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Purpose: Children with diplegic cerebral palsy (CP) have limited muscle tone, function, and sensorimotor function. Whole-body vibration (WBV) has been suggested to enhance muscle tone and function in diplegic CP. However, there were limited studies involving the effect of WBV on the tone and function of diplegic CP; we aimed to investigate the effect of WBV on muscle tone, function, and sensorimotor function in children with CP.
Patients And Methods: This is a single-blind randomized controlled clinical trial involving 54 spastic diplegic CP child recruited from local rehabilitation centers in the Ha'il region of Saudi Arabia, they were randomly divided into the WBV group (n = 28 with mean age of 9.47±1.92), which received standard physical therapy and WBV therapy, and the control group (n = 26 with mean age of 9.73±1.62) they received standard physical therapy three time per week for four weeks; Muscle tone, function, strength and Sensory motor integration were evaluated pre and post interventions.
Results: At baseline, the two groups had no significant differences. After treatment, the measured outcomes (function, muscle strength, and sensory motor integration) showed statistically significant differences (p < 0.05). However, muscle tone was not substantially improved (p = 0.10). In addition, within-group comparisons demonstrated substantial effects (p < 0.05) except Spasticity, Function, and trace assessment of the control group, where the p-values were(0.33, 0.06, and 0.54, respectively).
Conclusions: According to the findings in this study, both conventional physical therapy and WBV are beneficial in treating spastic diplegia.
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http://dx.doi.org/10.2147/JMDH.S538583 | DOI Listing |
J Integr Neurosci
August 2025
Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, and Xiangya Hospital of Central South University at Jiangxi, 330038 Nanchang, Jiangxi, China.
Sleep paralysis, colloquially known as "ghost pressing" is a state of momentary bodily immobilization occurring either at the onset of sleep or upon awakening. It is characterized by atonia during rapid eye movement (REM) sleep that continues into wakefulness, causing patients to become temporarily unable to talk or move but possessing full consciousness and awareness of their surroundings. Sleep paralysis is listed in the International Classification of Sleep Disorders, 3rd Edition (ICSD-3) as a parasomnia occurring during REM sleep that be classified as either isolated or narcolepsy-associated.
View Article and Find Full Text PDFImmunol Invest
September 2025
Respiratory and Critical Care Medicine, The 940th Hospital of Joint Logistics Support Force of chinese PLA, Lanzhou, China.
Background: Pulmonary neuroendocrine cells (PNECs) are specialized airway epithelial cells with dual sensory and secretory functions. They release bioactive mediators --including neuropeptides such as calcitonin gene-related peptide (CGRP) and gastrin-releasing peptide (GRP), and neurotransmitters such as 5-hydroxytryptamine (5-HT) and γ-aminobutyric acid (GABA) --that regulate airway smooth-muscle tone, mucus production, and immune responses. In chronic obstructive pulmonary disease (COPD), these PNEC-derived mediators contribute to airway inflammation, remodeling, and smooth-muscle dysfunction.
View Article and Find Full Text PDFUltrasound Q
December 2025
Department of Radiology, Mayo Clinic, Jacksonville, FL.
Idiopathic scrotal calcinosis (ISC) is a rare, benign dermatological condition consisting of deposits of calcium within the scrotal skin. On examination, ISC is characterized by painless, firm nodules and papules localized to the scrotal skin. Typically presenting in adolescence or early adulthood, ISC is more prevalent in males aged 20 to 40, though cases have been reported across all age groups.
View Article and Find Full Text PDFAm J Physiol Cell Physiol
September 2025
Center for Precision Medicine and Data Science, One Shields Avenue University of California, Davis, California.
The regulation of vascular tone underlies normal cardiovascular homeostasis, ensuring appropriate distribution of blood flow to tissues and maintenance of blood pressure. Computational modeling and simulation constitute a powerful framework for deciphering plausible mechanisms of autonomic signaling in vascular smooth muscle across spatial and temporal scales and allow for prediction of emergent nonlinear effects of perturbations. Integrative computational modeling approaches are now beginning to inform the precision use of calcium channel blockers, Angiotensin II type 1 receptor antagonists, and lipid-modulating therapies in cardiovascular disease.
View Article and Find Full Text PDFPercept Mot Skills
September 2025
Division of Physical Therapy Science, Graduate Course of Health and Social Work, Kanagawa University of Human Services, Yokosuka, Japan.
The control of muscle relaxation is not simply the cessation of a muscle contraction, but a dynamic control mechanism for the next movement. Muscle relaxation is triggered by neurophysiological control of the central nervous system. Here, two relaxation strategies were compared, Ballistic and Ramp conditions, and the dynamics of excitability changes between the two relaxation strategies were analyzed.
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