The Microbiota-Gut-Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders.

Introduction: The microbiota-gut-brain axis (MGBA), a complex two-way connection between the gut microbiota and the brain, has become a key regulator of neurological and neuropsychiatric disorders. Neurological disorders and gut microbiota dysbiosis are linked to these diseases. Changes in gut microbiota can lead to neurotransmitter imbalances, oxidative stress, and neuroinflammation.

Novel spectrophotometric approaches for analysis of solifenacin and silodosin in pharmaceutical preparations, human plasma, and environmental water samples: assessment of the methods' greenness and practicality.

The recent approval of a fixed-dose combination of silodosin (SOD) and solifenacin succinate (SOF) for overactive bladder syndrome has created a need for innovative analytical approaches enabling their simultaneous quantification. In this work, seven novel, eco-friendly, and cost-efficient spectrophotometric methods were developed for the concurrent determination of SOD and SOF. These methods overcome the limitations of conventional techniques by eliminating the need for complex instrumentation, labor-intensive procedures, and large volumes of hazardous organic solvents, offering a sustainable and accessible analytical alternative.

The PPAR-β/δ agonist GW0742 alleviates DNA damage and lupus nephritis in an animal model of systemic lupus erythematosus via restoring DNA repair gene expression.

Systemic lupus erythematosus (SLE) is a persistent autoimmune inflammatory disease associated with an elevated risk of kidney damage. The etiology of SLE remains unclear; nevertheless, current investigations increasingly indicate that increased DNA damage and deficiencies in the mechanisms of its repair might contribute to its pathogenesis, necessitating the identification and management of the disease. Therapies for SLE have improved considerably over recent decades.

Socio-Epidemiological Correlates of Anemia Among Non-Pregnant Females of East and West Uttar Pradesh, India: A NFHS-5 Secondary Data Analysis Highlighting the Need for Precision Public Policy.

Anemia remains a persistent public health challenge in India, disproportionately affecting women and undermining maternal and reproductive health outcomes. Despite nationwide efforts, the burden of anemia continues to vary widely across regions, reflecting complex socio-demographic determinants. This study aims to identify region-specific risk factors for anemia among non-pregnant women in East and West Uttar Pradesh (UP), India, using data from the National Family Health Survey (NFHS-5).

Clinical insights into catechin-based nanomedicine: a review of therapeutic potential in neurodegenerative diseases.

Neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, and Huntington's diseases are characterized by progressive neuronal loss, oxidative stress, neuroinflammation, and cognitive decline. The most prevalent and bioactive catechin in green tea, epigallocatechin-3-gallate (EGCG), has shown promise as a neuroprotective agent because of its many biological properties. The review discusses the potential of EGCG in combating neurodegeneration and cognitive impairments through antioxidant benefits and signaling pathways.

Natural bioactive compounds as notch signaling modulators: cutting-edge strategies for cancer therapy.

Natural bioactive compounds have demonstrated potential in altering the Notch signaling system, a crucial regulator of cancer development. This review discusses the molecular interactions of various substances such as flavonoids, polyphenols, terpenoids, and alkaloids with ligands, receptors, and downstream effectors. Terpenoids like curcumin can combat Notch-mediated medication resistance, while flavonoids like quercetin prevent Notch receptor activation.

System biology-based assessment of the molecular mechanism of epigallocatechin gallate in Parkinson's disease: via network pharmacology, in-silico evaluation & in-vitro studies.

Epigallocatechin gallate (EGCG) compound (IMPHY000226) has the potential to modulate multiple molecular mechanisms involved in Parkinson's disease. Multiple targets such as SIRT3, FOXO1, PRKAA1, PPARGC1A, and CREBBP directly regulate reactive oxygen species levels and oxidative stress, suggesting that targeting these genes could help prevent further cellular damage. EGCG targets were identified using Swiss target prediction, revealing 31 targets modulated by EGCG.

Computational Analysis of Liriodenine's Therapeutic Potential in Breast Cancer: Targeting EGFR and the Complex Oncogenic Network for Drug Discovery.

Triple-negative breast cancer is highly aggressive, with limited treatment options and high resistance to existing therapies. Liriodenine, a natural alkaloid, shows potential as an anticancer agent, but its therapeutic mechanisms require further investigation. This study aimed to explore liriodenine's potential as a multi-target therapeutic agent for breast cancer.

Clinical insights into the mechanisms of infectious microbes and microbiota in chronic neurologic and psychiatric diseases.

Chronic neurologic and psychiatric diseases such as schizophrenia, depression, Parkinson's, and Alzheimer's are increasingly linked to infectious microorganisms and gut microbiota. This review explores how pathogenic microorganisms and microbial communities impact neuropsychiatric, neurodegenerative, and neuroinflammatory processes, highlighting the gut-brain axis' crucial communication network in influencing behavior and brain function. Infectious agents like bacteria, viruses, and fungi cause disease by causing neurotoxic reactions, disrupting the blood-brain barrier, and activating neuroinflammatory cascades.

High-altitude physiology: Understanding molecular, pharmacological and clinical insights.

Acute mountain sickness (AMS), high-altitude pulmonary edema (HAPE), and high-altitude cerebral edema (HACE) are three common forms of altitude sickness. These conditions can be life-threatening, with symptoms like fatigue, dizziness, and headaches. Ascending to high elevations increases the likelihood of developing these conditions, with some individuals adapting quickly while others need to descend.

Transforming healthcare: the impact of artificial intelligence on diagnostics, pharmaceuticals, and ethical considerations - a comprehensive review.

Interpretability of results remains challenging in most health industries since patients may suffer life-threatening consequences from an inaccurate diagnosis. Artificial intelligence (AI) integration has arisen as a prominent technology in the healthcare sector, transforming the field by advancing early diagnostics, surgeries, and ethical concerns. The present review analyzes the multidimensional impact of AI on the health sector through enhancements in medical accuracy and diagnosis outcomes.

Recent advances in stem cell approaches to neurodegeneration: A comprehensive review with mechanistic insight.

The progressive nature of neurodegenerative diseases (NDs), such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis, presents substantial problems because current treatments are still obscure. Stem cell-based treatments are emerging as a viable solution to address the significant gaps in treating these severe diseases. This study provides a comprehensive analysis of the latest advancements in stem cell research, focusing on the treatment of NDs.

Corrigendum: Adeno-associated virus as an effective malaria booster vaccine following adenovirus priming.

[This corrects the article DOI: 10.3389/fimmu.2019.

Neuroprotective potential of epigallocatechin gallate in Neurodegenerative Diseases: Insights into molecular mechanisms and clinical Relevance.

Neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis pose significant challenges due to their complex pathophysiology and lack of effective treatments. Green tea, rich in the epigallocatechin gallate (EGCG) polyphenolic component, has demonstrated potential as a neuroprotective agent with numerous medicinal applications. EGCG effectively reduces tau and Aβ aggregation in ND models, promotes autophagy, and targets key signaling pathways like Nrf2-ARE, NF-κB, and MAPK.

Neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios as inflammatory markers in the assessment of glycemic status in diabetic patients of Asir region.

Background: Diabetes mellitus (DM) is a prevalent chronic metabolic condition characterized by high blood sugar levels, resulting from insufficient insulin production or ineffective insulin use, posing substantial global health issues. Research on the relationship between glycemic status and the ratio of neutrophils to lymphocytes (NLR) and monocytes to lymphocytes (MLR) is limited. This study aimed to fill these knowledge gaps by examining the connection between DM and inflammatory markers within the Asir region.

Therapeutic mechanistic study of novel indole derivatives as SIRTUIN3 modulators in Parkinson's disease with in vitro evaluation.

SIRT3 modulates reactive oxygen species and helps to reduce oxidative stress, resulting in a neuroprotective effect in Parkinson's disease. The work seeks to develop and synthesize novel, effective SIRT3 modulators, which will modify SIRT3 expression and generate the neuroprotective effect by downregulating reactive oxygen species. The synthesis of the new indole-based carboxamide derivatives IMW 1-16 was guided by molecular docking experiments with the SIRT3 wild-type protein.

Advancement in medical treatment for gastrointestinal stromal tumors (GISTs): a ray of hope.

Gastrointestinal stromal tumors (GISTs) present unique diagnostic and therapeutic challenges. This review highlights advancements facilitated by molecularly targeted therapies like imatinib for advanced, metastatic, and high-risk GISTs, underscoring their neoadjuvant/adjuvant utility and the importance of multidisciplinary care. Emerging avenues, including immunotherapy, PI3K/mTOR/HSP90 inhibitors, are examined, reflecting the evolving treatment landscape.

Alkaloids as neuroprotectors: targeting signaling pathways in neurodegenerative diseases.

Neurodegeneration is the progressive loss of neurons that results in neurodegenerative diseases (NDs). Currently, there are few effective treatments for NDs, such as Alzheimer's disease, Parkinson's disease, Multiple sclerosis, and Huntington's disease, which involve gradual neuronal death and cognitive deterioration. Alkaloids are naturally occurring molecules with a variety of biological properties.

Therapeutic potential of phytocompounds in rheumatoid arthritis: Molecular insights and clinical applications.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic involvement, inflammation, and the destruction of synovial joints. RA can be categorized as anti-citrullinated protein antibodies-positive or negative based on genetic risk factors and autoantibodies. This review systematically sourced articles related to RA, phytocompounds, signaling pathways, and clinical insights from primary medical databases, including Scopus, PubMed, and Web of Science.

Natural compounds and programmed necrosis: pioneering a new frontier in cancer treatments.

Programmed necrosis, a controlled cell death method that bypasses resistance mechanisms that render apoptosis ineffective, is a potential cancer treatment target. Due to their diverse biological activities and low side effects, natural products are being explored as modulators of programmed necrosis pathways. This review highlights the potential of natural compounds to target cancer cells while preserving healthy tissues and their interaction with essential programmed necrosis mechanisms like ferroptosis and necroptosis.

Unraveling Berberine's Molecular Mechanisms in Neuroprotection Against Neurodegeneration.

Neurodegenerative diseases (NDs) exhibit significant global public health challenges due to the lack of effective treatments. Berberine (BBR), a natural alkaloid compound in various plants, has been recognized for its potential neuroprotective properties. This review explores the current understanding of BBR's mechanisms of action and its therapeutic potential in preventing and treating NDs such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.

Exploring Cannabidiol-TRPV3 Mediated Biological Activities-Findings From Molecular Docking, Simulation and Proteins Network Interactions.

Transient receptor potential vanilloid 3 (TRPV3) is a thermosensitive calcium-permeable ion channel and has a function in sensory perception, epidermal barrier function, inflammation and keratinocyte proliferation. TRPV3 dysfunction is linked with chronic pain, atopic dermatitis and neurodegenerative disorders. This study compared the binding efficacy and molecular dynamics of cannabidiol- and eugenol-TRPV3 complex(s), elucidating their ligand-protein dynamics.