Amelioration of intestinal ischemia reperfusion injury by carvedilol via regulation of eNOS/VEGF-A and inflammasome/ IL1β/ TNFα pathways.

Intestinal ischemia reperfusion (IIR) is a life threating clinical disorder and a serious emergency case with high mortality rate. Finding ameliorative agents is a critical requisite to safeguard the tissue against its harmful effect not only on the intestine, but also on other organs especially the heart. Therefore, we tried in the current study to evaluate the role of carvedilol (CAR); an effective beta and alpha blocker with anti-oxidant, anti-apoptotic, anti-inflammatory properties and a metabolic regulator, on both cardiac and intestinal tissue in a model of IIR.

Immune regulation of TLR4/MYD88/ NF-κB/AP1/IL-6 pathway and modulation of aldosterone/PPARα receptors by eplerenone and fenofibrate in ovarian ischemia reperfusion induced injury.

Background: The immune system is deeply involved in the pathogenesis of different gynecological disorders including ovarian torsion that commonly occurs during surgical manipulation or within ovarian masses, affecting not only the ovaries, but it has remote effect on different organs particularly cardiac tissue. Early intervention and proper medical treatment are so important to preserve the ovaries and prevent distant organ damage. Accordingly, the aim of this work was to evaluate the possible ameliorative role of eplerenone (EPL) or fenofibrate (FEN) on ovarian and cardiac affection in an experimental model of ovarian ischemia/reperfusion (OIR).

Serum midkine level and its association with subclinical coronary artery calcification and carotid atherosclerosis in chronic kidney disease.

Background: There are no studies investigating the role of midkine (MK) in vascular calcification (VC) or vascular disease associated with chronic kidney disease (CKD). This study assessed serum MK level and investigated its relationship with carotid atherosclerosis and coronary artery calcification (CAC) in non-dialysis CKD.

Methods: The study comprised 80 controls and 185 adult patients with CKD at stages 3-5 who were free of cardiovascular diseases.

Predictors of renal outcomes and mortality in patients with renal vein thrombosis: a retrospective multicenter study.

Background: Studies on renal vein thrombosis have been conducted as case reports or case series. The renal outcomes and mortality risk of renal vein thrombosis have not been fully established. We aimed to investigate the clinical characteristics, treatment modalities, and predictors of renal outcomes and mortality in patients with renal vein thrombosis in a large multicenter cohort.