Conserved and distinct expression of circular RNAs in commercially used Marek's disease vaccine viruses.

Circular RNAs (circRNAs) are covalently closed RNA molecules, supporting a wide diversity of functions. While aberrant circRNA expression stands as a recognized hallmark of cancer development, our attention has turned to investigating their role in viral infections, specifically (GaHV-2, Marek's disease virus) infection. In a previous study focused on the virulent GaHV-2 strain, RB-1B, we extensively catalogued circRNAs produced from virulence genes, notably from the MEQ-vIL-8 and the latency-associated transcripts (LATs) gene.

seed-derived biochar as a sustainable and environmentally feed supplement in camel: impacts gas production, methane emissions, nutrient degradability and fermentation parameters, performance predictions.

Introduction: Climate change poses a significant environmental challenge to all living organisms. Camels exhibit notable resilience to these changes. Concurrently, the date palm (), a widely cultivated plant in tropical and subtropical regions, generates substantial seed waste.

A Novel Highly Sensitive Derivatization-Free Spectrofluorimetric Approach for Analysis of the Antifungal Terconazole in Dosage Forms, Biological Fluids, and Environmental Water Samples: Assessment of Greenness and Blueness Profiles.

In the current study, the triazole antifungal terconazole (TRZ) was determined using a novel, extremely sensitive, and environmentally friendly spectrofluorimetric approach. A methanolic solution of TRZ exhibited strong native fluorescence at 373 nm when excited at 241 nm. With a correlation coefficient of 0.

Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria.

The escalating prevalence of multidrug-resistant (MDR) bacteria presents a critical global health challenge, necessitating the urgent development of alternative antimicrobial strategies. Silver nanoparticles (AgNPs) have emerged as promising antimicrobial agents due to their broad-spectrum activity, unique physicochemical properties, and multiple mechanisms of bacterial inhibition. Their nanoscale size, high surface area-to-volume ratio, and ability to generate reactive oxygen species (ROS) make them highly effective against both Gram-positive and Gram-negative bacteria.

Tumor-expressed GPNMB orchestrates Siglec-9 TAM polarization and EMT to promote metastasis in triple-negative breast cancer.

Metastasis remains the leading cause of cancer-related mortality, driven by complex interactions within the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) play a pivotal role in metastatic progression, yet their molecular diversity and upstream regulators remain poorly defined. Glycoprotein nonmetastatic melanoma protein B (GPNMB), overexpressed in subsets of tumors including triple-negative breast cancer (TNBC), is implicated in epithelial-mesenchymal transition (EMT) and cancer stemness.

Continental maize mapping and distribution in Africa by integrating radar and optical imagery.

High-resolution, accurate mapping of crops is critical to enhance food security, resource efficiency, and policy effectiveness in agriculture across Africa, where maize remains a crucial staple crop. However, mosaic landscapes, common cloud cover, and scarce ground information have hindered large-area and field-level maize monitoring. This study presents a novel continent-wide framework for mapping maize cultivation across Africa for the 2023-2024 growing season at 10-m resolution using multi-temporal and multi-sensor remote sensing data.

Protective efficacy of nanoencapsulation of algal extract for preventing and controlling Clostridium botulinum in fish products.

Research is being conducted on the usage of algae extracts as natural preservatives in the storage of fish products to extend shelf life, maintain quality and safety, and satisfy consumer preferences. Laurencia obtusa (Hudson), Actinotrichia fragilis (Forsskål) Børgesen, and Gracilaria dendroids sp. nov.

Validation of a green and sensitive spectrofluorimetric method for determination of Bilastine and its application to pharmaceutical preparations, content uniformity test, and spiked human plasma.

Bilastine (BIL) is a new second-generation antihistaminic drug used for the management of urticaria and rhino-conjunctivitis symptoms. Herein, a spectrofluorimetric method for determining BIL is described. The method is very sensitive, simple, quick, and green.

Reprogramming the hepatic immune microenvironment with mirtazapine in early neoplastic transformation: Evidence from a diethylnitrosamine-induced rat model.

Hepatic neoplastic transformation is a multistep process driven by chronic inflammation, oxidative stress, immune evasion, and dysregulated cell proliferation. Intercepting these early events may offer a viable strategy for preventing hepatocellular carcinoma. In this study, we investigated the chemopreventive potential of mirtazapine, an FDA-approved antidepressant with known anti-inflammatory and antioxidant properties, in a diethylnitrosamine-induced rat model of early hepatic neoplasia.

Improved pulmonary embolism detection in CT pulmonary angiogram scans with hybrid vision transformers and deep learning techniques.

Pulmonary embolism (PE) represents a severe, life-threatening cardiovascular condition and is notably the third leading cause of cardiovascular mortality, after myocardial infarction and stroke. This pathology occurs when blood clots obstruct the pulmonary arteries, impeding blood flow and oxygen exchange in the lungs. Prompt and accurate detection of PE is critical for appropriate clinical decision-making and patient survival.

Design and optimization of a metamaterial absorber for enhanced solar cell efficiency and wide band microwave cross polarization conversion.

In this work, the design and construction of a metamaterial (MTM) absorber to increase solar cell efficiency is proposed. MTM is use as frequency selective surface (FSS) in the infrared band. The design is made up of a split ring resonator (SRR) imprinted on the substrate's top surface, with a copper layer serving as a ground on the back layer of the substrate material.

Methylene Blue Mitigates Doxorubicin-Induced Cardiotoxicity via KEAP1/NRF2/GPX-4/Caspase3 Modulation.

Doxorubicin (Dox) is a potent anthracycline antitumor drug whose clinical utility is significantly restricted by its dose-dependent, cumulative cardiotoxicity, driven by increased oxidative stress, impaired antioxidant defenses, and apoptosis-mediated cardiomyocyte loss. Methylene blue (MB), a phenothiazine derivative with well-documented redox-modulating properties, is being explored as a viable cardioprotective agent due to its antioxidant and anti-apoptotic effects. This study evaluated the protective role of MB against Dox-induced cardiotoxicity in rats by examining its impact on oxidative stress markers (Kelch-like ECH-associated protein 1; KEAP1, nuclear factor erythroid 2-related factor 2; NRF2, Glutathione peroxidase 4; GPX-4, 8-hydroxy-2'-deoxyguanosine; 8-OHdG), neurohormonal indicators (noradrenaline), cardiac injury biomarkers (troponin I), and apoptotic mediators (p53, Caspase-3).

Efficacy and Safety of Coenzyme Q10 in Idiopathic Male Infertility: A Systematic Review and Meta-Analysis of Randomized Trials.

Purpose: Despite numerous studies on coenzyme Q10 (CoQ10) as a treatment for idiopathic male infertility (IMI), clear clinical guidance remains lacking. This systematic review and meta-analysis (SRMA) aimed to evaluate the efficacy of CoQ10 and determine the optimal dose, formulation, and treatment duration compared to placebo or other therapies.

Materials And Methods: We searched PubMed, Science Direct, and Cochrane Library using relevant keywords to identify studies assessing CoQ10's effects on sperm parameters, seminal CoQ10 levels, and clinical pregnancy rates in men with IMI.

Amelioration of intestinal ischemia reperfusion injury by carvedilol via regulation of eNOS/VEGF-A and inflammasome/ IL1β/ TNFα pathways.

Intestinal ischemia reperfusion (IIR) is a life threating clinical disorder and a serious emergency case with high mortality rate. Finding ameliorative agents is a critical requisite to safeguard the tissue against its harmful effect not only on the intestine, but also on other organs especially the heart. Therefore, we tried in the current study to evaluate the role of carvedilol (CAR); an effective beta and alpha blocker with anti-oxidant, anti-apoptotic, anti-inflammatory properties and a metabolic regulator, on both cardiac and intestinal tissue in a model of IIR.

Changes in carcase composition, gastrointestinal morphometry and leg bone dimensions in different goose genotypes after a four-year reproductive period.

1. The aim of this study was a comparative analysis of three goose genotypes (Rypińska, Suwalska, Kartuska) after a four-year laying period at the National Research Institute of Animal Production, Waterfowl Genetic Resources Station in Dworzyska. It examined carcase composition as well as morphometric parameters of their digestive system and leg bones.

Interface engineering of a MXenes/PVDF mixed-matrix membrane for superior water purification: efficient removal of oil, protein and tetracycline.

This study developed a high-performance polyvinylidene difluoride (PVDF) mixed matrix membrane incorporating MXene nanosheets for efficient wastewater treatment. The addition of MXene significantly enhanced the water permeability and antifouling properties of PVDF ultrafiltration membranes, as confirmed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterization of the nanoadditive and SEM analysis of the modified membranes. The optimal membrane, blended with 0.

Proteomic profiling identifies serpin G1, ApoA-II, and LBP as potential biomarkers of dementia in an Egyptian cohort.

Background: Dementia, including Alzheimer's disease (AD), is a growing concern in Egypt, yet biomarker research in this population is scarce. Identifying serum biomarkers is essential for early diagnosis and understanding disease mechanisms in underrepresented groups.

Methods: We performed serum proteomic profiling on 20 Egyptian dementia patients and 10 cognitively unimpaired controls from the Egyptian Dementia Registry using mass spectrometry.

Effects of Gabapentin, Valsartan, and Codeine on hemato-biochemical and histological biomarkers of male catfish (Clarias gariepinus).

Pharmaceutical residues in aquatic environments are emerging contaminants of concern due to their potential sublethal and chronic impacts on aquatic organisms. This study aimed to evaluate the subacute toxicological effects of three widely used pharmaceuticals-gabapentin (GAB), valsartan (VAL), and codeine (COD)-on male African catfish (Clarias gariepinus). Fish were randomly assigned to four groups: a control group and three treatment groups exposed for 15 days to environmentally relevant concentrations of GAB (79.

Interactive effects of black sand and heat stress on coral reefs at Red Sea, Egypt.

Coral reefs, vital marine ecosystems, face increasing threats from climate change and localized stressors like black sand deposits, yet their combined impacts are underexplored. This pioneering study investigates the synergistic effects of rising temperatures and black sand on reef-building corals in the Red Sea, Egypt, focusing on Stylophora pistillata and Acropora hyacinthus. Coral samples were collected from Hurghada and exposed to a three-day laboratory experiment involving thermal stress (31 °C), black sand (300 mg/L), nano black sand (300 mg/L), and combinations thereof.

Effects on Jump Shooting Accuracy when Using Unstable Surfaces for Functional Balance Training of Youth Basketball Players.

This study examined the effects of a 10-week functional balance training program using unstable surfaces on dynamic postural control, lower-limb power, and technical shooting performance in adolescent male basketball players. Twenty-one participants were assigned to an experimental group (n = 11; age 16.14 ± 1.

Structural and optical properties of SnO nano-filler in eco-friendly PVA polymer for flexible optoelectronic applications.

Polyvinyl Alcohol (PVA) has garnered significant attention in the field of flexible optoelectronics due to its unique properties. This study investigates the effect of incorporating tin oxide (SnO) nanoparticles (NPs) with various concentrations (0, 2, 3, 4, and 5 wt%) on structural, optical, and dielectric properties of PVA films synthesized via the solution casting technique. XRD analysis revealed a 28% increase in crystallite size (from 25.

Corneal changes in estrogen-dependent breast cancer after hormonal treatment.

Aromatase inhibitors (AI) therapy is the treatment of choice for estrogen receptor-positive breast cancer (BC). While AIs effectively suppress tumor growth, estrogen deprivation may have negative impacts on the eyes. This work evaluated the anterior segment changes in estrogen-dependent BC after hormonal treatment.

Femoral neck locking plate versus multiple cannulated screws for femoral neck fractures in young adults: a randomized controlled trial.

Background: Managing femoral neck fractures (FNFs) in young adults remains a significant clinical dilemma. No single internal fixation method has demonstrated clear superiority. The aim of this study was to compare the clinical and radiographic outcomes of FNFs in young adults treated with femoral neck locking plate (FNLP) or conventional partially-threaded 6.

Expanding the Epidemiological and Phenotypic Spectrum of MEGDEL Syndrome: The First Case Report From Egypt.

MEGDEL syndrome is a rare autosomal recessive disease characterized by 3-methylglutaconic aciduria, deafness-dystonia, hepatopathy, encephalopathy, and leigh-like syndrome, which results from biallelic pathogenic variants in gene. The diagnosis is commonly challenging due to the diverse clinical manifestations. Herein, we report the first case of MEGDEL syndrome from the Egyptian population.

Novel di-aryl chalcone derived pyrazole linked to methane sulfonyl pharmacophore as potent selective COX-2 inhibitors; design, synthesis, molecular modeling, and anti-inflammatory activities.

Aim: Based on the structural features of both lonazolac and celecoxib, as an attempt to improve COX-2 selectivity, a series of novel di-aryl-chalcone derived pyrazole () was designed, synthesized, and evaluated for its COX-2 selective anti-inflammatory inhibitory activity.

Results: Derivatives , , , and displayed approximately two-folds greater COX-2 inhibitory effects (IC) than celecoxib, scoring IC of 0.446, 0.