The magneto-structural correlations of ferric and ferrous neutral complexes with the pyruvic acid thiosemicarbazone ligand.

Neutral iron(III) and iron(II) complexes based on the pyruvic acid thiosemicarbazone (Hthpy) ligand [Fe(Hthpy)(thpy)] (1) and [Fe(Hthpy)] (2) were synthesized, and deeper insights into magneto-structural correlation were gained by FT-IR spectroscopy, single crystal X-ray crystallography, dc magnetic characterization, Fe Mössbauer spectroscopy, and DFT calculations. The X-ray structures of complex 1 were established for the HS ( = 5/2) state at 295 K and the LS ( = 1/2) state at 150 K. The crystal packing of 1 at these temperatures corresponds to the triclinic 1̄ symmetry and contains pairs of [Fe(Hthpy)(thpy)] complexes interconnected by a shortened S⋯S contact.

Trends and Advancements in Smart Electrospun Food Fibers for the Management of Neurological Disorders.

Neurological disorders are complex conditions characterized by impairment of the nervous system, affecting motor, cognitive, and sensory functions. Current treatments meet substantial obstacles, primarily due to the difficulty of transporting drugs across the blood-brain barrier and ineffective therapy for nerve regeneration. Emerging technologies, such as electrospinning, offer innovative solutions to overcome these challenges.

The Association of SARS-CoV-2 Infection and COVID-19 Vaccination With Sudden Death: An Explorative Review.

Since its discovery, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has become the epicenter of public health concern. This was mainly attributed to the complexity of COVID-19 that resulted in variable disease progression with some developing asymptomatic infections, some suffering mild to moderate infections that resolved without the need for hospitalizations, and a few infected persons developing severe infections that required intensive care unit (ICU) admission and mechanical ventilation. The COVID-19 pandemic spread globally, affecting billions of people and killing millions.

Anti-obesity effects of water-dispersible turmeric extract via gut barrier and metabolite modulation in high-fat diet-fed mice.

Turmeric (Curcuma longa) exhibits anti-obesity properties, yet its low water solubility limits bioavailability. In this study, a water-dispersible turmeric rhizome extract (WDTE) was developed using nano-dispersion technology with maltodextrin as a wall material and characterized by UPLC-QTOF-MS, dynamic light scattering, and zeta potential analysis. The WDTE contained 10 identified metabolites, including five diarylheptanoids such as curcumin, demethoxycurcumin, and bisdemethoxycurcumin, with curcumin quantified at 7.

Design of a scandium-integrated MOF hybrid hydrogel for simultaneous dye adsorption and antibacterial activity.

In this study, a novel hybrid hydrogel incorporating a scandium-based metal-organic framework (scandium-integrated MOF-hydrogel hybrid) was developed using scandium nitrate, 1,4-naphthalenedicarboxylic acid, oxidized pectin, and chitosan. The synthesized scandium-integrated MOF-hydrogel hybrid demonstrated remarkable dual-functionality in both the adsorption of hazardous dye pollutants and the inhibition of pathogenic bacteria commonly found in wastewater. Characterization of the scandium-integrated MOF-hydrogel hybrid was performed using FT-IR, XRD, SEM, EDAX, CHNO elemental, BET, and XPS analyses, confirming successful MOF integration and a porous, reactive surface.

Multifunctional protective strategies for wooden cultural heritage: antimicrobial efficacy of polyacrylic resins, siloxane coupling agents, and silver nanoparticles.

Introduction: This study evaluates two innovative protective treatments for wooden cultural heritage objects vulnerable to biodeterioration. The first involves polyacrylic resin solutions embedded with silver nanoparticles (AgNPs), while the second uses the siloxane-based coupling agent 3-mercaptopropyltrimethoxysilane (3-MPTMS) to enhance AgNP adhesion to wood surfaces.

Methods: Antimicrobial, anti-biofilm, and anti-metabolic activities were assessed using both qualitative and quantitative assays against biodeteriogenic strains (, and ).

Ground Reaction Force Estimation via Time-aware Knowledge Distillation.

Human gait analysis with wearable sensors has been widely used in various applications, such as daily life healthcare, rehabilitation, physical therapy, and clinical diagnostics and monitoring. In particular, ground reaction force (GRF) provides critical information about how the body interacts with the ground during locomotion. Although instrumented treadmills have been widely used as the gold standard for measuring GRF during walking, their lack of portability and high cost make them impractical for many applications.

L. (onion) peel alleviates collagen and epinephrine-induced thrombosis in rats.

Thrombosis is a leading cause of cardiovascular diseases, driven by platelet aggregation, endothelial activation, and vascular occlusion. While L. (onion) is known for its health benefits, the antithrombotic potential of its peel remains underexplored.

Endolysin-based biocontrol strategies against in food: A comprehensive review.

poses significant challenges in the food industry due to its resistance in harsh environments and its ability to form biofilms. Endolysins represent a promising solution for controlling in the food industry, with potential applications during both production and storage. This review discusses various endolysins that effectively inhibit , emphasizing their optimal conditions and potential uses in food products.

Health: A Critique of Clinicians' Views and a Transgressive Model Based on Imagination.

In its first part, the article offers a critique of current definitions of health advanced in medical scholarship. It identifies and discusses their major problematic themes (e.g.

Alterations in 3D Chromatin Spatial Organisation in Tumourigenesis and Therapy Resistance of Glioblastoma: The Recent Advances in Understanding Molecular Mechanisms, Clinical Implications, and Therapeutic Perspectives.

Glioblastoma (GBM) remains one of the most aggressive and lethal forms of brain cancer, characterised by profound genetic, epigenetic, and phenotypic heterogeneity. Recent advancements in high-resolution genome mapping have unveiled the critical role of three-dimensional (3D) chromatin architecture-encompassing chromatin loops, topologically associating domains, and enhancer-promoter interactions-in driving GBM tumourigenesis and therapy resistance. This review summarises recent insights into the mechanistic contribution of 3D genome reorganisation in sustaining oncogenic transcriptional programs, promoting intratumoural heterogeneity, and facilitating adaptive resistance.

Relationship of vitamin D, fibrinogen and their ratio with acute coronary syndrome: A comparative analysis of unstable angina, NSTEMI, and STEMI.

Background: There is emerging evidence suggesting that vitamin D and fibrinogen play contrasting roles in ACS pathophysiology and their combined impact, expressed as the vitamin D/fibrinogen ratio, can be a potential biomarker for ACS severity. This study aimed to investigate the relationship between vitamin D, fibrinogen, and their ratio with ACS types, and assess their potential as risk stratification biomarkers.

Methods: This multicenter observational study was conducted in tertiary care hospitals in Afghanistan, Egypt, and Pakistan, including 300 ACS patients.

Engineering the Microbiome: a Novel Approach to Managing Autoimmune Diseases.

Autoimmune diseases occur when the immune system mistakenly attacks the body's own tissues, affecting millions of people and often requiring long-term treatment. Current therapies, such as immunosuppressants and biologics, help manage symptoms but can cause serious side effects. A promising new approach involves engineered microbiota-a method that modifies gut bacteria to influence immune function and potentially ease autoimmune conditions.

Forensic analysis and evaluation of file-wiping applications in Android OS.

Anti-forensics refers to techniques designed to obstruct the discovery of evidence in digital forensic investigations. File-wiping is one of the anti-forensic techniques that make data recovery impossible by overwriting data with specific patterns. This technique poses significant challenges to investigators.

Characterization of formaldehyde-induced hepatotoxicity based on proteometabolomic analysis.

Formaldehyde (FA) is a well-known environmental toxicant used in various industries, including biomedical, agriculture, and textiles, but poses significant health risks. Despite extensive research, the exact hepatotoxic mechanism of FA remains unclear. This study investigated FA-induced liver toxicity through an integrative analysis of proteomics and metabolomics in rat models, identifying 84 differentially expressed proteins and 66 metabolites.

Strategies in Tissue Regenerative Engineering for the Treatment of Human Infertility.

Regenerative engineering (RE) is the convergence of advanced stem cell science, material science, physics, clinical translation, and developmental biology to regenerate organ and complex tissue systems. It is a development of tissue engineering, which was first advanced as a method of restoration and repair of human tissue. In recent years, advances in regenerative techniques have shown promise in treating various clinical problems using existing advanced technology to harness the body's therapeutic and regenerative abilities.

A field-deployable lateral flow assay for rapid and sensitive detection of nanoplastics.

Plastic pollution has emerged as a global concern, with nanoplastics posing a distinct threat due to their small size, high mobility, and persistence. However, conventional nanoplastic detection techniques often rely on sophisticated instruments and extensive preprocessing, limiting their on-site applicability. This study aimed to develop a rapid and portable lateral flow assay (LFA) for on-site detection of nanoplastics smaller than 200 nm in environmental water samples.

Photocatalytic Activation of Dealuminated Zeolite through In Situ Formation of Defective Graphene.

Adsorbents such as zeolite are widely used for volatile organic compounds (VOCs) removal, but a practical challenge is the decrease in VOCs removal efficiency under humid environment by competitive adsorption between water vapor and VOCs, which requires frequent regeneration using external energy. A combination of zeolites with photocatalytic materials can address this issue by oxidizing adsorbed VOCs from the zeolite surface to CO gas under light irradiation. Herein, the in situ formation of photocatalytic active defect-rich graphene is presented on a commercial zeolite surface (ZSM-5) when properly dealuminated ZSM-5 is exposed to an acetaldehyde/humid air mixture under visible light.

Exploring the acute recovery effects of dry cupping therapy and electrical stimulation on anaerobic performance metrics in active individuals: A quasi-experimental crossover study.

Background: This quasi-experimental crossover study aimed to examine the acute effects of dry cupping therapy (DCT) and neuromuscular electrical stimulation (NMES) on fatigue and perceived exertion in anaerobic performance among physically active individuals.

Methods: Twelve male participants (mean age: 24.1 ± 2.

Needs for Technology-Enhanced Health Professions Education in Eastern and Southern Africa: Protocol for a Descriptive, Cross-Sectional Survey.

Background: The use of technology in its various forms has long been a feature of the education and training of health professionals in the industrialized world. As a result of the COVID-19 pandemic, health professions education institutions suddenly adopted "emergency remote teaching," and this experience exposed the vulnerabilities of countries in Eastern and Southern Africa regarding modes of teaching and learning. In this region, the needs to migrate to effective technology-enhanced learning are not explicit.

CRISPR/Cas9 in colorectal cancer: Revolutionizing precision oncology through genome editing and targeted therapeutics.

Colorectal cancer (CRC) remains a significant global health challenge, necessitating advanced molecular therapies to improve outcomes. The CRISPR/Cas9 genome-editing platform has emerged as a transformative tool in CRC research, enabling precise genomic modifications to suppress tumor progression, enhance chemosensitivity, and modulate oncogenic pathways. This review highlights CRISPR/Cas9 applications in CRC models, including MC38 murine and CaCO-2 cell lines, where targeted gene edits demonstrate tumor-suppressive effects.

Resistance of mature and elderly bodybuilders to anaerobic energy supply load.

Background: This study aims to assess the resistance level of beginner bodybuilders of mature and elderly age to strength training performed under anaerobic energy supply modes (creatine phosphokinase and glycolysis).

Methods: The study involved 60 men who had been engaged in bodybuilding for only 12 months. Group A included men aged 24 ± 1.

Impact of small molecule surfactant type and oil phase composition on Ostwald ripening in model food emulsions.

Unlabelled: Ostwald ripening destabilizes emulsified oils with significant water solubility, such as flavor oils, essential oils, and small triacylglycerols, by increasing oil droplet size over time. This study examined how small molecule surfactant types and oil phase composition affect Ostwald ripening rates in model oil-in-water emulsions. Emulsified -decane was stabilized using two non-ionic surfactants with the different structures: polyoxyethylene (100) stearyl ether or poloxamer P407.

Impact of emulsifier mixing and inhibitor type on Ostwald ripening of model food emulsions.

Unlabelled: This study examined how the ability to inhibit Ostwald ripening varies with ripening inhibitor type and how interfacial composition affects inhibitor efficiency. Emulsions were stabilized using Brij S100 and S20, which differ in ethylene oxide unit numbers, while medium-chain triglyceride (MCT) and ester gum (EG), possessing distinct molecular structures, were incorporated as ripening inhibitors. Ostwald ripening rate decreased with a higher proportion of Brij S20 at the interfacial membrane.

Experimental study on the compressive strength of fixed prosthetic restorations on tooth preparations with or without horizontal preparation.

Fixed prosthetic restorations, particularly those made entirely of zirconia, are widely used in clinical dental practice for the restoration of natural teeth. Their success largely depends on the design of the tooth preparation, especially the type of finish line, as well as the restoration's ability to withstand occlusal forces during mastication. Over 12 months, a total of 21 extracted teeth were initially collected, from which six were selected for this study.