Transmetatarsal amputation versus multiple toes amputations for non-ischemic diabetic foot infection management.

Background: The management of diabetic foot infections (DFIs) is a complex multidisciplinary process and often necessitates surgical interventions. Unfortunately, amputations such as single or multiple toes amputations (MTA) or full transmetatarsal amputation (TMA) are often the unavoidable solution. This study aimed to compare the clinical outcomes of TMA versus MTA in managing non-ischemic diabetic foot infections.

An open approach versus ultrasound approach for deep serratus anterior plane block for postoperative analgesia after modified radical mastectomy: A randomized controlled trial.

Background And Aims: Ultrasound-guided deep serratus anterior plane (SAP) block has recently gained popularity as an analgesic technique in breast surgery. However, the effectiveness of ultrasound depends largely on the quality of the equipment used, and the technique can be complicated by patient-related factors such as obesity. We hypothesized that the simpler open approach to deep SAP block would be non-inferior to the ultrasound-guided approach in providing analgesia for modified radical mastectomy.

Neuroprotective potential of fortunellin against titanium dioxide nanoparticles induced neurotoxicity via regulating NLRP3, HMGB1/RAGE, and NF-κB pathway: A biochemical, histological and in-silico experimentation.

Titanium dioxide nanoparticles (TiO-NPs) are used in the production of various industrial and commercial products and reported to cause neurotoxicity in Sprague Dawley rats. Fortunellin (FRN) is a potent flavonoid with diverse biological properties. This research experiment was performed to explore the protective role FRN against TiO-NPs induced brain damage.

Effectiveness of Incisional Negative Pressure Wound Therapy (iNPWT) in the Prevention of Post-Amputation Complications: Systematic review & Meta-analysis.

Objectives: Negative Pressure Wound Therapy (NPWT) is an advanced therapy utilizing sub-atmospheric pressure at the wound site to generate a controlled environment that promotes blood flow and stabilizes the wound area. However, its effectiveness in diminishing surgical site complications remains unproven effectively. We aim to assess the impact of iNPWT on the reduction of surgical wound complications, mortality rate, and improvement of healing rate following lower limb amputation.

The effect of 0.5 mg dose of colchicine on clinical outcomes in patients with acute myocardial infarction: An updated meta-analysis of randomized controlled trials.

Background: Inflammation plays a critical role in the progression of atherosclerosis, and the anti-inflammatory effects on clinical outcomes of patients with acute myocardial infarction (AMI) are still uncertain.

Objectives: We aimed to study the effects of a 0.5 mg dose of colchicine on clinical outcomes following AMI.

Ergonomic stress and surgical performance of general surgeons: a cross-sectional comparison of laparoscopic and open procedures.

Background: Surgeons are actively seeking ways to enhance operating room ergonomics. A comprehensive report on surgeon job-related disease and injuries could raise awareness, encourage workplace improvements, and emphasize the importance of ergonomic practices such as body posture awareness, appropriate operating room setup, and exercise to lessen discomfort and improve general health.

Purpose: To address the ergonomic challenges that surgeons in Jordan face during their work and to investigate how demographic variables may impact a surgeon's ability to perform open and laparoscopic procedures proficiently.

Current trends and future prospects of language models and processing systems in spine surgery - a scoping review.

Natural language processing (NLPs) and Large language models (LLM), such as ChatGPT, represent transformative advancements in artificial intelligence (AI). Their implementation into the medical field has a broad potential, and this review discusses the current trends and prospects of NLPs and LLMs in spine surgery, assessing their potential benefits, applications, and limitations. The methodology involved a comprehensive narrative review of existing English literature related to the use of NLPs and LLMs in spine surgery.

Evaluating the Impact of Diverse Driving Factors on Carbon Stock Variability in Tropical Dry Deciduous Forests of West Bengal, India.

Forest landscapes play a significant role in both global and local carbon cycles, mitigating climate change by sequestering atmospheric carbon. To maintain carbon stock and enhance sequestration from the atmosphere, it is important to quantify the effects of driving factors on carbon stock. Therefore, this study was designed to evaluate the effects of storing factors, maintaining factors, and disturbing factors on carbon stock, and to analyze the individual and combined effects of multiple factors.

Bidirectional Hypoxic Extracellular Vesicle Signaling Between Müller Glia and Retinal Pigment Epithelium Regulates Retinal Metabolism and Barrier Function.

The retina is highly sensitive to oxygen and blood supply, and hypoxia plays a key role in retinal diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). Müller glial cells, which are essential for retinal homeostasis, respond to injury and hypoxia with reactive gliosis, characterized by the upregulation of the glial fibrillary acidic protein (GFAP) and vimentin, cellular hypertrophy, and extracellular matrix changes, which can impair retinal function and repair. The retinal pigment epithelium (RPE) supports photoreceptors, forms part of the blood-retinal barrier, and protects against oxidative stress; its dysfunction contributes to retinal degenerative diseases such as AMD, retinitis pigmentosa (RP), and Stargardt disease (SD).

A comprehensive systematic review of randomized controlled trials on anesthetic agents in children's upper gastrointestinal endoscopy: highlighting safety concerns and efficacy.

Upper gastrointestinal endoscopy (GIE) is essential for diagnosing and treating gastrointestinal disorders in children aged 6-12 years, yet it often requires sedation due to the significant discomfort and pain involved. We conducted a PRISMA 2020-compliant systematic review of randomized controlled trials (RCTs) from PubMed, Web of Science, Scopus, and Ovid (inception to March 30, 2024). Inclusion criteria are as follows: RCTs comparing sedative regimens (e.

First detection of Rickettsia japonica in Hyalomma dromedarii ticks infesting camels from Egypt: A call for enhanced surveillance of tick-borne pathogens.

Tick-borne rickettsiosis has posed a significant threat to Egypt, with various pathogenic Rickettsia species being reported. In this study, 134 ticks were collected from camels in Esna City, Luxor, Egypt and all were identified as Hyalomma dromedarii through both morphological and molecular techniques. Using specific primers targeting the citrate synthase (gltA), outer membrane protein A (ompA) and 17 kD antigen (17 kDa) genes, Rickettsia japonica was detected via conventional and nested PCR assays.

Clinical Scoring Systems for the Assessment of Continence Following Anorectal Malformation Repair: A Comprehensive Review.

Despite advancements in surgical techniques and improved survival rates for anorectal malformation (ARM) patients, the lack of a standardized way for assessing bowel function and quality of life remains a challenge. Variability in scoring outcomes exists between systems due to inconsistencies in criteria and precise definitions, such as soiling, constipation, and continence. While older tools lack proper validation, newer scales, including the Rintala and Baylor Continence Scale (BCS), offer more structured assessment.

Efficient oxidative degradation of organic pollutants in real industrial effluents using a green-synthesized magnetite supported on biochar catalyst.

This study investigated the degradation of tetracycline (TCN) antibiotic catalytic activation of periodate (PI, IO ) using a novel composite catalyst composed of green-synthesized magnetite nanoparticles supported on water lettuce-derived biochar (MWLB). Characterization results revealed that the magnetic biochar possessed a porous structure, abundant surface functional groups, and high carbon and iron contents. Compared to conventional oxidants such as persulfate, hydrogen peroxide, and peroxymonosulfate, the PI-activated system demonstrated superior degradation efficiency.

Novel spectrophotometric approaches for analysis of solifenacin and silodosin in pharmaceutical preparations, human plasma, and environmental water samples: assessment of the methods' greenness and practicality.

The recent approval of a fixed-dose combination of silodosin (SOD) and solifenacin succinate (SOF) for overactive bladder syndrome has created a need for innovative analytical approaches enabling their simultaneous quantification. In this work, seven novel, eco-friendly, and cost-efficient spectrophotometric methods were developed for the concurrent determination of SOD and SOF. These methods overcome the limitations of conventional techniques by eliminating the need for complex instrumentation, labor-intensive procedures, and large volumes of hazardous organic solvents, offering a sustainable and accessible analytical alternative.

Complexation-based spectrofluorimetric method for besifloxacin determination: Combined experimental and computational insights.

Fluorescence-based analytical methods offer high sensitivity, cost-effectiveness, and simplicity for pharmaceutical analysis. Besifloxacin hydrochloride (Bfln.HCl), a fluoroquinolone antibiotic used to treat eye infections, exhibits native fluorescence that can be enhanced in acidic media.

Exploring the interplay between metabolic dysfunction-associated fatty liver disease and gut dysbiosis: Pathophysiology, clinical implications, and emerging therapies.

Metabolic dysfunction-associated fatty liver disease (MAFLD) now affects roughly one-quarter of the world's population, reflecting the global spread of obesity and insulin resistance. Reframing non-alcoholic fatty liver disease as MAFLD emphasizes its metabolic roots and spotlights the gut-liver axis, where intestinal dysbiosis acts as a key driver of hepatic injury. Altered microbial communities disrupt epithelial integrity, promote bacterial translocation, and trigger endotoxin-mediated inflammation that accelerates steatosis, lipotoxicity, and fibrogenesis.

Investigations on metabolic diseases of horses in Egypt.

Introduction: Obesity is a significant risk factor that predisposes horses to laminitis, equine metabolic syndrome, arthritis, heart disease, and respiratory issues.

Methods: Mares showing overweight or laminitis ( = 30), different BCS ( = 90) weighing 350-550 Kg were subjected to clinical and rump fat assessments. Blood samples were collected to measure circulating estradiol, progesterone, cortisol, insulin, insulin-like growth factor-1 (IGF-1), and leptin.

A Novel Highly Sensitive Derivatization-Free Spectrofluorimetric Approach for Analysis of the Antifungal Terconazole in Dosage Forms, Biological Fluids, and Environmental Water Samples: Assessment of Greenness and Blueness Profiles.

In the current study, the triazole antifungal terconazole (TRZ) was determined using a novel, extremely sensitive, and environmentally friendly spectrofluorimetric approach. A methanolic solution of TRZ exhibited strong native fluorescence at 373 nm when excited at 241 nm. With a correlation coefficient of 0.

Superficial and deep cervical plexus blocks versus patient-controlled analgesia in total laryngectomy; a randomized trial.

Introduction: The cervical plexus block (CPB) delivers analgesia for surgeries in the head and neck . Patient-controlled analgesia (PCA) has been utilized to enhance pain management. This study evaluates combined bilateral superficial and deep CPB versus PCA in postoperative pain management after total laryngectomy.

Functional Imaging in Alzheimer's Disease: A Systematic Review and Meta-Analysis of ASL-MRI and FDG-PET.

Background: Alzheimer's disease (AD) and mild cognitive impairment (MCI) are two common conditions associated with cognitive decline. With global dementia cases rising, identifying the most accurate imaging method for diagnosis is essential.

Methods: Following Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, we systematically reviewed studies utilizing arterial spin labeling magnetic resonance imaging (ASL-MRI) and [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for neurodegenerative disorders.

Coagulation markers as independent predictors of colorectal cancer aggressiveness.

Background: Colorectal cancer (CRC) is frequently associated with thrombosis with thrombotic events, such as deep vein thrombosis or pulmonary embolism, often correlate with poor clinical outcomes. Coagulation markers have been suggested as potential prognostic indicators for CRC severity. However, the relationship with clinicopathological characteristics in CRC remains unclear.

MDL-800 protects against inflammatory and metabolic dysfunction: role of SIRT6 in the cross-regulation of NFκB, AMPK, and PPAR signaling in rats.

Metabolic syndrome (MetSyn) is a complex, multifactorial disorder characterized by insulin resistance, dyslipidemia, hepatic steatosis, oxidative stress, and chronic inflammation, contributing substantially to the global burden of cardiometabolic diseases. Despite extensive research, effective pharmacological strategies that address the diverse and interconnected pathophysiological mechanisms of MetSyn are lacking. Sirtuin 6 (SIRT6), a NAD-dependent epigenetic regulator, has emerged as a critical modulator of metabolic and inflammatory homeostasis.

Impact of Deep Versus Shallow Tracheal Suctioning on Cardiovascular Indices and Suction Induced Complications Among Mechanically Ventilated Patients.

Background: Tracheal suctioning is a critical component of care for mechanically ventilated patients' treatment. The effectiveness and associated complications of suctioning can vary depending on the depth of catheter insertion. Although several guidelines assist nurses in selecting the appropriate suctioning technique, while the optimal suctioning depth remains uncertain.

The Efficacy and Safety of Seladelpar for Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis.

Background And Objective: Seladelpar is an oral, once-daily medication that improves cholestasis through its selective peroxisome proliferator-activated receptor (PPAR-δ) agonism. It shows promising efficacy in treating primary biliary cholangitis (PBC) patients.

Methods: A systematic review and meta-analysis synthesizing evidence from randomized controlled trials (RCTs) obtained from PubMed, Cochrane, Scopus, and WOS until July 19th, 2025.