Effect of a mixture of peppermint and clove oils on growth performance, carcass traits, blood parameters, and gut microbiota in broiler chickens.

This study aimed to assess the effect of supplementing Arbor Acre broiler chick diets with a blend of peppermint and clove oils on growth efficiency, blood indicators, and intestinal microbial communities. In a randomized experimental design, 250 unsexed, one-day-old Arbor Acre broiler chicks were allocated into 5 groups. Each group included 5 replicates, each containing 10 birds.

Correction: Multi-pronged molecular insights into flavonoid-mediated inhibition of squalene epoxidase: a pathway to novel therapeutics.

[This corrects the article DOI: 10.1039/D4RA09076D.].

Lysozyme-dequalinium encapsulation in a Zn-Fe LDH-chia seed matrix for enhanced antimicrobial dental therapeutics.

This study developed a lysozyme-dequalinium chloride-loaded Zn-Fe layered double hydroxide (LDH)-chia seed mucilage matrix for enhanced antimicrobial efficacy and sustained drug delivery. The optimized formulation (15% w/v Zn-Fe LDH-chia seed hybrid) achieved encapsulation efficiencies of 93.30 ± 1.

Nanotechnology-Enhanced Sunscreens: Balancing Efficacy, Safety, and Environmental Impact.

Sunscreen protects skin from harmful Ultra Violet (UV) rays, preventing skin diseases like cancer and premature aging. This review explores the role of nanotechnology in enhancing sunscreen formulations by incorporating green and sustainable ingredients. Nanoparticles such as titanium dioxide and zinc oxide effectively reflect UV rays, improving protection while minimizing white residue, thereby enhancing aesthetics, stability, and efficacy.

Correction: Green, innovative oral capsules of three anti-Parkinson's drugs: formulation, evaluation, and robust RP-HPLC validation.

Correction for 'Green, innovative oral capsules of three anti-Parkinson's drugs: formulation, evaluation, and robust RP-HPLC validation' by Samar M. Mahgoub , , 2025, , 6215-6230, https://doi.org/10.

Breaking the oncogenic alliance: advances in disrupting the MTDH-SND1 complex for cancer therapy.

Metadherin (MTDH/AEG-1/LYRIC) partners with Staphylococcal Nuclease Domain-Containing Protein 1 (SND1) to form an oncogenic hub that drives proliferation, survival and metastasis in many tumors. Interrupting this interaction dampens pivotal pathways-including NF-κB, PI3K/Akt and Wnt/β-catenin-and simultaneously promotes SND1 degradation, yielding broad antitumor effects. This review consolidates current knowledge of the MTDH-SND1 axis and highlights preclinical studies showing that genetic knock-out or pharmacologic blockade of the complex can sharply reduce primary growth and metastatic spread.

Emerging Electrochemical Approaches for the Early Detection of Programmed Cell Death.

Programmed cell death (apoptosis) safeguards tissue homeostasis, and its dysregulation is a hallmark of cancer, neurodegeneration, and immune disorders. Detecting the earliest biochemical signatures of apoptosis therefore offers a route to sharper diagnosis, real-time therapy monitoring, and data-driven drug discovery. Electrochemical biosensors are uniquely suited to this task because they translate molecular recognition events into electrical signals that are rapid, miniaturizable, and inherently compatible with point-of-care formats.

Boosting green hydrogen generation using Zn-substituted CoFeO catalysts prepared by sol-gel technique for water splitting applications.

Hydrogen has the potential to become a suitable alternative to the non-renewable sources like fossil fuels. The higher calorific values and ease of storage makes it better alternative to other renewable sources of energy. But the limiting factor for the usage of hydrogen is its inefficient production.

Breaking the CREB-CBP alliance: Progress, challenges, and therapeutic promise of small-molecule and peptide disruptors of the pKID-KIX interaction.

The kinase-inducible domain (pKID) of the transcription factor CREB engages the KIX domain of the co-activator CBP/p300 to drive signal-dependent gene expression that underpins cell proliferation, metabolism and survival. Aberrant CREB-CBP signaling is now implicated in numerous cancers and metabolic disorders, yet until recently the shallow, dynamic pKID-KIX interface was viewed as chemically intractable. This review integrates two decades of progress that overturns that paradigm.

Computational investigation of potential natural compounds as inhibitors of monkeypox virus cysteine proteinase.

Introduction: Monkeypox is a serious viral illness that is rarely seen but is spread from person to person and from animals to humans. Cysteine proteinase, an essential enzyme involved in the replication of the monkeypox virus (MPXV), is one of many possible therapeutic targets for MPXV. The primary function of this enzyme is to cleave the precursor polyprotein into the distinct proteins required for viral assembly.

, , and extracts in low-energy diets for rabbits: effects on performance, hematology, lipid metabolism, hepatorenal function, immunity and hormones.

Introduction: This research assessed the influence of probiotics in low-energy diets on the performance and health status of rabbits during the growing phase. The growth parameters, carcass metrics, serum immunological state, lipid profile, and hepatic and renal functioning of rabbits have been analysed.

Methods: One hundred male New Zealand White rabbits, aged 5 weeks, were split into five groups at random.

Probiotics in Nanotechnology-Driven Wound Healing: From Mechanistic Insight to Clinical Promise.

Chronic wounds, including diabetic foot ulcers and pressure sores, are becoming more prevalent due to aging populations and increased metabolic problems. These wounds often persist due to impaired healing, chronic inflammation, oxidative stress, and infections caused by multidrug-resistant pathogens, making conventional treatments-including antibiotics and antiseptics-largely inadequate. This creates an urgent need for advanced, biologically responsive therapies that can both combat infection and promote tissue regeneration.

Uncoupling toxic NO signaling: Progress, challenges, and therapeutic promise of disrupting the PSD-95/nNOS protein-protein interaction.

The interaction between postsynaptic density-95 (PSD-95) and neuronal nitric-oxide synthase (nNOS) forms a signaling hub that couples N-methyl-d-aspartate receptor (NMDAR) calcium influx to bursts of neurotoxic nitric oxide. Disrupting this protein-protein interaction (PPI) offers a strategy to suppress pathological NO production while sparing normal synaptic transmission-an advantage unattainable with channel blockers or active-site nNOS inhibitors. Over the past two decades, cell-penetrant peptides such as nerinetide (Tat-NR2B9c) have validated the target from rodent stroke models to phase-III clinical trials, while bivalent constructs achieve low-nanomolar affinity and extended brain exposure.

Green, innovative oral capsules of three anti-Parkinson's drugs: formulation, evaluation, and robust RP-HPLC validation.

Parkinson's disease (PD) remains a debilitating neurodegenerative disorder, with levodopa (LEV) as the cornerstone of its management. However, the long-term use of LEV is often complicated by motor fluctuations and dyskinesias, necessitating adjunct therapies such as carbidopa (CAR) and safinamide (SAF) to enhance efficacy and reduce side effects. Despite the promising therapeutic potential of this combination, the simultaneous analysis of the three drugs in pharmaceutical formulations poses significant analytical challenges.

Application of Green Cobalt Nanoparticles in the Diet of Broiler Chickens to Improve Sustainable Production and Health.

Background: Nanoparticles (NPs), such as green cobalt NPs (CoNPs), are easier to pass through cell membranes in animals and interact rapidly with biological systems. Therefore, using green CoNPs is one of the recommendations for enhancing the bioavailability of cobalt, thereby improving its absorption.

Objectives: The goal of this study was to explore the influences of biological nano-cobalt (BNCo) as a feed supplement on broiler growth performance, haematology, blood chemistry, antioxidant activities, immunological status, digestive enzymes and carcass characteristics.

Photocatalytic oxidation of ammonia using copper-mediated phosphotungstic acid intercalated sulfonated bentonite for sustainable eutrophication control: A case study from Lake Qarun.

This study introduces a novel photocatalyst-copper-mediated phosphotungstic acid intercalated acidified bentonite (Cu@PTA/SB)-for the efficient oxidation of ammonia in both synthetic aqueous solutions and eutrophic natural waters. The catalyst was synthesized by sulfonating carbonaceous bentonite, followed by intercalation of phosphotungstic acid and in situ deposition of copper nanoparticles. Physicochemical characterization confirmed a stable mesoporous structure with a surface area of 72.

Advanced photocatalytic degradation of Ibuprofen using CuO-Polypyrrole/activated carbon hydrogel for sustainable water purification: characterization and application.

The contamination of aquatic environments by pharmaceutical residues, particularly ibuprofen (IBU), necessitates effective removal strategies. This study presents the synthesis and characterization of CuO-polypyrrole/activated carbon hydrogel (Cu@Ppy/AC) as a photocatalyst for IBU degradation under visible light. Characterization techniques including XRD, FTIR, SEM, and BET confirmed the structural and physicochemical properties of Cu@Ppy/AC.

Modulating UDP-glucuronosyltransferase activity: Mechanisms, clinical implications, therapeutic strategies, and future directions in drug development.

UDP-glucuronosyltransferases (UGTs) are essential enzymes in the phase II metabolism of endogenous and exogenous compounds, playing a critical role in detoxification, drug metabolism, and clearance. Their function is crucial for the pharmacokinetics of numerous therapeutic agents, but UGT inhibition can result in altered drug metabolism, increased toxicity, or reduced efficacy. This review explores the mechanisms of UGT inhibition, its implications for drug metabolism and pharmacokinetics, and the clinical relevance of such inhibition in the context of drug-drug interactions (DDIs).

Mpox 2022 to 2025 Update: A Comprehensive Review on Its Complications, Transmission, Diagnosis, and Treatment.

Monkeypox virus (Mpox virus) is a zoonotic orthopoxvirus that has gained increased global attention due to recent outbreaks. The current review reports the latest update of Mpox cases from 25 February 2022 to 29 April 2025. It also evaluates the possible major complications in human life caused by Mpox.

Phenolic-based allosteric inhibition of PTP1B: unlocking new therapeutic potential for metabolic disorders.

Protein tyrosine phosphatase 1B (PTP1B) plays a critical role in insulin signaling and is associated with various metabolic diseases, including type 2 diabetes. In this study, we investigated the inhibitory potential of five phenolic compounds isolated from Tamarix aphylla against PTP1B. Using molecular docking, molecular dynamics (MD) simulations, and ADMET analysis, we assessed the binding modes, stability, and pharmacokinetic properties of these compounds.

Efficiency of Nanodelivery Systems for Encapsulation of Pomegranate and Onion Peel Extracts: Evaluation of Their Antimicrobial and Antioxidant Properties on Coated Chicken Burger.

Pomegranate and onion peels are rich in bioactive compounds (BCs), such as phenols and flavonoids, which are known for their antioxidant and antimicrobial properties. However, their potential in food applications is often limited due to issues with solubility, stability, and sensory acceptance. This study introduces a novel approach involving the use of chia seed nanoparticles (CSNPs) for the nanoencapsulation of pomegranate (PPE) and onion peel extracts (OPE), which enhances their stability and functionality.

Encapsulation of progesterone in reishi mushroom composite for optimized hormone replacement and targeted anticancer therapy.

Conventional hormone replacement therapy (HRT) and hormone-dependent cancer treatments face significant challenges, including poor bioavailability, rapid metabolism, and adverse side effects of progesterone, as well as limited targeting efficiency and systemic toxicity. To address these issues, this study develops an innovative progesterone-reishi mushroom () composite, leveraging the natural bioactive properties of reishi mushrooms to enhance therapeutic efficacy. The composite was prepared by encapsulating progesterone within the reishi mushroom matrix, achieving a high loading efficiency of 98.

Watercress-derived glucosinolates as potential allosteric PTP1B inhibitors: a dual in silico and in vitro study on insulin signaling modulation.

This study investigates the inhibitory potential of four glucosinolates-glucoerucin, glucoiberin, gluconasturtiin, and glucotropaeolin-isolated from watercress (Nasturtium officinale) against Protein Tyrosine Phosphatase 1B (PTP1B), a key regulator of insulin signaling. Molecular docking, molecular dynamics (MD) simulations, and MM/PBSA free energy calculations identified glucoerucin (-17.18 ± 3.

β-Glucuronidase Inhibition in Drug Development: Emerging Strategies for Mitigating Drug-Induced Toxicity and Enhancing Therapeutic Outcomes.

β-glucuronidase (βG) is a critical enzyme involved in the hydrolysis of glucuronide conjugates, significantly influencing drug metabolism, detoxification processes, and enterohepatic circulation. Although essential for maintaining physiological homeostasis, dysregulated βG activity has been implicated in diverse pathological conditions, including drug-induced toxicity, inflammation, and hormone-dependent cancers. Specifically, microbial βG expressed by gut microbiota can reactivate glucuronide-conjugated drugs, leading to adverse reactions through increased drug toxicity and reduced therapeutic efficacy.

Integrating metabolomics for precision nutrition in poultry: optimizing growth, feed efficiency, and health.

Nutrition is an important factor in poultry production. This review highlights how precision nutrition improves poultry performance through metabolomics, which is a multidisciplinary approach that integrates traditional nutrition with other fields, including biology, immunology, molecular biology, genetics, computer sciences, chemistry, biochemistry, mathematics, engineering, and technology sciences. For measuring the results of the body's biochemical activities and figuring out Living systems' dynamic, multi-parametric metabolic response to pathological stimuli, metabolomics can be a very useful instrument.