Effectiveness of injected versus topically applied platelet-rich plasma in diabetic foot ulcers: A randomized controlled trial with clinical and histopathological assessment.

Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes that can lead to significant morbidity. Autologous platelet-rich plasma (PRP), rich in growth factors and cytokines, has emerged as a promising treatment to enhance ulcer healing. This study aimed to compare the clinical and histological efficacy of injected PRP versus topically applied PRP and traditional wound care in the management of DFUs.

Bacterial Diversity Dynamics in Sandy Loam Soils in Tanzania Under Varying Fertilizer-Derived Uranium Concentrations.

The presence of radiotoxic uranium (U) in mineral fertilizers is of global concern. A pilot study was conducted in Tabora (Tanzania) to determine the release of U from three brands of phosphate fertilizers and its impact on soil bacteria. The experiment used three types of fertilizer: Minjingu Powder (MP), Nafaka Plus (NP), a mixed and granulated fertilizer made from Minjingu Phosphate Rock (MPR), and YaraMila Cereal (YC) fertilizer.

The potential role of long non-coding RNAs (HOTAIR and NEAT1) in patients with rheumatoid arthritis.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease related to multiple environmental, genetic, and epigenetic factors. It affects the articular joints, causing damage to both cartilage and bone. Hox transcript antisense intergenic RNA (HOTAIR) exists on chromosome 12 and regulates chromatin state and epigenetic factors.

Advanced integrated strategy for structural and mineralogical exploration of inaccessible regions employing remote sensing and multiscale analysis of aeromagnetic data.

Rugged terrains and remote desert environments present notable challenges for geological data analyses due to limited accessibility and scarcity of surface and subsurface data. One of such challenging areas is Wadi Dif, located in South Eastern Desert (SED) of Egypt. This study presents an integrated approach combining aeromagnetic and remote sensing data to effectively investigate such environments.

Cusp-overlap view versus three cusp coplanar view during transcatheter aortic valve replacement using self-expandable valves: a systematic review, meta-analysis and meta-regression.

Transcatheter aortic valve replacement (TAVR) is currently the treatment of choice for most patients with severe aortic stenosis. We conducted this meta-analysis to compare the outcomes of the cusp overlap technique (COT) versus the standard three-cusp technique during self-expandable valves implantation. We systematically searched PubMed, Scopus, Embase, Cochrane, and Web of Science (WOS) from inception to March 5, 2024.

Efficacy and safety of celecoxib in schizophrenia: a systematic review and meta-analysis of randomized controlled trials.

Background: The hypothesis of immune and inflammatory dysregulation has been supported in the pathogenesis of schizophrenia; this systematic review and meta-analysis aims to evaluate the efficacy and safety of celecoxib, which is a COX-2 inhibitor with anti-inflammatory effects, in the management of schizophrenia.

Methods: A comprehensive search of electronic databases, including PubMed, Scopus, Cochrane, and Web of Science, was performed in February 2025. We included only randomized controlled trials (RCTs) comparing celecoxib alone or as an adjunct to antipsychotics to placebo.

Short- and long-term captivity impacts on bird memory, corticosterone level, and oxidative stress genes: Perspectives on deep learning analysis.

Captivity can harm birds' behavior despite receiving care. The effects of captivity on birds' brain function have not been well studied. This study examined the effects of one-day and seven-day captivity stress on corticosterone levels, memory through novel object and place recognition, and Nrf2, cyclin D, and BMP4 gene expression as inflammatory indicators in hooded crows (Corvus cornix), common mynas (Acridotheres tristis), and cattle egrets (Bubulcus ibis).

The effect of educational intervention program on knowledge and willingness of medical students to take cervical cancer screening and human papillomavirus vaccine: A quasi-experimental study.

Background: Cervical cancer (CC) is a major public health issue. This study assessed the alteration in students' knowledge and willingness to undergo CC screening, and take human papilloma virus (HPV) vaccine after an educational intervention.

Materials And Methods: A quasi-experimental pre/post study design was adopted.

AI enhanced model predictive control for optimizing LPG recovery through integrated computational modeling design of experiments and multivariate regression.

Liquefied Petroleum Gas (LPG) recovery in debutanizer columns presents challenges in balancing operational efficiency and process stability under varying conditions. Conventional control strategies often fail to sustain optimal recovery. This study integrates process modeling and control, using Aspen HYSYS for steady-state simulation and dynamic implementation of model predictive control (MPC).

Investigating the possible role of toxoplasmosis and Interleukin-1β variants on the immune response in Egyptian diabetic patients.

The study assesses toxoplasmosis seroprevalence in Type 2 Diabetes Mellitus, identifies the potential risk factors, and examines IL-1β expression levels and polymorphisms in those infected with T. gondii. One hundred healthy controls and 200 diabetic patients participated in the study.

Epidemiologic and clinical profiles of colorectal cancer in Southern Egypt.

Purpose: To calculate the incidence of colorectal cancer in Southern Egypt and to describe the epidemiological profiles of people with colorectal cancer in this region.

Introduction: Colorectal cancer (CRC) is one of the common cancers in high income countries but historically CRC has been uncommon in low- and middle-income countries (LMICs). Egypt was among the first countries to report higher incidence of early-onset CRC under age 40.

DDoS classification of network traffic in software defined networking SDN using a hybrid convolutional and gated recurrent neural network.

Deep learning (DL) has emerged as a powerful tool for intelligent cyberattack detection, especially Distributed Denial-of-Service (DDoS) in Software-Defined Networking (SDN), where rapid and accurate traffic classification is essential for ensuring security. This paper presents a comprehensive evaluation of six deep learning models (Multilayer Perceptron (MLP), one-dimensional Convolutional Neural Network (1D-CNN), Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), Recurrent Neural Network (RNN), and a proposed hybrid CNN-GRU model) for binary classification of network traffic into benign or attack classes. The experiments were conducted on an SDN traffic dataset initially exhibiting class imbalance.

Robust zero-watermarking for color images using hybrid deep learning models and encryption.

Reliable zero-watermarking is a distortion-free approach to copyright protection, which has been a primary focus of digital watermarking research. Traditional zero-watermarking techniques often struggle to maintain resilience against geometric and signal processing attacks while ensuring high security and imperceptibility. Many existing methods fail to extract stable and distinguishable features, making them vulnerable to image distortions such as compression, filtering, and geometric transformations.

Assessment of terrestrial radionuclide exposure and contamination rates within the Mbaitoli area, Nigeria.

The Mbaitoli region is particularly vulnerable to various impacts associated with flooding, soil erosion, landslides, and water erosion. In light of these challenges, this study seeks to investigate the contamination and exposure rates of the radionuclides uranium (U), thorium (Th), and potassium (K) in the terrestrial environment of Mbaitoli, Imo State, as well as the associated radiological risks. Forty soil samples were collected from the Mbaitoli region and analysed via a sodium iodide (NaI(Tl)) detector spectrometry system.

MicroRNA 155 Expression and Treatment Response in Toxoplasma gondii-Infected Psoriasis Patients.

Introduction: Toxoplasma infection is highly prevalent among patients with different autoimmune diseases, including psoriasis patients. Pyrimethamine is an antiparasitic medication that has a variable treatment response in Toxoplasma-infected patients. This study investigates the demographic, biochemical, and genetic factors influencing the response to pyrimethamine treatment in Toxoplasma gondii-infected psoriasis patients.

The Impact of Whole Body Vibration on Muscle Tone, and Sensory Motor Function in Children with Spastic Diplegic Cerebral Palsy.

Purpose: Children with diplegic cerebral palsy (CP) have limited muscle tone, function, and sensorimotor function. Whole-body vibration (WBV) has been suggested to enhance muscle tone and function in diplegic CP. However, there were limited studies involving the effect of WBV on the tone and function of diplegic CP; we aimed to investigate the effect of WBV on muscle tone, function, and sensorimotor function in children with CP.

Intelligent routing for human activity recognition in wireless body area networks.

Human activity recognition (HAR), driven by machine learning techniques, offer the detection of diverse activities such as walking, running, and more. Considering the dynamic nature, limited energy and mobility of wireless body area networks (WBANs), HAR can play a significant role in enhancing WBANs performance. This paper genuinely bridges HAR's activity recognition capability using machine learning to develop a novel WBAN routing decisions adoptively.

Reduced graphene oxide/ bismuth tungstate-based photocatalysts for enhanced dye photodegradation and photoelectrochemical water splitting.

Semiconductor-based heterogeneous photocatalysis generates highly reactive charge carriers under solar illumination, making it a successful approach for wastewater purification and energy production applications. Herein, a simple solvothermal approach was used to generate a promising nanocomposite photocatalyst, reduced graphene oxide/bismuth tungstate (rGO/BiWO). Various analytical tools were utilized to characterize the as-prepared catalysts.

A descriptive medicolegal study of femicides in Zagazig City, Sharqia Governorate, Egypt.

Background And Objectives: Femicide represents the most severe manifestation of gender-based violence. Systematic data on femicide in Egypt remain limited despite its significant societal impact. This study analyzes epidemiological and medicolegal aspects of femicide cases to identify risk factors among vulnerable populations and inform evidence-based prevention policies.

Deletion of Clock Gene () in Astrocytes Shortens Clock Period but Does Not Affect Light-Mediated Phase Shifts in Mice.

The circadian clock is a self-sustaining oscillator with a period of approximately 24 h, enabling organisms to anticipate daily recurring events, such as sunrise and sunset. Since the circadian period is not exactly 24 h and the environmental day length varies throughout the year, the clock must be periodically reset to align an organism's physiology with the natural light/dark cycle. This synchronization, known as entrainment, is primarily regulated by nocturnal light, which can be replicated in laboratory settings using a 15 min light pulse (LP) and by assessing locomotor activity.

Evaluation of a Three-dimensional printable and two CAD/CAM hybrid resin materials used as permanent single tooth restoration: An in-Vitro study.

Objectives: To evaluate and compare three commercially available hybrid resin materials used for additive and subtractive production (CAD/CAM applications) of permanent single-tooth restorations.

Materials And Methods: One-hundred and twenty-five bar-shaped specimens (14 mm length, 2 mm width, and 2 mm thickness) of 3 different hybrid resin materials were used in this study, being classified into 5 groups (n = 25). Group I: Lava Ultimate, group II: Vita Enamic, group III: Flexcera Smile Ultra A, group IV: Flexcera Smile Ultra B and group V: Flexcera Smile Ultra C.

Impact of aortic angulation on outcomes in transcatheter aortic valve replacement with balloon-expandable and self-expanding valves: a systematic review and meta-analysis.

High aortic angulation (AA) can pose significant challenges during TAVR. This meta-analysis determines the impact of a horizontal aorta on TAVR outcomes with balloon-expandable (BEV) and self-expanding valves (SEVs). A comprehensive search was conducted from inception to June 2024.

Exploring the association of selected lower limb biomechanical variables on exacerbating pain, disability, and postural balance in female athletes with patellofemoral pain syndrome.

Objectives: This study aimed to investigate the associations of selected lower limb biomechanical variables with pain severity, disability, and postural balance in female athletes with Patellofemoral Pain Syndrome (PFPS).

Design: Cross-sectional study.

Setting: Biomechanics Laboratory.

Impact of Statins on Mortality and Cardiovascular Outcomes in Dialysis Patients With Atherosclerotic Cardiovascular Disease: A Systematic Review and Meta-Analysis.

Statins are a cornerstone in reducing cardiovascular risk in patients with atherosclerotic cardiovascular disease (ASCVD). However, current clinical guidelines don't recommend statin use in patients undergoing maintenance dialysis due to inconclusive evidence. We conducted a meta-analysis to assess the clinical effectiveness of statins in patients with established ASCVD and undergoing dialysis.