Click chemistry-driven post-imprinting of carboxylated polymer for Selective recognition of S-rivastigmine.

Here, in the present article, a novel molecularly imprinted polymer (MIP), S-RV-P, was prepared for the recognition and separation of the S-enantiomer of rivastigmine (S-RV) from its racemic form. Synthesis involved the formation of a poly(styrene-co-maleic anhydride) (PSM) matrix that was functionalized with 2-aminoethane-1-thiol (ATH) to introduce thiol and carboxylic acid functionalities to prepare the precursor HS-P-COOH. Post-imprinting was achieved through thiol-maleimide click crosslinking via bismaleimide (BMA) facilitated by S-RV to generate the resultant S-RV-P polymer.

Perineal salvage surgery for prolapse of ileal pouch anal anastomosis: Systematic review and meta-analysis.

Background: Ileal pouch anal anastomosis (IPAA) prolapse is a rare mechanical complication, with a paucity of literature on frequency and management. This study aimed to assess the prevalence and management outcomes of perineal salvage procedures (SPs) for IPAA prolapse.

Methods: Systematic search conducted in PubMed and Scopus with an additional search of relevant cross-referenced literature on experimental and observational human studies involving IPAA for ulcerative colitis or familial adenomatous polyposis from database inception to March 2023.

Application of Cs/GO/TiO as gas sensor.

Chitosan (Cs), a biodegradable, and low-cost polymer is a good choice for gas sensor applications. In this study, Cs was modified with graphene oxide (GO) and titanium dioxide (TiO), and its electronic properties were calculated using density functional theory (DFT) at B3LYP/LANL2DZ level. The calculated physical parameters include total dipole moment (TDM), HOMO/LUMO energy gap (ΔE), global reactivity descriptors and density of states (DOS) and mapping the electrostatic potential (MESP).

Bivalent transition metal complexes of triazole pyridine Schiff base with theoretical and biological investigations.

Copper(II), manganese(II), and mercury(II) complexes of 4-amino-5-(2-(1-pyridine-2-yl)ethylidene)hydrazinyl)-4H-1,2,4-triazole-3-thiol (HTAP) were synthesized and characterized using CHN analysis, FT-IR, H-NMR, C-NMR, UV-Vis, ESR, MS, PXRD, magnetic moment measurements, molar conductance, and TG/DTA. DFT calculations indicate octahedral geometries and the neutral bidentate or tridentate chelating behavior of the ligand. Cyclic voltammetry revealed the complexes' redox properties, and Job's method elucidated stoichiometric compositions in solution.

Controlling dodder (Cuscuta planiflora) in Egyptian clover with silica nanoparticles and a novel bioherbicide.

Dodder (Cuscuta planiflora) is a major parasitic plant species affecting the productivity of Egyptian clover (Trifolium alexandrinum L.), an important forage crop in Egypt. A field trial was executed on Egyptian clover heavily infested with dodder during the winter seasons of 2021/2022 and 2022/2023.

Efficacy of Transcranial Direct Current Stimulation in Patients with Primary Progressive Aphasia: A Systematic Review and Updated Meta-analysis.

Background: Primary progressive aphasia (PPA) is a group of dementias characterized by progressive loss of specific language functions with relative sparing of other cognitive domains. Transcranial direct current stimulation (tDCS) has been introduced as a potential therapeutic option for PPA. We aim to evaluate the efficacy of tDCS in improving cognitive and language functions in patients with PPA.

From Plants to Patients: Advancing Cancer Therapy With Bioengineered Exosomes and AI-Driven Innovations.

Cancer is a leading global cause of death, with complex pathogenesis and treatment challenges like poor selectivity, toxicity, and drug resistance. Nanotechnology offers transformative solutions, with plant-derived exosomes (EXOs) emerging as promising green nanomaterials for personalized cancer therapy because of their biocompatibility and minimal antigenicity, and eco-friendly production. This review discusses the potential of plant EXOs in cancer treatment, covering isolation methods, advantages over mammalian EXOs (e.

Endobronchial Zephyr valves for bronchoscopic lung volume reduction for severe emphysema: a systematic review and meta-analysis.

Background: Chronic obstructive pulmonary disease (COPD) causes permanent lung damage and is a global health issue. Bronchoscopic Lung Volume Reduction (BLVR) with Zephyr valves has increased COPD treatment choices for individuals with persistent symptoms despite maximal drug therapy.

Objectives: This systematic review and meta-analysis evaluated available Zephyr valve data in severe emphysema patients.

GLP-1 receptor agonists in Parkinson's disease: an updated comprehensive systematic review with meta-analysis.

Previous studies have demonstrated an increased risk of developing Parkinson's disease (PD) in patients with type 2 diabetes mellitus (T2DM), as well as more severe and rapid motor and non-motor deterioration in diabetic PD patients compared to their non-diabetic counterparts. Additional research has suggested that diabetic subjects treated with glucagon-like peptide-1 (GLP-1) receptor agonists exhibit a reduced incidence of PD compared to those receiving other anti-diabetic medications. GLP-1 receptor agonists are FDA-approved therapies for T2DM, and recent studies have explored their potential as repurposed treatments for neurodegenerative diseases, including PD, AD, and ALS, as well as cerebrovascular disorders.

Elemental and micromorphological analysis of ion releasing restoration/carious dentin interface.

The objective of the current study was to evaluate elemental analysis and micromorphological patterns at the interfaces between tooth substrates either sound or demineralized dentin and ion-releasing restorations, including conventional glass ionomer and ion-releasing composite. The evaluation was conducted immediately (after 24 h) and after six months of artificial saliva storage. A total of 48 sound human premolars were used in this study.

Prediction of ultimate load capacity of demountable shear stud connectors using machine learning techniques.

This study investigates the use of machine learning (ML) models to predict the ultimate load capacity of demountable shear connectors in steel-concrete composite structures. A dataset of 239 experimental and numerical records was assembled, incorporating critical features such as bolt diameter, bolt yield and ultimate strengths, concrete and grout compressive strengths, and multiple interfacial friction coefficients. Eight supervised ML algorithms were evaluated: Linear Regression, Ridge, Lasso, K-Nearest Neighbors (KNN), Support Vector Regression (SVR), Decision Tree, Random Forest, and XGBoost.

Ex-vivo Expansion of Cord Blood Hematopoietic Stem Cells in Serum-Free Medium with Feeder Layer - A New Hope for Successful Cord Blood Transplantation in Adults.

Umbilical cord blood is widely regarded as a viable option for allogeneic hematopoietic stem cell transplantation (HSCT) and serves as a potential alternative to bone marrow due to its numerous advantages. These include a non-invasive collection process, a high concentration of hematopoietic stem and progenitor cells, and a lower risk of graft rejection. However, its application in adult patients is limited by the suboptimal dose of stem cells available in a single umbilical cord blood unit.

Correction: Formulation of zein nanoparticles for augmenting the anti-inflammatory activity of dexketoprofen.

[This corrects the article DOI: 10.3389/fphar.2025.

A Meta-Analysis and Systematic Review on the Use of Adipose-Derived Mesenchymal Stem Cells for Knee Osteoarthritis Management.

Background: Knee osteoarthritis (KOA) is one of the most common forms of joint degeneration, frequently resulting in persistent pain, reduced mobility, and impaired quality of life. The disease is characterized by the progressive breakdown of articular cartilage, synovial inflammation, and subchondral bone changes. Conventional management options such as analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroid injections, and surgical procedures are primarily aimed at alleviating symptoms rather than reversing or halting disease progression.

Development of a Drug-Loaded Shape-Memory Polymer Urethral Stent (SMPUS) for Treatment of Prostatic Urethral Obstruction (PUO).

Prostatic urethral obstruction (PUO) is the urethral narrowing by the external pressure of an enlarged prostate, which hinders the ability to pass urine normally. The most common reasons for an enlarged prostate are prostate cancer and benign prostate hyperplasia. In this study, we aimed to develop a drug-loaded shape-memory polymer urethral stent (SMPUS) to address PUO.

Technical approaches for preservation of the temporalis muscle in neurosurgery: a systematic review.

Background: The temporalis muscle is commonly dissected and mobilized during craniotomy. Cosmetic and functional complications may arise from the improper handling of this muscle. Surgery for recurrent pathologies may be challenging due to adhesions and muscle damage.

Artificial intelligence in disease diagnostics: a comprehensive narrative review of current advances, applications, and future challenges in healthcare.

Introduction: Artificial intelligence (AI) is revolutionizing healthcare, particularly in disease diagnostics, by improving accuracy, efficiency, and personalization. Its applications span medical imaging, pathology, and personalized medicine, significantly enhancing patient outcomes. However, challenges such as ethical dilemmas, data privacy concerns, and algorithmic biases hinder its full integration into clinical practice.

Empowering Women for a Changing Climate: Exploring the Role of Environmental Literacy in Shaping Risk Perception and Climate Capability in Reproductive-Age Women.

Background: Climate change is a growing global concern with significant implications for public health, especially for women of reproductive age. Environmental literacy, climate capability, and risk perception are crucial in shaping individuals' responses to climate change.

Aim: The study aimed to evaluate environmental literacy, climate capability, and climate change risk perception among women of reproductive age and explore their interrelationships.

Immune thrombocytopenia as a rare initial manifestation and complication of Hodgkin lymphoma: a Pediatric case report.

Hodgkin lymphoma (HL) is a malignancy of the lymphatic system often associated with immune dysfunction. This case describes an 11-year-old boy presenting with epistaxis, petechiae, and thrombocytopenia (40 000/μl), initially diagnosed as immune thrombocytopenia (ITP). Further evaluation revealed lymphadenopathy and splenomegaly.

Revolutionizing recovery: The impact of designed digital care therapy on preventing Post-Intensive care syndrome.

Objectives: This study aims to evaluate the effect of implementing a designed digital care therapy (DCT) program on preventing post intensive care syndrome (PICS) among critically ill patients.

Methods: A quasi-experimental study was conducted on 120 patients in two ICUs at a tertiary hospital. Patients were randomly assigned to an intervention group (n = 60) that received DCT, including interactive games on mobiles and tablets, and a control group (n = 60) that received routine ICU care.

The synergetic potential of gold nanoparticles and bone marrow stem cells in regeneration of tongue defects (An experimental study on Rats).

Purpose: The tongue plays a vital role in physiological functions where tissue loss impairs the patient's life, so regenerative approaches are crucial. This study was performed to explore the synergetic possibility of gold nanoparticles (AuNPs) and bone marrow stem cells (BMSCs) in tongue defect regeneration.

Methods: Rats were subjected to surgical defects on the tongue's dorsal surface and divided into four groups: Group I (control): received no treatment, Group II (AuNPs): received 0.

Vaping leads tobacco consumption among university students in Arab countries: a study of behavioral and psychosocial factors associated with smoking.

Background: E-cigarettes use "vaping" is a growing public health concern. The Arabic-validated Vaping Attitude and Perceptions Scale (VAPeS) instrument assesses vaping determinants across five constructs: Social Influence, Perceived Harms, Vaping Pleasure, Behavioral Influences, and Economic and Self-Efficacy. We aimed to examine the prevalence of cigarette, e-cigarette, and narghile use among Arab university students and to identify the associations between demographic/VAPeS-related variables and the smoking attitudes among vapers.

Impact of Biological Therapy on Fatigue, Functional Status, and Health-Related Quality of Life in Rheumatoid Arthritis Patients: Results from Real-Life Practice.

Background: Rheumatoid arthritis (RA) is an autoimmune inflammatory condition that adversely affects health-related quality of life (HRQoL) by causing joint damage, pain, functional impairment, and fatigue.

Objectives: The aim of this study was to assess the impact of biological disease-modifying antirheumatic drugs (bDMARDs) on fatigue, functional disability, and HRQoL in an Egyptian cohort with RA.

Methods: This observational analytical prospective cohort study included RA patients who needed to start bDMARDs immediately after the enrolment visit at two Rheumatology and Immunology Units.

A novel anatomically guided strategy for evaluation of sufficient myotomy during peroral endoscopic myotomy in patients with achalasia.

Background And Aims: Peroral endoscopic myotomy (POEM) necessitates proper orientation of the anatomical landmarks throughout the whole procedure to assess the myotomy, which is the main target of POEM. Insufficient myotomy renders the procedure ineffective and may lead to nonresponse or recurrence, although longer myotomy may increase the risk of reflux. The current conventional methods for esophagogastric junction (EGJ) detection are often operator-dependent, time-consuming, and have questionable accuracy.