The Association Between ASA Score and Poor Quality of Recovery in Patients Undergoing Microsurgical Head and Neck Reconstruction.

Introduction: Early postoperative poor quality of recovery (PQR) correlates with higher perioperative complications. A higher American Society of Anesthesiologists (ASA) score is a well-recognized risk factor, and improving the physiological status may reduce the postoperative PQR rate. This study aimed to assess the association between ASA score and PQR after microsurgical free tissue transfer (FTT) to the head and neck.

Comparative effectiveness and acceptability of non-pharmacological interventions on improving social participation among older adults: a Bayesian network meta-analysis of randomised controlled trials.

Background: Social participation is recognised as a significant factor influencing the functional ability of older adults globally. However, current evidence remains inconclusive to determine which interventions are the most effective and widely acceptable.

Purpose: This study aimed to compare the effectiveness and acceptability of non-pharmacological interventions in improving social participation among older adults.

Causal Effects Between Anxiety-Depressive and Subjective Tinnitus in Europe: A Bidirectional Mendelian Randomization Study.

Unlabelled: This study aimed to explore the potential causal relationship between anxiety-depression and tinnitus using a bidirectional mendelian randomization (MR) approach. Utilizing genetic data from five UKB datasets, one IEU dataset, one EBI dataset encompassing traits linked to anxiety and depressive states, and tinnitus data sourced from the FinnGen project, we conducted two-sample MR analyses. Instrumental variables were selected based on stringent criteria, including genome-wide significance, clumping to ensure independence, and the exclusion of palindromic Single Nucleotide Polymorphisms and those associated with confounders.

Migraine and cochlear disease: A 2-sample bidirectional Mendelian randomized study.

This study aimed to explore the potential causal relationship between migraine and cochlear disease by using a bidirectional Mendelian randomization (MR) approach. We searched datasets related to migraine in the FinnGen database and genome-wide association studies catalog. We conducted 2-sample MR analyses.

Glycogen depletion in astrocytes induces sex-dimorphic remodeling of astrocytic and synaptic structures with concomitant anxiety-like behaviors and maternal care deficits.

Background: Maternal care is an instinctive social behavior indispensable for survival and gene transmission. Postpartum maternal behavior is profoundly affected by mother's emotional state via incompletely elucidated complex mechanisms including metabolic regulation. Brain glycogen, primarily located in astrocytes, is a potent modulator for brain plasticity and provides neuroprotection against bioenergetic insults.

Development and validation of a clinical-radiomics nomogram for predicting 180-day functional outcomes in patients with spontaneous thalamic hemorrhage.

Spontaneous thalamic hemorrhage (STH) is a severe type of hemorrhagic stroke with high mortality and disability rates. Identifying key risk factors for poor outcomes is crucial. This study developed and validated a clinical-radiomics nomogram to predict 180-day outcomes in STH patients.

Causal relationships between brain functional networks and tinnitus: A bidirectional 2-sample Mendelian randomization study.

This study aimed to discuss the potential causal relationship between brain functional networks and tinnitus using a bidirectional Mendelian randomization (MR) approach. Using genetic data from 6 datasets linked to brain functional networks, and tinnitus data sourced from the FinnGen project, we conducted 2-sample MR analyses. Instrumental variables (IVs) were selected based on stringent criteria, including genome-wide significance, clumping to ensure independence, and exclusion of palindromic single-nucleotide polymorphisms (SNPs) and those associated with confounders.

Study on the dissolution behavior of different celluloses in quaternary ammonium base/imidazole compound solvent system.

In this study, tetraethylammonium hydroxide solution and imidazole compounds (1-methylimidazole, 1-ethylimidazole, 1-propylimidazole) were used to develop a new green solvent system with high solubility, wide solubility range and fast dissolution rate. This system dissolved up to 18 wt% microcrystalline cellulose (DP = 171), and the solubility reached 15 wt% even at room temperature. At the same time, this solvent system exhibited strong solubility for cellulose with different degrees of polymerization, and dissolved 16 wt% cotton pulp cellulose (DP = 527) and 14 wt% hemp cellulose (DP = 2146), with significantly improved solubility.

Feasibility Study of an Indicator of Equivalent Potency of Multiple Anesthetics Normalized by Minimum Alveolar Concentration Derived From Response Surface Models.

Background: Minimum alveolar concentration (MAC) is used as the standard measure of potency for volatile anesthetic agents. However, there is a lack of effective and quantitative indicator of the combined potency of multiple coadministered inhalation and intravenous anesthetics. We hypothesized that an indicator of equivalent potency of multiple anesthetics, normalized by MAC and derived from response surface models as a fraction (abbreviated as eMAC fraction), can reflect the total potency of multiple anesthetics.

An eco-friendly flame retardant from chitosan, phytic acid, Fe-MOF endows thermoplastic polyurethane with enhanced fire safety and mechanical property based on hydrogen bond and π-π stacking.

Currently, achieving a satisfactory balance between flame retardancy and mechanical properties of thermoplastic polyurethane (TPU) composites faces significant challenges. To address these challenges, in this paper, an eco-friendly flame retardant from chitosan (CS), phytic acid (PA), and Fe-MOF (CS@PA@Fe-MOF) was synthesized and then introduced to TPU matrix. The non-covalent interaction including π-π stacking and hydrogen bonding that exist between the CS@PA@Fe-MOF units and TPU molecular chain can improve the interfacial compatibility of TPU composites, and contribute to imparting exceptional fire safety and superior mechanical performance to TPU composites.

Multiomics: Two-Sample, Bidirectional, Multivariate and Mediated Mendelian Randomization Analysis of Allergic Rhinitis.

Unlabelled: This study investigates the potential causal relationships among immune cells, plasma liposomes, and plasma metabolites in allergic rhinitis (AR) using a two-sample bidirectional multivariate and mediated Mendelian Randomization (MR) approach. Genetic data from five GWAS datasets covering traits linked to immune cells, plasma liposomes, plasma metabolites, and AR were used. Instrumental variables were selected based on strict criteria to ensure independence and exclude confounders.

Effectiveness of dexmedetomidine as a premedication for pediatric patients undergoing outpatient dental surgery under general anaethesia-systematic review and meta-analysis.

Pediatric patients undergoing outpatient dental surgery often exhibit instinctive resistance and fear in face of the unknown, which in turn creates obstacles to subsequent treatment. Appropriate sedation can increase compliance, decrease the incidence of adverse events, and lead to improved treatment outcomes. To evaluate the effectiveness of dexmedetomidine as pre-medication in children undergoing tooth extraction with general anesthesia, we searched databases including the Medline, Embase and Cochrane library for eligible trials.

The study on effects of acute exposure to high altitude hypoxia on cognitive function in lowlander.

The investigation of cognitive functions in response to high-altitude exposure has garnered increasing scientific interest. However, it remains unclear whether cognitive abilities are selectively impaired or what are the trends of the function. In this study, we examined the effects of acute exposure to 3800 m on cognition among 20 lowlanders (27.

Effect of remote ischemic preconditioning on perioperative neurocognitive disorder in elderly patients undergoing major surgery and associated genetic variant analysis: a randomized clinical trial.

Objective: To investigate whether remote ischemic preconditioning (RIPC) could reduce the incidence of perioperative neurocognitive disorder (PND) in elderly patients undergoing major surgery (> 2 h), to assess the potential of myeloid differentiation factor 2 (MD2) and cystatin C as biomarkers and to identify key genetic variants associated with PND.

Methods: From August 2020, 250 patients scheduled for major surgeries under general anesthesia were screened and 120 patients were randomly assigned to the control group or the RIPC group. After anesthesia induction, patients in the RIPC group received a blood pressure cuff around their right upper limb, which was pressurized to 200 mmHg to induce ischemia, whereas the cuff in the control group was pressurized to only 60 mmHg.

Exploring the genetic causal inference between plasma lipidome and hemorrhagic stroke.

Objectives: Recent research indicates that the plasma lipidome composition may undergo alterations following hemorrhagic stroke. Nevertheless, the causal inference between plasma lipidome and hemorrhagic stroke remains elusive.

Materials And Methods: Exposure data were achieved from a recent Genome-wide Association Study (GWAS) study of 179 lipid species involving 7174 individuals, while the outcome data were obtained from the FinnGen consortium (R10), including intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and non-traumatic intracranial hemorrhage (nITH).

Dopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine Addiction.

Feeding behavior changes induced by opioid addiction significantly contribute to the worsening opioid crisis. Activation of the reward system has shown to provoke binge eating disorder in individuals with opioid use disorder, whereas prolonged opioid exposure leads to weight loss. Understanding the mechanisms underlying these phenomena is essential for addressing this pressing societal issue.

Land cover changes reduce dust aerosol concentrations in Northern China (2000-2020).

Dust aerosols significantly impact climate, human health, and ecosystems, but how land cover changes (LCC) influence dust concentrations remains unclear. Here, we applied the Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) to assess the effects of LCC on dust aerosol concentrations from 2000 to 2020 in northern China. Based on land cover data derived from multi-source satellite remote sensing data, we conducted two simulation scenarios: one incorporating actual annual LCC and another assuming static land cover since 2000.

Contribution of dust emissions from farmland to particulate matter concentrations in North China Plain: Integration of WRF-Chem and WEPS model.

Wind erosion from farmland is a significant contributor to atmospheric particulate matter, particularly PM (atmospheric particulate matter with an aerodynamic diameter ≤ 10 μm), in regions with intensive agricultural activities such as the North China Plain (NCP). However, the specific impact of farmland dust emissions on regional air quality remains underexplored. This study integrated the Wind Erosion Prediction System (WEPS) model with the Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) to investigate the effect of agricultural dust emissions on PM concentrations in the NCP.

The High-Quality Genome Sequencing and Analysis of Red Raspberry ( L.).

Red raspberry ( L.), which is an important nutritional source for human health, belongs to fruit crops of the Rosaceae family. Here, we used Pacific Biosciences single-molecule real-time (SMRT) sequencing and high-throughput chromosome conformation capture (Hi-C) sequencing technologies to assemble genomes and reported a high-quality L.

Hollow transition metal chalcogenides derived from vanadium-based metal organic framework for hybrid supercapacitors with excellent energy-density and stability.

In-situ synthesized hollow transition metal chalcogenides have gained significant attention on account of their excellent electrochemical properties. Here, Ni-doped V-MOF (V(Ni)-MOF) nanorod arrays as precursor are first grown on nickel foam (NF). Subsequently, the nanorod arrays are converted into V(NiCo)-OH hollow nanotube arrays with cross-linked nanosheets by Co etching.

Integrated analysis of bulk and single-cell RNA sequencing reveals the impact of nicotinamide and tryptophan metabolism on glioma prognosis and immunotherapy sensitivity.

Background: Nicotinamide and tryptophan metabolism play important roles in regulating tumor synthesis metabolism and signal transduction functions. However, their comprehensive impact on the prognosis and the tumor immune microenvironment of glioma is still unclear. The purpose of this study was to investigate the association of nicotinamide and tryptophan metabolism with prognosis and immune status of gliomas and to develop relevant models for predicting prognosis and sensitivity to immunotherapy in gliomas.

Separation of Macro- and Micro-Texture to Characterize Skid Resistance of Asphalt Pavement.

The skid resistance of asphalt pavement is an important factor affecting road safety. However, few studies have characterized the contribution of the macro- and micro-texture to the skid resistance of asphalt pavement. In this paper, the generalized extreme studentized deviate (GESD) and neighboring-region interpolation algorithm (NRIA) were used to identify and replace outliers, and median filters were used to suppress noise in texture data to reconstruct textures.

Biomass-Derived Carbon Materials for Electrochemical Sensing: Recent Advances and Future Perspectives.

In recent years, biomass carbon materials have received widespread attention in the field of electrochemical sensors. As a new type of renewable green energy, biomass carbon has the advantages of low cost and abundant resources. After special treatment, it can be used as an ideal electrode material.

The effect of physical exercise on depression among college students: a systematic review and meta-analysis.

Objective: The goal of the present research was to evaluate the effectiveness of physical exercise intervention in enhancing psychological well-being and decreasing symptoms of depression among college students, adopting a systematic review and meta-analysis.

Methodology: The study was performed by searching four databases (PubMed, Embase, Web of Science, and the Cochrane Library) to determine randomized controlled trials (RCTs) exploring the impacts of physical exercise therapies among college students with symptoms of depression. The sequential execution of a meta-analyses, subgroup analyses, and publication bias analyses was accomplished utilizing the software package RevMan version 5.