98%
921
2 minutes
20
To construct a risk matrix for pediatric delirium in the intensive care unit (ICU), quantitatively evaluate the risk index of each risk factor, and provide a reference for optimizing the clinical management of pediatric delirium. Based on the risk matrix theory, a risk matrix was constructed for pediatric delirium in the ICU using literature research, Delphi expert consultation, and the Borda method. The 2-dimensional risk matrix revealed that of the 52 risk factors. 17, 20, and 15 were classified as extremely high risk, high risk, and medium risk, respectively. The Borda sequence value method revealed that the use of psychoactive drugs (medium and high doses) and the Pediatric Risk of Mortality score of >15 were classified as critical risk points. The risk matrix method can accurately identify the key risk factors for pediatric delirium and aid in developing evidence-based risk control measures and managing pediatric delirium in the ICU.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1177/00099228251356861 | DOI Listing |
Front Pharmacol
August 2025
General Surgery Department Three, Gansu Province Central Hospital, Lanzhou, China.
Fast and early detection of low-dose chemical toxicity is a critical unmet need in toxicology and human health, as conventional 2D culture models often fail to capture subtle cellular responses induced by sub-toxic exposures. Here, we present a bioengineered three-dimensional (3D) electrospun nanofibrous scaffold composed of polycaprolactone that enhances chromatin accessibility and primes fibroblasts for improved sensitivity to low-dose chemical stimuli in a short period. The scaffold mimics the extracellular matrix, providing topographical cues that reduce cytoskeletal tension and promote nuclear deformation, thereby increasing chromatin openness.
View Article and Find Full Text PDFCNS Neurol Disord Drug Targets
September 2025
College of Pharmacy, National University of Science and Technology, Muscat, Oman.
Neurological disorders are complex conditions characterized by impairment of the nervous system, affecting motor, cognitive, and sensory functions. Current treatments meet substantial obstacles, primarily due to the difficulty of transporting drugs across the blood-brain barrier and ineffective therapy for nerve regeneration. Emerging technologies, such as electrospinning, offer innovative solutions to overcome these challenges.
View Article and Find Full Text PDFTalanta
September 2025
Warsaw University of Technology, Faculty of Chemistry, Chair of Analytical Chemistry, Noakowskiego St. 3, 00-664, Warsaw, Poland. Electronic address:
The contamination of agricultural soils with military-grade explosives such as 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitro-1,3,5-triazaccyclohexane (RDX) and 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclohexane (HMX) is an emerging concern in post-conflict regions, where food crops may take up these compounds. This study presents a novel analytical approach for detecting explosive residues in wheat (Triticum aestivum L.) grown on contaminated substrates.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Department of Epidemiology, Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai, China.
Human papillomavirus (HPV) causes multiple diseases in both sexes. This study evaluates the cost-effectiveness and epidemiological impact - defined as reductions in HPV-related disease cases - of a gender-neutral vaccination (GNV) strategy in China's economically developed metropolises: Beijing, Shanghai, and Guangzhou. A discrete-time Markov model simulated no vaccination, female-only vaccination (FOV), and GNV strategies among 12-year-olds.
View Article and Find Full Text PDFJCI Insight
September 2025
Division of Cardiovascular Medicine, Department of Medicine.
Aortic valve stenosis is a progressive and increasingly prevalent disease in older adults, with no approved pharmacologic therapies to prevent or slow its progression. Although genetic risk factors have been identified, the contribution of epigenetic regulation remains poorly understood. Here, we demonstrated that histone deacetylase 3 (HDAC3) maintains aortic valve structure by suppressing mitochondrial biogenesis and preserving extracellular matrix integrity in valvular interstitial fibroblasts.
View Article and Find Full Text PDF