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This study aims to investigate the impact of continuous care on the rehabilitation outcomes of patients with acute cerebral infarction accompanied by dysphagia. This retrospective study involved 119 patients with acute cerebral infarction and dysphagia admitted to Wuhan No. 4 Hospital from June 2022 to December 2023. Patients were divided into an experimental group (n = 56) receiving standard care plus continuous care, and a control group (n = 63) receiving standard care alone. Continuous care included follow-up calls, home visits, health education, and personalized rehabilitation. Outcomes assessed included swallowing function, Barthel Index, quality of life (SF-36, Stroke-Specific Quality of Life), medication adherence, mental health, complications, and readmission rates. In the experimental group, swallowing function scores increased from 3.1 ± 1.2 at baseline to 5.0 ± 0.7 at 6 months, while the control group increased from 3.4 ± 1.3 to 4.2 ± 0.8 (P < .05). The Barthel Index in the experimental group improved from 40.5 ± 10.3 to 85.3 ± 10.7 at 6 months, compared to an increase from 41.2 ± 9.8 to 78.5 ± 12.3 in the control group (P < .05). SF-36 scores in the experimental group rose from 60.5 ± 8.1 to 75.0 ± 6.5, while the control group increased from 61.2 ± 7.9 to 68.0 ± 6.8 (P < .05). The Stroke-Specific Quality of Life scores in the experimental group increased from 100.5 ± 15.3 to 130.2 ± 10.9 at 6 months, whereas the control group increased from 101.2 ± 14.9 to 120.5 ± 12.5 (P < .05). Medication adherence significantly improved in the experimental group, with the proportion of highly adherent patients increasing from 42.9% to 80.4% (P < .001), compared to an increase from 41.1% to 62.5% in the control group (P = .02). The incidence of aspiration pneumonia significantly lower than the control group (P = .02). The readmission rate was 14.3% in the experimental group, significantly lower than 30.4% in the control group (P = .002). Additionally, anxiety and depression scores in the experimental group were significantly reduced (P < .001). Continuous care significantly improves swallowing function, activities of daily living, and mental health in patients with acute cerebral infarction and dysphagia. It also reduces complications and readmission rates, demonstrating substantial clinical value.
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http://dx.doi.org/10.1097/MD.0000000000043141 | DOI Listing |
Behav Brain Res
September 2025
Department of Pharmacology of the School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049-900, Ribeirao Preto, SP, Brazil. Electronic address:
Aims: Acute restraint stress (RS) has been reported to activate the supraoptic nucleus of the hypothalamus (SON). The aim of the present study was to evaluate the role of glutamatergic neurotransmission in the SON on autonomic [mean arterial pressure (MAP), heart rate (HR), and tail cutaneous temperature], neuroendocrine (plasma levels of corticosterone, oxytocin, and vasopressin), and behavioral responses to RS.
Methods: Male Wistar rats with bilateral SON cannulas received microinjections of NMDA or non-NMDA receptor antagonists or vehicle before restraint stress, and the effects on cardiovascular, tail temperature, hormonal, and behavioral responses were evaluated RESULTS: Microinjection of DL-AP7 or NBQX into the SON reduced MAP increases and tail temperature decreases induced by RS.
Can J Cardiol
September 2025
Division of Cardiology, Hartford HealthCare Heart and Vascular Institute, Hartford, CT, USA. Electronic address:
Post-transplant rejection surveillance remains a cornerstone of heart transplant care. Although endomyocardial biopsy (EMB) has long been the gold standard for detecting rejection, its invasive nature, interobserver variability in histologic interpretation, and limitations in distinguishing between acute cellular rejection (ACR) and antibody-mediated rejection have prompted interest in noninvasive techniques. Traditional biomarkers- such as troponin, C-reactive protein, brain natriuretic peptide, and donor-specific antibodies- offer supplementary assessments of graft function but lack the specificity and sensitivity required to be standalone markers.
View Article and Find Full Text PDFClin Exp Metastasis
September 2025
Department of Neurosurgery, Warren Alpert Medical School of Brown University, 593 Eddy Street - APC 6, Providence, RI, 02903, USA.
Significant variability exists in the use of corticosteroids for treating adverse radiation effects (ARE) after stereotactic radiosurgery (SRS) of brain metastasis (BM). Here, we determine the diagnostic utility of a quadrant-based, visual assessment of magnetic resonance (MR) FLAIR as an imaging biomarker for steroid-dependent ARE. FLAIR was assessed at four axial levels along the rostral-caudal axis of the cerebrum, defined by standard landmarks of superior temporal line, third ventricle, temporal horn, and fourth ventricle.
View Article and Find Full Text PDFNeuroscientist
September 2025
Department of Neurology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
Although intracerebral hemorrhage (ICH) and cerebral small vessel disease (cSVD) have long been considered distinct clinical entities, emerging evidence reveals significant overlap in their etiologies and imaging markers. This review aims to explore the relationship between ICH and cSVD, suggesting that ICH may represent an acute manifestation of small vessel disease. ICH is primarily caused by cerebral amyloid angiopathy and hypertension, while cSVD is mainly attributed to cerebral amyloid angiopathy and arteriolosclerosis.
View Article and Find Full Text PDFJ Am Heart Assoc
September 2025
Division of Experimental Cardiology, Department of Cardiology Erasmus MC University Medical Center Rotterdam The Netherlands.
Background: Despite successful recanalization after endovascular thrombectomy, more than half of patients with acute ischemic stroke with large-vessel occlusions experience an unsatisfactory outcome. Incomplete microvascular reperfusion may contribute to it, but its occurrence remains debated, partly due to clinical observations of hyperperfusion after recanalization. This study investigates the relationship between ischemia duration, infarct development, microclot presence, and cerebral perfusion in a swine model of focal cerebral ischemia and reperfusion.
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