Financial toxicity and psychological distress in cardiovascular non-cancer multimorbidity: a latent profile analysis and causal weighting.

Background: Cardiovascular disease with multimorbidity imposes substantial long-term financial burdens. Financial toxicity, the financial burden associated with healthcare, is increasingly recognized as a psychosocial stressor affecting health outcomes among chronically ill populations. However, its psychological heterogeneity in non-cancer patients is understudied.

digestibility of the polysaccharide fermented using and its improving effect on intestinal inflammation in zebrafish.

This study investigated the digestion characteristics of the polysaccharide fermented using (LA-rSFP) and its effects on dextran sulfate sodium-induced intestinal inflammation in zebrafish. The treatment substantially decreased the molecular weight of LA-rSFP and increased the reducing sugar content during gastrointestinal digestion. LA-rSFP considerably enhanced the activities of superoxide dismutase and catalase and markedly decreased malondialdehyde content, indicating a reduction in oxidative stress in the intestinal environment.

Introducing Fast Fourier Convolutions into Anomaly Detection.

Anomaly detection is inherently challenging, as anomalies typically emerge only at test time. While reconstruction-based methods are popular, their reliance on CNN backbones with local receptive fields limits discrimination and precise localization. We propose FFC-AD, a reconstruction framework using Fourier Feature Convolutions (FFCs) to capture global information early, and we introduce Hidden Space Anomaly Simulation (HSAS), a latent-space regularization strategy that mitigates overgeneralization.

Associated factors of anxiety and depressive symptoms among coal miners in Shanxi, China: a cross-sectional study.

Background And Objectives: Coal miners are exposed to a significant risk of anxiety and depression due to challenging work environment. However, there is a lack of studies comprehensively examining the associated factors of anxiety and depressive symptoms among coal miners. Our study aimed to identify these associated factors among Chinese coal miners in Shanxi Province.

The relationship between frailty in older adults and anxiety and depression in china: propensity score matching and network analysis.

Objective: Anxiety and depression are common mental disorders in the elderly. Concurrent frailty may lead to worse clinical outcomes. This study examined the network structures of anxiety and depression in frail and non-frail older adults.

Global, Regional, and National Trends in the Burden of Anxiety Disorders From 1992 to 2021: An Age-Period-Cohort Analysis Based on the Global Burden of Disease Study 2021.

Anxiety disorders pose a considerable global health challenge, ranking as the most prevalent type of mental illness. This study delineates the trends in incidence, prevalence, and years lived with disability (YLDs) for anxiety disorders at global, regional, and national levels between 1992 and 2021, with an emphasis on the independent effects of age, period, and birth cohort. Incidence, prevalence, and YLDs were selected as burden indicators of anxiety disorders, following the standardized methodologies of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, with data presented as numerical counts and age-standardized rates (ASRs) per 100,000 population.

High Oxygen Reduction Reaction Activity (SmSr)(NiFe)O ( = 1, 2, 3) Cathode with a Ruddlesden-Popper Structure for Low-Temperature Solid Oxide Fuel Cells.

The slow reaction kinetics of the oxygen reduction reaction (ORR) is one of the important challenges facing the development of a cathode in low-temperature solid oxide fuel cells (LT-SOFCs). Herein, we developed the (SmSr)(NiFe)O [-SSNF ( = 1, 2, 3)] cathode with a Ruddlesden-Popper (R-P) structure to investigate its oxygen ion conduction mechanism and cathodic ORR activity. Consequently, the cell device of the -SSNF ( = 3) cathode accomplished an impressive peak power density of 658 mW·cm.

Construction of a Risk Matrix for Pediatric Delirium in the Intensive Care Unit.

To construct a risk matrix for pediatric delirium in the intensive care unit (ICU), quantitatively evaluate the risk index of each risk factor, and provide a reference for optimizing the clinical management of pediatric delirium. Based on the risk matrix theory, a risk matrix was constructed for pediatric delirium in the ICU using literature research, Delphi expert consultation, and the Borda method. The 2-dimensional risk matrix revealed that of the 52 risk factors.

Cross-country inequalities in the epidemiology of chronic kidney disease due to type 2 diabetes mellitus, 1990-2021: findings from the global burden of disease study 2021.

Background: Chronic kidney disease due to type 2 diabetes mellitus (CKD-T2DM) is a predominant and life-threatening complication of T2DM, with significant inequalities in its epidemiological features globally. This study aimed to examine cross-country inequalities in the epidemiology of CKD-T2DM from 1990 to 2021.

Methods: Data were extracted from the Global Burden of Disease (GBD) 2021 study.

Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort study.

Background: As a pivotal reproductive factor, age at last live birth (ALLB) plays a critical role in a woman's health trajectory, including the risk of cardiovascular diseases.

Methods: In this prospective cohort study from the China Kadoorie Biobank (CKB), 148,456 parous postmenopausal women were included. ALLB was further classified equally into tertiles (<26 years, 26-29 years, and ≥30 years).

Therapeutic potential of a choline-zinc-vitamin E nutraceutical complex in ameliorating thioacetamide-induced nonalcoholic fatty liver pathology in zebrafish.

Choline has been proven to be effective in maintaining liver function. However, the effect of choline, in combination with other nutrients, on the improvement of non-alcoholic fatty liver disease (NAFLD) remains unclear. This study aimed to investigate the potential effect of the nutraceutical complex containing choline bitartrate, zinc citrate, and dl-α-Tocopheryl acetate on NAFLD in the zebrafish model.

Epidemiological and Molecular Characteristics of and spp. in Tan Sheep, Ningxia, Northwest China.

Piroplasmosis and anaplasmosis are important zoonotic diseases of animal origin, which can be transmitted by ticks to infect animals. However, there is limited information on the infection of piroplasmosis and anaplasmosis in Tan sheep in Ningxia, China. In order to understand the prevalence of piroplasmosis and anaplasmosis in Tan sheep in Ningxia, 150 blood samples of Tan sheep from farms in five urban areas of Ningxia were detected by PCR, and some positive samples were sequenced to establish a phylogenetic tree.

Mechanistic Insights Into for Diabetes Treatment via Network Pharmacology and Validation.

Purpose: There is an urgent need to develop antidiabetic medications with minimal side effects and low toxicity. , a food-medicine homologous in China, has been used to treat diabetes. This study was aimed to explore the active ingredients and mechanism of in the treatment of diabetes.

Global, regional and national trends in the epidemiology of rheumatoid arthritis from 1990 to 2021: an age-period-cohort effect analysis of the global burden of disease study 2021.

Background: Rheumatoid arthritis (RA) poses a significant global health challenge. This study examined trends in the incidence, prevalence and mortality of RA from 1990 to 2021 at global, regional and national levels, alongside age, period and cohort effects.

Methods: Age-standardised rates (per 100 000 population) on RA incidence, prevalence and mortality were extracted from the Global Burden of Disease (GBD) study 2021.

A Novel Diagnostic Model of Biomarkers in the Washing Fluid Obtained by EUS-FNA in Pancreatic Cancer.

Background And Aims: Currently, there are no biomarkers with high accuracy in the detection of pancreatic cancer. This article aims to evaluate the performance of a novel diagnostic model based on a combination of biomarkers in the washing fluid obtained by EUS-FNA with imaging examination in pancreatic cancer.

Methods: This study included 59 patients with pancreatic lesions who underwent EUS-FNA and were categorized into malignant and benign groups on the basis of pathology diagnosis.

Association between dietary habits and emotional and behavioral problems in children: the mediating role of self-concept.

Introduction: Increasing research has focused on the influence of diet on mental health and well-being. This study aimed to investigate dietary habits status and their associations with emotional and behavioral problems (EBPs) in pre-teen children, as well as explore the mediating effect of child self-concept in the associations between healthy dietary habits and EBPs.

Methods: A cross-sectional survey using stratified random sampling was conducted to recruit third-grade children and their caregivers.

BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway.

Background: Reduced oocyte quality is a key factor in age-related fertility decline, and there are no effective treatments available. The secretome of mesenchymal stem cells (MSC-sec) contains various bioactive factors and has the potential to improve oocyte quality. This study aimed to investigate the effective component and molecular mechanism of MSC-sec involved in improving oocyte quality from aged mice and humans.

Effects of lifestyle interventions on mental health in children and adolescents with overweight or obesity: a systematic review and meta-analysis.

Background: Childhood obesity and mental health disorders are increasingly prevalent. While lifestyle interventions are widely recognized as effective for managing obesity in children and adolescents, their effects on mental health remain unclear. This study aimed to systematically evaluate the effects of lifestyle interventions on mental health outcomes among children and adolescents with overweight or obesity.

Socioeconomic variations in the proportions of stroke attributable to reproductive profiles among postmenopausal women in China.

Background: This prospective study aimed to examine the individual and combined population attributable fractions (PAFs) of stroke and its subtypes associated with reproductive factors among Chinese postmenopausal women, highlighting variations across socioeconomic status (SES) stratas.

Methods: Data were from 138,873 Chinese postmenopausal women enrolled in the China Kadoorie Biobank. Reproductive factors evaluated in this study included early age at menarche, early age at menopause, advanced age at first live birth, high parity, history of stillbirth, history of miscarriage or termination, and non-lactation.

Global, regional and national temporal trends in incidence and mortality of non-Hodgkin lymphoma from 1992 to 2021: an age-period-cohort analysis.

Objectives: This study aimed to provide an overview of temporal trends in incidence and mortality of non-Hodgkin lymphoma (NHL) from 1992 to 2021 at global, regional, and national levels, with a special focus on their associations with age, period and cohort.

Methods: Data were obtained from the Global Burden of Disease Study 2021. We presented temporal trends in NHL incidence and mortality for the world and 204 countries and territories from 1992 to 2021.

Cross-Country Inequalities in Disease Burden and Quality of Care of Stroke, 1990-2021: A Systematic Analysis of the Global Burden of Disease Study 2021.

Background And Purpose: This study aims to assess the disease burden and care quality along with cross-country inequalities for stroke at global, regional, and national levels from 1990 to 2021.

Methods: Data on stroke were extracted from the Global Burden of Disease (GBD) study 2021 for the globe, five sociodemographic index (SDI) regions, 21 GBD regions, and 204 countries/territories. The disease burden was quantified using the age-standardized disability-adjusted life years rate (ASDR).

Effects of Exercise Interventions on Blood Pressure in Children and Adolescents With Overweight or Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

This systematic review and meta-analysis aimed to quantify the effect of exercise interventions on blood pressure (BP) among children and adolescents with overweight or obesity. A systematic search of five databases was conducted from inception to July 26, 2024, to identify relevant randomized controlled trials (RCTs). Study quality was assessed using the revised Cochrane Risk of Bias Tool for randomized controlled trials.

Timing of adverse childhood experiences and depressive, anxiety, comorbid symptoms among Chinese female nurses: A life course perspective.

Background: Nurses demonstrate a greater vulnerability to developing depressive and anxiety symptoms compared to the general population. Adverse Childhood Experiences (ACEs) are known risk factors for mental health issues, but impact of timing of these experiences remains unclear.

Objective: To investigate associations between timing of ACEs and depressive, anxiety, comorbid symptoms.

Artificial intelligence models assisting physicians in quantifying pancreatic necrosis in acute pancreatitis.

Background: Acute pancreatitis (AP) is a potentially life-threatening condition characterized by inflammation of the pancreas, which can lead to complications such as pancreatic necrosis. The modified computed tomography severity index (MCTSI) is a widely used tool for assessing the severity of AP, particularly the extent of pancreatic necrosis. The accurate and timely assessment of the necrosis volume is crucial in guiding treatment decisions and improving patient outcomes.