Berberine contributes to protecting against the cadmium-induced pancreatic damage: role of intestinal microbiome modulation and barrier function.

Cadmium (Cad) is a worldwide heavy metal pollutant associated with global health challenges. Alteration of the intestinal microbiome, due to chemicals' exposure, plays a vital role in the pathogenesis of gastrointestinal diseases such as pancreatic disorders. Hence, modulation of the gut microbiota might be a targeted approach to manage pancreatic diseases.

Promoting exciton dissociation of covalent organic frameworks via donor-acceptor characteristic modulation for enhanced HO photocatalytic production.

Post-synthetic modification (PSM) offers a promising approach for tailoring the compositional, structural, and electronic properties of covalent organic frameworks (COFs), thereby enhancing their exciton dissociation ability and facilitating charge transfer. The effectiveness of these approaches is largely compromised by the harsh conditions, complexity, and alteration of the original structure. Therefore, developing a facile yet effective PSM for modulating COFs' properties without altering the original geometry and/or structure is a challenge.

Complexation-based spectrofluorimetric method for besifloxacin determination: Combined experimental and computational insights.

Fluorescence-based analytical methods offer high sensitivity, cost-effectiveness, and simplicity for pharmaceutical analysis. Besifloxacin hydrochloride (Bfln.HCl), a fluoroquinolone antibiotic used to treat eye infections, exhibits native fluorescence that can be enhanced in acidic media.

Cross-country validation of the Arabic version of the WHO-5 Well-Being Index in non-clinical young adults from six Arab countries.

This study aimed to perform a cross-country validation of the Arabic version of the World Health Organization 5-item (WHO-5) Well-Being Index, in terms of factor structure, composite reliability, cross-gender measurement invariance and concurrent validity. We carried out a cross-sectional, web-based study on a total of 3,247 young adults (aged 18-35 years) from six Arab countries (Tunisia, Lebanon, Egypt, Jordan, Morocco and Kuwait). Confirmatory Factor Analysis showed that the one-factor model demonstrated acceptable fit across all six countries.

Development of SpyTag/SpyCatcher-driven thermostable cyclic laccase and its application in lignin and dye degradation and polymerization of phenolic compounds.

Laccases, belonging to the superfamily of multicopper oxidases, can perform electron oxidation on a broad range of substrates, releasing only water as a by-product. Although instability and aggregation significantly constrain the industrial use of these eco-friendly biocatalysts, it is a daunting challenge for current engineering strategies to elevate these crucial enzymatic characteristics simultaneously. Here, we developed a cyclizing laccase (CyLacc) using SpyTag/SpyCatcher technology, which endows the enzyme with high thermostability and high solubility.

The effect of sexually transmitted infections health education on youth knowledge and attitudes: a pre-post interventional study.

Background: One of the biggest issues facing public health is sexually transmitted infections, or STIs. Every day, about a million STIs are discovered worldwide.

Aim Of The Study: Current study aimed to evaluate how well health education sessions affected the level of improvement in STI knowledge and attitude.

Analgesic efficacy of different volumes in erector spinae plane block in patients undergoing single level lumbar spine fixation: a non-inferiority randomized trial.

Background: Using a lower volume (LVs) of local anaesthetic (LA) reduces the risk of toxicity, side effects, and cost. Our study assessed whether the lower LA volumes (10 or 15 ml) have the same analgesic efficacy as 20 ml of erector spinae plane block (ESPB) in single-level lumbar spine fixation.

Methods: Our non-inferiority, randomised, double-blind trial recruited sixty cases scheduled for single-level lumbar spine fixation.

Clinical and echocardiographic outcomes of sync-atrioventricular versus nominal optimization in correlation with QRS narrowing among CRT patients.

Background: Cardiac resynchronization therapy (CRT) has been established as a key component in the management of patients with heart failure (HF) with reduced ejection fraction in addition to pharmacologic therapy. Several automatic algorithms have been developed to optimize the timing cycle settings in CRT, especially AV delay which was associated with improvement of the response to CRT. The present study aims to investigate whether the novel device-based SyncAV algorithm could elicit better synchrony and acute hemodynamic response.

Design, synthesis, and anticancer evaluation of new Quinazoline hybrids: DNA intercalation, topoisomerase IIα inhibition, and in silico studies.

DNA intercalators and topoisomerases are regarded as prominent targets for cancer treatment. Herein, a novel series of quinazoline hybrids 5-14 were designed and synthesized as potent DNA intercalators and topoisomerase II inhibitors for cancer treatment. Their antiproliferative activity was evaluated in vitro across the NCI-60 human tumor cell lines panel.

L. Mitigates Hyperlipidemia-Induced Nonalcoholic Fatty Liver Disease in Experimental Rats: Future Pharmaceuticals.

Nonalcoholic fatty liver disease (NAFLD) associated with hyperlipidemia is a prevalent metabolic disorder, often triggered by high-fat diets (HFDs) in animal models. L. (AGs), rich in bioactive compounds, offers potential antioxidant and lipid-lowering benefits, making it a candidate for natural liver protection.

Correction: Rady et al. Foliar Nourishment with Nano-Selenium Dioxide Promotes Physiology, Biochemistry, Antioxidant Defenses, and Salt Tolerance in . 2021, , 1189.

It should be Ali A [...

Supramarginal Resection of Metastatic Brain Tumors: A Meta-Analysis Study.

: Over 30% of people who suffer from cancers are at risk of developing brain metastases. The typical recommended surgical therapy for metastases within the brain is gross total resection (GTR). Nevertheless, GTR solely may not always be adequate for disease management since remaining tumors can show local advancements and invasion.

Development of Glycyrrhizic Acid Nanoparticles for Modulating Gastric Ulcer Healing: A Comparative In Vivo Study Targeting Oxidative Stress and Inflammatory Pathways.

Gastric ulcer (GU) is a common gastrointestinal disorder that impacts quality of life. Currently, several drugs are available for GU treatment, including proton pump inhibitors like omeprazole (OMP); however, their use is limited by numerous potential adverse effects. Glycyrrhizic acid (GLY), a natural anti-inflammatory agent, exhibits promising gastroprotective properties; however, its use is likewise limited by numerous potential adverse effects.

Impact of veriflex and ICL on corneal biomechanics and endothelial cell density.

To evaluate endothelial cell density (ECD) and corneal biomechanical changes following implantation of Veriflex and Implantable Collamer Lens (ICL) phakic intraocular lenses (pIOLs) over a 12-month period. Sixty patients (117 eyes) were included in this prospective comparative study. 58 eyes underwent implantation with the Veriflex lens (Group I), while 59 eyes received the ICL (Group II).

Aromatic Volatile Compounds of Essential Oils: Distribution, Chemical Perspective, Biological Activity, and Clinical Applications.

Volatile, or essential, oils are the principal odorous components of certain plant species and constitute aliphatic and aromatic compounds in the oils' natural mix. The aromatic compounds are present in significant proportions in the oils of several plant species, usually referred to as aromatic plants, and hence the aromatic essential oils. These aromatic classes of compounds are abundant in oils of cloves, thyme, wintergreen, etc.

A Novel Artificial Eagle-Inspired Optimization Algorithm for Trade Hub Location and Allocation Method.

Aiming for convenience and the low cost of goods transfer between towns, this paper proposes a trade hub location and allocation method based on a novel artificial eagle-inspired optimization algorithm. Firstly, the trade hub location and allocation model is established, taking the total cost consisting of construction and transportation costs as the objective function. Then, to solve the nonlinear model, a novel artificial eagle optimization algorithm (AEOA) is proposed by simulating the collective migration behaviors of artificial eagles when facing a severe living environment.

Search for a Neutral Gauge Boson with Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for a heavy neutral spin-1 gauge boson (Z^{'}) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or W bosons is presented. The analysis is performed using LHC data at sqrt[s]=13  TeV, collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of 138  fb^{-1}. The data are consistent with the standard model predictions.

Interface engineering of a MXenes/PVDF mixed-matrix membrane for superior water purification: efficient removal of oil, protein and tetracycline.

This study developed a high-performance polyvinylidene difluoride (PVDF) mixed matrix membrane incorporating MXene nanosheets for efficient wastewater treatment. The addition of MXene significantly enhanced the water permeability and antifouling properties of PVDF ultrafiltration membranes, as confirmed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterization of the nanoadditive and SEM analysis of the modified membranes. The optimal membrane, blended with 0.

Levator Muscle Complex Exploration During Surgery for Simple Severe Congenital Ptosis.

Purpose: To describe the gross morphology of the levator palpebrae superioris (LPS) muscle complex in severe congenital ptosis with poor levator function (LF) and to evaluate the surgical outcomes when levator surgery was performed based on intraoperative factors.

Methods: This is a retrospective, interventional case series that includes children having simple severe congenital ptosis with LF ≤ 4 mm for whom levator muscle surgery was performed rather than preplanned frontalis suspension based on the intraoperative LPS muscle evaluation. The collected data included: demographics; ptosis measurements, including margin reflex distance 1 and LF; morphological appearance of LPS muscle and its aponeurosis (levator aponeurosis); surgical technique, and outcomes.

HOMA-IR, an independent predictor of advanced liver fibrosis in metabolic-dysfunction associated fatty liver disease: a cross-sectional study in Egyptian patients.

While metabolic dysfunction-associated fatty liver disease (MAFLD) includes the homeostatic model assessment for insulin resistance (HOMA-IR) as one of the criteria to define metabolic dysregulation, the newly proposed metabolic dysfunction-associated steatotic liver disease (MASLD) has removed this criterion. We investigated whether the HOMA-IR can serve as an independent predictive marker for significant fibrosis in subjects with MAFLD. This is a cross-sectional multicenter study.

Biological activities and application of Rosmarinus officinalis extract to improve the preservation and microbial qualities of some local meat products.

Because medicinal plants contain bioactive phenolic compounds with antibacterial, antioxidant, and other properties, they have been used in many parts of nutrition and healthcare. The atmosphere in which local meat products and vendors operate is still subpar. Every individual is impacted, either directly or indirectly, when food is contaminated by harmful germs and spoilage.

Ramadan fasting in smokers with primary headache disorders: Impact of nicotine dependence on headache frequency and severity.

Background: Nicotine withdrawal has not been studied before as a contributing factor for headache exacerbations during Ramadan. Therefore, we aimed to explore the impact of smoking status and nicotine dependence on the frequency and severity of primary headache disorders during fasting.

Methods: This prospective cohort study with pre-post comparisons was conducted on male smokers and nonsmokers with primary headache disorders.