Milk protein-based edible films enriched with clove and camphor essential oils: Characterization, bioactivity, and potential applications against periodontal pathogens.

This study investigated milk protein (MP)-based edible films incorporated with clove and camphor essential oils (EOs) as antimicrobial agents against dental pathogens. Gas chromatography-mass spectrophotometry revealed clove oil contained 72.2 % eugenol while camphor oil contained 69.

Neuro-protective Potential of Honey: A Narrative Review.

Apitherapy, the therapeutic use of bee products, has attracted attention for its potential in treating various ailments. Honey is unique among bee products because it has a high concentration of medicinal chemicals. In recent years, there has been growing concern about exploring the neuroprotective features of honey.

Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects.

The aura of the 21st century has been transformed due to a revolutionized health care system and modern industrial applications. However, human health and well-being are still a global challenge, affected by various metabolic and pathological morbidities, causing millions of mortalities. Cancer is one of the leading causes of fatalities globally, occurring due to pathogens, dietary factors, environmental toxins, occupational chemical exposure, and radiation.

Correction: Alshawwa et al. In Situ Biosynthesis of Reduced Alpha Hematite (α-FeO) Nanoparticles by L. Leaf Extract: Insights into Antioxidant, Antimicrobial, and Anticancer Properties. 2022, , 1252.

In the original publication [...

Green biosynthesis of bimetallic silver titanium dioxide nanoparticles using Pluchea indica with their anticancer, antimicrobial, and antioxidant activities.

Natural plant extracts provide a cost-effective and eco-friendly option for the synthesis of bimetallic nanoparticles, as opposed to traditional chemical or physical methods. This research involved the bio-fabrication of silver-titanium dioxide bimetallic nanoparticles (Ag-TiO BNPs) utilizing the leaf extract of Pluchea indica. The Ag-TiO BNPs underwent characterization through UV-vis spectroscopy, FTIR, TEM, XRD, and DLS techniques.

An Updated Review of the Anticancer Mechanisms and Therapeutic Potential of Naringenin.

The revolution in the 21st century has witnessed the development of the industrial and healthcare systems. Human health and well-being are still global challenges despite this modernization and advancement. Cancer is extensively affecting people, demanding special attention and an effective dietary approach.

A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy.

The continuous progression of cancerous severity due to the interaction of physical (ultraviolet radiation), chemical (smoking, mycotoxins, and heavy metals), and biological (microbial populations) carcinogens inspired scientists to develop a correlation between active therapeutic agents and cancer proliferation. This review highlights the molecular mechanism by which lycopene imparts its anticancerous role, focusing on clinical and animal trials to validate its effectiveness. The antioxidant profile of lycopene promotes anticancerous properties that reduce cancer prevalence by activating cell signaling pathways and gene expression (involved in cancer cell proliferation).

Phytochemical profiling and evaluation of antioxidant, anticancer, antimicrobial and antibiofilm activities of endophytic fungi isolated from Lavandula stricta.

The emergence of multidrug-resistant pathogens underscores the urgent need for novel antimicrobial agents. In this study, ten endophytic fungal isolates (Ls1-Ls10) were isolated for the first time from Lavandula stricta and evaluated for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella oxytoca, and Candida albicans. The most potent fungal isolate Ls1 was identified as Sarocladium kiliense using morphological and molecular techniques.

Green synthesis of hydroxypropyl methylcellulose-collagen nanocomposites containing CuO@CrO nanoparticles: Antimicrobial, antioxidant, and anticancer activities against MG-63 osteosarcoma cells.

Bimetallic nanoparticles are potential biological materials distinguished by their multifunctional biological characteristics. This study addresses the critical need for multifunctional therapeutic materials that can simultaneously combat antimicrobial resistance, promote wound healing, and provide anticancer activity three major challenges in modern healthcare. This study presents nanocomposite-based polysaccharides, namely hydroxypropyl methylcellulose (HPMC) and collagen, synthesized in situ with bimetallic CuO@CrO nanoparticles.

Physiological and Molecular Responses of Anabaena laxa to Rac-Metalaxyl Fungicide: Exploring Metabolic and Oxidative Changes.

Rac-metalaxyl is a widely used fungicide for managing plant diseases; however, its environmental persistence and potential toxicity to aquatic microorganisms raise significant ecological concerns. Despite its widespread application, there is limited understanding of how cyanobacteria, which play vital ecological roles in aquatic systems, respond to such chemical stressors. This study addresses this gap by investigating the physiological and metabolic responses of the cyanobacterium Anabaena laxa to rac-metalaxyl exposure.

Chemical Analysis and Health Benefits of a Novel Polysaccharide Produced by Paenibacillus mucilaginosus.

Researchers have been fascinated by the remarkable properties of naturally occurring polysaccharides in recent years. We focused on extracting, refining, and analyzing an exopolysaccharide secreted for the first time by the bacterium Paenibacillus mucilaginosus, which was isolated from agricultural soil and identified by 16S rRNA sequence techniques. The polymer's elemental composition was analyzed, focusing on three primary constituents.

Effect of UV-C radiation on chemical profile and pharmaceutical application in vitro of Aloe vera oil.

The uncontrolled exposure to ultra violet (UV) radiation have many adverse impacts on human health. UV could be divided into three main classes according to wave length range where UV-C (200-280) is one of these classes. Aloe vera oil is a common product in markets with many cosmetic and medicinal applications.

Phytochemical characterization of peanut oil and its ozonized form to explore biological activities in vitro.

Peanut (Arachis hypogaea) is a perennial leguminous crop grown worldwide. This study aims to investigate the chemical composition and pharmaceutical applications of peanut oil using experimental methods for both crude peanut oil and its ozonized form. The peanut oil was exposed to ozone for five hours at flow rates ranging from 0 to 7 L/min to complete the ozonization process.

Nutraceutical Potential of Anthocyanins: A Comprehensive Treatise.

Anthocyanins (Anthos; flower and kyanos; blue) are natural coloring compounds from the flavonoids class that include cyanidin, peonidin, delphinidin, malvidin, pelargonidin, and petunidin. Recently, the role of anthocyanins in disease prevention, especially inflammation, diabetes, cancer, neuro-disorders, hepato-renal protective, and immuno-modulation properties has been highlighted. The current review covered the literature on the pharmacokinetics and pharmacological effects of anthocyanins, especially absorption, distribution, metabolism, and excretion (ADME).

Anthocyanins: From Natural Colorants to Potent Anticancer Agents.

Cancer is a prevalent global disease affecting ~20 million individuals, and this burden causes the death of ~9.7 million people in 2024. The prevalence rate is continuously increasing due to exposure to harmful environmental and occupational contaminants (toxins and chemicals), compromised immune response, genetic modifications, and poor lifestyle and dietary practices.

Emerging ultrafast technologies in biotechnology.

This review highlights the transformative applications of ultrafast technologies in biotechnology, focusing on their ability to provide real-time visualization and precise manipulation of biomolecular processes. Femtosecond lasers have enhanced precision in gene editing, minimizing off-target effects, while ultrafast spectroscopy has advanced understanding of protein folding pathways, enzymatic activity, and energy transfer mechanisms. Notable findings include the identification of protein folding intermediates linked to misfolding diseases, improved insights into enzymatic catalysis through hydration studies, and the development of real-time monitoring systems for CRISPR gene editing.

The biomass and health-enhancing qualities of lettuce are amplified through the inoculation of arbuscular mycorrhizal fungi.

With lettuce being one of the most important green crops in the world, it is important to improve its growth and nutritive value. To this end, arbuscular mycorrhizal fungus (AMF) application to improve nutrient-dense foods and the production of bioactive compounds in plants is a promising approach. AMF is applied to increase plant growth, primary metabolism, mineral profile and accumulation of secondary (phenols, flavonoids) metabolites.

Decoding the Molecular Mechanisms of miRNAs: Protein Interactions in Schizophrenia Pathogenesis.

Schizophrenia is now diagnosed mostly based on symptoms and physical signs rather than the patient's pathological and physiological markers. While oncologists once felt satisfied when their patients experienced a long remission, today, they are leading research into innovative treatments with molecularly targeted drugs, as well as strategies to enhance diagnostic accuracy and alleviate symptoms as the disease advances.Because biomarkers reflect an organism's physiological, physical, and biochemical state, they are very beneficial and have a wide range of real-- world uses.

Synthesis of novel MgO-ZnO nanocomposite using Pluchea indica leaf extract and study of their biological activities.

The biosynthesis of bimetallic nanoparticles using plant extracts has garnered significant attention due to their eco-friendly and cost-effective nature. This study aimed to biosynthesize magnesium oxide-zinc oxide nanocomposite (MgO-ZnO nanocomposite) using Pluchea indica leaf extract for the first time, with a focus on characterizing its physicochemical properties and evaluating its biological activities. The biosynthesized MgO-ZnO nanocomposite was fully characterized, revealing an absorbance peak at 300 nm using UV-vis spectroscopy.

Unveiling the in vitro activity of extracted Euphorbia trigona via Supercritical Fluid Extraction against pathogenic yeasts, obesity, cancer, and its wound healing properties.

Natural products of plant origin are being explored as safe alternatives for illness management. Their extraction processes play a crucial role in determining their phytochemical and pharmacological properties. In this context, Euphorbia trigona was extracted using Supercritical Fluid Extraction with CO (SFE-CO) at two operating temperatures: 20 °C and 40 °C.

A comprehensive study on characterization of biosynthesized copper-oxide nanoparticles, their capabilities as anticancer and antibacterial agents, and predicting optimal docking poses into the cavity of S. aureus DHFR.

The eco-friendly method of producing copperـoxide nanoparticles through the use of okra fruit extract is a simple, economical, rapid, and sustainable technique. The resultant copperـoxide nanoparticles (CuO NP) were analyzed with several analytical methods, such as UV-vis spectroscopy, FourierـTransform Infrared Spectroscopy (FT-IR), and X-Ray Diffraction (XRD), Zeta potential, TransmissionـElectron Microscopy (TEM) and EnergyـDispersive X-ray (EDX) analysis. The CuO NP exhibited a maximum absorbance at 381 nm.

Comparative Analysis of Diagnostic Techniques for Helicobacter pylori Infection: Insights for Effective Therapy.

Effective therapy against Helicobacter pylori hinges on a timely and accurate diagnosis. The objective is to assess H. pylori infection in dyspeptic patients and compare various indicative tests.

Isoflavones: Promising Natural Agent for Cancer Prevention and Treatment.

Isoflavones are currently being investigated by researchers in order to demonstrate their ability to prevent the proliferation of cancer cells. The current review aimed to demonstrate the potential of isoflavones to eliminate cancerous cells in the stomach, liver, lung, breast, and prostate, as their anticancer properties are due to the ability to block the signaling pathways of the extracellular signal-controlled kinase (MAPK/ERK) and proteasome (PI3K/AKT/mTOR). Isoflavones can inhibit the cell division of various cancer cells.

Extraction of mango seed kernels via super fluid extraction and their anti-H. pylori, anti-ovarian and anti prostate cancer properties.

Despite the discovery of many plant-based drugs, research is still ingoing, in addition to using safer and more effective methods in the extraction process. Presently, Super Fluid Extraction (SFE) was applied to extract the mango seed kernels (MSK) at two operating temperatures 30 and 50 °C with studying their biological activities. MSK extract via SFE at operating temperatures 30 °C showed high yield 0.

Anti-dengue Viral Protein NS5 and Antibacterial Efficacy of Andrographolide from Andrographis paniculata: An In Silico Approach.

The current study examines the anti-dengue and antibacterial potential and in silico drug development of the andrographolide against the pathogens Staphylococcus aureus (1JIJ) and Pseudomonas aeruginosa (6MVN) and the dengue viral protein NS5. The phytochemical analysis identified the presence of flavonoids, alkaloids, saponins, tannins, phenols, glycosides, and steroids in the Andrographis paniculata methanolic leaf extract. Based on the GC-MS analysis, andrographolide was identified as the primary chemical constituent of the medicinal plant A.