Comparative Study of Transcriptome Profiles of Mouse Livers and Skins Infected by Fork-Tailed or Non-Fork-Tailed .

() is a worldwide spread pathogen which penetrates host skin and then induces several diseases in infected host, such as fibrosis, formation of granulomas, hepatocirrhosis, and hepatomegaly. In present study, for the first time, transcriptomic profiles of mouse livers and skins infected by fork-tailed cercaria or non-fork-tailed cercaria were analyzed by using RNA-seq. The present findings demonstrated that transcriptomic landscapes of livers and skins infected by fork-tailed cercaria or non-fork-tailed cercaria were different. has great influence on hepatic metabolic processes. Fork-tailed cercaria upregulated hepatic metabolic processes, while non-fork-tailed cercaria downregulated hepatic metabolic processes. For the metabolism process or the metabolism enzyme expressional change, the pharmacokinetics of host could be changed during infection, regardless the biotypes of cercariae. The changes of infected skins focused on upregulation of immune response. During the skin infection period, fork-tailed cercaria infection induced stronger immune response comparing with that immune response triggered by non-fork-tailed cercaria. The transcription factor enrichment analysis showed that Irf7, Stat1 and Stat2 could play important roles in gene regulation during fork-tailed cercaria infection.