Irisin-Based Nanocomposites for Antioxidant Purpose and the Promotion of Osteogenesis in the Inflammatory Microenvironment.

Current clinical periodontitis treatments including surgical treatment and antibacterial treatment might cause excessive immune response in the host and cannot effectively promote the regeneration of periodontal tissue. In this study, we explored irisin serving as a novel biomarker in gingival tissues from periodontitis patients and confirmed its immunoregulatory roles, including its capacity to scavenge reactive oxygen species (ROS) and suppress inflammatory responses, through activation of the P53 and PPAR-γ signaling pathways. Furthermore, we established a bioactive glass nanoparticle compound with irisin (IR-nBG) and evaluated its antioxidant and osteoimmunomodulatory properties in a ROS-rich inflammatory microenvironment.

Machine learning prediction and interpretability analysis of high-risk chest pain: a study from the MIMIC-IV database.

Background: High-risk chest pain is a critical presentation in emergency departments, frequently indicative of life-threatening cardiopulmonary conditions. Rapid and accurate diagnosis is pivotal for improving patient survival rates.

Methods: We developed a machine learning prediction model using the MIMIC-IV database (n = 14,716 patients, including 1,302 high-risk cases).

Maternal vitamin D regulates the metabolic rearrangement of offspring CD4 T cells in response to intestinal inflammation.

Children with autism spectrum disorders often have increased susceptibility to intestinal inflammation. However, the mechanisms and prevention of gastrointestinal immune dysfunction remain unclear. We demonstrate that maternal high vitamin D (VitD) level can rescue abnormal intestinal immune phenotypes in offspring that exhibit autism-like phenotypes due to exposure to maternal inflammation.

The impact of social activity on cardiovascular disease risk among middle-aged and older adults in China: a nationwide cohort study based on the CHARLS database.

Objective: This study aims to examine the relationship between social activity and the risk of cardiovascular disease (CVD) in middle-aged and older adults in China.

Methods: We used data from the China Health and Retirement Longitudinal Study (CHARLS) collected between 2011 and 2020. The study followed 4,099 participants aged 45 and older, all free from cardiovascular disease at baseline (2011), over a 9-year period.

Small-area association of hourly ambient temperature and acute morbidity.

Previous studies have reported the association between daily temperature and morbidity at city level, but small-area association of hourly temperature and acute morbidity is limited. We aimed to assess the association between hourly temperature and acute morbidity at the smallest administrative units (communities), and to explore the sources of regional heterogeneity. This case time series design was conducted using 145,678 non-accidental ambulance dispatch records in 328 communities in Fuzhou, China (2019-2024).

Structural basis of RNA polymerase complexes in African swine fever virus.

African swine fever virus is highly contagious and causes a fatal infectious disease in pigs, resulting in a significant global impact on pork supply. The African swine fever virus RNA polymerase serves as a crucial multifunctional protein complex responsible for genome transcription and regulation. Therefore, it is essential to investigate its structural and functional characteristics for the prevention and control of African swine fever.

Anti-noise performance analysis in amplitude-modulated collinear holographic data storage using deep learning.

In an amplitude-modulated collinear holographic data storage system, optical system aberration and experimental noise due to the recording medium often result in a high bit error rate (BER) and low signal-to-noise ratio (SNR) in directly read detector data. This study proposes an anti-noise performance analysis using deep learning. End-to-end convolutional neural networks were employed to analyze noise resistance in encoded data pages captured by the detector.

Insight into the potential of M-NbS (M = Pd, Ti and V) monolayers as anode materials for alkali ion (Li/Na/K) batteries.

Doping engineering significantly improves the electrochemical characteristics of electrode materials in alkali ion batteries. Herein, first-principles calculations were performed to systematically explore the effects of metal atom doping in NbS monolayers by substituting the Nb atoms with metal M atoms (M = Pd, Ti and V) on the structural stability and electrochemical performances. The results demonstrate that M-NbS monolayers can exhibit superior characteristics, including outstanding mechanical flexibility, excellent electronic conductivity, fast charge-discharge rate, low open circuit voltage and high theoretical capacity for alkali ion (Li, Na, and K) storage.

Epitaxial Growth of Multicolor Lanthanide MOFs by Ultrasound for Photonic Barcodes.

Epitaxially grown lanthanide metal-organic frameworks (Ln MOFs) exhibit multicolor and characteristic Ln emission with sharp emission bands, which are of great value in the field of information security and anti-counterfeiting. Epitaxial growth of Ln MOFs is generally achieved by solvothermal or hydrothermal methods, which suffer from challenges such as high reaction temperature and long growth time. Here, we report the fast epitaxial growth of multicolor lanthanide MOFs by an ultrasonic method at room temperature.

hsa_circ_0072309 Inhibits Oncogenesis in Hepatocellular Carcinoma by Epigenetic Activation of its Host Gene.

Recently, numerous studies have revealed the participation of circular RNAs (circRNAs) in cancer progression. Likewise, this research focused on circRNAs in hepatocellular carcinoma (HCC). A lowly expressed circRNA hsa_circ_0072309 in HCC was screened by analyzing the circRNA microarray GSE242797 and GSE216115 and identified in clinical specimens and cells.

Synergistic design of a semi-hollow core-shell structure and a metal-organic framework-derived Co/Zn selenide coated with MXene for high-performance lithium-sulfur batteries.

Lithium-sulfur batteries have garnered significant interest as potential energy storage systems for the future, owing to their remarkable theoretical specific capacity (1675 mA h g) and energy density (2600 W h kg). However, their development has been severely impeded by several challenges, including the low intrinsic conductivity of sulfur, volume expansion issues, and the polysulfide shuttle effect. To address these issues, polar metal compounds with nanostructures featuring hollow shells and catalytic functions have emerged as promising materials for designing advanced lithium-sulfur batteries.

Transcriptomic, 16S ribosomal ribonucleic acid and network pharmacology analyses shed light on the anticoccidial mechanism of green tea polyphenols against Eimeria tenella infection in Wuliangshan black-boned chickens.

Background: Eimeria tenella is an obligate intracellular parasitic protozoan that invades the chicken cecum and causes coccidiosis, which induces acute lesions and weight loss. Elucidating the anticoccidial mechanism of action of green tea polyphenols could aid the development of anticoccidial drugs and resolve the problem of drug resistance in E. tenella.

Visible-Light-Induced Annulation of Iodonium Ylides and 2-Isocyanobiaryls to Access 6-Arylated Phenanthridines.

A 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4-CzIPN)-photocatalyzed cascade arylation/cyclization reaction of 2-isocyanobiaryls and iodonium ylides was established for the synthesis of 6-arylated phenanthridines. This is the first example of employing iodonium ylides as aryl radical sources in a visible-light-induced radical cascade cyclization reaction.

Drug-eluting bead transarterial chemoembolization could improve the hepatic hemodynamics of patients with unresectable hepatocellular carcinoma: a retrospective cohort study.

Background: Transarterial chemoembolization (TACE) is widely used for patients with unresectable hepatocellular carcinoma (HCC); however, previous studies have demonstrated that conventional TACE (cTACE) might affect hepatic hemodynamics, which both associate with liver cirrhosis and survival. Drug-eluting bead TACE (DEB-TACE) improves treatment efficacy and safety, but its effects on the hepatic hemodynamics of HCC patients with cirrhosis remain unknown.

Methods: This retrospective cohort study included unresectable HCC patients treated with DEB-TACE from April 2018 to September 2020, who had limited tumor burden and liver function.

Photosynthesis of 3-Alkylated Coumarins from Carboxylic Acids Catalyzed by a NaS-Based Electron Donor-Acceptor Complex.

A simple and practical electron donor-acceptor (EDA) strategy to synthesize various 3-alkylated coumarins from easily available coumarins and naturally abundant carboxylic acids under photocatalyst-, oxidant-, and additive-free and mild conditions is reported. Using NaS as the catalytic electron donor, a series of primary, secondary, and tertiary carbon radicals can be efficiently generated, and the EDA complex can be regenerated without an alkaline additive.

A randomized controlled trial to verify the irrigation of salivary glands in relieving xerostomia in patients with Sjögren's syndrome.

Objective: To verify the effect of triamcinolone acetonide (TA) and major salivary glands saline irrigation on relieving xerostomia in Sjögren's syndrome (SS) patients.

Methods: The enrolled 49 SS patients were randomly assigned to the control group (no irrigation, n=16), saline group (irrigation with saline, n=17) and TA group (irrigation with TA, n=16). Fourteen cases of each group were treated differently but received the same examinations.

Electrocatalytic three-component synthesis of 4-halopyrazoles with sodium halide as the halogen source.

The first example of the electrocatalytic multicomponent synthesis of 4-chloro/bromo/iodopyrazoles from hydrazines, acetylacetones and sodium halides under chemical oxidant- and external electrolyte-free conditions has been developed. Sodium halides played a dual role as a halogenation reagent and a supporting electrolyte. Mechanism studies revealed that the bromination reaction proceeded an ionic pathway, whereas both chlorination and iodination proceeded a radical pathway.

The Endoplasmic Reticulum-Stressed Head and Neck Squamous Cell Carcinoma Cells Induced Exosomal miR-424-5p Inhibits Angiogenesis and Migration of Humanumbilical Vein Endothelial Cells Through LAMC1-Mediated Wnt/β-Catenin Signaling Pathway.

Under endoplasmic reticulum (ER) stress, tumor plays multifaceted roles in endothelial cell dysfunction through secreting exosomal miRNAs. However, for the head and neck squamous cell carcinoma (HNSCC), it is still unclear about the impact of ER-stressed HNSCC cell derived exosomes on vascular endothelial cells. To address this gap, herein, systemic research was conducted including isolation and characterization of ER-stressed HNSCC cell (HN4 cell line as an model) derived exosomes, identification of regulatory exosomal miRNAs, target exploration and downstream signaling pathway investigation of exosomal miRNAs in human umbilical vein endothelial cell (HUVEC).

LINC00536 promotes hepatocellular carcinoma progression via the miR-203b-5p/VEGFA axis.

LncRNAs exert comprehensive effects in regulating the initiation and deterioration of hepatocellular carcinoma (HCC). However, the specific expression profiles and functional mechanisms of LINC00536 in HCC need to be disclosed. The study is intended to clarify the leverage of LINC00536 in HCC and investigate the potential mechanisms for the regulatory role of LINC00536 in the progression of HCC.