Promoting exciton dissociation of covalent organic frameworks via donor-acceptor characteristic modulation for enhanced HO photocatalytic production.

Post-synthetic modification (PSM) offers a promising approach for tailoring the compositional, structural, and electronic properties of covalent organic frameworks (COFs), thereby enhancing their exciton dissociation ability and facilitating charge transfer. The effectiveness of these approaches is largely compromised by the harsh conditions, complexity, and alteration of the original structure. Therefore, developing a facile yet effective PSM for modulating COFs' properties without altering the original geometry and/or structure is a challenge.

ERO1α regulates colon cancer progression and 5-FU resistance through the miR-451a/ARF1 axis.

Background: Colon cancer (CC) is one of the three most common cancers worldwide. In the treatment of CC, 5-fluorouracil (5-FU) is one of the main components of chemotherapeutic combinations, but severe chemical resistance still occurs. In addition, endoplasmic reticulum (ER) oxidoreductase-1α (ERO1α) has been shown to be highly expressed in CC, but its specific molecular mechanisms remain unclear.

Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism.

Hypoxia-induced Pyrroline-5-Carboxylate Reductase 1 (PYCR1) is implicated in bladder cancer (BC), but its specific role remains elusive. This study investigated how PYCR1 promotes BC progression through glycolysis, histone H3 Lysine 18 Lactylation (H3K18la), and Solute Carrier Family 6 Member 14 (SLC6A14)-driven glutamine catabolism. Here, BC cell lines were cultured under hypoxia to evaluate changes in PYCR1 expression, glycolysis, and lactate production.

GPT-4 vs. Radiologists: who advances mediastinal tumor classification better across report quality levels? A cohort study.

Background: Accurate mediastinal tumor classification is crucial for treatment planning, but diagnostic performance varies with radiologists' experience and report quality.

Purpose: To evaluate GPT-4's diagnostic accuracy in classifying mediastinal tumors from radiological reports compared to radiologists of different experience levels using radiological reports of varying quality.

Materials And Methods: We conducted a retrospective study of 1,494 patients from five tertiary hospitals with mediastinal tumors diagnosed via chest CT and pathology.

HOX11 gene overexpression is associated with recurrence of acute B lymphoblastic leukaemia.

This research aimed to elucidate the association of Homeo Box 11 (HOX11) gene overexpression with refractory acute B-cell lymphoblastic leukaemia (B-ALL). In this investigation, 209 patients with B-ALL, who were treated in Guangdong Province between 2019 and 2024, were included. At the initial diagnosis, the RNA was obtained from bone marrow for genetic testing via Real-time Quantitative Polymerase Chain Reaction (RQ-PCR).

Plasmodium yoelii infection regulates M1 macrophage polarization and function through TLR7/STAT3 signaling pathway.

Macrophages play a crucial role in innate immunity and are essential for resisting Plasmodium infection. However, the regulatory mechanisms of Plasmodium infection on macrophage function and subsequent effects on adaptive immune responses remain incompletely understood. In this study, we investigated the functional regulatory mechanism of macrophages during Plasmodium yoelii (P.

Nutrient-Driven Metabolic Activation and Microbial Restructuring Induced by Endophytic in Blight-Affected Forest Soils.

The climate-driven acceleration of forest disease outbreaks has intensified the demand for sustainable biocontrol strategies. In this study, we evaluated the effects of the endophytic bacterium csuftcsp75 on soil properties, microbial communities, and functional metabolism in soils affected by shoot blight. Soil physicochemical analysis, carbon substrate utilization profiling (AWCD), and diversity indices (the Shannon, Simpson, and McIntosh indices) were integrated to assess the microbial responses under different inoculation treatments.

Self-Driving Laboratory for Accelerated On-Surface Synthesis under Ultrahigh Vacuum.

The automation of experimentation has accelerated advances in materials synthesis. While most automated platforms operate under atmospheric conditions, many synthesis processes require ultrahigh vacuum (UHV) environments with stringent constraints. We present a self-driving synthetic platform that integrates robotics, automation, and machine learning to address the challenges of UHV-based materials synthesis.

Effect of technology-based acceptance and commitment therapy for smoking cessation: A systematic review and meta-analysis.

Background: Tobacco use remains one of the world's greatest public health challenges, contributing substantially to morbidity and mortality. Effective and accessible smoking cessation interventions are essential to reducing tobacco-related health risks. Acceptance and Commitment Therapy (ACT) has demonstrated efficacy in enhancing quit rates.

Isoptericola rhizosphaerae sp. nov. and Isoptericola aurantiacus sp. nov. two novel bacteria isolated from rhizosphere soil.

Two actinobacterial strains, designated GXG3202 and GXG9306, were isolated from the rhizosphere soil of Avicennia marina in Beihai, Guangxi Zhuang Autonomous Region, China. Phylogenetic analysis of the 16S rRNA gene sequence revealed that both strains clustered in distinct subclades in the genus Isoptericola, sharing high sequence similarity with Isoptericola halotolerans YIM 70177 (98.8% and 97.

Research progress on the role of exercise-regulated reactive astrocytes in the prevention and treatment of Parkinson's disease.

Astrocytes generally perform protective roles, such as the release of neurotrophic factors, glutamate metabolism, transfer of healthy mitochondria to neurons, and maintenance of the blood-brain barrier. Nonetheless, in the context of Parkinson's disease (PD), astrocytes may become dysfunctional, contributing to neurotoxicity, which is intricately linked to the etiological factors of PD. Intervening to prevent the conversion of astrocytes into neurotoxic phenotypes has demonstrated neuroprotective effects, potentially averting the degeneration of dopaminergic neurons and mitigating behavioral deficits in PD model mice.

Bioactive siRNA-Based Liposomes Promoted Tendon-Bone Healing in Osteoporotic Mice by Recovering the Stemness of CD248 TSPCs.

Osteoporosis significantly impairs tendon-bone healing, increasing the risk of rotator cuff tears and postoperative retearing. Tendon stem/progenitor cells (TSPCs) are vital for tendon repair, with their stemness crucial to healing outcomes. This study investigated the role of CD248 in regulating TSPC stemness and assessed the therapeutic potential of si-CD248-loaded liposomes in promoting tendon-bone healing under osteoporotic conditions.

Conductive dendrite engineering of single-crystalline two-dimensional dielectric memristors.

Ultralow-power non-volatile memristors are key elements in electronics. Generally, power reduction of memristors compromises data retention, a challenge known as the "power-retention dilemma," due to the stochastic formation of conductive dendrites in resistive-switching materials. Here, we report the results of conductive dendrite engineering in single-crystalline two-dimensional (2D) dielectrics in which directional control of filamentary distribution is possible.

Simultaneous double primary malignant tumors of MSS/pMMR ascending colon cancer and MSI-H/dMMR duodenal cancer with nearly 2 years of recurrence-free survival after MDT-guided comprehensive treatment: a case report.

The exceedingly rare clinical presentation of synchronous ascending colon carcinoma with duodenal adenocarcinoma demonstrating discordant mismatch repair protein expression patterns forms the cornerstone of this investigation. Through detailed analysis of a unique case featuring co-occurring MSS/pMMR ascending colon adenocarcinoma and MSI-H/dMMR duodenal adenocarcinoma, this study demonstrates the successful implementation of multidisciplinary therapeutic protocols achieving 22-month progression-free survival post-radical resection. These clinical findings offer empirical evidence for optimizing clinical management while systematically addressing diagnostic complexities and treatment dilemmas inherent to synchronous dual primary intestinal carcinomas.

Pentraxin 3 promotes the expression of pro-inflammatory cytokines and the migration of macrophages in myocarditis.

Background: This study aims to investigate the expression of Pentraxin 3 (PTX3) and Nod-like receptor family pyrin domain-containing 3 (NLRP3) in myocarditis and to elucidate their roles and potential interplay in the pathogenesis of myocarditis.

Methods: Immunofluorescence staining was performed on myocardial autopsy specimens from deceased patients with severe myocarditis or severe trauma. H9C2 cardiomyocytes were divided into five groups: Control, Lipopolysaccharide (LPS), LPS + PTX3 overexpression, LPS + small interfering RNA targeting PTX3 (si-PTX3), and LPS + PTX3 overexpression + si-NLRP3.

Highly selective electrochemical sensing of hydroquinone and catechol using Co nanoparticles anchored on N-doped carbon nanotube hollow sphere.

Background: Hydroquinone (HQ) and catechol (CC), two important isomers with similar structures, are highly toxic, often coexisting, and impeding each other in the simultaneous detection. Electrochemical technique provides a promising alternative toward the quantification of HQ and CC, due to its inherent advantages in terms of highly sensitive reaction, ease of monitoring, low-cost, simplicity and quick response. Development of a sensing material with outstanding electrocatalytic capabilities and its utilization for the fabrication of an electrochemical sensor for highly selective monitoring of HQ and CC is of great significance.

Effect of Continuous Lipopolysaccharide Induction on Oxidative Stress and Heart Injury in Weaned Piglets.

After weaning, piglets no longer consume breast milk, and their immune system is not yet fully developed. At this time, if weaned piglets are infected with , their subsequent growth will be seriously affected. In the present study, 48 healthy 28-day-old weaned piglets (6.

Magnetic resonance imaging evaluation and analysis of influencing factors of early uterine seromuscular layer injury after high-intensity focused ultrasound ablation of uterine fibroids.

Background: High-intensity focused ultrasound (HIFU) is being used more frequently to treat uterine fibroids, with many researchers conducting studies on efficacy prediction and evaluation. However, research related to seromuscular layer injury is limited. Therefore, this study aimed to identify the factors contributing to seromuscular layer injury following HIFU ablation of uterine fibroids, using magnetic resonance imaging (MRI) as the evaluation tool.

Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer.

Cancer immunotherapy is the most promising method for tumor therapy, while ferroptosis could activate the immunogenicity of cancer and strengthen the cellular immune response. However, limited by the complex tumor microenvironment, the abundant glutathione (GSH) and low reactive oxygen species (ROS) seriously weaken ferroptosis and the immune response. Herein, the authors report photothermal metal-phenolic networks (MPNs) supplied with buthionine sulfoximine (BSO) by reducing levels of GSH and then trapping the tumor cells in the ferroptosis and immunotherapy cascade loop to eliminate colorectal cancer (CRC).

Study on the Anti-Fatigue Effects of Polysaccharides from Erjing Formula.

Background: The traditional Chinese recipe "Erjing Formula", composed of HuangJing and GouQi, is recognized for its tonifying and revitalizing properties, but the active components responsible for these effects are poorly explored. This study investigated the antifatigue effects of Erjing Formula polysaccharides (EJFP).

Methods: Mice were treated with EJFP and subjected to weight-loaded swimming tests.

An Unusual Cause of Complete Atrioventricular Block and Aortic Regurgitation.

We report a rare case of Behçet's disease (BD) causing aortic regurgitation and complete atrioventricular block (AVB) in conjunction with pacemaker pocket infection. We emphasize the need to consider the possibility of BD in young and middle-aged patients who present with aortic valve prolapse with regurgitation combined with complete AVB with elevated inflammatory markers.

Value of a combined magnetic resonance-enhanced and diffusion-weighted imaging dual-sequence radiomics model in predicting the efficacy of high-intensity focused ultrasound ablation for uterine fibroids.

Objective: To establish a joint radiomics model based on T1 contrast-enhanced (T1C) imaging and diffusion-weighted imaging (DWI), and investigate its value in predicting the efficacy of high-intensity focused ultrasound (HIFU) in ablating uterine fibroids.

Methods: This multicenter retrospective study included 195 patients with uterine fibroids. Their data were divided into training (n = 120), internal test (n = 30), and external test (n = 45) sets.

CLMP increases 5-fluorouracil sensitivity in colorectal cancer through the inhibition of autophagy.

Background: We aimed to explore the biological function of CLMP in colorectal cancer (CRC) and to determine the effect of CLMP on 5-fluorouracil (5-FU) sensitivity in CRC.

Methods: Sixteen pairs of CRC tissues and paracancerous tissues were collected. Immortalized intestinal epithelial cell lines and human CRC cell lines were purchased, and the cells were treated with DMSO and 5-FU.

Multi-sequence magnetic resonance imaging radiomics combined with imaging features predicts the difficulty of HIFU treatment of uterine fibroids.

To establish a multivariate linear regression model for predicting the difficulty of high-intensity focused ultrasound (HIFU) ablation of uterine fibroids based on multi-sequence magnetic resonance imaging radiomics features. A retrospective analysis was conducted on 218 patients with uterine fibroids who underwent HIFU treatment, including 178 cases from Yongchuan Hospital of Chongqing Medical University and 40 cases from the Second Affiliated Hospital of Chongqing Medical University (external validation set). Radiomics features were extracted and selected from magnetic resonance images, and potentially related imaging features were collected.