC patients who received nCRT followed by surgery was conducted from January 2018 to December 2023.

Duckweed (Lemna minor L.) as a natural-based solution completely offsets the increase in ammonia volatilization induced by soil drying and wetting cycles in irrigated paddies.

One of the primary pathways of nitrogen loss in rice fields, ammonia (NH) volatilization resulting in low nitrogen use efficiency and contributes significantly to near-surface atmospheric pollution. Duckweed (Lemna minor L.), a common small floating plant in rice fields, often completely covers the water surface.

An in vitro biomechanical evaluation of integrated lateral plate combined with oblique lateral interbody fusion in different bone conditions.

Oblique lateral interbody fusion (OLIF) is a minimally invasive surgery for the treatment of lumbar degenerative diseases (LDD). Under normal bone mass(NB), supplemental with lateral plate (LP) fixation has been proven to provide stability and reduce complications. However, it is unclear whether OLIF combined with LP fixation can achieve satisfactory fixation effects in cases of osteoporosis(OP) or osteopenia (OS)? In this study, Eighteen L3-5 spinal specimens from 3 to 6 months old fresh calves were equally divided into 3 groups: group A (NB), group B (OS) and group C (OP).

Lensless On-Chip Chemiluminescence Imaging for High-Throughput Single-Cell Heterogeneity Analysis.

High-throughput single-cell heterogeneity imaging and analysis is essential for understanding complex biological systems and for advancing personalized precision disease diagnosis and treatment. Here, we present a miniaturized lensless chemiluminescence chip for high-throughput single-cell functional imaging with subcellular resolution. With the sensitive chemiluminescence sensing and wide field of view of contact lensless imaging, we demonstrated the chemiluminescent imaging of over 1000 single cells, and their membrane glycoprotein and the high-throughput single-cell heterogeneity of membrane protein imaging were examined for precision analysis.