First detection of Rickettsia japonica in Hyalomma dromedarii ticks infesting camels from Egypt: A call for enhanced surveillance of tick-borne pathogens.

Tick-borne rickettsiosis has posed a significant threat to Egypt, with various pathogenic Rickettsia species being reported. In this study, 134 ticks were collected from camels in Esna City, Luxor, Egypt and all were identified as Hyalomma dromedarii through both morphological and molecular techniques. Using specific primers targeting the citrate synthase (gltA), outer membrane protein A (ompA) and 17 kD antigen (17 kDa) genes, Rickettsia japonica was detected via conventional and nested PCR assays.

Detection and Genomic Characteristics of NDM-19- and QnrS11-Producing O101:H5 Strain Phylogroup A: ST167 from a Poultry Farm in Egypt.

This study describes the first complete genomic sequence of an NDM-19 and QnrS11-producing multidrug-resistant (MDR) isolate collected from a fecal swab from a poultry farm in 2019 in Egypt. The was identified by PCR screening and DNA sequencing. The isolate was then subjected to antimicrobial susceptibility testing, conjugation and transformation experiments, and complete genome sequencing.

Differential Effects of Chitosan-Salicylic Acid Nanocomposite and Salicylic Acid on Cucumber Mosaic Virus in Cucumber.

Cucumber mosaic virus (CMV) is a destructive viral pathogen of vegetables, fruits, grains, and ornamentals across the globe. This study investigated the comparative antiviral efficacy of chitosan-salicylic acid nanocomposite (Ch/SA NC) and salicylic acid (SA) against CMV in cucumber plants. Transmission electron microscopy (TEM) analyses revealed that Ch/SA NCs can aggregate on the viral coat protein surface, suggesting direct nanoparticle-virus interaction.

Efficacy of risankizumab across GRAPPA domains in psoriatic arthritis: a pooled analysis of patients from the phase 3 KEEPsAKE 1 and 2 studies.

Objective: To assess the efficacy of long-term treatment with risankizumab across the updated Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) domains and key related conditions of psoriatic arthritis (PsA).

Methods: This post hoc analysis primarily used data from the phase 3 KEEPsAKE 1 trial of adult patients with PsA, with data from KEEPsAKE 2 pooled for prespecified outcomes. Outcomes measuring risankizumab efficacy across key GRAPPA-recognised domains of PsA (peripheral arthritis, enthesitis, dactylitis, skin and nail psoriasis, axial disease) and PsA-related conditions such as inflammatory bowel disease (IBD) and uveitis were assessed over 100 weeks of treatment (~2 years).

The Lived Experience of Patients Diagnosed with Vitiligo and a Preliminary Conceptual Disease Model: Insights from Patients, Patient Advocates, and Clinicians.

Introduction: Patients with vitiligo experience high disease and psychosocial burden, and dissatisfaction with current treatment options, highlighting a need to understand the disease from a patient perspective. This study gathered insights from key opinion leaders (KOLs) and patient advocates on a conceptual disease model of vitiligo and gained patient perspectives through qualitative interviews on the disease burden and concepts important to patients with nonsegmental vitiligo (NSV), and what degree and anatomical location of repigmentation may constitute a meaningful change with treatment.

Methods: This cross-sectional, observational study involved virtual, semi-structured, qualitative interviews with expert KOLs treating patients with vitiligo, patient advocates, and patients diagnosed with NSV.

Long-Term Safety and Efficacy of Risankizumab to Treat Moderate-to-Severe Plaque Psoriasis: Final LIMMitless Phase 3, Open-Label Extension Trial Results.

Background: Psoriasis is a chronic, inflammatory disease requiring long-term therapy. Risankizumab, an anti-interleukin-23 monoclonal antibody, is approved to treat moderate-to-severe plaque psoriasis in adults.

Objective: The aim was to assess the long-term safety and efficacy of continuous risankizumab treatment through 6 years in adults with moderate-to-severe plaque psoriasis.

Evaluation of CEMIP in diagnosis of pancreatic carcinoma in comparison with other traditional markers.

Screening and early diagnosis of pancreatic cancer (PC) are crucial for improving its prognosis. In the current study, we aimed to evaluate the clinical utility of serum cell migration inducing protein in pancreatic cancer patients (CEMIP). This study was conducted on 50 newly diagnosed pancreatic cancer patients, aged from 49 to 77 years.

First detection of spp. in and molecular characterization of piroplasmids in southern Egypt.

Piroplasmosis is a tick-borne disease that can affect livestock, particularly cattle. Its causative pathogens are intracellular apicomplexan parasites belonging to the order Piroplasmida. We recently identified one such emergent pathogen ( spp.

The Epidemiology of Atopic Dermatitis among Adults and Adolescents with Alopecia Areata in the United States.

This study evaluated the prevalence, incidence, and relative risk of comorbid atopic dermatitis (AD) among patients with alopecia areata (AA) using data from the Merative MarketScan Research Databases. Eligible patients had ≥1 inpatient or ≥2 outpatient claims for AA between January 1, 2017 and October 31, 2023; were aged ≥12 years; and were continuously enrolled during the ≥5-year baseline period through the 6-month follow-up period; index date was the earliest date of AA diagnosis. AD prevalence (%) and incidence (cases per 1000 person-years) among patients with AA are reported and stratified by disease severity; a subgroup analysis was performed among adolescents (aged 12-17 years).

Dorsal- vs ventral-onlay buccal mucosal graft urethroplasty for urethral strictures: a meta-analysis.

Objective: To compare ventral- and dorsal-onlay buccal mucosal graft (BMG) urethroplasty in patients with urethral stricture, as the optimal placement of BMG in urethroplasty for bulbar urethral strictures remains debated.

Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library. Studies comparing dorsal- and ventral-onlay BMG urethroplasty were analysed.

Drug repositioning: Identification of potent inhibitors of NS3 protease and NS5 RdRp for control of DENV infection.

Dengue virus (DENV) threatens global health; specific antiviral drugs are required to combat it. Such anti-DENV therapeutics can be rapidly developed by repositioning the drugs approved for other indications. This study investigated six medications of different classes drawn from a library of molecules.

Molecular prevalence and phylogenetic characterization of Francisella-like endosymbionts in ticks infesting camels and cattle from Southern Egypt.

Ticks serve as vectors for numerous pathogens affecting human and animal health and harbor various microorganisms, including Francisella-like endosymbionts (FLEs), whose potential pathogenicity remains uncertain. In Egypt, data on FLEs, particularly in Southern Egypt, are limited, despite the importance of tick-borne pathogen surveillance in livestock. This study represents the first report of FLEs in Southern Egypt and the first detection of FLEs in Rhipicephalus annulatus in Egypt.

Molecular detection of Rickettsia aeschlimannii, Borrelia theileri, and Francisella-like endosymbionts in Camelus dromedarius and dogs in Luxor, Egypt.

Vector-borne bacterial pathogens can cause disease in a range of animals, including dromedary camels and dogs, but epidemiological and molecular studies on these pathogens are scarce in southern Egypt. In this study, we screened camels and dogs in southern Egypt (Luxor) for vector-borne bacterial pathogens, with molecular analysis of 200 blood samples collected from camels and dogs in the region. The Rickettsia aeschlimannii gltA gene was detected in 5% (5/100) of camel blood samples and 1% (1/100) of dog blood samples.

First detection and molecular characterization of Mycoplasma species in camels, cattle, buffalo, and their associated ticks from southern Egypt.

Mycoplasma species are wall-less bacteria that infect multiple mammalian orders, including livestock, and are associated with economically significant diseases. In Egypt, molecular data on the presence and diversity of Mycoplasma spp. in camels, cattle, buffalo, and their associated ticks remain limited, despite their potential impact on livestock health and productivity.

Corrigendum to "Once-daily upadacitinib versus placebo in adults with extensive non-segmental vitiligo: a phase 2, multicentre, randomised, double-blind, placebo-controlled, dose-ranging study" [eClinicalMedicine 73(2024) 102655].

[This corrects the article DOI: 10.1016/j.eclinm.

Propofol versus Dexmedetomidine for Sedation of Cancer Patients Undergoing Endoscopic Retrograde Cholangiopancreatography: Randomized Single-Blinded Controlled Study.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a primary diagnostic and therapeutic option for pancreaticobiliary pathologies.

Objectives: This study aimed to investigate the efficacy and safety of dexmedetomidine versus propofol during ERCP in cancer patients.

Methods: This randomized controlled single-blinded trial was conducted with 202 cancer patients aged 21 to 60 years, of both sexes, with a body mass index of 18.

Climate change and geographical distribution projections for major leaf beetles (Coleoptera: Chrysomelidae) in Saudi Arabia.

Climate change has a substantial impact on the quality and diversity of insect pests, which may have adverse ecological and economic effects. The family Chrysomelidae represents one of the most economically and ecologically important groups within Coleoptera, with species acting as agricultural pests and contributing substantially to biodiversity in arid regions. Based on bioclimatic, topographic, and vegetation data, the current and future distributions of 4 chrysomelids (Caryedon acaciae (Gyllenhal, 1833), Chaetocnema pulla Chapuis, 1879, Phyllotreta cheiranthi Weise, 1903, and Spermophagus sericeus (Geoffroy, 1785)) in Saudi Arabia were predicted using MaxEnt modeling for 2050 under 2 Shared Socioeconomic Pathways (SSPs), SSP126 (low emission) and SSP585 (high emission) scenarios.

Real-World Effectiveness of Risankizumab in Patients with Moderate-to-Severe Psoriasis: Interim Analysis from the VALUE Global Prospective Post-marketing Observational Study at 25 Months.

Introduction: Risankizumab is approved for treating moderate-to-severe psoriasis. This interim analysis at 25 months evaluated the effectiveness of risankizumab compared with other approved biologics (OtherBios) among patients with moderate-to-severe psoriasis in the 37-month VALUE post-marketing observational study.

Methods: Patients diagnosed with psoriasis were enrolled in a 2:1 ratio to risankizumab or OtherBios, as prescribed by their physicians.

Ultrasound-guided rhomboid intercostal block combined with subserratus plane block vs pectoral nerve block type-2 in analgesia for breast-conserving surgery (randomized, controlled study).

Introduction: The most frequent malignancy in women is the breast cancer, the rhomboid intercostal and subserratus plane (RISS) block is a novel regional approach.

Objectives: This study evaluated the analgesic efficacy of the RISS block compared to type 2 Pectoral Nerve (PECS II) block in breast cancer patients following breast-conserving surgery (BCS).

Methods: This randomized controlled trial comprised 69 women with breast cancer scheduled for unilateral BCS under general anesthesia, randomly allocated into 3 equal groups.

Impact of polyvinyl chloride nano-plastics on the biochemical status of Oreochromis niloticus under a predicted global warming scenario.

Plastic pollution and global warming are widespread issues that lead to several impacts on aquatic organisms. Despite harmful studies on both subjects, there are few studies on how temperature increases plastics' adverse effects on aquatic animals, mainly freshwater species. So, this study aims to clarify the potential impact of temperature increases on the toxicological properties of polyvinyl chloride nano-plastics (PVC-NPs) in Nile tilapia (Oreochromis niloticus) by measuring biochemical and oxidative biomarkers.

Comparative study between high and low dose methylene blue infusion in septic cancer patients: a randomized, blinded, controlled study.

Purpose: Septic shock is a common threat, and is the primary cause of death in almost all critical care units. Mortality of septic shock remains exceedingly high. The early use of methylene blue (MB) in different doses as adjunctive to vasopressors has promising results.

Efficacy and safety of risankizumab versus methotrexate in patients with moderate-to-severe plaque psoriasis: results from IMMbrace, a randomized, double-blind, phase 3 study with an open-label extension period in Brazil.

Background: Psoriasis, a chronic, inflammatory skin disease, requires long-term therapy. Risankizumab is a humanized immunoglobulin G1 monoclonal antibody that specifically inhibits interleukin 23 by binding to its p19 subunit.

Objective: The authors assessed the efficacy and safety of risankizumab compared with methotrexate in adults with moderate-to-severe plaque psoriasis.