Prevalence and Characterization of the Antimicrobial Resistance and Virulence Profiles of in Ready-to-Eat (Meat, Chicken, and Tuna) Pizzas in Mansoura City, Egypt.

is a high-priority foodborne pathogen contributing to several food poisoning outbreaks. Methicillin- and vancomycin-resistant (MRSA and VRSA), pose significant public health concerns due to their potential for serious illness, antibiotic resistance, and transmission within both healthcare and community settings. These bacteria can cause numerous infections, ranging from skin and soft tissue infections to life-threatening conditions like bloodstream infections, pneumonia, and endocarditis.

Gestation-Stage Related Changes in the IGF System Components in the Equine Placenta.

The insulin-like growth factor (IGF) system regulates implantation, placental development, and angiogenesis in eutherian mammals. However, little is known about the changes in this system in equine placenta (chorioallantois; CA) and the endometrium (EN) during pregnancy, or the relationship to vascular endothelial growth factor () expression. The current study investigated the expression of the IGF system components, namely the ligands ( and ), their receptors (, , and ), and their binding proteins ( and s) in equine CA at 45 days, 4, 6, 10, and 11 months of gestational age (GA) and immediately postpartum (PP), and in equine EN at 4, 6, 10, and 11 months GA.

A Natural Polyphenol, Chlorogenic Acid, Attenuates Obesity-Related Metabolic Disorders in Male Rats via miR-146a-IRAK1-TRAF6 and NRF2-Mediated Antioxidant Pathways.

Chronic high-fat diet (HFD) feeding in male rats causes significant metabolic as well as inflammatory disturbances, including obesity, insulin resistance, dyslipidemia, liver and kidney dysfunction, oxidative stress, and hypothalamic dysregulation. This study assessed the therapeutic effects of chlorogenic acid (CGA), a natural polyphenol, administered at 10 mg and 100 mg/kg/day for the last 4 weeks of a 12-week HFD protocol. Both CGA doses reduced body weight gain, abdominal circumference, and visceral fat accumulation, with the higher dose showing greater efficacy.

Multifaceted role of Moringa oleifera leaf extract as antimicrobial, growth enhancer and mitigator of salt stress in tomato seedlings.

Research on L.‘s potential applications as a dietary supplement, medicinal herb and plant growth enhancer under biotic and abiotic stresses has increased recently. Our study aimed to investigate the phytochemical screening of Moringa leaf aqueous extract (MLAE) and to determine its antimicrobial activity against pathogenic bacteria and fungi.

Multislice CT-guided evaluation of collagen-chitosan composite in promoting antebrachiocarpal arthrodesis in a rabbit model.

Background: Arthrodesis is a critical procedure for restoring stability and relieving pain in severely damaged joints. Successful bone fusion remains a significant challenge, often necessitating the use of biomaterials to enhance healing. Collagen and chitosan, two natural polymers with established biocompatibility and osteoconductive properties, have shown promise in regenerative medicine applications.

Proteus mirabilis in ICU Patients: Prevalence, Risk Factors, and Future Expectations of Bloodstream Infections.

Background is an emerging but under-recognized cause of bloodstream infections (BSIs) in intensive care unit (ICU) settings, where invasive procedures and immunocompromised states increase vulnerability. Despite its clinical importance, the epidemiology and risk factors associated with BSIs remain poorly understood, especially in low- and middle-income countries. Gap Most existing studies generalize Gram-negative pathogens without isolating the specific impact of in ICU populations.

Enhancement of Growth Performance and Health Status in Heat-Stressed Growing Rabbits Using Alpha-Lipoic Acid-Loaded Chitosan Nanoparticles.

Objective: This study is the first to study the effect of Alpha-lipoic acid-loaded chitosan nanoparticles (ALA-CHNPs) on growth performance, feed utilization, and health in heat-stressed growing rabbits.

Methods: A total of one hundred healthy 5-week-old rabbits were randomly divided into four groups of 25, each receiving diets supplemented with 0, 100, 200, or 400 mg ALA-CHNPs per kilogram.

Results: The dietary supplementation significantly improved growth performance, feed conversion ratio, physiological responses, liver weight, and dressing percentage.

Does Bariatric Surgery Affect Pregnancy in Women in the Childbearing Period? A Retrospective Single Center Study.

Background: Severe obesity is a significant public health challenge, affecting women's reproductive health in the childbearing period. Bariatric surgery is an effective weight loss method for management of severe obesity and increase fertility. It may result in nutritional deficiency which adversely affects the maternal and fetal outcome.

A novel dynamic Nelder-based Electric Eel Foraging algorithm for global optimization and pathological colorectal cancer image segmentation.

Colorectal cancer (CRC) is a major global health concern, where timely and precise diagnosis is crucial for effective treatment. In medical imaging, accurate segmentation of pathological regions is essential for guiding diagnostic decisions and treatment strategies. However, traditional metaheuristic-based segmentation methods often face challenges like slow convergence, suboptimal threshold determination, and inadequate balancing between exploration and exploitation, which can limit their effectiveness in multi-threshold image segmentation (MTIS) of CRC pathology images.

Open source Arabic research paper dataset for natural language processing.

Recent advancements in applications such as natural language processing (NLP), applied linguistics, indexing, data mining, information retrieval, and machine translation have emphasized the need for robust datasets and corpora. While there exist many Arabic corpora, most are derived from social media platforms like X or news sources, leaving a significant gap in datasets tailored to academic research. To address this gap, the ARPD, Arabic Research Papers Dataset, is developed as a specialized resource for Arabic academic research papers.

Radiation Assessment and Geochemical Characteristics of U, Ra, Th, and K of Selected Specialized Granitic Occurrences, Saudi Arabia, Arabian Shield.

Between approximately 725 and 518 Ma, a suite of specialized felsic plutons and granitic stocks were emplaced across the Arabian Shield, many of which are now recognized as highly mineralized prospects enriched in rare earth elements (REEs), rare metals, and radioactive elements bearing mineralizations. The current investigation focused on the radiological and geochemical characterization of naturally occurring radionuclides, specifically U, Ra, Th, and K, within three strategically selected granitic prospects, namely, J. Tawlah albite granite (TW), J.

Soft robotic gloves versus mirror therapy: a long-term comparative study on hand function and motor recovery in post-stroke rehabilitation.

Objective: This study aimed to compare the long-term effects of soft robotic gloves (SRGs) and mirror therapy on hand function and motor recovery in post-stroke patients.

Methods: A single-blinded, randomized controlled comparative study was conducted on 49 patients with chronic stroke assigned randomly to either the SRGs or mirror therapy group. Both groups underwent an 8-week intervention alongside conventional rehabilitation.

Antimicrobial Resistance Genotypes and Mobile Genetic Elements of Poultry-Derived : A Retrospective Genomic Study from the United States.

The presence of antibiotic resistance in commensal bacteria may be an influential factor in the persistence of resistance in pathogens. This is especially critical for that consumers may be exposed to through the consumption of uncooked meat. In this study, isolates previously recovered from poultry in the US between 2001 and 2012 were whole-genome sequenced to identify their antibiotic resistance genes and mobile genetic elements.

The Gut Microbiota Metabolite Urolithin B Mitigates Cholestatic Liver Injury in Mice via Modulating the Crosstalk Between PPARα, Nrf2, and NF-κB Signaling Pathways.

Urolithin (Uro)-B, a gut microbiota metabolite of ellagic acid, has recently gained considerable attention due to its beneficial bioactivities. This study investigated the potential hepatoprotective effect of Uro-B against alpha-naphthyl isothiocyanate (ANIT)-induced cholestatic liver injury (CLI) in mice and explored the possible involved mechanisms. Mice were treated with Uro-B (50 and 100 mg/kg) for four days and received ANIT (75 mg/kg) once on the second day.

Adaptive Differentiated Parrot Optimization: A Multi-Strategy Enhanced Algorithm for Global Optimization with Wind Power Forecasting Applications.

The Parrot Optimization Algorithm (PO) represents a contemporary nature-inspired metaheuristic technique formulated through observations of Pyrrhura Molinae parrot behavioral patterns. PO exhibits effective optimization capabilities by achieving equilibrium between exploration and exploitation phases through mimicking foraging behaviors and social interactions. Nevertheless, during iterative progression, the algorithm encounters significant obstacles in preserving population diversity and experiences declining search effectiveness, resulting in early convergence and diminished capacity to identify optimal solutions within intricate optimization landscapes.

Exploring novel thiazolo[5,4-f]quinoline-based scaffolds as promising antimicrobial agents through synthesis and molecular insights.

In pursuit of novel antimicrobial agents, a series of thiazolo[5,4-f]quinoline derivatives incorporating pyridine and thiophene moieties were synthesized and structurally characterized using IR and H-NMR spectroscopy. The synthetic strategy employed diverse condensation and cyclization reactions involving cyanoacetamide intermediates, aryl isothiocyanates, and α-halocarbonyl compounds. The resulting compounds were evaluated for their antimicrobial efficacy against Staphylococcus aureus, Escherichia coli, and Candida albicans.

Bio-guided discovery of antibacterial metabolites from .

Bio-guided isolation from the Red Sea-derived yielded two new metabolites, 15-deoxy-15-amino-citreohybridonol () and chrysogenotoxin (), alongside five known compounds: emodin (), chrysophanol (), (2-ethylhexyl) phthalate (), haenamindole (), and citreorosein (). Compound exhibited broad-spectrum antibacterial activity against both Gram-positive (MIC: 0.31-0.

Artificial Intelligence in Gestational Diabetes Care: A Systematic Review.

Background: Artificial intelligence (AI) has emerged as a transformative tool for advancing gestational diabetes mellitus (GDM) care, offering dynamic, data-driven methods for early detection, management, and personalized intervention.

Objective: This systematic review aims to comprehensively explore and synthesize the use of AI models in GDM care, including screening, diagnosis, management, and prediction of maternal and neonatal outcomes. Specifically, we examine (1) study designs and population characteristics; (2) the use of AI across different aspects of GDM care; (3) types of input data used for AI modeling; and (4) AI model types, validation strategies, and performance metrics.

Effect of Statin Therapy on Neurological Outcomes in Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis of 1464 Patients.

Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition complicated by cerebral vasospasm and deterioration of neurological functions. Statins have been proven to reduce the incidence of vasospasm and limit the neurological deterioration with controversial data. We aimed to give a comprehensive assessment of statins in patients with aSAH.

Narrative review of metabolic syndrome and its relationships with non-alcoholic fatty liver disease, gonadal dysfunction and obstructive sleep apnea.

Background: Metabolic syndrome is an emerging health problem, and its prevalence is rapidly increasing. Therefore, we first aimed to investigate its pathophysiology, focusing on the insulin resistance state and the consumption of high-calorie diets. In addition, previous studies have shown an association between metabolic syndrome and non-alcoholic fatty liver disease, gonadal dysfunction and obstructive sleep apnea, but little is known about the nature of the relationship between metabolic syndrome and these conditions.

Enhancing Rahmani Ram Semen Cryosurvival Through Oral Moringa Oil and Microencapsulation: In Vivo and In Silico Mechanistic Insights.

Cryopreservation of ram semen is challenged by the high polyunsaturated fatty acid content in spermatozoa, which leads to increased oxidative stress and cellular damage. This study explored the potential of orally administered moringa oil (MO) or its microencapsulated form (MON) to protect ram spermatozoa during cryopreservation by assessing their effects on semen quality, antioxidant capacity, apoptosis, seminal metabolic enzyme activity, as well as molecular docking study. Fifteen Rahmani rams were randomly split into three groups (n = 5 per group) and fed a basal diet.

Optimal Cutoff for the Neutrophil-to-Lymphocyte Ratio as a Tool for Pre-chemotherapy Prognosis Stratification of Breast Cancer Patients.

Introduction The neutrophil-to-lymphocyte ratio (NLR) is an established inflammatory marker in cancer patients. The optimal cut-off as an independent prognostic factor for breast cancer (BC) progression in patients undergoing chemotherapy remains debatable, hindering effective stratification. This study explored the optimal NLR cut-off by comparing various thresholds and assessing their effectiveness in stratifying BC patients according to prognosis.

Deciphering the binding mechanism of tafamidis to calf thymus DNA: multimodal spectroscopic, thermodynamic, and computational perspectives.

The interaction between small molecules and biological macromolecules is a crucial area of research with significant implications across various scientific disciplines. Tafamidis is a clinically approved drug for transthyretin-mediated amyloidosis, yet its molecular interactions with biological macromolecules such as DNA remain unexplored. Investigating such interactions is crucial for understanding its broader pharmacodynamic profile and potential off-target effects.

Associations of the Healthy Beverage Index and the risk of colorectal cancer: a case-control study.

Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality worldwide. Emerging evidence suggests that dietary patterns can significantly influence CRC risk, with beverages playing a critical role. The Healthy Beverage Index (HBI) is a tool to assess the healthfulness of beverage consumption, yet its relationship with colorectal cancer risk has not been extensively studied.

Clinical and molecular findings in actin-related inborn errors of immunity: the middle East and North Africa registry.

Background: The majority of monogenic inborn errors of immunity presenting as actinopathies were reported originally from the Middle East and North Africa (MENA) countries indicating a high prevalence of these entities in the region. However, their prognosis is unclear due to rarity and lack of comprehensive treatment outcomes.

Methods: We evaluated clinical, immunological, and genetic abnormalities associated with 15 genetic entities of actinopathies.