From Stories to Science: Mapping Global Trends in Narrative Medicine Research (2004-2024).

Narrative medicine is defined as a medical approach that utilizes the power of stories, both patients' illness narratives and healthcare providers' reflective accounts, to promote healing, foster empathy, and enhance the therapeutic relationship through close attention to the language, metaphor, and meaning embedded in illness experiences. Despite its growing importance in contemporary healthcare, comprehensive bibliometric analyses of narrative medicine research trends remain limited. This study aims to systematically map global research patterns, identify key contributors, and analyze thematic evolution in narrative medicine literature over the past two decades.

Comparison of pregnancy outcomes after history-indicated and ultrasound-indicated cervical cerclage: A systematic review and meta-analysis.

Objective: To compare maternal and neonatal outcomes in women with a previous history of pregnancy loss and/or preterm delivery who underwent ultrasound-indicated cerclage (UIC) or history-indicated cerclage (HIC).

Methods: PubMed, Web of Science, Scopus, and Embase databases were searched for observational studies and randomized controlled trials (RCT) from inception to 30 April 2024. Eligible studies should have compared the outcomes of women with singleton pregnancies who underwent UIC or HIC.

A Pathology-Based Risk Stratification Model for Predicting Occult Lesions in Papillary Thyroid Carcinoma Patients: Validation Using 5-Year Thermal Ablation Outcome Data.

Background: Thermal ablation (TA) is a minimally invasive alternative for patients with papillary thyroid carcinoma (PTC). However, sonographically occult lesions may lead to new tumor development during follow-up monitoring. This study involved developing and validating a prediction model for identifying patients at high risk of new tumors after receiving TA.

Singleplex real-time PCR and duplex PCR platform for the rapid detection of hypervirulent .

Hypervirulent (HvKP) is a notorious zoonotic pathogen that poses a significant threat to public health, as it can cause severe infections with high morbidity and mortality among young and healthy individuals. Commonly, a positive string test is primarily used to identify HvKP strains, but which is laborious and time-consuming. A rapid assay to identify HvKP is needed for public health personnel to track the spread of these strains and provide timely efforts for their control.

Emotional Suppression Characteristics and Influencing Factors of Ovarian Cancer Patients - Latent Profile Analysis.

Background: This quantitative study aimed to analyze the potential categories of emotional suppression characteristics and explore the influencing factors of different categories among ovarian cancer chemotherapy patients in Western Region of China.

Methods: From September 2024 to March 2025, a convenience sampling method was used to administer a questionnaire to ovarian cancer chemotherapy patients at a gynecology center within a university hospital situated in the Northwest region of China. The investigation employed general information questionnaires, the Emotional Inhibition Scale (EIS), Social Constraint Scales (SCS), Family APGAR Index (APGAR), and the Hospital Anxiety and Depression Scale (HADS).

Study on rehabilitation effect of continuous nursing on patients with dysphagia in acute cerebral infarction.

This study aims to investigate the impact of continuous care on the rehabilitation outcomes of patients with acute cerebral infarction accompanied by dysphagia. This retrospective study involved 119 patients with acute cerebral infarction and dysphagia admitted to Wuhan No. 4 Hospital from June 2022 to December 2023.

Investigation of the Enhancement Effect of Coloading of Compounds with Different Hydrophobicities on the Stability of a Phospholipid/Bile Salt Mixed Micellar System.

Bile acid salt (BAS) micellar structures containing phospholipids (PPLs) have many important applications in the field of drug delivery on account of their biocompatibility, but improving their structural stability is a crucial issue for further development. Combined with our previous findings, we hypothesized that coloading of drugs with different hydrophobicities can enhance the structural stability of the micelles. Puerarin (PUE) and tanshinone IIA (TSA) from the Chinese couplet medicines, Radix Puerariae-Salvia miltiorrhiza, were chosen as the model hydrophobic compound pair to be encapsulated into mixed micelles composed of BAS and PPL (BPMM), to form four mixed micellar systems, including blank BPMM, single-drug-carrying BPMM (namely, PUE-loaded BPMM (P-BPMM) and TSA-loaded BPMM (T-BPMM)), and coloaded BPMM (PT-BPMM).

Extracellular vesicles isolated from SphK1 inhibitor SKI II-medium restrain the migration of colorectal cancer.

Background: Colorectal cancer is a chronic disease particularly detrimental to human health. Although there have been many studies on colorectal cancer and extracellular vesicles (EVs), it is unknown whether SKI II, an inhibitor of sphingosine kinase 1 (SphK1), uses EVs as transporters to inhibit colorectal cancer migration. This research aimed to investigate whether EVs, which were isolated from SphK1 inhibitor SKI II-medium, affected on E-cadherin and vimentin and the cell migration of colorectal cancer cells.

Robust S3Former deep learning model for the direct diagnosis and prediction of natural organic matter (NOM) from three-dimensional excitation-emission-matrix (3D-EEM) data.

The non-destructive, three-dimensional excitation-emission matrix (3D-EEM) based on fluorescence spectroscopy has been widely used in natural organic matter (NOM) monitoring in aquatic environments. However, the direct recognition of the species and concentration of NOM from 3D-EEM data remains challenging, especially under more complex scenarios such as in NOM mixtures and during ultrafiltration. In this work, first, we constructed a 3D-EEM spectral dataset for multi-task learning under various conditions.

Chronic exposure to environmental concentrations of 6PPDQ induces neurotoxicity via perturbing multiple neurotransmission pathways in zebrafish.

Previous research has demonstrated acute toxicity of 6PPD-quinone (6PPDQ), the ozonation product of tire-manufacturing additive 6PPD; however, chronic effects on aquatic organisms under real-world conditions remain unclear. We exposed 2-month-old zebrafish to 6PPDQ at concentrations of 2, 20 and 200 µg/L for 30 days. Whole-body desorption electrospray ionization-mass spectrometry (DESI-MS) revealed accumulation mainly in the muscle, abdomen, and brain of zebrafish exposed to 200 µg/L 6PPDQ, which was verified by MS quantification of muscle and brain tissues.

Positive Collaboration in Rehabilitation Nursing Enhances Fall Efficacy and Confidence in Elderly Patients with Cerebral Infarction.

Background: Cerebral infarction is a prevalent disabling condition among the elderly, often leading to limb dysfunction and psychological challenges that significantly impair quality of life. Traditional nursing approaches have primarily focused on physical rehabilitation; however, growing evidence highlights the importance of psychological factors-such as emotional well-being and rehabilitation confidence-in influencing recovery outcomes. Positive collaboration in rehabilitation nursing, which involves coordinated efforts among patients, healthcare providers, and family members, has emerged as a holistic approach to enhance both physical and psychological recovery.

Individual cardiorespiratory fitness exercise prescription for older adults based on a back-propagation neural network.

Introduction: To explore and develop a backpropagation neural network-based model for predicting and generating exercise prescriptions for improving cardiorespiratory fitness in older adults.

Methods: The model is based on data from 68 screened studies. In addition, the model was validated with 64 older adults aged 60-79 years.

Clinical evaluation of personalized treatment guided by PCR detection from fecal samples: a real-world study.

Background: Growing antibiotic resistance in () diminishes eradication therapy effectiveness, emphasizing the need for accurate, non-invasive diagnostic techniques. This study aims to assess the clinical utility of PCR analysis of fecal samples for detecting antibiotic resistance in guiding personalized treatment for infection.

Methods: A retrospective, observational study was conducted across 13 hospitals within Jiangsu Province.

Occurrence and human exposure assessment of PFAS in river and groundwater around a closed fluorochemical plant in China.

Studies have demonstrated that point source emissions constitute the main direct source of PFASs in water. However, if production/usage and emission from a specific point are stopped, does the point source still present a threat to surrounding waters? In this study, the occurrence and potential human exposure to 17 PFASs in the surrounding ambient river and ground/drinking water within a 13 km around the facility were assessed. Of the 17 PFASs analyzed, 11 were frequently detected in river and groundwater samples, with perfluorobutane sulfonate (PFBS) (36.

A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus.

Current thrombolytic therapies primarily function by converting plasminogen into plasmin, a process dependent on the fibrin-activator complex. This dependence, coupled with the substantial molecular size of plasmin, constrains its effectiveness in degrading D-dimer and restricts its diffusion within thrombi. Here, we introduce a small facultative plasminogen-independent thrombolytic enzyme, snFPITE, isolated from Sipunculus nudus.

Exercise Improves the Cytoskeletal and Metabolic Functions of Brown Adipocytes Through the ADRβ3/COX2-Ywhah Axis.

Brown adipose tissue (BAT) is a critical target for obesity treatment, and exercise can enhance BAT function through the activation of ADRβ3. However, the molecular mechanisms underlying BAT metabolism following the exercise-induced activation of ADRβ3 remain unclear. This study utilized RNA sequencing, Western blotting, Oil Red O staining, weighted gene co-expression network analysis (WGCNA), and machine learning to investigate the role of the ADRβ3-COX2 pathway in lipid metabolism in brown adipocytes.

V-O-Ru Heterogeneous Interphase Reversible Reconstruction Endowing ZnVO·7.4HO/0.65RuO Cathode Robust H/Zn Storage.

Intercalation-type layered vanadium oxides have been widely explored as cathode materials for aqueous zinc-ion batteries (AZIBs). However, attaining both high power density and superior stability remains a formidable challenge. Herein, layered vanadium oxides are pre-intercalated with Zn to form ZnVO·7.

Branched-Chain Amino Acid Supplementation Enhances Substrate Metabolism, Exercise Efficiency and Reduces Post-Exercise Fatigue in Active Young Males.

Branched-chain amino acids (BCAAs, isoleucine, leucine, and valine) are commonly applied to promote muscle protein synthesis. However, the effects of BCAAs on exercise-induced substrate metabolism, performance and post-exercise fatigue during endurance exercise remain unclear. In a double-blind cross-over design, eleven active males completed 1 h of constant load exercise (CLE) at 60% VOmax power followed by a time to exhaustion (TTE) test at 80% VOmax power after supplementation with BCAAs or placebo on consecutive three days.

FeOHSO@C Cathode with Low Strain and High Pseudocapacitance for Advanced Potassium-Ion Batteries.

Iron-based polyanionic cathode materials in potassium-ion batteries (KIBs) have appealed to an increasing number of interest due to these advantages of low cost, environmental friendliness and excellent structural stability. However, these inherent drawbacks of inferior electronic conductivity and terrible nanostructural stability hinder its practical application. Here, we report a novel low-strain iron-based polyanion-type cathode material FeOHSO@C for KIBs.

Development of Fluorophilic Magnetic Adsorbents with Ultrahigh Adsorption Capacity from Red Mud: Defluorination Behavior and Mechanisms.

To address the low fluoride (F) adsorption capacity of red mud (RM)-based adsorbents, a novel Mn-coated RM adsorbent (Mn-RM) was prepared by Mn loading from red mud. Mn-RM features a 3D heteropolyhedral structure, which provides abundant functional groups for F adsorption. The maximum equilibrium adsorption capacity ( ) of Mn-RM for F is 141.

Intermittent Theta Burst Stimulation Over Cerebellum Facilitates Neurological Recovery in Poststroke Depression via the cAMP/PKA/CREB Pathway.

Background: Stroke causes somatic dysfunction and psychological disorders, leading to poststroke depression (PSD). This study investigates mood alterations in PSD models via cerebellar intermittent theta burst stimulation (iTBS).

Methods: PSD animal models were developed using middle cerebral artery occlusion and chronic unpredictable mild stress procedures.

A clinical data-driven machine learning approach for predicting the effectiveness of piperacillin-tazobactam in treating lower respiratory tract infections.

Background: In hospitalized patients, inadequate antibiotic dosage leading to bacterial resistance and increased antimicrobial use intensity due to overexposure to antibiotics are common problems. In the present study, we constructed a machine learning model based on patients' clinical information to predict the clinical effectiveness of Piperacillin-tazobactam (TZP) (4:1) in treating bacterial lower respiratory tract infections (LRTIs), to assist clinicians in making better clinical decisions.

Methods: We collected data from patients diagnosed with LRTIs or equivalent diagnoses admitted to the Department of Pulmonary and Critical Care Medicine at Shanghai Pudong Hospital, Shanghai, between January 1, 2021, and July 31, 2023.

Characterization of cross-resistance gene optrA-carrying Campylobacter coli.

Campylobacter is a significant foodborne pathogen causing human campylobacteriosis. The optrA gene, which encodes an ABC-F protein, confers cross-resistance to oxazolidinones and phenicols, and recent studies have identified the emergence of optrA in Campylobacter. However, detailed information of optrA- carrying C.

Readiness for Discharge, Quality of Discharge Teaching, Anxiety and Depression in Surgical Patients With Cervical Cancer: A Cross-Sectional Survey.

Purpose: This quantitative study aimed to determine whether the quality of discharge teaching, anxiety, depression, and various demographic and disease-related factors predict discharge readiness among cervical cancer surgical patients in Western Region of China.

Methods: From November 2023 to May 2024, a convenience sampling method was employed to administer a questionnaire to cervical cancer surgery patients at a tertiary Grade A specialized hospital in Xinjiang. The survey included a patient general information questionnaire, the Quality of Discharge Teaching Scale (QDTS), the Generalized Anxiety Disorder 7-item Scale (GAD-7), a questionnaire assessing the readiness for discharge of gynecological malignant tumor surgery patients under the enhanced recovery after surgery (ERAS) model, and the Patient Health Questionnaire-9 (PHQ-9).

Treating human cancer by targeting EZH2.

Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that primarily inhibits downstream gene expression by tri-methylating histone H3, which is usually overexpressed in tumors and participates in many processes such as tumor occurrence and development, invasion, migration, drug resistance, and anti-tumor immunity as an oncogene, making it an important biomarker in cancer therapy. Collectively, several transcription factors and RNAs cooperate to facilitate the elevated expression of EZH2 in cancer. Although the significance of blocking EZH2 in cancer for inhibiting cancer progression is widely recognized, the clinical application of EZH2 inhibitors continues to encounter numerous challenges.