Stimulation of the production of proteases from Penicillium verrucosum isolated from Egyptian soil.

The uses of proteolytic enzymes in manufacturing procedures are numerous. Researchers are investigating a number of strategies to find, rework, or artificially produce enzymes with improved suitability for manufacturing processes in light of the growing needs and uses. Alkaline protease production was assessed in fungal strains that were obtained from soil using the serial dilution technique.

Interleukin-13 (rs20541 A/G) Gene Polymorphism and Chance of Acquiring Hepatitis B in the Egyptian Population.

Context And Objective: An important worldwide health concern is infection with the hepatitis B virus (HBV), especially in underdeveloped nations. Gene polymorphisms encoding pro- and anti-inflammatory cytokines can influence how an HBV infection presents clinically. As mediators, cytokines play important functions in the immunological and inflammatory systems.

Association of Interleukin-27 (IL-27) rs181206 T/C and rs17855750 T/G Gene Polymorphisms and the Risk of Hepatitis B Infection among Egyptians.

Background And Objective: HBsAg incidence in Egypt is at a range of 2 to 7%. Antiviral immunity is linked to interleukin-27 (IL27), a cytokine that is produced by two genes: EBI3 and p28. IL-27 gene SNPs can alter the susceptibility to infection of HVB by impacting the production and/or function of cytokines.

Cardioprotective effect of Cymbopogon proximus and febuxostat on venlafaxine induced subacute cardiotoxicity in adult male Albino rats: Histological and immunohistochemical study.

Cardiotoxicity linked to the commonly prescribed antidepressant venlafaxine represents a major worldwide clinical challenge and patient safety concern. There is a pressing need for efficient interventions because there are currently no recognized protective agents that specifically target venlafaxine-induced cardiac damage. Cymbopogon proximus is a natural plant whose extract contains antioxidants and anti-inflammatory properties.

Epidermal Growth Factor (EGF rs4444903) Gene Polymorphism and Risk of HCC in Egyptian HCV Cirrhotic Patients.

Background: Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer in Egypt, largely due to the widespread presence of hepatitis C virus. Symptoms of HCC often appear only at an advanced stage, making early detection essential through advanced methods. This study aimed to explore the association between the rs4444903 gene polymorphism in the epidermal growth factor and the likelihood of developing HCC in individuals with cirrhosis.

Mycorrhizal symbiosis and application of vitamin B3-treated Trichoderma Harzianum HE24 additively trigger immunity responses in faba bean plants against Rhizoctonia root rot and promote the plant growth and yield.

Background: Faba bean is a valuable legume crop, known for its high nutritional value and nitrogen fixing ability. Rhizoctonia root rot of faba bean, caused by , severely affects the plant growth and yield. This study aimed to evaluate the effect of symbiosis with arbuscular mycorrhizal fungi (AMF) and application of vitamin B3-treated HE24 on plant immune responses against Rhizoctonia root rot under greenhouse conditions.

Design, synthesis, and molecular modeling of new 1,2,4-triazole-containing indole compounds as aromatase antagonists for the treatment of breast cancer.

Recently, the incidence of breast cancer has increased among postmenopausal women. This highlights the need for improved aromatase inhibitors with fewer side effects than those currently available. This study focuses on designing and evaluating potential aromatase inhibitors containing the 1,2,4-triazole/indole hybrid, given their proven impact in this respect.

Evaluation of a Novel Strain from Egyptian Soil for Biological Control of in Greenhouse Cucumber Plantations.

Background: Infestation in greenhouse cucumber with the two-spotted spider mite ( Koch) commonly causes severe damage to crop quality and quantity and increases crop production costs.

Objective: This study was conducted to investigate the efficacy of high-abamectinproducing isolates of against -infested cucumber and to assess their impact on biochemical stress markers in these vegetables.

Methods: In this study, 72 non-antagonistic were isolated from rhizospheric soil samples collected from eight different locations in Egypt and screened for their ability to produce the secondary metabolite, abamectin.

and Assessment of the Antiviral Potential of Green Tea, Green Coffee, Pomegranate Peel, and Orange Peel.

Background: Viral infections pose a great burden for humankind and many viruses have no effective treatments. Hepatitis A Virus (HAV) and Coxsackie-B4 (Cox- B4) are common viruses having many drawbacks. Using plant extracts as antiviral agents is a globally applied approach due to its efficacy and minimal adverse effects.

The protective effect of Ambrosia maritima versus vitamin D3 against gentamicin-induced acute cortical kidney injury in adult male albino rats: Histological and immunohistochemical study.

Gentamicin (GM) is a broad-spectrum antibiotic widely used for severe bacterial infections, but itis associated with acute nephrotoxicity. Ambrosia maritima L. is an annual herbaceous plant that has avariety of medicinal and antioxidant activities.

extract is effective against -induced pneumonia in male albino rats.

frequently causes pneumonia; it is the eighth leading cause of death and one of the most common infectious causes of mortality. is well known for its various therapeutic effects. The goal of this study is to evaluate the efficacy of ciprofloxacin and in treating pneumonia in infected rats.

UPLC-QTOF-MS/MS Analysis, Antioxidant, Antiarthritic Potentials and Molecular Docking of Clusia rosea Jacq. Cultivated in Egypt.

Clusiaceae comprises many biologically active plants, among them Clusia rosea Jacq., which possesses antibacterial and anti-HIV activities. In the current study, the phytochemical constituents of C.

Enhanced skin penetration and clinical antifungal activity of eugenol encapsulated in aspasomes.

Fungal infections are among the common diseases affecting the skin, which necessitate either topical or systemic delivery of antifungal agents. Eugenol was reported to exhibit antifungal properties, but owing to its poor skin-penetration ability, it requires encapsulation within delivery carriers. This study aimed to enhance the skin penetration and antifungal efficacy of eugenol through encapsulation in novel aspasomal formulations.

In vitro detection of antimicrobial impact, organic acids production and phytochemical screening of Musa acuminata wastes after treatment with fungi.

The current study was performed to evaluate the bioactivity of banana wastes against some bacterial and fungal isolates, organic acids production, antioxidant and to screen the phytochemicals were present in Musa acuminate (M. acuminate) wastes. The waste was processed by some microbial species.

Elucidation of the possible synergistic effect of Torulaspora delbrueckii and ciprofloxacin in a rat model of induced pulmonary fibrosis and infected with Klebsiella pneumonia: An in vivo study.

The lungs are constantly subjected to enormous amounts of air and potentially transmitted agents, leading to a high incidence of severe and complex ailments urging the demand for defensive actions to maintain their regular function. Numerous studies have demonstrated how certain probiotics have many advantages including hindering pulmonary exacerbations in individuals with cystic fibrosis, which encourages the idea of combining them with approved antibiotics as a therapeutic choice for treatment patients with lung fibrosis who also have bacterial infections. This investigation aimed to test the possibility of a combination of Torulaspora delbrueckii as a probiotic with ciprofloxacin in an animal model having pulmonary fibrosis with a moderate load of Klebsiella pneumonia.

Metabolite Profiling and Toxicity, Antioxidant, and Antitumor Evaluation of Micromeria biflora Aerial Parts Extract Combined with ADMET Prediction and Molecular Docking Analysis.

Micromeria biflora is widely used traditionally for various disorders, such as wounds, nosebleeds, and sinusitis. The study was conducted to investigate the chemical and pharmacological properties of M. biflora aerial parts.

Innovative antifungal Therapy: In vivo evaluation of 3-Ethyl-6,7-Dihydroxy-2-Phenyl-Chromen-4-One purified from Alpinia officinarum on Cryptococcus neoformans.

Cryptococcus neoformans infections pose a significant challenge to human health, particularly due to the lack of effective drugs and the severe side effects of those currently available. This study aimed to evaluate the efficacy of a purified compound, 3-ethyl-6,7-dihydroxy-2-phenyl-chromen-4-one (EDPC), extracted from Alpinia officinarum, in comparison to fluconazole, in treating rat models infected with C. neoformans.

Bimetallic selenium/zinc oxide nanoparticles: biological activity and plant biostimulant properties.

Extracts of medicinal seeds can be used to synthesize nanoparticles (NPs) in more environmentally friendly ways than physical or chemical ways. For the first time, aqueous extract from unexploited grape seeds was used in this study to create Se/ZnO NPS utilizing a green technique, and their antimicrobial activity, cytotoxicity, antioxidant activities, and plant bio stimulant properties of the economic Vicia faba L. plant were evaluated.

Mechanisms governing bystander activation of T cells.

The immune system is endowed with the capacity to distinguish between self and non-self, so-called immune tolerance or "consciousness of the immune system." This type of awareness is designed to achieve host protection by eliminating cells expressing a wide range of non-self antigens including microbial-derived peptides. Such a successful immune response is associated with the secretion of a whole spectrum of soluble mediators, e.

Chemical Characterization, Evaluation of Acute Oral Toxicity, and Anti-Diabetic Activity of Aloe sabaea Flowers Extract on Alloxan-Induced Diabetic Rats.

The study aimed to conduct chemical profiling, acute in-vivo toxicity evaluation, and the potential anti-diabetic effect of standardized Aloe sabaea flowers ethanolic extracts (ASFEE) on alloxan-induced diabetic rats. The chemical composition was analyzed using GC-MS and TLC techniques. The oral acute toxicity study was performed according to the WHO 2000 and the OECD 420 guidelines.

Evaluation of in-vitro antioxidant activity, acute oral toxicity, and pancreatic and hepatic protective effects of Aloe rubroviolacea flowers extract against CCl toxicity in a rat model.

Ethnopharmacological Relevance: Aloe rubroviolacea (Arabian Aloe) was widely cultured and commonly used in traditional medicine. Aloe species was highly recommended in folk medicine for abdominal pain, intestinal infection, intestinal colic, obesity, and gynaecological pain after childbirth.

Aim Of The Work: The present work aimed to conduct chemical profiling, in-vitro antioxidant activity, in-vivo oral acute toxicity study of A.

Synergistic effects of quercetin-loaded CoFeO@Liposomes regulate DNA damage and apoptosis in MCF-7 cancer cells: based on biophysical magnetic hyperthermia.

Introduction: Breast cancer (BC) is the most common malignancy in women globally. Significant progress has been made in developing structural nanoparticles (NPs) and formulations for targeted smart drug delivery (SDD) of pharmaceuticals, improving the precision of tumor cell targeting in therapy.

Significance: Magnetic hyperthermia (MHT) treatment using magneto-liposomes (MLs) has emerged as a promising adjuvant cancer therapy.

Antioxidant, antibacterial, and molecular docking of methyl ferulate and oleic acid produced by Aspergillus pseudodeflectus AUMC 15761 utilizing wheat bran.

Secondary metabolites (SMs) are the primary source of therapeutics and lead chemicals in medicine. They have been especially important in the creation of effective cures for conditions such as cancer, malaria, bacterial and fungal infections, neurological and cardiovascular problems, and autoimmune illnesses. In the present study, Aspergillus pseudodeflectus AUMC 15761 was demonstrated to use wheat bran in solid state fermentation (SSF) at optimum conditions (pH 7.