Shape optimisation of rim structure of aluminium alloy car wheels based on 90° impact test.

Automotive wheels are critical components for vehicular safety, with the rim subjected primarily to radial bending loads during operation. Balancing rim thickness and structural integrity under these loading conditions is imperative. This paper develops and validates an innovative shape optimisation approach utilising the 90° wheel impact test methodology.

Identification, expression profiling and potential functional roles of nuclear receptors in the social aphid Pseudoregma bambucicola.

Background: Nuclear receptors (NRs) constitute a superfamily of transcription factors that regulate diverse biological processes. In insects, NRs not only govern essential physiological functions including metabolism, development, and reproduction, but also play pivotal roles in regulating caste differentiation and division of labor within social insect colonies. Pseudoregma bambucicola is a species of social aphid in which adults exhibit a specialized reproductive division of labor.

Study on the dissolution behavior of different celluloses in quaternary ammonium base/imidazole compound solvent system.

In this study, tetraethylammonium hydroxide solution and imidazole compounds (1-methylimidazole, 1-ethylimidazole, 1-propylimidazole) were used to develop a new green solvent system with high solubility, wide solubility range and fast dissolution rate. This system dissolved up to 18 wt% microcrystalline cellulose (DP = 171), and the solubility reached 15 wt% even at room temperature. At the same time, this solvent system exhibited strong solubility for cellulose with different degrees of polymerization, and dissolved 16 wt% cotton pulp cellulose (DP = 527) and 14 wt% hemp cellulose (DP = 2146), with significantly improved solubility.

Effects of fermented bamboo fiber on intestinal health and fecal pollutants in weaned piglets.

Introduction: Weaning stress adversely affects piglet growth and development, thereby reducing the economic efficiency of pig farming operations. Furthermore, pig feces are a major source of environmental pollution, underscoring the need for effective strategies to mitigate fecal output at its source.

Methods: This study investigated the effects of dietary supplementation with fermented bamboo fiber (FBF) on growth performance, intestinal barrier integrity, gut microbiota composition, and fecal pollutant levels in weaned piglets.

Correction: Fan et al. A Human DPP4-Knockin Mouse's Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV. 2018, , 448.

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Efficient 5-hydroxymethylfurfural production in ChCl-based deep eutectic solvents using boric acid and metal chlorides.

Bio-based 5-hydroxymethylfurfural (5-HMF) production in DESs has garnered significant attention due to its effectiveness and environmental friendliness. In this study, acidic ChCl-based DESs and ChCl-fructose DES were compared in terms of 5-HMF production in the presence of four acids, namely boric acid, oxalic acid, citric acid, and -toluenesulfonic acid. Simultaneously, two types of ChCl-fructose and ChCl-glucose DESs were explored in combination with boric acid for 5-HMF production respectively.

Assessment of cold resistance in tobacco varieties using JIP-test parameters and seedling growth.

Cold stress (CS) is a significant natural hazard, and distinguishing between plant cold resistance and sensitivity is critical for cultivar breeding and the development of germplasm resources. This study used 205 tobacco (Nicotiana tabacum L.) varieties from around the world to investigate the changes in the chlorophyll a fluorescence (OJIP) transients, JIP-test parameters, and seedling growth caused by seven days of CS (5°C) treatment.

Integrative transcriptomic analysis reveals the molecular responses of tobacco to magnesium deficiency.

Introduction: Magnesium (Mg) is a crucial macronutrient for plants. Understanding the molecular responses of plants to different levels of Mg supply is important for improving cultivation practices and breeding new varieties with efficient Mg utilization.

Methods: In this study, we conducted a comprehensive transcriptome analysis on tobacco ( L.

sp. nov. and sp. nov., two species isolated from fermentation cellar-producing sauce-flavour Chinese baijiu.

is an important microbial component in pit mud due to its ability to produce alcohol and short-chain fatty acids. This study presents the characterization and taxonomy of two Gram-stain-positive, strictly anaerobic, rod-shaped mesophilic bacterial strains, designated MT-113 and MT-5, isolated from pit mud in a fermentation cellar used for producing sauce-flavour Chinese baijiu. Phylogenetic analysis based on genome and 16S rRNA gene sequences of strains MT-113 and MT-5 indicates their affiliation with the genus (Cluster I of the Clostridia), with FW431 and WLY-B-L2 as the closest related species.

Hydrophobic Modification of Cellulose Acetate and Its Application in the Field of Water Treatment: A Review.

With the inherent demand for hydrophobic materials in processes such as membrane distillation and unidirectional moisture conduction, the preparation and application development of profiles such as modified cellulose acetate membranes that have both hydrophobic functions and biological properties have become a research hotspot. Compared with the petrochemical polymer materials used in conventional hydrophobic membrane preparation, cellulose acetate, as the most important cellulose derivative, exhibits many advantages, such as a high natural abundance, good film forming, and easy modification and biodegradability, and it is a promising polymer raw material for environmental purification. This paper focuses on the research progress of the hydrophobic cellulose acetate preparation process and its current application in the water-treatment and resource-utilization fields.

Numerical simulation on 90° impact test of aluminium alloy wheel with the effect of tyre.

Car wheels are crucial to automobile safety, requiring a rigorous test before production. A 90° impact test simulates the frontal impact and its influences on the wheel structure, replicating dynamic driving conditions. A novel modelling approach is illustrated for the 90° impact test simulation and investigates the feasibility of excluding the tyre.

Genomic and transcriptomic analyses of a social hemipteran provide new insights into insect sociality.

The origin of sociality represents one of the most important evolutionary transitions. Insect sociality evolved in some hemipteran aphids, which can produce soldiers and normal nymphs with distinct morphology and behaviour through parthenogenesis. The lack of genomic data resources has hindered the investigations into molecular mechanisms underlying their social evolution.

Spontaneous Brain Activity Abnormalities in Patients With Temporal Lobe Epilepsy: A Meta-Analysis of 1474 Patients.

Background: Abnormalities in resting-state functional brain activity have been detected in patients with temporal lobe epilepsy (TLE). The results of individual neuroimaging studies of TLE, however, are frequently inconsistent due to small and heterogeneous samples, analytical flexibility, and publication bias toward positive findings.

Purpose: To investigate the most consistent regions of resting-state functional brain activity abnormality in patients with TLE through a quantitative meta-analysis of published neuroimaging data.

Integrative analysis of the transcriptome and proteome reveals the molecular responses of tobacco to boron deficiency.

Background: Boron (B) is an essential micronutrient for plants. Inappropriate B supply detrimentally affects the productivity of numerous crops. Understanding of the molecular responses of plants to different B supply levels would be of significance in crop improvement and cultivation practices to deal with the problem.

Mitochondria-associated endoplasmic reticulum membranes involve in oxidative stress-induced intestinal barrier injury and mitochondrial dysfunction under diquat exposing.

Many factors induced by environmental toxicants have made oxidative stress a risk factor for the intestinal barrier injury and growth restriction, which is serious health threat for human and livestock and induces significant economic loss. It is well-known that diquat-induced oxidative stress is implicated in the intestinal barrier injury. Although some studies have shown that mitochondria are the primary target organelle of diquat, the underlying mechanism remains incompletely understood.

Significance of non-motor symptoms and development of a screening tool for osteoporosis in Parkinson's disease.

Background And Purpose: Parkinson's disease (PD) patients have a higher likelihood of having osteoporosis compared to controls, therefore deserving special attention. This study was to 1) investigate the association of non-motor symptoms with osteoporosis amongst PD patients, and 2) develop screening tools for osteoporosis.

Materials And Methods: PD Patients were included (n = 109).

Prognostic characteristics of a six-gene signature based on ssGSEA in sarcoma.

Background: Sarcoma is a rare malignant tumor originating of the interstitial or connective tissue with a poor prognosis. Next-generation sequencing technology offers new opportunities for accurate diagnosis and treatment of sarcomas. There is an urgent need for new gene signature to predict prognosis and evaluate treatment outcomes.

High-sensitivity profiling of dipeptides in sauce-flavor Baijiu Daqu by chemical derivatization and ultrahigh-performance liquid chromatography coupled with high-resolution mass spectrometry.

Dipeptides in sauce-flavor Baijiu Daqu are protein degradation products during the fermentation of Daqu, which are believed to play a crucial role in the flavor and quality of Baijiu. Herein, we integrated dansyl chloride derivatization with ultrahigh-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS) for comprehensively profiling dipeptides in Daqu. The derivatization efficiency was higher than 99.

Risperidone plasma level, and its correlation with CYP2D6 gene polymorphism, clinical response and side effects in chronic schizophrenia patients.

Background: To explore the influence of CYP2D6 genetic polymorphism on risperidone metabolism, thereby affecting risperidone's effects and safeties in patients with chronic schizophrenia.

Methods: Sixty-nine subjects with chronic schizophrenia treated with risperidone were recruited. CYP2D6 genotypes was determined using targeted sequencing and translated into phenotype using activity system.

Multi-omics analysis reveals PUS1 triggered malignancy and correlated with immune infiltrates in NSCLC.

Non-small cell lung cancer (NSCLC) is the main pathological type of lung cancer. In this study, multi-omics analysis revealed a significant increase of pseudouridine synthase 1 (PUS1) in NSCLC and the high expression of PUS1 was associated with shorter OS (Overall Survival), PFS (Progression Free Survival), and PPS (Post Progression Survival) of NSCLC patients. Clinical subgroup analysis showed that PUS1 may be involved in the occurrence and development of NSCLC.

Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.

MTOR (mechanistic target of rapamycin kinase) complex 1 (MTORC1) orchestrates diverse environmental signals to facilitate cell growth and is frequently activated in cancer. Translocation of MTORC1 from the cytosol to the lysosomal surface by the RRAG GTPases is the key step in MTORC1 activation. Here, we demonstrated that transcription factors MEF2A and MEF2D synergistically regulated MTORC1 activation via modulating its cyto-lysosome shutting.

Mechanistic insight into homogeneous catalytic crosslinking behavior between cellulose and epoxide by explicit solvent models.

Inspired by recent advances on functional modification of cellulosic materials, the crosslinking behaviors of epoxide with cellulose under the catalysis of different homogeneous catalysts including HO, Brønsted acid, Brønsted base, Lewis acid and neutral salt were systematically investigated using density functional theory (DFT) methods with hybrid micro-solvation-continuum approach. The results showed that catalytic activity, reaction mechanism and regioselectivity are determined by the combined effect of catalyst type, electronic effect and steric hindrance. All the homogeneous catalysts have catalytic activity for the crosslinking reaction, which decreases in the order of NaOH > HCl > NCl > MCl > CHCOOH > NaCl (N = Fe, Al; M = Zn, Ca).

Combined transcriptome and proteome analysis revealed the molecular regulation mechanisms of zinc homeostasis and antioxidant machinery in tobacco in response to different zinc supplies.

Zinc (Zn) is an essential micronutrient for plants. Adequate regulation of Zn uptake, transport and distribution, and adaptation to Zn-deficiency stress or Zn-excess toxicity are crucial for plant growth and development. However, little has been done to understand the molecular responses of plants toward different Zn supply levels.