Publications by authors named "Jian-Fa Yang"
is an obligate intracellular parasite of phylum Apicomplexa that poses a huge threat to pregnant hosts, and induces tragic outcomes for pregnant hosts, fetuses and newborns. However, the molecular mechanism underlying the tragic consequences caused by remains to be revealed. In the present study, we applied RNA-seq to study the transcriptomic landscape of the whole reproductive organ of pregnant mice post infection, aiming to reveal the key altered biological characters of reproductive organs of pregnant mice that could contribute to the tragic outcomes caused by infection.
View Article and Find Full Text PDFBackground: is a globally distributed zoonotic protozoan parasite in humans and animals. Infection is widespread in dairy cattle, especially in calves, resulting in neonatal enteritis, production losses and high mortality. However, the occurrence of spp.
View Article and Find Full Text PDFBackground: Eimeria tenella is an obligate intracellular parasitic protozoan that invades the chicken cecum and causes coccidiosis, which induces acute lesions and weight loss. Elucidating the anticoccidial mechanism of action of green tea polyphenols could aid the development of anticoccidial drugs and resolve the problem of drug resistance in E. tenella.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to assess the prevalence of a food-borne protozoan in Holstein cattle across various regions of Yunnan Province, China, involving analysis of 524 fecal samples.
- The results indicated a total infection rate of 2.48%, with Chuxiong having the highest rate at 5.71%, while no infections were found in Kunming.
- Phylogenetic analysis revealed that some samples were closely related to human strains, suggesting a potential risk of zoonosis, highlighting the need for improved prevention and control measures in the region.
Prevalence and multilocus genotyping of in Holstein cattle in Yunnan, China.
Front Vet Sci
October 2022
Article Synopsis
- * The highest infection rate was found in preweaned calves (33.7%), with lower rates in postweaned calves (24.5%), growing cattle (23.0%), and adults (17.3%).
- * Genetic analysis showed that the majority of infections were due to assemblage E, while mixed infections with assemblage A were also detected; this study establishes important baseline data for managing protozoon infections in dairy cattle.
Seroprevalence and risk factors of and infection in black goats in Yunnan Province, Southwestern China.
Front Vet Sci
October 2022
and are two obligate intracellular protozoan parasites that can cause reproductive failure and production losses. To date, there is no data of and seroprevalence in black goats in Yunnan Province, southwestern China. In the present study, a total of 734 serum samples were collected from black goats in four different counties of Yunnan Province.
View Article and Find Full Text PDFspp. are important foodborne and waterborne pathogens in humans and animals, causing diarrheal diseases. Cattle are one of the reservoirs of infection in humans.
View Article and Find Full Text PDFMolecular Detection and Genotyping of in Black Goats () in Yunnan Province, Southwestern China.
Animals (Basel)
November 2021
is a fungus-like protist that can parasitize in the intestines of humans and various animals causing a threat to public health. However, there has been no data for prevalence and genotypes in black goats in Yunnan Province, Southwestern China. In this study, 907 fecal samples were collected from black goats in 5 counties from Yunnan Province.
View Article and Find Full Text PDFPrevalence and Novel Genotypes Identification of in Dairy Cattle in Yunnan Province, China.
Animals (Basel)
October 2021
Article Synopsis
- The study focuses on a fungus-like protist parasite known to cause diarrhea and enteric diseases, particularly in cattle and humans.
- Researchers collected 841 fecal samples from dairy cattle and buffalo in Yunnan province, China, and found a low prevalence of 0.59%, identifying five genotypes including two novel ones.
- The findings suggest dairy cattle can potentially transmit this parasite to humans, emphasizing the need for effective prevention strategies against microsporidiosis.
Article Synopsis
- - The study investigated the prevalence and genetic types of certain enteric pathogens in pet dogs and cats in Yunnan province, China, utilizing fecal samples from 433 animals (262 dogs and 171 cats) and advanced DNA techniques.
- - The results showed that dogs had higher infection rates (13.7%, 8.0%, 4.6%) compared to cats (1.2%, 2.3%, 0.6%) for the pathogens examined, with living conditions affecting the prevalence in dogs but not in cats.
- - Notably, three new genotypes were discovered, along with several human-pathogenic types, indicating that pet pets may pose a zoonotic risk to public health, highlighting the need
Article Synopsis
- Yunling cattle, a unique breed from Yunnan Province, China, were studied to assess if they are infected with Giardia duodenalis and Cryptosporidium spp.
- The study revealed an overall prevalence rate of 10.49% for G. duodenalis and 0.77% for Cryptosporidium spp., with age identified as a significant risk factor for G. duodenalis infection.
- Two types of G. duodenalis and two species of Cryptosporidium were identified, marking the first report of these parasites in Yunling cattle and providing important baseline data for future research.
Article Synopsis
- - The study surveyed serum samples from 481 domestic black-boned sheep and goats in Yunnan province, China, to assess the seroprevalence of a specific Gram-negative bacteria unknown in these animals.
- - Results showed that approximately 20.79% tested positive for antibodies, with significant differences in seroprevalence among regions, and higher rates in male animals compared to females.
- - This research represents the first report of seroprevalence in these species in the region and serves as a foundational step for future efforts to manage the infection.
Article Synopsis
- Amebiasis is a worldwide parasitic disease that can cause serious symptoms like abdominal pain and diarrhea, with limited data available on its prevalence in nonhuman primates (NHPs) in southwestern China.
- The study collected 505 fecal samples from macaques and found that 9.31% tested positive for various species of Entamoeba, indicating differences in prevalence based on breed and feed type.
- Four species of Entamoeba were identified, with E. dispar being the most common, highlighting a low prevalence but high diversity of these parasites in NHPs in Yunnan Province.
First report of Cryptosporidium spp. infection and risk factors in black-boned goats and black-boned sheep in China.
Parasitol Res
September 2020
Article Synopsis
- Cryptosporidium is a protozoan parasite that can infect the gastrointestinal tracts of various animals, posing a risk to the health and productivity of black-boned goats and sheep, which can lead to significant economic losses in the livestock industry.
- A study in Yunnan province, China, analyzed 590 fecal samples from these animals and found an overall infection prevalence of 13.2%, with higher rates in goats (18.0%) compared to sheep (8.1%).
- Three species of Cryptosporidium were identified, with C. muris being the most common, and this research marks the first report of Cryptosporidium infection in these animals in China, paving the way for improved understanding and management of
Article Synopsis
- - The study aimed to analyze the presence and genetic characteristics of Toxoplasma gondii in cats, rats, and chickens in Yunnan Province's border areas by collecting 259 samples in total.
- - The detection rates of T. gondii were found to be 15.96% in cats, 15.52% in rats, and 6.54% in chickens, resulting in an overall average infection rate of 11.97%.
- - The study identified the T. gondii genotype ToxoDB#9 in cats and rats, but could not determine a genotype in chickens due to low DNA concentration, contributing valuable information for controlling T. gondii infections in both humans and animals.
Blastocystis is an enteral eukaryote with an omnipresent existence in animals and humans globally. Animals have been proposed to be a major reservoir for the transmission of Blastocystis to individuals due to their high prevalence and large amount of zoonotic subtypes. However, limited data on Blastocystis infection in experimental macaques in China exists.
View Article and Find Full Text PDFToxoplasma gondii and Neospora caninum are two closely related protozoan parasites which can cause abortion and significant economic losses in sheep and goats. However, it is yet to know whether black-bone sheep and goats are infected with T. gondii and N.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on the prevalence and genotypes of Giardia duodenalis in black-boned sheep and goats, native breeds from Yunnan Province, China, highlighting its public health impact and economic significance.
- - Fecal samples from 661 animals were analyzed, revealing a significantly higher infection rate in sheep (21.8%) compared to goats (4.8%), with variations noted across different counties and age groups.
- - Both zoonotic and animal-specific assemblages of G. duodenalis were identified, with assemblage E being the most common; a total of 16 multilocus genotypes were discovered, emphasizing the diversity of the infection in these breeds.
Cytauxzoon felis Infection in Domestic Cats, Yunnan Province, China, 2016.
Emerg Infect Dis
February 2019
We performed a molecular survey for Cytauxzoon felis infection in 311 domestic cats in Yunnan Province, China, in 2016 and found a prevalence of 21.5%. C.
View Article and Find Full Text PDFOccurrence and Multilocus Genotyping of in Yunnan Black Goats in China.
Biomed Res Int
February 2019
is an important zoonotic parasite which can parasitize in the intestines of humans and various animals. However, the information about the prevalence and genetic diversity of in goats in China is limited. It is yet to be known whether Yunnan black goats, a unique goat breed in subtropical Yunnan province, southwestern China, are infected with Thus, a total of 907 fecal samples were collected from Yunnan black goats in five regions in Yunnan province, to estimate the prevalence and genotypes of using a PCR-based approach.
View Article and Find Full Text PDFArticle Synopsis
- Enterocytozoon bieneusi is a widespread pathogen in sheep and goats that poses risks to livestock development and public health, but limited research exists on native breeds in China.
- In a study in Yunnan province, 70 out of 661 fecal specimens (about 10.59%) tested positive for the pathogen in both black-boned sheep and goats, with no significant prevalence difference between the two species.
- Twelve genotypes of E. bieneusi were identified, including ten known variants and two new ones, with phylogenetic analysis showing some of these genotypes are zoonotic, indicating potential transmission to humans and the need for better infection management strategies among local livestock.
Article Synopsis
- Microsporidiosis is a significant zoonotic disease that can cause severe diarrhea, but there is a lack of data on the prevalence of Enterocytozoon bieneusi in Asiatic black bears in southwestern China.
- A study found that the overall prevalence of E. bieneusi among these bears was 19.75%, with the highest rate (33.33%) found in Xishuangbanna.
- The research identified four known genotypes and 13 novel genotypes of the parasite, highlighting the potential zoonotic risks associated with E. bieneusi in this region and providing essential data for future prevention and control efforts.
Article Synopsis
- The study investigates how two types of cercaria, fork-tailed and non-fork-tailed, affect liver and skin in mice, revealing distinct transcriptomic profiles for each type of infection.
- Fork-tailed cercaria enhanced liver metabolic processes, whereas non-fork-tailed cercaria suppressed them, affecting the pharmacokinetics during infection.
- In terms of immune response, fork-tailed cercaria triggered a stronger reaction in infected skin compared to non-fork-tailed cercaria, with key transcription factors identified that may regulate gene expression during the infection.
Genetic characterization of Toxoplasma gondii in Yunnan black goats (Capra hircus) in southwest China by PCR-RFLP.
Parasit Vectors
January 2015
Article Synopsis
- Toxoplasma gondii is a widely spread protozoan parasite that can infect various warm-blooded animals, including Yunnan black goats in China, but little is known about its genetic diversity in this specific population.
- The study involved collecting samples from the liver, lung, and lymph nodes of 403 black goats, using semi-nested PCR to detect T. gondii infection and then analyzing the positive samples for genetic markers through PCR-RFLP technology.
- Findings indicated that 4.96% of the samples tested positive for T. gondii, with the first identification of ToxoDB genotypes #9 and #10 in these goats, highlighting the potential public health risks
Genetic characterization of Toxoplasma gondii from cats in Yunnan Province, Southwestern China.
Parasit Vectors
April 2014
Article Synopsis
- The study focuses on the genetic diversity of Toxoplasma gondii, a parasite found in cats, specifically in Yunnan province, southwestern China.
- Researchers extracted DNA from various cat tissues to analyze the presence of T. gondii using advanced PCR techniques.
- The findings revealed that 25.14% of tested stray cats were positive for T. gondii, identifying multiple genotypes, including a notable occurrence of Type II T. gondii, highlighting potential public health risks.