Neuroprotective potential of fortunellin against titanium dioxide nanoparticles induced neurotoxicity via regulating NLRP3, HMGB1/RAGE, and NF-κB pathway: A biochemical, histological and in-silico experimentation.

Titanium dioxide nanoparticles (TiO-NPs) are used in the production of various industrial and commercial products and reported to cause neurotoxicity in Sprague Dawley rats. Fortunellin (FRN) is a potent flavonoid with diverse biological properties. This research experiment was performed to explore the protective role FRN against TiO-NPs induced brain damage.

Diagnostic Forensic Tools in the Investigation of Electrocution Fatalities: A Case Study.

Electrocution is a leading cause of occupational fatalities, frequently occurring at voltages typical of household electrical systems (220-250 V). This study presents a comprehensive forensic investigation of a 35-year-old labourer's electrocution death in Dubai. The methodology employed included forensic medico-legal examination, histological analysis, trace evidence analysis and forensic engineering investigation.

adhesins, specifically Als3, a key target to understand and mitigate.

The emergence of , a multidrug-resistant fungal pathogen with unique heterogenic characteristics and clades, raised significant concerns globally, particularly in healthcare settings. pathogenicity resides in its adaptability and resilience, with the ability to form robust biofilms and adhere to host tissues and medical devices. Adhesins, particularly Als3, primarily mediate these processes.

Exploring the Therapeutic Potential of and Extracts: Current Strategies, Emerging Applications, and Sustainability Utilization.

This review explores the therapeutic potential of (onion) and (garlic), focusing specifically on their antidiabetic, cardioprotective, and antibacterial effects. These widely used medicinal plants are rich in bioactive compounds that contribute to their broad spectrum of pharmacological activities. Based on over two decades of scientific literature, this review synthesizes findings from more than 20 years of research to highlight the efficacy of these plant extracts.

Sustainable valorization of olive by-products: environmental impact, biotechnological and probiotic approaches for bioactive recovery in alignment with circular bioeconomy.

The olive oil industry generates vast amounts of by-products, including olive pomace, olive mill wastewater, olive pits, and olive leaves, which pose serious environmental and economic challenges. However, these residues are rich in bioactive compounds such as polyphenols, dietary fibers, unsaturated fatty acids, and sugar derivatives, making them valuable resources for sustainable valorization. This review explores innovative biotechnological and probiotic-driven approaches to convert olive waste into high-value products, aligning with the United Nations Sustainable Development Goals (SDGs), particularly SDG 12 (Responsible consumption and production) and SDG 13 (Climate action).

Comparison of the ALKA and CRS scores to predict outcomes among patients with coronavirus disease 2019 infection in United Arab Emirates.

Introduction: The coronavirus disease 2019 (COVID-19) pandemic resulted in significant global mortality and morbidity, with emerging mutant strains continuing to potentially precipitate severe respiratory illness. Two clinical assessment tools, namely, the COVID-19 Risk of Complications Score (CRS), based on 13 comorbidities, and the ALKA (age, lactate dehydrogenase, kidney function, and albumin) score have been developed to predict disease severity among patients who are symptomatic at presentation. This study aimed to compare the performance of these two risk-scoring systems in predicting hospital admission, critical illness, and mortality.

seed-derived biochar as a sustainable and environmentally feed supplement in camel: impacts gas production, methane emissions, nutrient degradability and fermentation parameters, performance predictions.

Introduction: Climate change poses a significant environmental challenge to all living organisms. Camels exhibit notable resilience to these changes. Concurrently, the date palm (), a widely cultivated plant in tropical and subtropical regions, generates substantial seed waste.

Modulatory role of in oxidative stress, apoptosis, and gene expression in a rat model of dexamethasone-induced hepatotoxicity.

The rising prevalence of hyperlipidemia and hepatic disorders has intensified interest in the therapeutic use of functional foods and botanical drugs. , a blue-green microalga, is known for its antioxidant, anti-inflammatory, and lipid-lowering properties. However, its potential hepatoprotective effects, particularly against glucocorticoid-induced liver damage, remain underexplored.

Recent Advancements in Lipid Nanoparticles-Based Phytoactives Delivery Systems for Neurodegenerative Diseases.

Neurodegenerative diseases, including Alzheimer's and Parkinson's diseases, pose a significant and continuous burden on the healthcare system, urging the search for innovative therapeutical approaches targeting the central nervous system. Nowadays, no definitive treatment can effectively modulate the neuronal degeneration associated with such diseases. The current line of therapies is primarily symptomatic and suffers several drawbacks.

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin.

Introduction: An unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as a crucial factor in the immunopathology of SARS-CoV-2 infection. Complement alternative pathway has been linked to the excessive inflammation in severe SARS-CoV-2 infection in which decreased levels of factor H (FH) and elevated levels of properdin (FP) were observed.

Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria.

The escalating prevalence of multidrug-resistant (MDR) bacteria presents a critical global health challenge, necessitating the urgent development of alternative antimicrobial strategies. Silver nanoparticles (AgNPs) have emerged as promising antimicrobial agents due to their broad-spectrum activity, unique physicochemical properties, and multiple mechanisms of bacterial inhibition. Their nanoscale size, high surface area-to-volume ratio, and ability to generate reactive oxygen species (ROS) make them highly effective against both Gram-positive and Gram-negative bacteria.

Rapid and Accurate Estimation of Quantum Average Electron Densities Using Newly-Defined Atom Types.

A new computational tool, the Average Electron Density Estimator (AED-Est), has been developed along with a new scheme for assigning atom type, the AAA scheme. This combination of the AED-Est and the AAA scheme is designed to rapidly estimate properties, including electron populations, volumes, and average electron density (AED) values, with high precision and an accuracy comparable to values computed at the quantum levels. AED-Est gave comparable results when using three different sets/subsets of various neutral molecules.

Knowledge and experience of local emergency care staff on stroke recognition and acute care in the United Arab Emirates.

Introduction: Cerebrovascular diseases are among the top three causes of death in the United Arab Emirates. The acute stroke care survey among emergency care personnel in Alain City aims to assess the experience, knowledge and attitude of emergency department staff about acute stroke care to identify areas for educational and training interventions.

Method: This is an observational cross-sectional Face-to-Face electronic survey of the Emergency care doctors and nurses across four emergency/urgent care centres in Alain, the United Arab Emirates.

Layer-by-Layer Assembled Perovskite/Polymer Photoelectrochemical Devices with Enhanced Performance and Stability.

Organic-inorganic hybrid perovskites (OIHPs) offer a promising pathway for the development of low-cost and efficient solar hydrogen production systems. Despite remarkable advancements, poor chemical stability of the OIHPs in aqueous environments limits their practical applications. Herein, we design a photoelectrochemical (PEC) device consisting of layer-by-layer assembled P(VDF-TrFE)/CHNHPbBr (MAPbBr) hybrid films that simultaneously achieve efficient and stable solar water splitting.

Development of antimicrobial paper from unbleached bamboo ASAM pulps reinforced with nanofibrillated cellulose and chitosan.

Despite being biodegradable, paper packages have restricted use in food packaging because of their strong tendency to absorb moisture and their high permeability to liquids and gasses from the environment. Consequently, investigating the application of biodegradable biopolymers, such as nanofibrillated cellulose and chitosan, to enhance characteristics is a pertinent technique. This study developed paper from unbleached bamboo alkaline sulfite anthraquinone and methanol (ASAM) pulps by incorporating nanofibrillated cellulose (NFC) and the antimicrobial agent chitosan (CS) into the papermaking process, offering a sustainable solution for advanced food packaging systems.

Nanomagnesium promotes moso bamboo tolerance to cadmium toxicity: insights from photosynthesis phenomics, oxidative metabolism, and cellular adjustments.

Cadmium (Cd) stress severely hampers plant growth in forest ecosystems. Although magnesium oxide nanoparticles (MgONPs) are known to reduce Cd toxicity in numerous plant species, their detoxification mechanisms in Moso bamboo () remain unexplored. The present study investigates how MgONPs mitigate the Cd-induced phytotoxic effects in by examining morpho-physiological and cellular oxidative repair mechanisms.

Isolation of multiple plant growth-promoting fungi and their effect on rice growth improvement on non-grain converted land.

Introduction: Land cultivation is the cornerstone of national food security. However, with the development of non-grain production on cultivated land, China has to use less cultivated land to feed a larger population of the world. To effectively resolve issues caused by non-grain production on cultivated land, Zhejiang Province has initiated efforts to restore non-grain-converted land back to grain cultivation.

Selective vulnerability of stellate cells to gut dysbiosis: neuroanatomical changes in the medial entorhinal cortex.

Introduction: The gut microbiota plays a critical role in regulating brain structure and function via the microbiota-gut-brain axis. Antibiotic-induced gut dysbiosis (AIGD) has been linked to neuroanatomical changes and cognitive deficits. However, its impact on neuronal morphology in layer II of the medial entorhinal cortex (mECII), a region central to spatial memory, remains poorly understood.

Calcium modified mesoporous silica from marble for the removal of cadmium, lead, chromium, iron, and manganese from Siwa Oasis groundwater.

This study assessed the health risks of heavy metal contamination in groundwater in Siwa Oasis, Egypt's northwestern desert, and their potential decontamination using a marble-based nanoporous Ca-MCM-41 structure as an adsorbent. Fe, Cd, Cr, Pb, and Mn contents exceeded World Health Organization (WHO) guidelines with potential non-carcinogenic risks and carcinogenic risks based on the hazard index (HI) and Monte Carlo simulations. Ca-MCM-41 showed significant performances in the removal of most of these toxic ions with batch saturation uptake capacities of 239 mg/g Cd(II), 252 mg/g Fe(II), 308 mg/g Pb(II), 132 mg/g Cr(VI), and 154.

Case Report: Rare Bilateral Double Profunda Femoris Artery Variation: Clinical Implications and Considerations.

Introduction: The profunda femoris artery (PFA) is the largest branch of the femoral artery supplying the thigh. The study reports a rare occurrence of bilateral double profunda artery in a male cadaver, aiming to inform surgeons of such variations to avoid complications during surgical interventions.

Methods: This study was conducted during routine dissections using 5-10% formalin-fixed lower limbs of a male cadaver at the Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, UAE.

Effectiveness of first line therapy for Helicobacter pylori infection in children and adolescents: A multicenter study in the United Arab Emirates.

Globally, gastric infection with Helicobacter pylori has a high prevalence. Bacterial eradication is crucial to prevent long-term complications such as gastric cancer. There is a standard recommended first-line therapy with a desirable eradication goal of 90%, but this is non-achievable in most trials in children.

A Systematic Review of School-Based Behavioral Interventions and the Symbolic Labor of Inclusion for Children with Chronic Illness.

Chronic illness affects children's health and disrupts the spatial and temporal aspects of schooling by complicating attendance, interrupting learning routines, and exposing institutional rigidity. While many educational systems treat chronicity as an exception to be managed, this review reconceptualizes it as a pedagogical and symbolic challenge to normative assumptions about inclusion, care, and participation. To systematically examine how school-based behavioral and psychosocial interventions support children and adolescents with chronic health conditions (CHCs) in inclusive educational settings and to analyze what these interventions reveal about institutional practices of care and recognition.

Correction: Green, innovative oral capsules of three anti-Parkinson's drugs: formulation, evaluation, and robust RP-HPLC validation.

Correction for 'Green, innovative oral capsules of three anti-Parkinson's drugs: formulation, evaluation, and robust RP-HPLC validation' by Samar M. Mahgoub , , 2025, , 6215-6230, https://doi.org/10.

Characterization of dietary fiber and soluble carbohydrates in date fruits (Phoenix dactylifera L.).

Understanding the physicochemical and structural properties of the dietary fiber present in date fruits is useful for its onward processing for food and non-food applications. This research fractionated dietary fiber from four date fruit cultivars into soluble and insoluble fractions and studied their structural features and physicochemical and thermal properties. Total dietary fibers content ranged 3.

Light-mediated CO release from a tricarbonyl manganese(i) complex with a bidentate quinoxaline ligand.

Reaction between 2-(pyridin-2-yl)quinoxaline (L) and [MnBr(CO)] afforded a dark-stable -[MnBr(CO)L] that releases CO upon exposure to visible light (468-525 nm). Different structural elucidation methods, including X-ray crystallography, were used to thoroughly characterize the structure of the organometallic compound. Prior to recording the profiles of dark-stability and photolysis in various organic solvents, the complex's solvatochromism features were examined experimentally and through quantum chemical calculations.