Tetrahedral DNA Framework-Engineered Magnetic Nanozyme for Visual Biomarker Sensing via Alkaline Phosphatase-Triggered Signal Switching.

Point-of-care (POC) detection of prostate-specific antigen (PSA) is critical for the early screening and monitoring of prostate cancer (PCa), which facilitates timely intervention and personalized treatment. However, existing POC platforms suffer from inadequate detection sensitivities, susceptibility to matrix interference, and complex sample pretreatment. To address these issues, we proposed a naked-eye and colorimetric sensing platform based on magnetic nanozyme (FeO@ZIF-67@Pt) integrated with a tetrahedral DNA framework (TDF) and alkaline phosphatase (ALP)-triggered hydrolysis reaction for PSA detection with superior sensing performances.

Case Report: Polymyxin E-associated reversible leukopenia.

Introduction: With the increasing challenge of antibiotic resistance, polymyxin E is considered a last-line treatment option for infections caused by highly resistant bacteria. However, its use may lead to various adverse reactions, such as nephrotoxicity, neurotoxicity, and allergic reactions.

Case Presentation: This study describes a case of polymyxin E-associated leukopenia in a 50-year-old female treated for infection.

Research hotspots and frontiers of application of mass spectrometry breath test in respiratory diseases.

Mass spectrometry (MS)-based breath analysis has emerged as a promising non-invasive approach for diagnosing and monitoring respiratory diseases through the identification of volatile organic compounds (VOCs). This study conducted a comprehensive bibliometric analysis of 467 publications (2003-2024) to map global research trends, influential contributors, and thematic hotspots in this field. Results showed a sustained annual growth rate of 11.

Mechanism of for the treatment of diabetic kidney disease based on network pharmacology.

Background: Although has been used for the treatment of diabetic kidney disease (DKD), the relevant mechanisms remain unclear. The purpose of this study was to investigate the potential targets and mechanisms of in treating DKD, utilizing network pharmacology.

Methods: Active compounds of were obtained from the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform database.

Mitochondrial Homeostasis in Cancer: Functions and Targeted Therapies.

The dysregulation of mitochondrial homeostasis in tumor cells plays a significant role in tumorigenesis and progression. Mitochondria within tumor cells exhibit extensive mutations, proliferation, and fragmentation to accommodate heightened metabolic and energy requirements. This disruption of mitochondrial homeostasis is intricately linked to tumor cell proliferation, invasion, metastasis, energy metabolism, and redox balance.

Strain and Kinetics Synergy in Octahedral High-Entropy Cathodes Enables Ultra-Durable Sodium-Ion Batteries.

High-entropy oxides represent a paradigm shift in sodium-ion battery cathodes by utilizing entropy-driven structural stabilization to address the intrinsic challenges of lattice strain and sluggish ion kinetics. However, conventional high-entropy oxides face challenges in synthesis complexity and insufficient mechanistic insights into strain-kinetics coupling. Here, a high-entropy O3-type layered oxide, NaNiCoFeMnZnCuTiO (NNCFMZCT), is proposed featuring seven transition metals in a single crystallographic site, to synergistically optimize Na⁺ diffusion and structural resilience.

Prediction of Human Pathogenic Start Loss Variants Based on Multi-channel Features.

Start loss variants occur at the start codon that can disrupt the normal translation initiation process, potentially resulting in the production of abnormal protein isoforms. Although numerous computational methods have been developed to aid in the large-scale interpretation of genetic variants, they often show limited predictive accuracy for start-loss variants. A significant limitation of the majority of these methods is their dependence on manually curated features, which restricts their ability to predict variants that have not been studied and characterized.

Identification of QTLs for aphid (Melanaphis sacchari) resistance in sorghum (Sorghum bicolor) based on BSA-seq and analysis of candidate genes.

Aphid infestation significantly reduces the yield and forage quality of sorghum, underscoring the urgent need to identify and develop aphid-resistant sorghum varieties. Marker-assisted selection (MAS) remains one of the most effective strategies for enhancing aphid resistance in sorghum. In this study, an F segregating population derived from a cross between the aphid-resistant variety IS23514 and the susceptible variety IS23992 was employed to map aphid resistance genes using bulked segregant analysis based on whole-genome resequencing (BSA-seq) and Insertion-Deletion (InDel) marker analysis.

Minimalist infrared computational imaging with double-sided diffractive single-lens system.

The hybrid-order monolithic imaging diffractive (HMID) lens was designed to address the issue of negative dispersion of diffractive optical elements (DOEs) in infrared minimalist optical systems. However, the imaging quality is negatively impacted by processing errors and aberrations of the HMID when it is expanded for large aperture use. The initial goal of minimalist imaging is contradicted by traditional optical techniques like adding additional lenses to eliminate aberrations, so we proposed a joint optical-algorithmic processing method in this paper to address the above issues.

Monolithically integrated passive photonic silicon chip for nano-g level acceleration tri-axial detection.

This paper proposes a nano-g level monolithically integrated tri-axial passive photonic accelerometer chip using uniform silicon-based micromachining with a low-frequency band. The silicon sensing units are designed with compact gradient-type and asymmetric S-type spring beams, allowing superior sensitivity in low-frequency band and tri-axial consistency. The spring-mass structures behave with uniform 460 μm thickness, significantly simplifying the silicon micromachining and improving process yield.

European and African ancestry-specific plasma protein-QTL and metabolite-QTL analyses identify ancestry-specific T2D effector proteins and metabolites.

In this study, we generated and integrated plasma proteomics and metabolomics with the genotype datasets of over 2300 European (EUR) and 400 African (AFR) ancestries to identify ancestry-specific multi-omics quantitative trait loci (QTLs). In total, we mapped 954 AFR pQTLs, 2848 EUR pQTLs, 65 AFR mQTLs, and 490 EUR mQTLs. We further applied these QTLs to ancestry-stratified type-2 diabetes (T2D) risk to pinpoint key proteins and metabolites underlying the disease-associated genetic loci.

Association mapping and candidate gene identification for drought tolerance in sorghum.

Introduction: Water is essential for plant growth, and drought is one of the most predominant constraints on crop yield. Sorghum is a well-known drought-tolerant crop model, and sorghum landraces possess novel alleles for local adaptation.

Methods: In this study, we evaluated a sorghum mini core panel of 239 landraces sampled globally for shoot and root growth under simulated drought conditions using 10% and 20% polyethylene glycol (PEG) in 2020 and 2024, and measured drought tolerance using the seedling tolerance coefficient (STC).

growth and field emission of single-crystal HfC nanotips.

Nanotips exhibit a low turn-on field and high emission current density, and are considered promising candidates in future cold-field emitters. However, it is difficult to fabricate an emitter with ultra-fine curvature radius, outstanding collimation and stable interfacial adhesion. In this study, we developed an technique that enables the fabrication of single-crystal hafnium carbide (HfC) nanotips on top of tungsten (W).

[Retracted] Twist induces epithelial‑mesenchymal transition in cervical carcinogenesis by regulating the TGF‑β/Smad3 signaling pathway.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that, for the Transwell migration and invasion assay experiments shown in Fig. 3C and D on p. 1791, two pairs of the data panels appeared to be overlapping, suggesting that the same data may have been used in this figure to represent data that were intended to show the results from differently performed experiments.

Tetrahedron DNA Nanostructures as microRNA Inhibitors to Alleviate Acute Pancreatitis.

Acute pancreatitis (AP) is an inflammatory pancreatic disorder characterized by tissue damage and necrosis. It not only affects the pancreas but also triggers systemic inflammatory responses, leading to multiorgan failure and potentially death. In recent years, microRNA (miRNA) sponges have demonstrated promise to enhance AP treatment outcomes by inhibiting specific miRNAs.

Renal dysfunction and outcomes for thrombolysis-treated stroke beyond 4.5 hours: Trace-Ⅲ post hoc analysis.

Objective: Concerns regarding bleeding risks have limited the use of intravenous thrombolysis in acute ischemic stroke (AIS) patients with renal dysfunction (RD). This study investigated the impact of RD on the efficacy and safety of Tenecteplase (TNK) thrombolysis in AIS patients with large vessel occlusions (LVO) beyond the 4.5 h window.

Causal Effects Between Anxiety-Depressive and Subjective Tinnitus in Europe: A Bidirectional Mendelian Randomization Study.

Unlabelled: This study aimed to explore the potential causal relationship between anxiety-depression and tinnitus using a bidirectional mendelian randomization (MR) approach. Utilizing genetic data from five UKB datasets, one IEU dataset, one EBI dataset encompassing traits linked to anxiety and depressive states, and tinnitus data sourced from the FinnGen project, we conducted two-sample MR analyses. Instrumental variables were selected based on stringent criteria, including genome-wide significance, clumping to ensure independence, and the exclusion of palindromic Single Nucleotide Polymorphisms and those associated with confounders.

Global burden and trends in ovarian cancer attributable to environmental risks and occupational risks in females aged 20-49 from 1990 to 2021, with projections to 2050: a cross-sectional study.

Background: Ovarian cancer is the eighth most common cancer globally, with environmental and occupational exposures emerging as critical determinants of ovarian carcinogenesis. Despite accumulating evidence, comprehensive global assessments of the burden of ovarian cancer attributable to these risks remain limited, especially among women aged 20-49 years.

Methods: We conducted a cross-sectional analysis using data from the Global Burden of Disease (GBD) Study 2021 to evaluate the global burden of ovarian cancer associated with environmental risks and occupational risks among females aged 20-49 years from 1990 to 2021.

Polygenic prediction of body mass index and obesity through the life course and across ancestries.

Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.

A preliminary study on the clinical characteristics of lacrimal duct obstruction in patients with a history of anterior uveitis.

Aim: This study aimed to investigate the clinical features of lacrimal duct obstruction (LDO) in patients with a history of anterior uveitis (AU) and explore preventive strategies by analyzing their demographic, anatomical, and surgical outcome profiles.

Methods: We retrospectively reviewed 40 LDO patients (58 eyes) with a history of AU, treated between 2020 and 2024, comparing them to non-AU LDO controls. Data included demographics, AU-epiphora temporal relationships, obstruction characteristics (location, extent, and adhesions), and surgical outcomes.

Characterization of Temporal and Spatial Changes of Endemic Fluorosis Due to Coal-Burning Pollution - China, 2009-2023.

What Is Already Known About This Topic?: Coal-burning pollution type of endemic fluorosis poses a serious health threat to rural inhabitants in certain regions of China.

What Is Added By This Report?: The detection rate of dental fluorosis among children aged 8-12 years in China's coal-burning endemic fluorosis areas showed a significant decreasing trend from 2009 to 2023. Nine provincial-level administrative divisions (PLADs) were classified as low-prevalence clusters, while only Yunnan was identified as a high-prevalence cluster during 2022-2023.

Identification of novel protective loci for executive function using the trail making test part B in the Long Life Family Study.

The Trail Making Test (TMT) Part B (TMT-B), a well-established assessment of cognitive function, is a frequent component of diagnostic assessments for Mild Cognitive Impairment and dementia in older adults. Identifying the genetic variants associated with the TMT-B will not only gain insights of genetic determinants of cognitive function, but also the molecular mechanisms for dementia. Published GWAS to date for TMT-B suffer from relatively low power due to the use of population level data and imputation methods.

RasGRP4 Exacerbates Diabetic Kidney Fibrosis via Aloxe3-Mediated Oxidative Stress and Scar-Associated Macrophage Activation.

Renal fibrosis is an irreversible pathological feature of diabetic kidney disease (DKD), and targeting macrophage phenotype is a promising strategy to prolong it. Ras guanine nucleotide-releasing protein 4 (RasGRP4) is a signaling protein involved in immune regulation. This study aimed to investigate how RasGRP4 contributes to kidney fibrosis by regulating scar-associated macrophages (SAM).

Patient-Reported Outcomes in Adults with Moderate-to-Severe Atopic Dermatitis Treated with Stapokibart over 52 weeks: A Post Hoc Analysis of a Phase 3 Trial.

Introduction: Atopic dermatitis (AD) significantly impairs quality of life and requires long-term management. This post hoc analysis aimed to evaluate the effect of stapokibart (an anti-IL-4Rα antibody) on patient-reported outcomes (PROs) in adults with moderate-to-severe AD from a phase 3 trial (NCT05265923).

Methods: Eligible patients were randomized 1:1 to receive stapokibart 300 mg (loading dose 600 mg) (n = 251) or placebo (n = 249) every 2 weeks (Q2W) for 16 weeks.

Successful multimodality treatment of anorectal melanoma after wide local excision: a case report.

Objective: The purpose of this case report is to explore the efficacy of comprehensive treatment of anal melanoma and to provide reference for the treatment of anal melanoma.

Methods: A rare case of anorectal melanoma was collected. After local excision, the patient was treated with a combination of the anti-vascular survival drug bevacizumab, anti-PD-1 immunotherapy and other treatments, and the patient's prognosis and survival were observed.