Mechanism of for the treatment of diabetic kidney disease based on network pharmacology.

Background: Although has been used for the treatment of diabetic kidney disease (DKD), the relevant mechanisms remain unclear. The purpose of this study was to investigate the potential targets and mechanisms of in treating DKD, utilizing network pharmacology.

Methods: Active compounds of were obtained from the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform database.

Molecular Subtypes and Biomarkers of Ulcerative Colitis Revealed by Sphingolipid Metabolism-Related Genes: Insights from Machine Learning and Molecular Dynamics.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with disrupted lipid metabolism. This study aimed to uncover novel molecular subtypes and biomarkers by integrating sphingolipid metabolism-related genes (SMGs) with machine learning approaches. Using data from the GEO and GeneCards databases, 29 UC-related SMGs were identified.

Integrative Multi-Omics Analysis Reveals Key Metabolic Regulators and Prognostic Biomarkers in Pediatric and Adult Thyroid Cancer.

Thyroid cancer, including papillary thyroid carcinoma (PTC) and anaplastic thyroid carcinoma (ATC), exhibits distinct molecular characteristics in adult and pediatric populations. Understanding these differences is vital for identifying therapeutic targets and prognostic biomarkers. We performed an integrative multi-omics analysis combining proteomics, phosphoproteomics, metabolomics, and RNA sequencing data from adult and pediatric thyroid cancer cohorts.

Dexamethasone treatment is associated with a higher HBsAg sero-clearance rate in HBeAg-positive patients with hepatitis B flares.

Purpose: Short-term dexamethasone has been used in patients with chronic hepatitis B flares to reduce inflammation in the liver. We aim to identify the potential population that may benefit from dexamethasone treatment.

Methods: A retrospective cohort study was conducted involving 856 hospitalized hepatitis B e antigen-positive patients with chronic hepatitis B flares.

Research progress of ASIC family in tumors.

As a proton-gated cation channel, the acid-sensitive ion channels (ASICs) is capable of sensing changes in the extracellular pH value. ASICs are widely distributed and apart from physiological functions, play a role in various diseases related to acidity, such as pain, inflammation, and ischemia. Moreover, studies have shown that ASICs also have an impact on the occurrence, development, invasion, metastasis, and drug resistance of tumors under acidosis conditions.

Risk Stratification for Diffuse Large B-Cell Lymphoma by Integrating Interim F-FDG PET-CT Analysis and the NCCN-IPI: A Multicenter Retrospective Study.

Our study aimed to assess the prognostic significance of the interim National Comprehensive Cancer Network International Prognostic Index and PET-CT-related parameters for predicting patient outcomes and achieving precise risk stratification for diffuse large B-cell lymphoma (DLBCL) patients. We retrospectively analyzed the clinicopathological and PET-CT data of 498 patients diagnosed with DLBCL across three medical centers in China. 418 patients were eligible for subsequent analysis after excluding those with incomplete data and 70% of which were randomly selected as the discovery cohort, whereas the remaining 30% constituted the validation cohort.

Characterization of Pulmonary Sclerosing Pneumocytoma Assessed by F-FDG PET/CT.

Background: This study evaluated the presentation of pulmonary sclerosing pneumocytoma (PSP) in F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) with the aim of increasing awareness of the disease.

Methods: Retrospective analysis was performed on 46 PSP patients who had F-FDG PET/CT before surgery or pathological examination from January 2011 to December 2023. The F-FDG PET/CT manifestations of PSP were summarized, and the correlation between the maximum diameter of the tumor and PET metabolic parameters was analyzed, including the maximum standardized uptake value (SUV), the mean SUV (SUV), the peak SUV (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG).

Precision nutrition management in hyperlipidemia-associated acute pancreatitis: mechanistic insights and personalized therapeutic approaches.

Hyperlipidemia-associated acute pancreatitis (HLAP), an acute inflammatory disorder triggered by dyslipidemia, has witnessed a rising global incidence with significant health implications. The pathogenesis of HLAP involves complex interactions among lipid metabolism dysregulation, inflammatory cascades, and oxidative stress. Conventional therapeutic approaches, while providing partial symptomatic relief, exhibit limitations in addressing individual variability.

Maternal vitamin D regulates the metabolic rearrangement of offspring CD4 T cells in response to intestinal inflammation.

Children with autism spectrum disorders often have increased susceptibility to intestinal inflammation. However, the mechanisms and prevention of gastrointestinal immune dysfunction remain unclear. We demonstrate that maternal high vitamin D (VitD) level can rescue abnormal intestinal immune phenotypes in offspring that exhibit autism-like phenotypes due to exposure to maternal inflammation.

An analysis of prognostic risk and immunotherapy response of glioblastoma patients based on single-cell landscape and nitrogen metabolism.

Glioblastoma (GBM) is a highly invasive brain tumor of astrocytic origin. Nitrogen metabolism plays an instrumental role in the growth and progression of various tumors, including GBM. This study intended to mine nitrogen metabolism-related biomarkers for GBM-related research of prognosis and immunotherapy.

The NR3C2-SIRT1 signaling axis promotes autophagy and inhibits epithelial mesenchymal transition in colorectal cancer.

Colorectal cancer (CRC) is one of the most aggressive and lethal cancers with a complex pathogenesis, there is an urgent need to find new drug therapeutic targets. This study highlights the important role of the NR3C2-SIRT1 signaling axis in the metastasis mechanism of CRC. Our findings revealed that the expression of NR3C2 in CRC tissues was lower than that in adjacent non-cancerous tissues, and was negatively correlated with N stage by bioanalysis, IHC, western blot and qRT-PCR.

Genome-wide screening and validation of exosome-derived TLN1 as a regulator of epithelial-mesenchymal transition in lung cancer.

In addition to embryonic development, wound healing, and tissue fibrosis, epithelial-mesenchymal transition (EMT) is another process that enhances tumor invasiveness and metastatic activity. Exosomes transport a variety of bioactive components between cells and are crucial for cell‒cell communication in multiple complex biological processes, including cancer. Although a few studies have shown that exosomes encapsulate microRNAs that induce a pro-EMT tumor microenvironment, a systematic survey of potential EMT-related regulators in lung cancer exosomes is still lacking.

Subcritical water extraction improves the ability of Auricularia cornea var. Li. Polysaccharides to stabilize hydrogels and emulsion gels.

In this work, polysaccharides from Auricularia cornea var. Li. (ACP) were extracted by a novel subcritical water extraction (SWE) method.

Joint analysis of single-cell RNA sequencing and bulk transcriptome reveals the heterogeneity of the urea cycle of astrocytes in glioblastoma.

Background: Glioblastoma (GB) is incurable with a dismal prognosis. Single-cell RNA sequencing (scRNA-seq) is a pivotal tool for studying tumor heterogeneity. The dysregulation of the urea cycle (UC) frequently occurs in tumors, but its characteristics in GB have not been illuminated.

Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs.

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress has been made in understanding the pathogenesis of NAFLD, identifying multiple therapeutic targets and providing new directions for drug development.

Development of a core outcome set and core measurement set for kangaroo mother care: a study protocol.

Background: Kangaroo mother care (KMC) is a care of preterm and low birthweight infants carried skin-to-skin contact with the mother's chest and breastfeeding when possible. KMC has been proven to reduce mortality and morbidity in these infants. However, research on KMC has been limited by significant variability and inconsistency in reported outcomes across studies.

Intratumoral and peritumoral radiomics for preoperative prediction of neoadjuvant chemotherapy effect in breast cancer based on F-FDG PET/CT.

Objective: To investigate the value of F-FDG PET/CT-based intratumoral and peritumoral radiomics in predicting the efficacy of neoadjuvant chemotherapy (NAC) for breast cancer.

Methods: 190 patients who met the inclusion and exclusion criteria from 2017 to 2022 were studied. Features were extracted from the PET/CT intratumoral and peritumoral regions, feature selection was performed through the correlation analysis, t-tests, and least absolute shrinkage and selection operator regression (LASSO).

Visual impairment as the initial presentation in multiple myeloma: a case report and literature review.

Background: Multiple myeloma (MM) is a type of blood cancer, which rarely infiltrates the central nervous system (CNS) and lacks specific neurological symptoms. The prognosis is often poor, as the disease progresses rapidly. Herein, we present a rare case of MM with CNS involvement.

Evaluation of prognostic risk factors of triple-negative breast cancer with F-FDG PET/CT parameters, clinical pathological features and biochemical indicators.

Introduction: Breast cancer is a heterogeneous disease comprising various molecular subtypes, including Luminal A, Luminal B, human epidermal growth factor receptor-2 (HER2) positive, and triple negative types, each with distinct biological characteristics and behaviors. Triple negative breast cancer (TNBC) remains a particularly challenging subtype worldwide. Our study aims to evaluate whether Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (F-FDG PET/CT) parameters, clinical pathological features, and biochemical indicators serve as prognostic risk factors for TNBC.

Localized regional environmental risk in mountainous urban areas of Southwest China: identification, assessment, and management strategies in Kunming.

In recent decades, the escalating frequency of environmental risk events, arising from sources such as industrial accidents, chemical spills, or other anthropogenic activities, has intensified threats to the ecological environment. The targeted identification of high-risk areas, formulation of control lists for key risk sources within regions, and the implementation of differentiated management strategies remain significant challenges. This study employed an administrative region environmental risk assessment and gridded environmental risk analysis method to comprehensively evaluate the environmental risks in the city of Kunming, China.

c-MET is an important marker for acid-driven metastasis and anti-immune in colorectal cancer.

Background: The tumor microenvironment plays an important role in cancer progression, especially acidic microenvironment which distinguish cancer from normal tissues and immune microenvironment. This study was the first to investigate whether acidic microenvironment affects colorectal metastasis through MET and the relationship between MET and immune microenvironment.

Methods: We used TCGA and GEO databases to predict MET expression, its relationship with clinical features, and biological function it mediated, and validated its expression with clinical data, as well as to verify that MET mediates acidic microenvironment-induced colorectal cancer metastasis by inducing EMT at the cellular and animal levels.

Discovery of alkaline laccases from basidiomycete fungi through machine learning-based approach.

Background: Laccases can oxidize a broad spectrum of substrates, offering promising applications in various sectors, such as bioremediation, biomass fractionation in future biorefineries, and synthesis of biochemicals and biopolymers. However, laccase discovery and optimization with a desirable pH optimum remains a challenge due to the labor-intensive and time-consuming nature of the traditional laboratory methods.

Results: This study presents a machine learning (ML)-integrated approach for predicting pH optima of basidiomycete fungal laccases, utilizing a small, curated dataset against a vast metagenomic data.

ASIC3-activated key enzymes of de novo lipid synthesis supports lactate-driven EMT and the metastasis of colorectal cancer cells.

Acidic microenvironments is a cancer progression driver, unclear core mechanism hinders the discovery of new diagnostic or therapeutic targets. ASIC3 is an extracellular proton sensor and acid-sensitive, but its role in acidic tumor microenvironment of colorectal cancer is not reported. Functional analysis data show that colorectal cancer cells respond to specific concentration of lactate to accelerate invasion and metastasis, and ASIC3 is the main actor in this process.