Design, synthesis and biological evaluation of triazolo[1,5-a]pyrimidine derivatives as new antiproliferative agents with multikinase inhibitory activity.

Two series of triazolo[1,5-a]pyrimidines were designed and synthesized as antiproliferative agents targeting multi kinase inhibition aiming to increase potency and combat drug resistance. The synthesized compounds were tested for their antiproliferative activity. The triazolopyrimidine derivatives 9b, 9c, 12b and 12c showed promising anticancer activities, in particular, compounds 12b and 12c displayed broad spectrum antiproliferative potential against NCI cancer cell lines with GI mean value of 10.

Mitigating salinity and cadmium stress in rice ( L.) using PGPR and salicylic acid: rhizosphere, health risk, and physiological insights.

Soil contamination with salinity and heavy metals such as cadmium (Cd) is becoming a serious global problem due to the rapid development of the social economy. Although plant growth-promoting rhizobacteria PGPR and organic agents such as salicylic acid (SA) are considered major protectants to alleviate abiotic stresses, the study of these bacteria and organic acids to ameliorate the toxic effects of salinity and Cd remains limited. Therefore, the present study was conducted to investigate the individual and combined effects of PGPR and SA on enhancing the phytoremediation of salinity (100 mM NaCl) and Cd (50 µM CdCl₂) using rice ( L.

Development of a Sensitive Fluorimetric Method for Atomoxetine Determination in Tablets and Plasma Using a Dansyl Chloride Derivatization Approach.

New, eco-friendly method for analyzing atomoxetine (AXT) was developed using dansyl chloride as a fluorescent derivative. The method demonstrated a linear range from 50.0 to 900.

Novel antibacterial, antioxidant, and anti-inflammatory aminated chitosan hybrid quinoline Schiff base as multi-target agent: Design, molecular docking, and toxicity assessment.

This study involves the synthesis of a novel 7-ethoxy-3-formyl-2-morpholino quinoline (MQ) derivative, which was hybridized with aminated chitosan (AMCH) to yield a new AMCH-MQ Schiff base. Structural characterization via H NMR, FTIR, electronic spectra, XRD, and TGA confirmed successful hybridization. Ion exchange capacity decreased from 28.

Effectiveness of Incisional Negative Pressure Wound Therapy (iNPWT) in the Prevention of Post-Amputation Complications: Systematic review & Meta-analysis.

Objectives: Negative Pressure Wound Therapy (NPWT) is an advanced therapy utilizing sub-atmospheric pressure at the wound site to generate a controlled environment that promotes blood flow and stabilizes the wound area. However, its effectiveness in diminishing surgical site complications remains unproven effectively. We aim to assess the impact of iNPWT on the reduction of surgical wound complications, mortality rate, and improvement of healing rate following lower limb amputation.

The effect of 0.5 mg dose of colchicine on clinical outcomes in patients with acute myocardial infarction: An updated meta-analysis of randomized controlled trials.

Background: Inflammation plays a critical role in the progression of atherosclerosis, and the anti-inflammatory effects on clinical outcomes of patients with acute myocardial infarction (AMI) are still uncertain.

Objectives: We aimed to study the effects of a 0.5 mg dose of colchicine on clinical outcomes following AMI.

Relationship of vitamin D, fibrinogen and their ratio with acute coronary syndrome: A comparative analysis of unstable angina, NSTEMI, and STEMI.

Background: There is emerging evidence suggesting that vitamin D and fibrinogen play contrasting roles in ACS pathophysiology and their combined impact, expressed as the vitamin D/fibrinogen ratio, can be a potential biomarker for ACS severity. This study aimed to investigate the relationship between vitamin D, fibrinogen, and their ratio with ACS types, and assess their potential as risk stratification biomarkers.

Methods: This multicenter observational study was conducted in tertiary care hospitals in Afghanistan, Egypt, and Pakistan, including 300 ACS patients.

Impact of Subthalamic Nucleus Deep Brain Stimulation on Gastrointestinal Symptoms and Gastric Emptying in Parkinson's Disease: A Systematic Review and Meta-Analysis.

Objective: This systematic review and meta-analysis evaluates the efficacy of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in improving gastric motility in patients with Parkinson's disease (PD).

Materials And Methods: A systematic search was conducted in Scopus, Web of Science, PubMed, and Cochrane CENTRAL until December 15, 2024. Observational studies and clinical trials evaluating DBS effects on gastric motility and gastric emptying in patients with PD were included.

Effectiveness of injected versus topically applied platelet-rich plasma in diabetic foot ulcers: A randomized controlled trial with clinical and histopathological assessment.

Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes that can lead to significant morbidity. Autologous platelet-rich plasma (PRP), rich in growth factors and cytokines, has emerged as a promising treatment to enhance ulcer healing. This study aimed to compare the clinical and histological efficacy of injected PRP versus topically applied PRP and traditional wound care in the management of DFUs.

Synthesis, in vivo analgesic activity, molecular docking and density functional theory analysis of acyl hydrazide derivatives of mefenamic acid.

This study explores the synthesis of new acyl hydrazide derivatives of mefenamic acid as potent analgesics with enhanced safety profiles. Thirteen compounds were synthesized via hydrazide intermediate functionalization and characterized spectroscopically (H/C NMR, and HRESI-MS). In vivo evaluation (acetic acid writhing, formalin paw licking, and tail immersion tests) revealed significant peripheral and central analgesic activity, with compounds 5 (N'-(4-chlorobenzoyl)) and 11 (N'-(2,4-dichlorophenyl)) outperforming mefenamic acid (81.

A novel sulfamoylphenyl-dihydro-thiadiazole derivative as a dual EGFR and carbonic anhydrase inhibitor for cancer therapy.

A novel sulfamoylphenyl-dihydro-thiadiazole derivative (compound 14) has been designed and synthesized as a dual inhibitor targeting EGFR and human carbonic anhydrases (hCA_IX and hCA_XII). Computational studies, including density functional theory (DFT), molecular docking, and molecular dynamics simulations, confirmed its stability, favorable binding interactions, and reactivity profiles. Compound 14 showed potent inhibition of EGFR (IC₅₀ = 10.

Transgenerational Effects of Cadmium and Copper Exposure on Development, Reproduction, and Midgut Integrity in (Diptera: Culicidae): Implications for Vector Ecology Under Metal Pollution.

Heavy metal contamination in freshwater ecosystems poses persistent threats to aquatic organisms and public health. This study evaluates the transgenerational toxicity of cadmium chloride and copper sulfate on , focusing on development, reproduction, and midgut histopathology over two successive generations. Larval bioassays showed cadmium chloride to be more toxic than copper sulfate, with early instars exhibiting higher sensitivity (LC = 8.

A comprehensive systematic review of randomized controlled trials on anesthetic agents in children's upper gastrointestinal endoscopy: highlighting safety concerns and efficacy.

Upper gastrointestinal endoscopy (GIE) is essential for diagnosing and treating gastrointestinal disorders in children aged 6-12 years, yet it often requires sedation due to the significant discomfort and pain involved. We conducted a PRISMA 2020-compliant systematic review of randomized controlled trials (RCTs) from PubMed, Web of Science, Scopus, and Ovid (inception to March 30, 2024). Inclusion criteria are as follows: RCTs comparing sedative regimens (e.

D-optimal design-based optimization of Etoricoxib cubogel for management of arthritis; In vitro and in vivo Evaluation.

Etoricoxib (Et) is selective COX-2 inhibitor with several drawbacks after oral administration. Current study focused on formulating targeted Et cubogel for management of osteoarthritis. Interaction between formulation factors; (glyceryl-monooleate (GMO) and Poloxamer407 (Px)) concentrations and process parameters (melting/solvent-evaporation preparation methods) was investigated using D-optimal design.

Efficacy of Injectable Platelet-Rich Fibrin Versus Platelet-Rich Plasma Injection in Degenerative Temporomandibular Joint.

Background: Degenerative joint disease is a chronic condition marked by the gradual breakdown in the articular cartilage, together with alterations in the underlying bone and surrounding soft tissues, leading to ongoing joint deterioration. This investigation was conducted to evaluate the differences between efficacy of injectable platelet rich fibrin (I-PRF) versus platelet rich plasma (PRP) injection in degenerative temporomandibular joint (TMJ).

Methods: The investigation was conducted on a cohort of 20 patients aged over 18 years, both sexes, with unilateral or bilateral TMJ Osteoarthritis.

Comparative analysis of structural, radiation shielding, and optical properties in ZIF-8 and BDC-Cu (MOFs) for utilization in various applications.

In this study, we conducted a comprehensive analysis of the structural properties of ZIF-8 and BDC-Cu using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and Thermal gravimetric analysis (TGA). By studying the structural characteristics of these MOFs, we aim to understand how their unique properties influence their effectiveness as radiation shielding materials. The FTIR analysis confirmed the existence of metal-ligand and OH bonds that influence interactions with electromagnetic radiation and potentially contribute to shielding properties.

Exploring the interplay between metabolic dysfunction-associated fatty liver disease and gut dysbiosis: Pathophysiology, clinical implications, and emerging therapies.

Metabolic dysfunction-associated fatty liver disease (MAFLD) now affects roughly one-quarter of the world's population, reflecting the global spread of obesity and insulin resistance. Reframing non-alcoholic fatty liver disease as MAFLD emphasizes its metabolic roots and spotlights the gut-liver axis, where intestinal dysbiosis acts as a key driver of hepatic injury. Altered microbial communities disrupt epithelial integrity, promote bacterial translocation, and trigger endotoxin-mediated inflammation that accelerates steatosis, lipotoxicity, and fibrogenesis.

Optimizing ketamine dosing strategies across diverse clinical applications: a comprehensive review.

Ketamine has emerged as a versatile therapeutic agent with applications spanning anesthesia, pain management, and psychiatric disorders. This review examines ketamine's clinical utility across diverse administration routes, including intravenous, intramuscular, intranasal, and oral, emphasizing the need to individualize dosing regimens. We explore factors influencing ketamine dosing, such as patient characteristics (age, weight, comorbidities), concomitant medications, and desired clinical effects, while balancing efficacy and side effects.

Modulatory role of in oxidative stress, apoptosis, and gene expression in a rat model of dexamethasone-induced hepatotoxicity.

The rising prevalence of hyperlipidemia and hepatic disorders has intensified interest in the therapeutic use of functional foods and botanical drugs. , a blue-green microalga, is known for its antioxidant, anti-inflammatory, and lipid-lowering properties. However, its potential hepatoprotective effects, particularly against glucocorticoid-induced liver damage, remain underexplored.

Stimulation of the production of proteases from Penicillium verrucosum isolated from Egyptian soil.

The uses of proteolytic enzymes in manufacturing procedures are numerous. Researchers are investigating a number of strategies to find, rework, or artificially produce enzymes with improved suitability for manufacturing processes in light of the growing needs and uses. Alkaline protease production was assessed in fungal strains that were obtained from soil using the serial dilution technique.

Pre-lacrimal window maxillary sinus surgery: a computed tomography analysis and classification.

Background: The pre-lacrimal window (PLW) approach is a promising technique for accessing otherwise inaccessible maxillary sinus lesions. The objective of this study was to determine the computed tomography (CT) dimensions, measurements, and grading of the PLW.

Methods: One hundred paranasal CT scans were included in the study.

Clinical outcomes of tetralogy canal repair: A multidisciplinary perspective.

Objectives: To assess the surgical outcomes of atrioventricular septal defect associated with Tetralogy of Fallot (AVSD)-TOF repair performed at 2 specialized cardiac centers.

Methods: From May 2012 to December 2024, 20 patients diagnosed with AVSD-TOF who underwent surgical repair were included.

Results: The median age at the time of surgical repair was 13 months, with a median weight of 8.

MDL-800 protects against inflammatory and metabolic dysfunction: role of SIRT6 in the cross-regulation of NFκB, AMPK, and PPAR signaling in rats.

Metabolic syndrome (MetSyn) is a complex, multifactorial disorder characterized by insulin resistance, dyslipidemia, hepatic steatosis, oxidative stress, and chronic inflammation, contributing substantially to the global burden of cardiometabolic diseases. Despite extensive research, effective pharmacological strategies that address the diverse and interconnected pathophysiological mechanisms of MetSyn are lacking. Sirtuin 6 (SIRT6), a NAD-dependent epigenetic regulator, has emerged as a critical modulator of metabolic and inflammatory homeostasis.

Antimicrobial susceptibility patterns of Escherichia coli from various clinical sources.

Background: , frequently abbreviated as , is a common gastrointestinal tract inhabitant in both people and animals. It may also be found in soil, aquatic settings, and plants.

Aim: The purpose of the study was to identify the frequency and three susceptibilities of in various clinical samples taken from patients in the Jazan area.

Diagnostic accuracy of interleukin-6 (IL-6) as a significant biomarker in late-onset neonatal sepsis: an updated systematic review and meta-analysis.

Unlabelled: Late-onset neonatal sepsis (LONS) remains a leading cause of morbidity and mortality in neonates, particularly among preterm and low birth weight infants. Interleukin-6 (IL-6) has emerged as a promising biomarker for early detection of LONS, yet the diagnostic performance of IL-6 remains inconsistent across studies. This meta-analysis aimed to evaluate the overall diagnostic accuracy of IL-6 in detecting LONS and to assess the certainty of evidence using the GRADE approach.