Efficacy and Safety of Esaxerenone for Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Esaxerenone, a novel non-steroidal mineralocorticoid receptor antagonist, has shown promising results in the treatment of essential hypertension (HTN). This study aims to comprehensively analyze the effectiveness of esaxerenone to control BP in patients with essential HTN. A systematic search was performed on PubMed, Scopus, Web of Science (WOS), and Cochrane Library from inception until January 2025 for randomized controlled trials (RCTs) comparing esaxerenone with standard HTN usual care.

Methylene Blue Mitigates Doxorubicin-Induced Cardiotoxicity via KEAP1/NRF2/GPX-4/Caspase3 Modulation.

Doxorubicin (Dox) is a potent anthracycline antitumor drug whose clinical utility is significantly restricted by its dose-dependent, cumulative cardiotoxicity, driven by increased oxidative stress, impaired antioxidant defenses, and apoptosis-mediated cardiomyocyte loss. Methylene blue (MB), a phenothiazine derivative with well-documented redox-modulating properties, is being explored as a viable cardioprotective agent due to its antioxidant and anti-apoptotic effects. This study evaluated the protective role of MB against Dox-induced cardiotoxicity in rats by examining its impact on oxidative stress markers (Kelch-like ECH-associated protein 1; KEAP1, nuclear factor erythroid 2-related factor 2; NRF2, Glutathione peroxidase 4; GPX-4, 8-hydroxy-2'-deoxyguanosine; 8-OHdG), neurohormonal indicators (noradrenaline), cardiac injury biomarkers (troponin I), and apoptotic mediators (p53, Caspase-3).

Parental Knowledge, Attitude and Practices Toward Cariogenic Potential of Pediatric Oral Medications.

: Sugar added to pediatric oral medications may increase the risk of dental caries and erosion. Parental awareness and practices play a crucial role in minimizing the oral health risks associated with such medications. Therefore, the aim was to assess parents' knowledge, attitudes, and practices regarding the cariogenic potential of pediatric oral medications in the Kingdom of Saudi Arabia.

Effect of connector size and configuration on the fracture resistance of a long-span implant-supported monolithic zirconia fixed partial denture (An in vitro Study).

Background: Monolithic zirconia fixed partial dentures (FPDs) have gained popularity due to their high strength, biocompatibility and reduced veneer chipping compared to bilayered restorations. However, the connector region remains a critical point of mechanical failure, especially in long span implant supported FPDs subjected to high masticatory forces. The purpose of this in vitro study was to compare the fracture resistance of implant-supported Y-TZP (yttria-stabilized tetragonal zirconia polycrystal) fixed partial dentures (FPDs) with two connector sizes (9 mm² and 12 mm²) and two connector cross-sectional shapes (oval and circular).

Proteus mirabilis in ICU Patients: Prevalence, Risk Factors, and Future Expectations of Bloodstream Infections.

Background is an emerging but under-recognized cause of bloodstream infections (BSIs) in intensive care unit (ICU) settings, where invasive procedures and immunocompromised states increase vulnerability. Despite its clinical importance, the epidemiology and risk factors associated with BSIs remain poorly understood, especially in low- and middle-income countries. Gap Most existing studies generalize Gram-negative pathogens without isolating the specific impact of in ICU populations.

Non-alcoholic steatohepatitis incidence in patients with psoriasis vulgaris.

Background And Aims: Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD), characterized by hepatic inflammation and damage due to fat accumulation. Psoriasis patients show higher NASH incidence due to overlapping risk factors like obesity and insulin resistance. The study aimed to determine the incidence of non-alcoholic steatohepatitis in patients with psoriasis vulgaris.

miRNA-mediated resistance mechanisms in prostate cancer: implications for targeted therapy and metastatic progression.

Prostate cancer (PCa) remains a leading cause of cancer-related morbidity and mortality in men, with progression to castration-resistant and metastatic disease driven largely by therapeutic resistance. While numerous reviews have cataloged dysregulated microRNAs (miRNAs) in prostate cancer, this review offers a novel, mechanism-centered synthesis focused specifically on miRNA-mediated resistance pathways across standard treatment modalities-including androgen deprivation therapy (ADT), enzalutamide, docetaxel, and radiotherapy. Rather than providing a broad survey of miRNA functions, we prioritize miRNAs with robust experimental validation in PCa (e.

Discovery of new thiadiazole-based VEGFR-2 inhibitors: design, synthesis, cytotoxicity, and apoptosis induction.

Background: Vascular endothelial growth factor receptor-2 (VEGFR-2) is a validated target in cancer therapy. However, approved inhibitors like sorafenib are often limited by off-target toxicity and resistance. This study aimed to develop novel thiadiazole-based VEGFR-2 inhibitors with improved selectivity and safer profiles.

The Involvement of RIPK-3/Caspase-8 Inhibition and Nrf2/HO-1 Upregulation in the Protective Effect of Umbelliferone Against Chlorpyrifos-Induced Pulmonary Toxicity.

Chlorpyrifos (CPF) is a pesticide commonly used for pest management. Regretfully, there is evidence that pesticides can cause pulmonary toxicity. The phytochemical umbelliferone (UMB) possesses anti-inflammatory and antioxidant bioactivities.

Impact of telemedicine on mortality, hospital admissions, and length of stay in pediatric emergencies: a systematic review and meta-analysis.

Background: Pediatric emergencies pose significant challenges in healthcare. Telemedicine offers a promising solution by enabling remote assessments, improving specialist access, reducing unnecessary ER visits and admissions, optimizing resources, and enhancing patient satisfaction. This systematic review and meta-analysis uniquely aimed to quantify the effect of telemedicine on key outcomes in pediatric emergency and post-emergency care.

Impact of veriflex and ICL on corneal biomechanics and endothelial cell density.

To evaluate endothelial cell density (ECD) and corneal biomechanical changes following implantation of Veriflex and Implantable Collamer Lens (ICL) phakic intraocular lenses (pIOLs) over a 12-month period. Sixty patients (117 eyes) were included in this prospective comparative study. 58 eyes underwent implantation with the Veriflex lens (Group I), while 59 eyes received the ICL (Group II).

Bioprotective potential of biosynthesized copper oxide nanoparticles and copper phosphite against Alternaria-solani-induced leaf spot in pepper plants.

Alternaria solani leaf spot disease (ASLS) poses a serious threat to global crop production, including peppers, resulting in notable economic losses. Bio-nanotechnology offers promising solutions for combating plant pathogens by promoting plant defenses and inhibiting pathogen growth. This study explores the effectiveness of copper oxide nanoparticles (CNPs) and copper phosphite (MAXIFOS CU®) in controlling A.

Eco-Friendly Simultaneous Quantification of Domperidone and Safinamide by Spectral Resolution using deconvoluted Synchronous Fluorescence: Application to Spiked Human Plasma.

A novel, eco-friendly deconvoluted synchronous spectrofluorimetric method has been developed and validated for the simultaneous determination of domperidone (DOM) and safinamide (SAF), a potential combination used to address Parkinson's disease-associated gastrointestinal dysfunction. Their combined administration necessitates a reliable analytical method for therapeutic monitoring and formulation quality control. Traditional spectrofluorimetric techniques fail to resolve the significant spectral overlap between these two compounds.

Effect of Thermal Ageing on Flexural Strength and Microhardness of Novel High-Performance Polymer (Nanoksa G-Plus) in Comparison to a Widely Used Bio-HPP/PEEK.

The dental industry is continuously developing high-performance polymer (HPP) materials with different qualities for denture frameworks. The aim of this in vitro study was to assess how thermal ageing (TA) affects the flexural strength (FS) and microhardness of two different HPP materials: Nanoksa G-plus and Bio-HPP/PEEK. The TA process was carried out for 5000 cycles at 5 °C and 55 °C in distilled water.

Green synthesis of gamma rays-induced melanin-based bismuth oxide nanoparticles for evaluation of the antibacterial and anti-virulence activities against extra-intestinal pathogenic bacteria.

The rise of microorganisms that are resistant to drugs is one of the significant challenges facing the health sector. The need to identify effective alternatives facing bacterial diseases is significantly highlighted. Nanomaterials have the potential to be a game-changing weapon in the battle against infectious diseases.

Effect of Statin Therapy on Neurological Outcomes in Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis of 1464 Patients.

Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition complicated by cerebral vasospasm and deterioration of neurological functions. Statins have been proven to reduce the incidence of vasospasm and limit the neurological deterioration with controversial data. We aimed to give a comprehensive assessment of statins in patients with aSAH.

cfDNA Key genomic markers in HCV-Induced hepatocellular carcinoma in Egyptian patients.

Background: Malignant liver disease is among the highest in the world, with hepatocellular carcinoma (HCC) accounting for up to 90 % of all cases. In Egypt, HCC poses a significant public-health concern, representing 47.17 % of cancer cases.

Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study.

A novel series of quinazoline-based compounds were designed and synthesized as modified analogues to certain known VEGFR-2 inhibitors, as an extension of our work on the design and synthesis of new VEGFR-2 inhibitors. The anti-proliferative properties of the synthesized compounds were assessed against three tumor cell lines (MCF-7, HepG-2, and K-562). Compounds 8a (IC = 0.

Central Composite Design Assisted Spectrofluorimetric Determination of Solifenacin via Quenching of Acid Red 51: Application in Pharmaceutical Formulations and Plasma.

This study describes the development and validation of a novel photochemical sensing platform based on the fluorescence quenching mechanism between acid red 51 (AR51) and solifenacin succinate (SLF). Upon excitation at 530 nm, AR51 exhibits native fluorescence at 554 nm, which undergoes significant quenching in the presence of SLF through ion pair complex formation. The photophysical interaction was characterized by Stern-Volmer analysis, revealing a quenching constant of 1.

Application of Cs/GO/TiO as gas sensor.

Chitosan (Cs), a biodegradable, and low-cost polymer is a good choice for gas sensor applications. In this study, Cs was modified with graphene oxide (GO) and titanium dioxide (TiO), and its electronic properties were calculated using density functional theory (DFT) at B3LYP/LANL2DZ level. The calculated physical parameters include total dipole moment (TDM), HOMO/LUMO energy gap (ΔE), global reactivity descriptors and density of states (DOS) and mapping the electrostatic potential (MESP).

Clinical and Pathological Characteristics of Presumed Trematode-Induced Granulomatous Uveitis in Egyptian Pediatric Patients Referred to Memorial Institute Kids Eye Unit.

Purpose: To fully characterize the clinical and pathological characteristics of PTIGU (Presumed Trematode-Induced Granulomatous) in pediatric patients and therefore enhance its diagnostic accuracy and treatment modalities.

Methods: A retrospective descriptive observational study was conducted at the specialized uveitis clinic of MIKE (Memorial Institute for Kids' Eye unit), Memorial Institute for Ophthalmic Research, Giza, Egypt. The study involved 125 eyes of 105 children diagnosed with PTIGU.

Effects of anesthesia on tumor perfusion and infiltration during brain tumor neurosurgery.

Brain tumor surgeries are among the most challenging procedures in neurosurgery, necessitating careful anesthetic management to achieve maximal tumor resection while preserving neurological function. Anesthesia affects key physiological parameters, including cerebral blood flow, intracranial pressure, and blood-brain barrier permeability, which are crucial in determining surgical outcomes. This mini-review examines the effects of various anesthetic agents, such as propofol, isoflurane, and sevoflurane, on tumor perfusion and infiltration, highlighting their potential to modulate tumor biology through mechanisms involving immune response, angiogenesis, and molecular pathways.