Bloodstream Infection in a Patient with Aortic Valve Replacement: Case Report and Genomic Analysis.

is usually a commensal of the oropharynx but can occasionally cause invasive disease. Herein, we report a rare case of bacteremia in a female with a 7-year history of aortic valve replacement (AVR), who presented with persistent fever but no respiratory symptoms or valvular vegetations. Blood cultures yielded , identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and confirmed via 16S rRNA sequencing.

Current Understanding of Epithelial-Derived Alarmins in Chronic Rhinosinusitis with Nasal Polyps.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory condition characterized by persistent sinus inflammation and tissue remodeling. Epithelial-derived alarmins, including thymic stromal lymphopoietin (TSLP), interleukin-33 (IL-33), and interleukin-25 (IL-25), are critical mediators that initiate and amplify immune responses in CRSwNP. These alarmins are secreted by stressed or damaged nasal epithelial cells in response to environmental insults, such as allergens, microbial infections, pollutants, and proteases.

Federated k-means based on clusters backbone.

Federated clustering is a distributed clustering algorithm that does not require the transmission of raw data and is widely used. However, it struggles to handle Non-IID data effectively because it is difficult to obtain accurate global consistency measures under Non-Independent and Identically Distributed (Non-IID) conditions. To address this issue, we propose a federated k-means clustering algorithm based on a cluster backbone called FKmeansCB.

Histopathologic features of chronic rhinosinusitis with nasal polyps in patients from high-altitude Xizang region.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease with varying patterns across regions.

Objective: This study aims to investigate the clinical and histopathological features of CRSwNP in Xizang, a high-altitude region in China.

Materials And Methods: We retrospectively analyzed the histopathological features of CRSwNP patients from Shanghai and Xizang who underwent functional endoscopic sinus surgery (FESS) between 2017 and 2024.

Branched-Chain Amino Acid Supplementation Enhances Substrate Metabolism, Exercise Efficiency and Reduces Post-Exercise Fatigue in Active Young Males.

Branched-chain amino acids (BCAAs, isoleucine, leucine, and valine) are commonly applied to promote muscle protein synthesis. However, the effects of BCAAs on exercise-induced substrate metabolism, performance and post-exercise fatigue during endurance exercise remain unclear. In a double-blind cross-over design, eleven active males completed 1 h of constant load exercise (CLE) at 60% VOmax power followed by a time to exhaustion (TTE) test at 80% VOmax power after supplementation with BCAAs or placebo on consecutive three days.

One-Shot Secure Federated K-Means Clustering Based on Density Cores.

Federated clustering (FC) performs well in independent and identically distributed (IID) scenarios, but it does not perform well in non-IID scenarios. In addition, existing methods lack proof of strict privacy protection. To address the above issues, we propose a new secure federated k-means clustering framework to achieve better clustering results under privacy requirements.

Genomic epidemiology of ceftriaxone-resistant non-typhoidal Salmonella enterica strain in China.

Non-typhoidal Salmonella (NTS) is one of the top causes of diarrhea worldwide. Ceftriaxone is commonly recommended as the initial treatment option for Salmonella infections due to its antibacterial effectiveness. The objective of this study was to investigate the molecular epidemiological characteristics of NTS and to compare the phenotypic and genotypic profiles of antimicrobial resistance in multidrug-resistant Salmonella strains by sequencing 329 NTS strains collected from a county-level hospital between 2018 and 2021.

Machine learning models to predict 30-day mortality for critical patients with myocardial infarction: a retrospective analysis from MIMIC-IV database.

Background: The identification of efficient predictors for short-term mortality among patients with myocardial infarction (MI) in coronary care units (CCU) remains a challenge. This study seeks to investigate the potential of machine learning (ML) to improve risk prediction and develop a predictive model specifically tailored for 30-day mortality in critical MI patients.

Method: This study focused on MI patients extracted from the Medical Information Mart for Intensive Care-IV database.

Case Study and Genomic Analysis of a Hypervirulent ST25 Strain in a Liver Cirrhosis Patient.

Bloodstream infections (BSIs) caused by () are associated with high morbidity and mortality rates. This study presents a sequence type 25 (ST25) strain of hypermucoid A1 isolated from the blood of a patient with liver cirrhosis (LC) who succumbed to severe infections. We performed whole-genome sequencing of A1, which revealed virulence factors and antibiotic resistance genes.

HDAC5 deacetylates c-Myc and facilitates cell cycle progression in hepatocellular carcinoma cells.

Histone deacetylase 5 (HDAC5) is an enzyme that deacetylates lysine residues on the N-terminal of histones and other proteins. It has been reported that HDAC5 deacetylates p53, the critical factor regulating cell cycle, in response to cellular stress, but the transcriptional products haven't been identified. Herein, we used p53 signaling pathway qPCR-chip to determine how HDAC5-mediated deacetylation of p53 affects cell cycle.

The validity and reliability of the My Jump 2 app for measuring vertical stiffness in male college players.

Background: Vertical stiffness (K) can be used to evaluate sports performance and injury risk in players. The My Jump 2 smartphone application (App), is increasingly being used by researchers, coaches, and players in the competitive sports field. We aimed to analyze the reliability and concurrent validity of the My Jump 2 app for measuring K in male college players.

Esculetin Alleviates IL-1β-Evoked Nucleus Pulposus Cell Death, Extracellular Matrix Remodeling, and Inflammation by Activating Nrf2/HO-1/NF-kb.

Inflammation, extracellular matrix metabolic dysfunction, and oxidative stress are key pathogenic characteristics of intervertebral disk degeneration (IVDD), a major pathogenic cause of low back pain. Esculetin possesses anti-injury, anti-inflammation, and antinociceptive properties. This study aimed to explore its role in IVDD.

Genomic and epidemiological characterization of a bla-carrying ST34 Salmonella enterica serotype Typhimurium in China.

Objectives: Consuming contaminated food and water is a leading cause of food poisoning, with Salmonella being one of the primary culprits. The aim of this study is to elucidate the genomic characteristics of a bla-carrying S. enterica strain recovered from a patient with diarrhoea in China.

Age-Related Effect of Uric Acid on Contrast-Induced Acute Kidney Injury of Patients Undergoing Coronary Angiography.

Background: The association between uric acid (UA) and contrast-induced acute kidney injury (CI-AKI) following coronary angiography (CAG) has been established. However, whether the association would vary with age remained undetermined.

Methods: We performed the retrospective analysis based on the Cardio-renal Improvement II study, (ClinicalTrials.

Bacteremia in an Immunocompetent Patient with SARS-CoV-2 Infection: A Case Report.

We report a case of bacteremia in a 73-year-old patient with SARS-CoV-2 infection and right lower abdominal tenderness in China. The microbiological features and genomic epidemiological characteristics of worldwide were investigated to identify the possible sources of infection. Whole-genome sequencing of WD-I2 was performed using an Illumina NovaSeq 6000 platform.

Bacteremia Caused by a Serotype Ob5 Vibrio cholerae Strain in a Cirrhotic Patient in China.

The increasing incidence of non-O1/non-O139 Vibrio cholerae (NOVC) has been observed worldwide. However, septicemia caused by NOVC remains a rare condition that has received limited attention. Currently, there are no established treatment guidelines for bloodstream infections caused by NOVC, and the understanding of this condition mainly relies on individual case reports.

Adaptive Density Spatial Clustering Method Fusing Chameleon Swarm Algorithm.

The density-based spatial clustering of application with noise (DBSCAN) algorithm is able to cluster arbitrarily structured datasets. However, the clustering result of this algorithm is exceptionally sensitive to the neighborhood radius () and noise points, and it is hard to obtain the best result quickly and accurately with it. To solve the above problems, we propose an adaptive DBSCAN method based on the chameleon swarm algorithm (CSA-DBSCAN).

TRIM55 inhibits colorectal cancer development via enhancing protein degradation of c-Myc.

Background: Colorectal cancer (CRC) is one of the most common and lethal malignancies which including colon and rectum cancer. Tripartite motif containing 55 (TRIM55) is an E3 ubiquitin ligase belonging to the TRIM family. Although the aberrant TRIM55 expression has been implicated in several tumors, its functional role, and molecular mechanisms in CRC remain unknown.

E2F1 promotes cell cycle progression by stabilizing spindle fiber in colorectal cancer cells.

Background: E2F1 is a transcription factor that regulates cell cycle progression. It is highly expressed in most cancer cells and activates transcription of cell cycle-related kinases. Stathmin1 and transforming acidic coiled-coil-containing protein 3 (TACC3) are factors that enhance the stability of spindle fiber.

Emergence of a Multidrug-Resistant Co-Carrying a New Variant and Genes Recovered from a Urinary Tract Infection.

Background: Carbapenem-resistant Enterobacterales (CRE) are a significant threat to worldwide public health, resulting in increased morbidity, death, hospitalization time and healthcare expenses. Here, the genomic and phylogenetic characteristics of a multidrug-resistant isolate carrying both the new variant and gene obtained from a urinary tract infection in China are investigated.

Methods: Antimicrobial susceptibility of 779 was evaluated by using the broth microdilution method.

MicroRNA-139-5p inhibits inflammatory and oxidative stress responses of Salmonella-infected macrophages through modulating TRAF6.

Evidence indicates that macrophages play an important role in the immune system. Therefore, research involving inflammatory and oxidative stress responses in macrophages is of great significance. Many factors contribute to inflammation and oxidative stress, including Salmonella.

LatinPSO: An algorithm for simultaneously inferring structure and parameters of ordinary differential equations models.

Simultaneously inferring both the structure and parameters of Ordinary Differential Equations (ODEs) for a complex dynamic system is more practical in many systems identification problems, but it remains challenging due to the complexity of the underlying search space. In this research, we propose a novel algorithm based on Particle Swarm Optimization (PSO) and Latin Hypercube Sampling (LHS) to address the above problem. The proposed algorithm is termed LatinPSO, and it can be effectively used for inferring the structure and parameters of ODE models through time course data.

Density propagation based adaptive multi-density clustering algorithm.

The performance of density based clustering algorithms may be greatly influenced by the chosen parameter values, and achieving optimal or near optimal results very much depends on empirical knowledge obtained from previous experiments. To address this limitation, we propose a novel density based clustering algorithm called the Density Propagation based Adaptive Multi-density clustering (DPAM) algorithm. DPAM can adaptively cluster spatial data.